DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia

Clinical Cancer Research

Volumn 8, Issue 7, 2002, Pages 2217-2224

  Garcia Manero, Guillermo ^a   Daniel, Jerry ^a   Smith, Terry L ^a   Kornblau, Steven M ^a   Lee, Ming Sheng ^a   Kantarjian, Hagop M ^a   Issa, Jean Pierre J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CVAD PROTOCOL; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DNA; DOXORUBICIN; PRIMER DNA; TUMOR MARKER; TUMOR PROTEIN; VINCRISTINE; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN;

ACUTE LYMPHOCYTIC LEUKEMIA; ADULT; ARTICLE; CPG ISLAND; DNA METHYLATION; FEMALE; GENETICS; HUMAN; MALE; METHODOLOGY; POLYMERASE CHAIN REACTION; PROMOTER REGION; ADULT DISEASE; AGE; ANTIGEN EXPRESSION; HUMAN CELL; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROGNOSIS;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CPG ISLANDS; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; DOXORUBICIN; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); TUMOR MARKERS, BIOLOGICAL; VINCRISTINE; HUMAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035992430     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Cancer epigenetics comes of age
2. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
3. CpG island methylator phenotype in colorectal cancer
4. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
5. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
6. Hypermethylation of multiple genes in pancreatic adenocarcinoma
7. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
8. Methylation profiling in acute myeloid leukemia
9. Acute lymphoblastic leukemia
10. The hyper-CVAD regimen in adult acute lymphocytic leukemia
11. DNA methylation changes in hematologic malignancies: Biologic and clinical implications
12. DNA methylation patterns in the calcitonin gene region at first diagnosis and at relapse of acute lymphoblastic leukemia (ALL)
13. Hypermethylation of calcitonin gene in adult acute leukemia at diagnosis and during complete remission
14. The estrogen receptor CpG island is methylated in most hematopoietic neoplasms
15. Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia
16. INK4B CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
17. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: Potential prognostic implications
18. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia
19. p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation
20. HIC1 hypermethylation is a late event in hematopoietic neoplasms
21. Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5′ CpG island methylation
22. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
23. Hypermethylation of E-cadherin in leukemia
24. Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia
25. High sensitivity mapping of methylated cytosines
26. DNA methylation and developmental genes in lymphomagenesis: More questions than answers?
27. Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells
28. Methylation and silencing of the thrombospondin-1 promoter in human cancer
29. Methylation of the ABL1 promoter in chronic myelogenous leukemia: Lack of prognostic significance
30. Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia
31. ABL1 methylation in Ph-positive ALL is exclusively associated with the P210 form of BCR-ABL
32. Methylation of the neutral endopeptidase gene promoter in human prostate cancers
33. The type 2 CD10/neutral endopeptidase 24.11 promoter: Functional characterization and tissue-specific regulation by CBF/NF-Y isoforms
34. Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia
35. Dissecting complex epigenetic alterations in breast cancer using CpG island microarrays
36. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter Phase II study in elderly patients
37. Decitabine studies in chronic and acute myelogenous leukemia
38. Methylation analysis in patients with CML treated with the hypomethylating drug decitabine