-
1
-
-
0028098165
-
Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
-
Cordon-Cardo, C., Latres, E., Drobnjak, M., Oliva, M. R., Pollack, D., Woodruff, J. M., Marechal, V., Chen, J., Brennan, M. F., and Levine, A. J. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res., 54: 794-799, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 794-799
-
-
Cordon-Cardo, C.1
Latres, E.2
Drobnjak, M.3
Oliva, M.R.4
Pollack, D.5
Woodruff, J.M.6
Marechal, V.7
Chen, J.8
Brennan, M.F.9
Levine, A.J.10
-
2
-
-
0036157247
-
Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods
-
Lu, M. L., Wikman, F., Omtoft, T. F., Charytonowicz, E., Rabbani, F., Zhang, Z., Dalbagni, G., Pohar, K. S., Yu, G., and Cordon-Cardo, C. Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods. Clin. Cancer Res., 8: 171-179, 2002.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 171-179
-
-
Lu, M.L.1
Wikman, F.2
Omtoft, T.F.3
Charytonowicz, E.4
Rabbani, F.5
Zhang, Z.6
Dalbagni, G.7
Pohar, K.S.8
Yu, G.9
Cordon-Cardo, C.10
-
3
-
-
0036655060
-
Alternative and aberrant splicing of MDM2 mRNA in human cancer
-
Bartel, F., Taubert, H., and Harris, L. C. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell, 2: 9-15, 2002.
-
(2002)
Cancer Cell
, vol.2
, pp. 9-15
-
-
Bartel, F.1
Taubert, H.2
Harris, L.C.3
-
4
-
-
0037443035
-
Pre-mRNA splicing and human disease
-
Faustino, N. A. and Cooper, T. A. Pre-mRNA splicing and human disease. Genes Dev., 17: 419-437, 2003.
-
(2003)
Genes Dev.
, vol.17
, pp. 419-437
-
-
Faustino, N.A.1
Cooper, T.A.2
-
5
-
-
14444281159
-
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53
-
Lundgren, K., Montes de Oca Luna, R., McNeill, Y. B., Emerick, E. P., Spencer, B., Barfield, C. R., Lozano, G., Rosenberg, M. P., and Finlay, C. A. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev., 11: 714-725, 1997.
-
(1997)
Genes Dev.
, vol.11
, pp. 714-725
-
-
Lundgren, K.1
Montes De Oca Luna, R.2
McNeill, Y.B.3
Emerick, E.P.4
Spencer, B.5
Barfield, C.R.6
Lozano, G.7
Rosenberg, M.P.8
Finlay, C.A.9
-
6
-
-
0032989098
-
Overproduction of MDM2 in vivo disrupts S phase independent of E2F1
-
Reinke, V., Bortner, D. M., Amelse, L. L., Lundgren, K., Rosenberg, M. P., Finlay, C. A., and Lozano, G. Overproduction of MDM2 in vivo disrupts S phase independent of E2F1. Cell Growth & Differ., 10: 147-154, 1999.
-
(1999)
Cell Growth & Differ.
, vol.10
, pp. 147-154
-
-
Reinke, V.1
Bortner, D.M.2
Amelse, L.L.3
Lundgren, K.4
Rosenberg, M.P.5
Finlay, C.A.6
Lozano, G.7
-
7
-
-
0032417695
-
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
-
Jones, S. N., Hancock, A. R., Vogel, H., Donehower, L. A., and Bradley, A. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc. Natl. Acad. Sci. USA, 95: 15608-15612, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15608-15612
-
-
Jones, S.N.1
Hancock, A.R.2
Vogel, H.3
Donehower, L.A.4
Bradley, A.5
-
8
-
-
0033580236
-
MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice
-
Alkhalaf, M., Ganguli, G., Messaddeq, N., Le Meur, M., and Wasylyk, B. MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene, 18: 1419-1434, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 1419-1434
-
-
Alkhalaf, M.1
Ganguli, G.2
Messaddeq, N.3
Le Meur, M.4
Wasylyk, B.5
-
9
-
-
0034596987
-
MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis
-
Ganguli, G., Abecassis, J., and Wasylyk, B. MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. EMBO J., 19: 5135-5147, 2000.
-
(2000)
EMBO J.
, vol.19
, pp. 5135-5147
-
-
Ganguli, G.1
Abecassis, J.2
Wasylyk, B.3
-
10
-
-
0030892531
-
MDM-2 protein is expressed in different layers of normal human skin
-
Dazard, J. E., Augias, D., Neel, H., Mils, V., Marechal, V., Basset-Seguin, N., and Piette, J. MDM-2 protein is expressed in different layers of normal human skin. Oncogene, 14: 1123-1128, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 1123-1128
-
-
Dazard, J.E.1
Augias, D.2
Neel, H.3
Mils, V.4
Marechal, V.5
Basset-Seguin, N.6
Piette, J.7
-
11
-
-
0029743891
-
Amplification of MDM2 inhibits MyoD-mediated myogenesis
-
Fiddler, T. A., Smith, L., Tapscott, S. J., and Thayer, M. J. Amplification of MDM2 inhibits MyoD-mediated myogenesis. Mol. Cell. Biol., 16: 5048-5057, 1996.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5048-5057
-
-
Fiddler, T.A.1
Smith, L.2
Tapscott, S.J.3
Thayer, M.J.4
-
12
-
-
0030791113
-
Involvement of p53 in cell differentiation and development
-
Almog, N. and Rotter, V. Involvement of p53 in cell differentiation and development. Biochim. Biophys. Acta, 1333: F1-F27, 1997.
-
(1997)
Biochim. Biophys. Acta
, vol.1333
-
-
Almog, N.1
Rotter, V.2
-
13
-
-
0033594491
-
p63 is a p53 homologue required for limb and epidermal morphogenesis
-
Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., and Bradley, A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature, 398: 708-713, 1999.
-
(1999)
Nature
, vol.398
, pp. 708-713
-
-
Mills, A.A.1
Zheng, B.2
Wang, X.J.3
Vogel, H.4
Roop, D.R.5
Bradley, A.6
-
14
-
-
0033594485
-
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
-
Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C., Sharpe, A., Caput, D., Crum, C., and McKeon, F. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature, 398: 714-718, 1999.
-
(1999)
Nature
, vol.398
, pp. 714-718
-
-
Yang, A.1
Schweitzer, R.2
Sun, D.3
Kaghad, M.4
Walker, N.5
Bronson, R.T.6
Tabin, C.7
Sharpe, A.8
Caput, D.9
Crum, C.10
McKeon, F.11
-
15
-
-
0033372016
-
Association of p63 with proliferative potential in normal and neoplastic human keratinocytes
-
Parsa, R., Yang, A., McKeon, F., and Green, H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J. Invest. Dermatol., 113: 1099-1105, 1999.
-
(1999)
J. Invest. Dermatol.
, vol.113
, pp. 1099-1105
-
-
Parsa, R.1
Yang, A.2
McKeon, F.3
Green, H.4
-
16
-
-
0029057464
-
p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein
-
Weinberg, W. C., Azzoli, C. G., Chapman, K., Levine, A. J., and Yuspa, S. H. p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. Oncogene, 10: 2271-2279, 1995.
-
(1995)
Oncogene
, vol.10
, pp. 2271-2279
-
-
Weinberg, W.C.1
Azzoli, C.G.2
Chapman, K.3
Levine, A.J.4
Yuspa, S.H.5
-
17
-
-
0027528673
-
High levels of p53 protein in UV-irradiated normal human skin
-
Hall, P. A., McKee, P. H., Menage, H. D., Dover, R., and Lane, D. P. High levels of p53 protein in UV-irradiated normal human skin. Oncogene, 8: 203-207, 1993.
-
(1993)
Oncogene
, vol.8
, pp. 203-207
-
-
Hall, P.A.1
McKee, P.H.2
Menage, H.D.3
Dover, R.4
Lane, D.P.5
-
18
-
-
0032102824
-
MDM2 expression during mouse embryogenesis and the requirement of p53
-
Leveitlard, T., Gorry, P., Niederreither, K., and Wasylyk, B. MDM2 expression during mouse embryogenesis and the requirement of p53. Mech. Dev., 74: 189-193, 1998.
-
(1998)
Mech. Dev.
, vol.74
, pp. 189-193
-
-
Leveitlard, T.1
Gorry, P.2
Niederreither, K.3
Wasylyk, B.4
-
19
-
-
0032893878
-
Regulation of the p53 protein by the MDM2 oncoprotein - Thirty-eighth G.H.A. Clowes Memorial Award Lecture
-
Freedman, D. A. and Levine, A. J. Regulation of the p53 protein by the MDM2 oncoprotein - thirty-eighth G.H.A. Clowes Memorial Award Lecture. Cancer Res., 59: 1-7, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 1-7
-
-
Freedman, D.A.1
Levine, A.J.2
-
20
-
-
0030777230
-
The mdm2 proto-oncogene
-
Haines, D. S. The mdm2 proto-oncogene. Leuk. Lymphoma, 26: 227-238, 1997.
-
(1997)
Leuk. Lymphoma
, vol.26
, pp. 227-238
-
-
Haines, D.S.1
-
21
-
-
0032952004
-
Mdm2: The ups and downs
-
Juven-Gershon, T. and Oren, M. Mdm2: the ups and downs. Mol. Med., 5: 71-83, 1999.
-
(1999)
Mol. Med.
, vol.5
, pp. 71-83
-
-
Juven-Gershon, T.1
Oren, M.2
-
22
-
-
0033959744
-
MDM2 - Master regulator of the p53 tumor suppressor protein
-
Momand, J., Wu, H. H., and Dasgupta, G. MDM2 - master regulator of the p53 tumor suppressor protein. Gene, 242: 15-29, 2000.
-
(2000)
Gene
, vol.242
, pp. 15-29
-
-
Momand, J.1
Wu, H.H.2
Dasgupta, G.3
-
23
-
-
0030800922
-
Mdm2: Keeping p53 under control
-
Piette, J., Neel, H., and Marechal, V. Mdm2: keeping p53 under control. Oncogene, 15: 1001-1010, 1997.
-
(1997)
Oncogene
, vol.15
, pp. 1001-1010
-
-
Piette, J.1
Neel, H.2
Marechal, V.3
-
24
-
-
0032475878
-
Signaling to p53: Breaking the MDM2-p53 circuit
-
Prives, C. Signaling to p53: breaking the MDM2-p53 circuit. Cell, 95: 5-8, 1998.
-
(1998)
Cell
, vol.95
, pp. 5-8
-
-
Prives, C.1
-
25
-
-
0031828874
-
p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes
-
Tron, V. A., Trotter, M. J., Tang, L., Krajewska, M., Reed, J. C., Ho, V. C., and Li, G. p53-regulated apoptosis is differentiation dependent in ultraviolet B-irradiated mouse keratinocytes. Am. J. Pathol., 153: 579-585, 1998.
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 579-585
-
-
Tron, V.A.1
Trotter, M.J.2
Tang, L.3
Krajewska, M.4
Reed, J.C.5
Ho, V.C.6
Li, G.7
-
26
-
-
0031857331
-
p53-dependent regulation of nucleotide excision repair in murine epidermis in vivo
-
Tron, V. A., Trotter, M. J., Ishikawa, T., Ho, V. C., and Li, G. p53-dependent regulation of nucleotide excision repair in murine epidermis in vivo. J. Cutan. Med. Surg., 3: 16-20, 1998.
-
(1998)
J. Cutan. Med. Surg.
, vol.3
, pp. 16-20
-
-
Tron, V.A.1
Trotter, M.J.2
Ishikawa, T.3
Ho, V.C.4
Li, G.5
-
27
-
-
0032864278
-
Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction
-
Song, S. and Lambert, P. F. Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction. Am. J. Pathol., 155: 1121-1127, 1999.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1121-1127
-
-
Song, S.1
Lambert, P.F.2
-
28
-
-
0029590161
-
MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest
-
Dubs-Poterszman, M. C., Tocque, B., and Wasylyk, B. MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest. Oncogene, 11: 2445-2449, 1995.
-
(1995)
Oncogene
, vol.11
, pp. 2445-2449
-
-
Dubs-Poterszman, M.C.1
Tocque, B.2
Wasylyk, B.3
-
30
-
-
0037590194
-
Regulation of MyoD activity and muscle cell differentiation by MDM2, pRb, and Spl
-
Guo, C. S., Degnin, C., Fiddler, T. A., Stauffer, D., and Thayer, M. J. Regulation of MyoD activity and muscle cell differentiation by MDM2, pRb, and Spl. J. Biol. Chem., 278: 22615-22622, 2003.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22615-22622
-
-
Guo, C.S.1
Degnin, C.2
Fiddler, T.A.3
Stauffer, D.4
Thayer, M.J.5
-
31
-
-
0032080297
-
The human oncoprotein MDM2 arrests the cell cycle: Elimination of its cell-cycle-inhibitory function induces tumorigenesis
-
Brown, D. R., Thomas, C. A., and Deb, S. P. The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis. EMBO J., 17: 2513-2525, 1998.
-
(1998)
EMBO J.
, vol.17
, pp. 2513-2525
-
-
Brown, D.R.1
Thomas, C.A.2
Deb, S.P.3
-
32
-
-
0345824732
-
Cell Cycle Regulatory Functions of the Human Oncoprotein MDM2
-
Deb, S. P. Cell Cycle Regulatory Functions of the Human Oncoprotein MDM2. Mol. Cancer Res., 1: 1009-1016.
-
Mol. Cancer Res.
, vol.1
, pp. 1009-1016
-
-
Deb, S.P.1
-
33
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao, Z. X., Chen, J., Levine, A. J., Modjtahedi, N., Xing, J., Sellers, W. R., and Livingston, D. M. Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature, 375: 694-698, 1995.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
Chen, J.2
Levine, A.J.3
Modjtahedi, N.4
Xing, J.5
Sellers, W.R.6
Livingston, D.M.7
-
34
-
-
0033082231
-
RB regulates the stability and the apoptotic function of p53 via MDM2
-
Hsieh, J. K., Chan, F. S., O'Connor, D. J., Mittnacht, S., Zhong, S., and Lu, X. RB regulates the stability and the apoptotic function of p53 via MDM2. Mol. Cell, 3: 181-193, 1999.
-
(1999)
Mol. Cell
, vol.3
, pp. 181-193
-
-
Hsieh, J.K.1
Chan, F.S.2
O'Connor, D.J.3
Mittnacht, S.4
Zhong, S.5
Lu, X.6
-
35
-
-
0029028353
-
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein
-
Martin, K., Trouche, D., Hagemeier, C., Sorensen, T. S., La Thangue, N. B., and Kouzarides, T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature, 375: 691-694, 1995.
-
(1995)
Nature
, vol.375
, pp. 691-694
-
-
Martin, K.1
Trouche, D.2
Hagemeier, C.3
Sorensen, T.S.4
La Thangue, N.B.5
Kouzarides, T.6
-
36
-
-
0033998439
-
Apoptotic and growth-promoting activity of E2F modulated by MDM2
-
Loughran, O. and La Thangue, N. B. Apoptotic and growth-promoting activity of E2F modulated by MDM2. Mol. Cell. Biol., 20: 2186-2197, 2000.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2186-2197
-
-
Loughran, O.1
La Thangue, N.B.2
-
37
-
-
0031992159
-
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
-
Kowalik, T. F., DeGregori, J., Leone, G., Jakoi, L., and Nevins, J. R. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth & Differ., 9: 113-118, 1998.
-
(1998)
Cell Growth & Differ.
, vol.9
, pp. 113-118
-
-
Kowalik, T.F.1
DeGregori, J.2
Leone, G.3
Jakoi, L.4
Nevins, J.R.5
-
38
-
-
0032939925
-
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
-
Blattner, C., Sparks, A., and Lane, D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol. Cell. Biol., 19: 3704-3713, 1999.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3704-3713
-
-
Blattner, C.1
Sparks, A.2
Lane, D.3
-
39
-
-
0037182756
-
Mdm2 inhibition of p53 induces E2F1 transactivation via p21
-
Wunderlich, M. and Berberich, S. J. Mdm2 inhibition of p53 induces E2F1 transactivation via p21. Oncogene, 21: 4414-4421, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 4414-4421
-
-
Wunderlich, M.1
Berberich, S.J.2
-
40
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts, A., Steegenga, W. T., Riteco, N., van Laar, T., Dekker, P., Bazuine, M., van Ham, R. C., van der Houven van Oordt, W., Hateboer, G., van der Eb, A. J., and Jochemsen, A. G. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J., 15: 5349-5357, 1996.
-
(1996)
EMBO J.
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
Van Laar, T.4
Dekker, P.5
Bazuine, M.6
Van Ham, R.C.7
Van Der Houven Van Oordt, W.8
Hateboer, G.9
Van Der Eb, A.J.10
Jochemsen, A.G.11
-
41
-
-
0031194666
-
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx
-
Shvarts, A., Bazuine, M., Dekker, P., Ramos, Y. F., Steegenga, W. T., Merckx, G., van Ham, R. C., van der Houven van Oordt, W., van der Eb, A. J., and Jochemsen, A. G. Isolation and identification of the human homolog of a new p53-binding protein, Mdmx. Genomics, 43: 34-42, 1997.
-
(1997)
Genomics
, vol.43
, pp. 34-42
-
-
Shvarts, A.1
Bazuine, M.2
Dekker, P.3
Ramos, Y.F.4
Steegenga, W.T.5
Merckx, G.6
Van Ham, R.C.7
Van Der Houven Van Oordt, W.8
Van Der Eb, A.J.9
Jochemsen, A.G.10
-
42
-
-
0036606416
-
mdmx is a negative regulator of p53 activity in vivo
-
Finch, R. A., Donoviel, D. B., Potter, D., Shi, M., Fan, A., Freed, D. D., Wang, C. Y., Zambrowicz, B. P., Ramirez-Solis, R., Sands, A. T., and Zhang, N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res., 62: 3221-3225, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
Shi, M.4
Fan, A.5
Freed, D.D.6
Wang, C.Y.7
Zambrowicz, B.P.8
Ramirez-Solis, R.9
Sands, A.T.10
Zhang, N.11
-
43
-
-
0036311067
-
Mdm4 (Mdmx) rcgulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini, D., Denchi, E. L., Danovi, D., Jochcmsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., and Marine, J. C. Mdm4 (Mdmx) rcgulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol., 22: 5527-5538, 2002.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Denchi, E.L.2
Danovi, D.3
Jochcmsen, A.4
Capillo, M.5
Gobbi, A.6
Helin, K.7
Pelicci, P.G.8
Marine, J.C.9
-
44
-
-
0042405145
-
Physical and functional interactions between PML and MDM2
-
Wei, X., Yu, Z. K., Ramalingam, A., Grossman, S. R., Yu, J. H., Bloch, D. B., and Maki, C. G. Physical and functional interactions between PML and MDM2. J. Biol. Chem., 278: 29288-29297, 2003.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 29288-29297
-
-
Wei, X.1
Yu, Z.K.2
Ramalingam, A.3
Grossman, S.R.4
Yu, J.H.5
Bloch, D.B.6
Maki, C.G.7
-
45
-
-
0034644731
-
A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
-
Boyd, M. T., Vlatkovic, N., and Haines, D. S. A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J. Biol. Chem., 275: 31883-31890, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31883-31890
-
-
Boyd, M.T.1
Vlatkovic, N.2
Haines, D.S.3
-
46
-
-
0032545222
-
p53-independent role of MDM2 in TGF-β1 resistance
-
Sun, P., Dong, P., Dai, K., Hannon, G. J., and Beach, D. p53-independent role of MDM2 in TGF-β1 resistance. Science, 282: 2270-2272, 1998.
-
(1998)
Science
, vol.282
, pp. 2270-2272
-
-
Sun, P.1
Dong, P.2
Dai, K.3
Hannon, G.J.4
Beach, D.5
-
47
-
-
0034644653
-
Differcnt sensitivity of the transforming growth factor-β cell cycle arrest pathway to c-Myc and MDM-2
-
Blain, S. W. and Massague, J. Differcnt sensitivity of the transforming growth factor-β cell cycle arrest pathway to c-Myc and MDM-2. J. Biol. Chem., 275: 32066-32070, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32066-32070
-
-
Blain, S.W.1
Massague, J.2
-
48
-
-
0031835660
-
The Mdm2 oncoprotein interacts with the cell fate regulator Numb
-
Juven-Gershon, T., Shifman, O., Unger, T., Elkeles, A., Haupt, Y., and Oren, M. The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol. Cell. Biol., 18: 3974-3982, 1998.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 3974-3982
-
-
Juven-Gershon, T.1
Shifman, O.2
Unger, T.3
Elkeles, A.4
Haupt, Y.5
Oren, M.6
-
49
-
-
0037459201
-
Mammalian Numb is a target protein of Mdm2, ubiquitin ligase
-
Yogosawa, S., Miyauchi, Y., Honda, R., Tanaka, H., and Yasuda, H. Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem. Biophys. Res. Commun., 302: 869-872, 2003.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.302
, pp. 869-872
-
-
Yogosawa, S.1
Miyauchi, Y.2
Honda, R.3
Tanaka, H.4
Yasuda, H.5
-
50
-
-
0034666178
-
MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε
-
Vlatkovic, N., Guerrera, S., Li, Y., Linn, S., Haines, D. S., and Boyd, M. T. MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε. Nucleic Acids Res., 28: 3581-3586, 2000.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 3581-3586
-
-
Vlatkovic, N.1
Guerrera, S.2
Li, Y.3
Linn, S.4
Haines, D.S.5
Boyd, M.T.6
-
51
-
-
0038412776
-
Stimulation of human DNA polymerase ε by MDM2
-
Asahara, H., Li, Y., Fuss, J., Haines, D. S., Vlatkovic, N., Boyd, M. T., and Linn, S. Stimulation of human DNA polymerase ε by MDM2. Nucleic Acids Res., 31: 2451-2459, 2003.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2451-2459
-
-
Asahara, H.1
Li, Y.2
Fuss, J.3
Haines, D.S.4
Vlatkovic, N.5
Boyd, M.T.6
Linn, S.7
-
52
-
-
0029760621
-
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain
-
Elenbaas, B., Dobbelstein, M., Roth, J., Shenk, T., and Levine, A. J. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol. Med., 2: 439-451, 1996.
-
(1996)
Mol. Med.
, vol.2
, pp. 439-451
-
-
Elenbaas, B.1
Dobbelstein, M.2
Roth, J.3
Shenk, T.4
Levine, A.J.5
-
53
-
-
0027999512
-
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes
-
Marechal, V., Elenbaas, B., Piette, J., Nicolas, J. C., and Levine, A. J. The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol. Cell. Biol., 14: 7414-7420, 1994.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 7414-7420
-
-
Marechal, V.1
Elenbaas, B.2
Piette, J.3
Nicolas, J.C.4
Levine, A.J.5
-
54
-
-
0030941037
-
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis
-
Marechal, V., Elenbaas, B., Taneyhill, L., Piette, J., Mechali, M., Nicolas, J. C., Levine, A. J., and Moreau, J. Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis. Oncogene, 14: 1427-1433, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 1427-1433
-
-
Marechal, V.1
Elenbaas, B.2
Taneyhill, L.3
Piette, J.4
Mechali, M.5
Nicolas, J.C.6
Levine, A.J.7
Moreau, J.8
-
55
-
-
0033771948
-
Identification of a cryptic nucleolar-localization signal in MDM2
-
Lohrum, M. A., Ashcroft, M., Kubbutat, M. H., and Vousden, K. H. Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol., 2: 179-181, 2000.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 179-181
-
-
Lohrum, M.A.1
Ashcroft, M.2
Kubbutat, M.H.3
Vousden, K.H.4
-
56
-
-
0029862953
-
The TATA box binding protein
-
Burley, S. K. The TATA box binding protein. Curr. Opin. Struct. Biol., 6: 69-75, 1996.
-
(1996)
Curr. Opin. Struct. Biol.
, vol.6
, pp. 69-75
-
-
Burley, S.K.1
-
57
-
-
0027340097
-
Interaction between a transcriptional activator and transcription factor IIB in vivo
-
Colgan, J., Wampler, S., and Manley, J. L. Interaction between a transcriptional activator and transcription factor IIB in vivo. Nature, 362: 549-553, 1993.
-
(1993)
Nature
, vol.362
, pp. 549-553
-
-
Colgan, J.1
Wampler, S.2
Manley, J.L.3
-
58
-
-
0028932431
-
N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation
-
Leng, P., Brown, D. R., Shivakumar, C. V., Deb, S., and Deb, S. P. N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation. Oncogene, 10: 1275-1282, 1995.
-
(1995)
Oncogene
, vol.10
, pp. 1275-1282
-
-
Leng, P.1
Brown, D.R.2
Shivakumar, C.V.3
Deb, S.4
Deb, S.P.5
-
59
-
-
0027218671
-
Interaction between an acidie activator and transcription factor TFIIB is required for transcriptional activation
-
Roberts, S. G., Ha, I., Maldonado, E., Reinberg, D., and Green, M. R. Interaction between an acidie activator and transcription factor TFIIB is required for transcriptional activation. Nature, 363: 741-744, 1993.
-
(1993)
Nature
, vol.363
, pp. 741-744
-
-
Roberts, S.G.1
Ha, I.2
Maldonado, E.3
Reinberg, D.4
Green, M.R.5
-
60
-
-
1842378642
-
The MDM2 C-terminal region binds to TAF11250 and is required for MDM2 regulation of the cyclin A promoter
-
Leveillard, T. and Wasylyk, B. The MDM2 C-terminal region binds to TAF11250 and is required for MDM2 regulation of the cyclin A promoter. J. Biol. Chem., 272: 30651-30661, 1997.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30651-30661
-
-
Leveillard, T.1
Wasylyk, B.2
-
61
-
-
0032185124
-
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
-
Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z. X., Kumar, S., Howley, P. M., and Livingston, D. M. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell, 2: 405-415, 1998.
-
(1998)
Mol. Cell
, vol.2
, pp. 405-415
-
-
Grossman, S.R.1
Perez, M.2
Kung, A.L.3
Joseph, M.4
Mansur, C.5
Xiao, Z.X.6
Kumar, S.7
Howley, P.M.8
Livingston, D.M.9
-
62
-
-
0032127947
-
Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function
-
Thomas, A. and White, E. Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function. Genes Dev., 12: 1975-1985, 1998.
-
(1998)
Genes Dev.
, vol.12
, pp. 1975-1985
-
-
Thomas, A.1
White, E.2
-
63
-
-
0033928263
-
Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells
-
Wasylyk, C. and Wasylyk, B. Defect in the p53-Mdm2 autoregulatory loop resulting from inactivation of TAF(II)250 in cell cycle mutant tsBN462 cells. Mol. Cell. Biol., 20: 5554-5570, 2000.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5554-5570
-
-
Wasylyk, C.1
Wasylyk, B.2
-
64
-
-
0037470040
-
The acetylase activity of p300 is dispensable for MDM2 stabilization
-
Zeng, S. X., Jin, Y., Kuninger, D. T., Rotwein, P., and Lu, H. The acetylase activity of p300 is dispensable for MDM2 stabilization. J. Biol. Chem., 278: 7453-7458, 2003.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 7453-7458
-
-
Zeng, S.X.1
Jin, Y.2
Kuninger, D.T.3
Rotwein, P.4
Lu, H.5
-
65
-
-
0036565875
-
MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: A novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
-
Gu, L., Findley, H. W., and Zhou, M. MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia. Blood, 99: 3367-3375, 2002.
-
(2002)
Blood
, vol.99
, pp. 3367-3375
-
-
Gu, L.1
Findley, H.W.2
Zhou, M.3
-
66
-
-
0035834428
-
Regulation of receptor fate by ubiquitination of activated β2-adrenergic receptor and β-arrestin
-
Shenoy, S. K., McDonald, P. H., Kohout, T. A., and Lefkowitz, R. J. Regulation of receptor fate by ubiquitination of activated β2-adrenergic receptor and β-arrestin. Science, 294: 1307-1313, 2001.
-
(2001)
Science
, vol.294
, pp. 1307-1313
-
-
Shenoy, S.K.1
McDonald, P.H.2
Kohout, T.A.3
Lefkowitz, R.J.4
-
67
-
-
0035960759
-
β-arrestin and Mdm2, unsuspected partners in signaling from the cell surface
-
Strous, G. J. and Schantl, J. A. β-Arrestin and Mdm2, unsuspected partners in signaling from the cell surface. Sci. STKE, 110: PE41, 2001.
-
(2001)
Sci. STKE
, vol.110
-
-
Strous, G.J.1
Schantl, J.A.2
-
68
-
-
0031710479
-
The INK4a/ARF tumor suppressor: One gene-two products-two pathways
-
Chin, L., Pomerantz, J., and DePinho, R. A. The INK4a/ARF tumor suppressor: one gene-two products-two pathways. Trends Biochem. Sci., 23: 291-296, 1998.
-
(1998)
Trends Biochem. Sci.
, vol.23
, pp. 291-296
-
-
Chin, L.1
Pomerantz, J.2
DePinho, R.A.3
-
69
-
-
0032493350
-
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
-
Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., and Sherr, C. J. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. USA, 95: 8292-8297, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8292-8297
-
-
Kamijo, T.1
Weber, J.D.2
Zambetti, G.3
Zindy, F.4
Roussel, M.F.5
Sherr, C.J.6
-
70
-
-
0032549704
-
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
-
Pomerantz, J., Schreiber-Agus, N., Liegeois, N. J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H. W., Cordon-Cardo, C., and DePinho, R. A. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell, 92: 713-723, 1998.
-
(1998)
Cell
, vol.92
, pp. 713-723
-
-
Pomerantz, J.1
Schreiber-Agus, N.2
Liegeois, N.J.3
Silverman, A.4
Alland, L.5
Chin, L.6
Potes, J.7
Chen, K.8
Orlow, I.9
Lee, H.W.10
Cordon-Cardo, C.11
DePinho, R.A.12
-
71
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a focus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang, Y., Xiong, Y., and Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a focus deletion impairs both the Rb and p53 tumor suppression pathways. Cell, 92: 725-734, 1998.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
72
-
-
0033536063
-
P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2
-
Tao, W. and Levine, A. J. P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2. Proc. Natl. Acad. Sci. USA, 96: 6937-6941, 1999.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6937-6941
-
-
Tao, W.1
Levine, A.J.2
-
73
-
-
0034044571
-
MDM2 oncogene as a novel target for human cancer therapy
-
Zhang, R. and Wang, H. MDM2 oncogene as a novel target for human cancer therapy. Curr. Pharm. Des., 6: 393-416, 2000.
-
(2000)
Curr. Pharm. Des.
, vol.6
, pp. 393-416
-
-
Zhang, R.1
Wang, H.2
-
74
-
-
0037118583
-
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland
-
Foster, C. J. and Lozano, G. Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland. Oncogene, 21: 3525-3531, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 3525-3531
-
-
Foster, C.J.1
Lozano, G.2
-
75
-
-
0035852788
-
p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101
-
Ruland, J., Sirard, C., Elia, A., MacPherson, D., Wakeham, A., Li, L., de la Pompa, J. L., Cohen, S. N., and Mak, T. W. p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc. Natl. Acad. Sci. USA, 98: 1859-1864, 2001.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1859-1864
-
-
Ruland, J.1
Sirard, C.2
Elia, A.3
MacPherson, D.4
Wakeham, A.5
Li, L.6
De La Pompa, J.L.7
Cohen, S.N.8
Mak, T.W.9
-
76
-
-
0035852716
-
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
-
Li, L., Liao, J., Ruland, J., Mak, T. W., and Cohen, S. N. A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control. Proc. Natl. Acad. Sci. USA, 98: 1619-1624, 2001.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1619-1624
-
-
Li, L.1
Liao, J.2
Ruland, J.3
Mak, T.W.4
Cohen, S.N.5
-
77
-
-
0034644506
-
Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
-
Rics, S., Biederer, C., Woods, D., Shifman, O., Shirasawa, S., Sasazuki, T., McMahon, M., Oren, M., and McCormick, F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell, 103: 321-330, 2000.
-
(2000)
Cell
, vol.103
, pp. 321-330
-
-
Rics, S.1
Biederer, C.2
Woods, D.3
Shifman, O.4
Shirasawa, S.5
Sasazuki, T.6
McMahon, M.7
Oren, M.8
McCormick, F.9
-
78
-
-
0032504783
-
p14ARF links the tumour suppressors RB and p53
-
Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., and Vousden, K. H. p14ARF links the tumour suppressors RB and p53 [letter]. Nature, 395: 124-125, 1998.
-
(1998)
Nature
, vol.395
, pp. 124-125
-
-
Bates, S.1
Phillips, A.C.2
Clark, P.A.3
Stott, F.4
Peters, G.5
Ludwig, R.L.6
Vousden, K.H.7
-
79
-
-
0030696331
-
Induction of Mdm2 and enhancement of cell survival by bFGF
-
Shaulian, E., Resnitzky, D., Shifman, O., Blandino, G., Amsterdam, A., Yayon, A., and Oren, M. Induction of Mdm2 and enhancement of cell survival by bFGF. Oncogene, 15: 2717-2725, 1997.
-
(1997)
Oncogene
, vol.15
, pp. 2717-2725
-
-
Shaulian, E.1
Resnitzky, D.2
Shifman, O.3
Blandino, G.4
Amsterdam, A.5
Yayon, A.6
Oren, M.7
-
80
-
-
0037505736
-
p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor α-positive breast cancer cells
-
Phelps, M., Darley, M., Primrose, J. N., and Blaydes, J. P. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor α-positive breast cancer cells. Cancer Res., 63: 2616-2623, 2003.
-
(2003)
Cancer Res.
, vol.63
, pp. 2616-2623
-
-
Phelps, M.1
Darley, M.2
Primrose, J.N.3
Blaydes, J.P.4
-
81
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo, L. D. and Donner, D. B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA, 98: 11598-11603, 2001.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
82
-
-
0036710512
-
The PTEN Mdm2, p53 tumor suppressor-oncoprotein network
-
Mayo, L. D. and Donner, D. B. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem. Sci., 27: 462-467, 2002.
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 462-467
-
-
Mayo, L.D.1
Donner, D.B.2
-
83
-
-
0035736487
-
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
-
Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., and Hung, M. C. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol., 3: 973-982, 2001.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 973-982
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Zou, Y.4
Spohn, B.5
Hung, M.C.6
-
84
-
-
0035883863
-
Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
-
Sengupta, S. and Wasylyk, B. Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev., 15: 2367-2380, 2001.
-
(2001)
Genes Dev.
, vol.15
, pp. 2367-2380
-
-
Sengupta, S.1
Wasylyk, B.2
-
85
-
-
0035186743
-
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
-
Wang, H., Nan, L., Yu, D., Agrawal, S., and Zhang, R. Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms. Clin. Cancer Res., 7: 3613-3624, 2001.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3613-3624
-
-
Wang, H.1
Nan, L.2
Yu, D.3
Agrawal, S.4
Zhang, R.5
|