Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa

Nature Genetics

Volumn 34, Issue 1, 2003, Pages 75-79

  Tamaru, Hisashi ^a   Zhang, Xing ^b   McMillen, Debra ^a   Singh, Prim B ^c   Nakayama, Jun ichi ^d,f   Grewal, Shiv I ^d   Allis, C David ^e   Cheng, Xiaodong ^b   Selker, Eric U ^a  

^a UNIVERSITY OF OREGON   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^f RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL DNA; HISTONE H3; LYSINE;

ARABIDOPSIS; ARTICLE; CHROMATIN; DNA METHYLATION; FUNGUS MUTANT; HETEROCHROMATIN; MAMMAL; NEUROSPORA CRASSA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROCESSING; SPECIES DIFFERENCE; YEAST;

DNA METHYLATION; DNA, FUNGAL; FUNGAL PROTEINS; GENES, FUNGAL; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; LYSINE; METHYLATION; METHYLTRANSFERASES; MUTATION; NEUROSPORA CRASSA; PROTEIN PROCESSING, POST-TRANSLATIONAL;

ARABIDOPSIS; DROSOPHILA MELANOGASTER; FUNGI; MAMMALIA; MELANOGASTER; NEUROSPORA; NEUROSPORA CRASSA;

EID: 0037693853     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1143     Document Type: Article

References (30)

1. Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
2. Litt, M.D., Simpson, M., Gaszner, M., Allis, C.D. & Felsenfeld, G. Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus. Science 293, 2453-2455 (2001).
3. Noma, K., Allis, C.D. & Grewal, S.I. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293, 1150-1155 (2001).
4. Santos-Rosa, H. et al. Active genes are tri-methylated at K4 of histone H3. Nature 419, 407-411 (2002).
5. Rea, S. et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406, 593-599 (2000).
6. Nakayama, J., Rice, J.C., Strahl, B.D., Allis, C.D. & Grewal, S.I. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110-113 (2001).
7. Heard, E. et al. Methylation of histone H3 at Lys9 is an early mark on the X chromosome during X inactivation. Cell 107, 727-738 (2001).
8. Johnson, L., Cao, X. & Jacobsen, S. Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation. Curr. Biol. 12, 1360-1367 (2002).
9. Schotta, G. et al. Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J. 21, 1121-1131 (2002).
10. Tamaru, H. & Selker, E.U. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414, 277-283 (2001).
11. Jackson, J.P., Lindroth, A.M., Cao, X. & Jacobsen, S.E. Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase. Nature 416, 556-560 (2002).
12. Tachibana, M., Sugimoto, K., Fukushima, T. & Shinkai, Y. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276, 25309-25317 (2001).
13. Czermin, B. et al. Drosophila Enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites. Cell 111, 185-196 (2002).
14. Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P. & Reinberg, D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893-2905 (2002).
15. Zhang, X. et al. Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell 111, 117-127 (2002).
16. Boggs, B.A. et al. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat. Genet. 30, 73-76 (2002).
17. Gendrel, A.V., Lippman, Z., Yordan, C., Colot, V. & Martienssen, R.A. Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1. Science 297, 1871-1873 (2002).
18. Cowell, I.G. et al. Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma 111, 22-36 (2002).
19. Selker, E.U. Premeiotic instability of repeated sequences in Neurospora crassa. Annu. Rev. Genet. 24, 579-613 (1990).
20. Selker, E.U. et al. The methylated component of the Neurospora crassa genome. Nature (in the press).
21. Margolin, B.S. et al. A methylated Neurospora 5S rRNA pseudogene contains a transposable element inactivated by RIP. Genetics 149, 1787-1797 (1998).
22. Hays, S.M., Swanson, J. & Selker, E.U. Identification and characterization of the genes encoding the core histones and histone variants of Neurospora crassa. Genetics 160, 961-973 (2002).
23. Kouzminova, E.A. & Selker, E.U. Dim-2 encodes a DNA-methyltransferase responsible for all known cytosine methylation in Neurospora. EMBO J. 20, 4309-4323 (2001).
24. Nakayama, J., Klar, A.J. & Grewal, S.I. A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis. Cell 101, 307-317 (2000).
25. Singer, M.J., Marcotte, B.A. & Selker, E.U. DNA methylation associated with repeat-induced point mutation in Neurospora crassa. Mol. Cell. Biol. 15, 5586-5597 (1995).
26. Rountree, M.R. & Selker, E.U. DNA methylation inhibits elongation but not initiation of transcription in Neurospora crassa. Genes Dev. 11, 2383-2395 (1997).
27. Peters, A.H. et al. Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat. Genet. 30, 77-80 (2001).
28. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120 (2001).
29. Bannister, A.J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124 (2001).
30. Foss, H.M., Roberts, C.J., Claeys, K.M. & Selker, E.U. Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation. Science 262, 1737-1741 (1993).