Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2

Genes and Development

Volumn 15, Issue 18, 2001, Pages 2367-2380

  Sengupta, S ^a   Wasylyk, B ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Bax; Endothelial cells; G6Pase; Hypoxia; P21WAF1 CIP1; PEPCK

Indexed keywords

DEXAMETHASONE; DNA; GENE PRODUCT; GLUCOCORTICOID RECEPTOR; LIGAND; LIGASE; MITOMYCIN C; PROTEASOME; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME ACTIVITY; FORCE; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; STRESS; TUMOR SUPPRESSOR GENE;

CELLS, CULTURED; CYTOPLASM; DEXAMETHASONE; HUMANS; HYDROLYSIS; LIGANDS; MITOMYCIN; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTORS, GLUCOCORTICOID; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035883863     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.202201     Document Type: Article

References (78)

1. Stabilization of wildtype p53 by hypoxia-inducible factor 1α
2. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: Gene structure and 5′-flanking sequence
3. The contribution of the RING finger domain of MDM2 to cell cycle progression
4. Regulation of endothelial nitric-oxide synthase during hypoxia
5. Stress signals utilize multiple pathways to stabilize p53
6. Predominant localization of phosphoenolpyruvate carboxykinase mRNA in the periportal zone of rat liver parenchyma demonstrated by in situ hybridization
7. The glucocorticoid receptor is required for stress erythropoiesis
8. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
9. Distinct TFIID complexes mediate the effect of different transcriptional activators
10. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
11. Redox regulation of p53 during hypoxia
12. Dexamethasone suppresses apoptosis in a human gastric cancer cell line through modulation of bcl-x gene expression
13. High-efficiency transformation of mammalian cells by plasmid DNA
14. Mapping of the p53 and mdm-2 interaction domains
15. Molecular chaperone interactions with steroid receptors: An update
16. CTS1: A p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties
17. Multiple epithelial cell-derived factors enhance neutrophil survival. Regulation by glucocorticoids and tumor necrosis factor-alpha
18. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
19. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
20. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
21. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
22. A transcriptionally active DNA-binding site for human p53 protein complexes
23. Acute hypoxia upregulates NOS gene expression in rats
24. The MDM2 RING-finger domain is required to promote p53 nuclear export
25. Dexamethasone induced proliferation of cultured retinal pigment epithelial cells
26. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
27. Glucocorticoids inhibit serum depletion-induced apoptosis in T lymphocytes expressing Bcl-2
28. The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function
29. Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene
30. MdmX protects p53 from Mdm2-mediated degradation
31. Hypoxic effects on the expression of mineralocorticoid and glucocorticoid receptors in human renal cortex epithelial cells
32. p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
33. The Mdm2 oncoprotein interacts with the cell fate regulator Numb
34. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
35. Mutagenesis of the glucocorticoid receptor in mice
36. Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
37. Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment
38. Regulation of p53 in response to DNA damage
39. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: Regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP
40. Enhanced proliferation of human fibroblasts, in the presence of dexamethasone, is accompanied by changes in p21Waf1/Cip1/Sdi1 and the insulin-like growth factor type 1 receptor
41. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
42. p53 down-regulates ER-responsive genes by interfering with the binding of ER to ERE
43. Estrogen receptor protects p53 from deactivation by human double minute-2
44. Apoptotic and growth-promoting activity of E2F modulated by MDM2
45. Nuclear exclusion of p53 in a subset of tumors requires MDM2 function
46. Apoptosis and cancer: The failure of controls on cell death and cell survival
47. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
48. Estradiol induces functional inactivation of p53 by intracellular redistribution
49. Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage
50. Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas
51. Modulations of glucocorticoid-induced apoptosis linked to the p53 deletion and to the apoptosis susceptibility gene Rapop1
52. Mechanism of gluconeogenesis inhibition in rat hepatocytes isolated after in vivo hypoxia
53. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
54. Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock
55. Cellular physiology and molecular events in hypoxia-induced apoptosis
56. Glucocorticoids protect against apoptosis induced by serum deprivation, cyclic adenosine 3′,5′-monophosphate and p53 activation in immortalized human granulosa cells: Involvement of Bcl-2
57. The function of steroid hormone receptors is inhibited by the hsp90-specific compound geldanamycin
58. Tumour regression in a ligand inducible manner mediated by a chimeric tumour suppressor derived from p53
59. Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells
60. The ARF/p53 pathway
61. The cellular response to p53: The decision between life and death
62. Hdmx stabilizes Mdm2 and p53
63. Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis
64. A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
65. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
66. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
67. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
68. An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53
69. Precise epitope mapping of the murine transformation-associated protein, p53
70. NIH 3T3 cells malignantly transformed by mot-2 show inactivation and cytoplasmic sequestration of the p53 protein
71. p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
72. Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells
73. Involvement of 3′,5′-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene
74. Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents
75. Inhibition by dexamethasone of transforming growth factor β 1-induced apoptosis in rat hepatoma cells: A possible association with Bcl-xL induction
76. MDM2-dependent ubiquitination of nuclear and cytoplasmic P53
77. Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation
78. Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues