-
1
-
-
0028845142
-
Inactivation of the CDKN2/P16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
-
Herman JG, Merlo A, Mao L, Lapidus RG, Issa JPJ, Davidson NE, Sidransky D, Baylin SB: Inactivation of the CDKN2/P16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55:4525, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 4525
-
-
Herman, J.G.1
Merlo, A.2
Mao, L.3
Lapidus, R.G.4
Issa, J.P.J.5
Davidson, N.E.6
Sidransky, D.7
Baylin, S.B.8
-
2
-
-
0029011539
-
5′ CPG island methylation is associated with transcriptional silencing of the tumour suppressor P16/CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5′ CPG island methylation is associated with transcriptional silencing of the tumour suppressor P16/CDKN2/MTS1 in human cancers. Nat Med 1:686, 1995
-
(1995)
Nat Med
, vol.1
, pp. 686
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
Baylin, S.B.7
Sidransky, D.8
-
3
-
-
0028875205
-
Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
-
Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA: Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55:4531, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 4531
-
-
Gonzalez-Zulueta, M.1
Bender, C.M.2
Yang, A.S.3
Nguyen, T.4
Beart, R.W.5
Van Tornout, J.M.6
Jones, P.A.7
-
4
-
-
0030612290
-
P16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas
-
Wong DJ, Barrett MT, Stoger R, Emond MJ, Reid BJ: p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Cancer Res 57:2619, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 2619
-
-
Wong, D.J.1
Barrett, M.T.2
Stoger, R.3
Emond, M.J.4
Reid, B.J.5
-
5
-
-
0028787221
-
CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine
-
Otterson GA, Khleif SN, Chen W, Coxon AB, Kaye FJ: CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. Oncogene 11: 1211, 1995
-
(1995)
Oncogene
, vol.11
, pp. 1211
-
-
Otterson, G.A.1
Khleif, S.N.2
Chen, W.3
Coxon, A.B.4
Kaye, F.J.5
-
6
-
-
0030046322
-
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15(INK4B)
-
Herman JG, Jen J, Merlo A, Baylin SB: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15(INK4B). Cancer Res 56:722, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 722
-
-
Herman, J.G.1
Jen, J.2
Merlo, A.3
Baylin, S.B.4
-
7
-
-
0031025368
-
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
-
Herman JG, Civin CI, Issa JP, Collector MI, Sharkis SJ, Baylin SB: Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 57:837, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 837
-
-
Herman, J.G.1
Civin, C.I.2
Issa, J.P.3
Collector, M.I.4
Sharkis, S.J.5
Baylin, S.B.6
-
8
-
-
0031035406
-
Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
-
Batova A, Diccianni MB, Yu JC, Nobori T, Link MP, Pullen J, Yu AL: Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia. Cancer Res 57:832, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 832
-
-
Batova, A.1
Diccianni, M.B.2
Yu, J.C.3
Nobori, T.4
Link, M.P.5
Pullen, J.6
Yu, A.L.7
-
9
-
-
0030714115
-
Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia
-
Iravani M, Dhat R, Price CM: Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. Oncogene 15:2609, 1997
-
(1997)
Oncogene
, vol.15
, pp. 2609
-
-
Iravani, M.1
Dhat, R.2
Price, C.M.3
-
10
-
-
0030612423
-
Hypermethylation of the p15INK4B gene in myelodysplastic syndromes
-
Uchida T, Kinoshita T, Nagai H, Nakahara Y, Saito H, Hotta T, Murate T: Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood 90:1403, 1997
-
(1997)
Blood
, vol.90
, pp. 1403
-
-
Uchida, T.1
Kinoshita, T.2
Nagai, H.3
Nakahara, Y.4
Saito, H.5
Hotta, T.6
Murate, T.7
-
11
-
-
0032523011
-
Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
-
Quesnel B, Guillerm G, Vereecque R, Wattel E, Preudhomme C, Bauters F, Vanrumbeke M, Fenaux P: Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood 91:2985, 1998
-
(1998)
Blood
, vol.91
, pp. 2985
-
-
Quesnel, B.1
Guillerm, G.2
Vereecque, R.3
Wattel, E.4
Preudhomme, C.5
Bauters, F.6
Vanrumbeke, M.7
Fenaux, P.8
-
12
-
-
8244232501
-
Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas
-
Malumbres M, Perez de Castro I, Santos J, Melendez B, Mangues R, Serrano M, Pellicer A, Fernandez-Piqueras J: Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas. Oncogene 14:1361, 1997
-
(1997)
Oncogene
, vol.14
, pp. 1361
-
-
Malumbres, M.1
Perez De Castro, I.2
Santos, J.3
Melendez, B.4
Mangues, R.5
Serrano, M.6
Pellicer, A.7
Fernandez-Piqueras, J.8
-
13
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM, Baylin SB: Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91:9700, 1994
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9700
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
Samid, D.7
Duan, D.S.8
Gnarra, J.R.9
Linehan, W.M.10
Baylin, S.B.11
-
14
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, Kolodner R: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57:808, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 808
-
-
Kane, M.F.1
Loda, M.2
Gaida, G.M.3
Lipman, J.4
Mishra, R.5
Goldman, H.6
Jessup, J.M.7
Kolodner, R.8
-
15
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JPJ, Markowitz S, Willson JKV, Hamilton SR, Kinzler KW, Kane MF, Kolodner RD, Vogelstein B, Kunkel TA, Baylin SB: Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 95:6870, 1998
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6870
-
-
Herman, J.G.1
Umar, A.2
Polyak, K.3
Graff, J.R.4
Ahuja, N.5
Issa, J.P.J.6
Markowitz, S.7
Willson, J.K.V.8
Hamilton, S.R.9
Kinzler, K.W.10
Kane, M.F.11
Kolodner, R.D.12
Vogelstein, B.13
Kunkel, T.A.14
Baylin, S.B.15
-
16
-
-
0028849277
-
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
-
Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs, WB, Pitha PM, Davidson NE, Baylin SB: E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55:5195, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 5195
-
-
Graff, J.R.1
Herman, J.G.2
Lapidus, R.G.3
Chopra, H.4
Xu, R.5
Jarrard, D.F.6
Isaacs, W.B.7
Pitha, P.M.8
Davidson, N.E.9
Baylin, S.B.10
-
17
-
-
0026546877
-
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
-
Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW, Molloy PL, Paul CL: A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 89:1827, 1992
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 1827
-
-
Frommer, M.1
McDonald, L.E.2
Millar, D.S.3
Collis, C.M.4
Watt, F.5
Grigg, G.W.6
Molloy, P.L.7
Paul, C.L.8
-
18
-
-
0030925099
-
Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors
-
Stirzaker C, Millar DS, Paul CL, Warnecke PM, Harrison J, Vincent PC, Frommer M, Clark SJ: Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors. Cancer Res 57:2229, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 2229
-
-
Stirzaker, C.1
Millar, D.S.2
Paul, C.L.3
Warnecke, P.M.4
Harrison, J.5
Vincent, P.C.6
Frommer, M.7
Clark, S.J.8
-
19
-
-
0032521402
-
The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines
-
Gonzalgo ML, Hayashida T, Bender CM, Pao MM, Tsai YC, Gonzales FA, Nguyen HD, Nguyen TT, Jones PA: The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Res 58:1245, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 1245
-
-
Gonzalgo, M.L.1
Hayashida, T.2
Bender, C.M.3
Pao, M.M.4
Tsai, Y.C.5
Gonzales, F.A.6
Nguyen, H.D.7
Nguyen, T.T.8
Jones, P.A.9
-
20
-
-
0030874380
-
Methylation of discrete regions of the o6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
-
Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS, Futscher BW: Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 17:5612, 1997
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5612
-
-
Watts, G.S.1
Pieper, R.O.2
Costello, J.F.3
Peng, Y.M.4
Dalton, W.S.5
Futscher, B.W.6
-
21
-
-
0030823671
-
Methylation hot spots in the 5′ flanking region denote silencing of the o6-methylguanine-DNA methyltransferase gene
-
Qian XC, Brent TP: Methylation hot spots in the 5′ flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. Cancer Res 57:3672, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 3672
-
-
Qian, X.C.1
Brent, T.P.2
-
22
-
-
0032485196
-
CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site
-
Mancini DN, Rodenhiser DI, Ainsworth PJ, O'Malley FP, Singh SM, Xing W, Archer TK: CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene 16:1161, 1998
-
(1998)
Oncogene
, vol.16
, pp. 1161
-
-
Mancini, D.N.1
Rodenhiser, D.I.2
Ainsworth, P.J.3
O'Malley, F.P.4
Singh, S.M.5
Xing, W.6
Archer, T.K.7
-
23
-
-
0029843950
-
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
-
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB: Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93:9821, 1996
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9821
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
24
-
-
0028618304
-
Deletion of p16 and p15 genes in brain tumors
-
Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B: Deletion of p16 and p15 genes in brain tumors. Cancer Res 54:6353, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 6353
-
-
Jen, J.1
Harper, J.W.2
Bigner, S.H.3
Bigner, D.D.4
Papadopoulos, N.5
Markowitz, S.6
Willson, J.K.7
Kinzler, K.W.8
Vogelstein, B.9
-
25
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
-
Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156, 1987
-
(1987)
Anal Biochem
, vol.162
, pp. 156
-
-
Chomczynski, P.1
Sacchi, N.2
-
26
-
-
0027537296
-
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene
-
Ohtani-Fujita N, Fujita T, Aoike A, Osifchin NE, Robbins PD, Sakai T: CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 8:1063, 1993
-
(1993)
Oncogene
, vol.8
, pp. 1063
-
-
Ohtani-Fujita, N.1
Fujita, T.2
Aoike, A.3
Osifchin, N.E.4
Robbins, P.D.5
Sakai, T.6
-
27
-
-
0028106737
-
Dependence of transcriptional repression on CpG methylation density
-
Hsieh CL: Dependence of transcriptional repression on CpG methylation density. Mol Cell Biol 14:5487, 1994
-
(1994)
Mol Cell Biol
, vol.14
, pp. 5487
-
-
Hsieh, C.L.1
-
28
-
-
0025735111
-
Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR
-
Pfeifer GP, Riggs AD: Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR. Genes Dev 5:1102, 1991
-
(1991)
Genes Dev
, vol.5
, pp. 1102
-
-
Pfeifer, G.P.1
Riggs, A.D.2
-
29
-
-
0027203606
-
Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
-
Bartolomei MS, Webber AL, Brunkow ME, Tilghman SM: Epigenetic mechanisms underlying the imprinting of the mouse H19 gene. Genes Dev 7:1663, 1993
-
(1993)
Genes Dev
, vol.7
, pp. 1663
-
-
Bartolomei, M.S.1
Webber, A.L.2
Brunkow, M.E.3
Tilghman, S.M.4
-
30
-
-
0343953594
-
Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
-
Myohanen SK, Baylin SB, Herman JG: Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res 58:591, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 591
-
-
Myohanen, S.K.1
Baylin, S.B.2
Herman, J.G.3
-
31
-
-
0032578509
-
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
-
Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, Herman JG: Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 95:11891, 1998
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11891
-
-
Belinsky, S.A.1
Nikula, K.J.2
Palmisano, W.A.3
Michels, R.4
Saccomanno, G.5
Gabrielson, E.6
Baylin, S.B.7
Herman, J.G.8
-
32
-
-
0029973718
-
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
-
Vertino PM, Yen RW, Gao J, Baylin SB: De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol Cell Biol 16:4555, 1996
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4555
-
-
Vertino, P.M.1
Yen, R.W.2
Gao, J.3
Baylin, S.B.4
-
33
-
-
0030868694
-
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation
-
Graff JR, Herman JG, Myohanen S, Baylin SB, Vertino PM: Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem 272:22322, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 22322
-
-
Graff, J.R.1
Herman, J.G.2
Myohanen, S.3
Baylin, S.B.4
Vertino, P.M.5
-
34
-
-
0028884312
-
Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site
-
Li JM, Nichols MA, Chandrasekharan S, Xiong Y, Wang XF: Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site. J Biol Chem 270:26750, 1995
-
(1995)
J Biol Chem
, vol.270
, pp. 26750
-
-
Li, J.M.1
Nichols, M.A.2
Chandrasekharan, S.3
Xiong, Y.4
Wang, X.F.5
|