Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53-/- mice

American Journal of Pathology

Volumn 162, Issue 1, 2003, Pages 343-352

  Tong, Wei Min ^a   Ohgaki, Hiroko ^a   Huang, Huatao ^a   Granier, Christelle ^a   Kleihues, Paul ^a   Wang, Zhao Qi ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; PROTEIN PATCHED 1; RECEPTOR PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MATH1; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CANCER INCIDENCE; CANCER MODEL; CARCINOGENESIS; CEREBELLUM; CHROMOSOME ABERRATION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DNA REPAIR; DNA STRAND BREAKAGE; GENE DISRUPTION; GRANULE CELL; MEDULLOBLASTOMA; MOUSE; NONHUMAN; NULL ALLELE; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0037219382     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63825-4     Document Type: Article

References (56)

1. Kleihues P, Cavenee WK: World Health Organization Classification of Tumours. Pathology and Genetics: Tumours of the Nervous System Lyon, IARC Press, 2000, pp 129-137
2. Lantos PL, Louis DN, Rosenblum MK, Kleihues P: Greenfield's Neuropathology, Ed. 7. London, Arnold, 2002, pp 117-132
3. Kleihues P, Schauble B, zur Hausen A, Esteve J, Ohgaki H: Tumors associated with p53 germline mutations: A synopsis of 91 families. Am J Pathol 1997, 150:1-13
4. Malkin D: The Li-Fraumeni Syndrome. The Genetic Basis of Human Cancer. Edited by Vogelstein B, Kinzler KW. New York, McGraw-Hill, 1998, pp 393-407
5. Hahn H, Wicking C, Zaphiropoulous PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE: Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996, 85:841-851
6. Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein Jr EH, Scott MP: Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996, 272:1668-1671
7. Hamilton SR, Liu B, Parsons RE, Papadopoulos N, Jen J, Powell SM, Krush AJ, Berk T, Cohen Z, Tetu B, Burger PC, Wood PA, Taqi F, Booker SV, Petersen GM, Offerhaus GJA, Tersmette AC, Giardiello FM, Vogelstein B, Kinzler KW: The molecular basis of Turcot's syndrome. N Engl J Med 1995, 332:839-847
8. Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring M, Petersen I, Holl T, Wiestler OD, Kleihues P: Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system. Mol Carcinog 1993, 8:74-80
9. Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J, Sorensen N, Berthold F, Henk B, Schmandt N, Wolf HK, von Deimling A, Wainwright B, Chenevix-Trench G, Wiestler OD, Wicking C: Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 1997, 57:2085-2088
10. Raffel C, Jenkins RB, Frederick L, Hebrink D, Alderete B, Fults DW, James D: Sporadic medulloblastomas contain ptc1h mutations. Cancer Res 1997, 57:842-845
11. Xie J, Johnson RL, Zhang X, Bare JW, Waldman FM, Cogen PH, Menon AG, Warren RS, Chen LC, Scott MP, Epstein Jr EH: Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res 1997, 57:2369-2372
12. Wolter M, Reifenberger J, Sommer C, Ruzicka T, Reifenberger G: Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res 1997, 57:2581-2585
13. Zurawel RH, Chiappa S, Allen C, Raffel C: Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res 1998, 58: 896-899
14. Huang H, Mahler-Araujio BM, Sankila A, Chimeli L, Yonekawa Y, Kleihues P, Ohgaki H: APC mutations in sporadic medulloblastomas. Am J Pathol 2000, 156:433-437
15. Dahmen RP, Koch A, Denkhaus D, Tonn JC, Sorensen N, Berthold F, Behrens J, Birchmeier W, Wiestler OD, Pietsch T: Deletions of axin1, a component of the wnt/wingless pathway, in sporadic medulloblastomas. Cancer Res 2001, 61:7039-7043
16. Wechsler-Reya RJ, Scott MP: The developmental biology of brain tumors. Annu Rev Neurosci 2001, 24:385-428
17. Goodrich LV, Milenkovic L, Higgins KM, Scott MP: Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997, 277:1109-1113
18. Wetmore C, Eberhart DE, Curran T: The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res 2000, 60:2239-2246
19. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery Jr CA, Butel JS, Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 1992, 356: 215-221
20. Harvey M, McArthur MJ, Montagomery Jr CA, Butel JS, Bradley A, Donehower LA: Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet 1993, 5:225-229
21. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA: Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994, 4:1-7
22. Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A: Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 2000, 14:994-1004
23. Wetmore C, Eberhart DE, Curran T: Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched. Cancer Res 2001, 61:513-516
24. Khanna KK, Jackson SP: DNA double-strand breaks: Signaling, repair, and the cancer connection. Nat Genet 2001, 27:247-254
25. Pierce AJ, Stark JM, Araujo FD, Moynahan ME, Berwick M, Jasin M: Double-strand breaks and tumorigenesis. Trends Cell Biol 2001, 11: S52-S59
26. Lindahl T, Satoh MS, Poirier GG, Klungland A: Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci 1995, 20:405-411
27. Herceg Z, Wang Z-Q: Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity, and cell death. Mutat Res 2001, 477:97-110
28. Tong WM, Cortes U, Wang Z-Q: Poly(ADP-ribose) polymerase: A guardian angel protecting the genome and suppressing tumourigenesis. Biochim Biophys Acta Rev Cancer 2001, 1552:27-37
29. Morrison C, Smith GCM, Stingl L, Jackson SP, Wagner EF, Wang Z-Q: Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Nat Genet 1997, 17:479-482
30. Tsutsumi M, Masutani M, Nozaki T, Kusuoka O, Tsujiuchi T, Nakagama H, Suzuki H, Konishi Y, Sugimura T: Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity. Carcinogenesis 2001, 22:1-3
31. Tong WM, Hande MP, Lansdorp PM, Wang Z-Q: DNA strand break-sensing molecule PARP cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol 2001, 21:4046-4054
32. Wang Z-Q, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF: Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 1995, 9:509-520
33. Helms AW, Johnson JE: Progenitors of dorsal commissural interneurons are defined by MATH1 expression. Development 1998, 125: 919-928
34. Tong WM, Bises G, Sheinin Y, Ellinger A, Genser D, Potzi R, Wrba F, Wenzl E, Roka R, Neuhold N, Peterlik M, Cross HS: Establishment of primary cultures from human colonic tissue during tumor progression: Vitamin-D responses and vitamin-D-receptor expression. Int J Cancer 1998, 75:467-472
35. Ben-Arie N, Bellen HJ, Armstrong DL, McCall A, Gordadze PR, Guo Q, Matzuk MM, Zoghbi HY: Math1 is essential for genesis of cerebellar granule neurons. Nature 1997, 390:169-172
36. Yokota N, Aruga J, Takai S, Yamada K, Hamazaki M, Iwase T, Sugimura H, Mikoshiba K: Predominant expression of human zic in cerebellar granule cell lineage and medulloblastoma. Cancer Res 1996, 56:377-383
37. Michiels EM, Oussoren E, Van Groenigen M, Pauws E, Bossuyt PM, Voute PA, Baas F: Genes differentially expressed in medulloblastoma and fetal brain. Physiol Genomics 1999, 1:83-91
38. Helms AW, Abney AL, Ben-Arie N, Zoghbi HY, Johnson JE: Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development 2001, 127:1185-1196
39. Menessier-de Murcia J, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver FJ, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G: Requirement of poly (ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 1997, 94:7303-7307
40. Wang Z-Q, Stingl L, Morrison C, Jantsch M, Los M, Schulze-Osthoff K, Wagner EF: PARP is important for genomic stability but dispensable in apoptosis. Genes Dev 1997, 11:2347-2358
41. Masutani M, Nozaki T, Nishiyama E, Shimokawa T, Tachi Y, Suzuki H, Nakagama H, Wakabayashi K, Sugimura T: Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice. Mol Cell Biochem 1999, 193:149-152
42. Tong WM, Galendo D, Wang Z-Q: Role of DNA break-sensing molecule poly(ADP-ribose) polymerase (PARP) in cellular function and radiation toxicity. Cold Spring Harbor Symp Quant Biol 2000, 65:583-591
43. Van der Burgt I, Chrzanowska KH, Smeets D, Weemaes C: Nijmegen breakage syndrome. J Med Genet 1996, 33:153-156
44. German J, Ellis NA: Bloom Syndrome. The Genetic Basis of Human Cancer. Edited by Vogelstein B, Kinzler KW. New York, McGraw-Hill, 1998, pp 301-316
45. Auerbach AD, Buchwald M, Joenje H: Fanconi Anemia. The Genetic Basis of Human Cancer. Edited by Vogelstein B, Kinzler KW. New York, McGraw-Hill, 1998, pp 317-332
46. Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ: Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 1998, 280:1089-1091
47. Juluri K, Ha HC, Snyder SH: Nervous System Functions of Poly(ADP-Ribose) Polymerase-1. PARP as a Therapeutic Target. Edited by Zhang J. London, CRC Press, 2002, pp 1-18
48. Ha HC, Snyder SH: Poly(ADP-ribose) polymerase-1 in the nervous system. Neurobiol Dis 2000, 7:225-239
49. Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M, Nunez G, Krammer PH, Peter ME, Debatin KM: Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997, 57:4956-4964
50. Vrieling H: Mitotic maneuvers in the light. Nat Genet 2001, 28:101-102
51. Sanchez-Garcia I: Consequences of chromosomal abnormalities in tumor development. Annu Rev Genet 1997, 31:429-453
52. Matise MP, Joyner AL: Gli genes in development and cancer. Oncogene 1999, 18:7852-7859
53. Dahmane N, Sanchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz I, Altaba A: The Sonic hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development 2001, 128:5201-5212
54. Kraus JA, Koch A, Albrecht S, von Deimin A, Wiestler OD, Pietsch T: Loss of heterozygosity at locus F138 on chromosome 1q in human medulloblastoma. Int J Cancer 1996, 67:11-15
55. Reardon DA, Michalkiewicz E, Boyett JM, Sublett JE, Entrekin RE, Ragsdale ST, Valentine MB, Behm FG, Li H, Heideman RL, Kun LE, Shapiro DN, Look AT: Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 1997, 57:4042-4047
56. Pietsch T, Koch A, Wiestler OD: Molecular genetic studies in medulloblastomas: Evidence for tumor suppressor genes at the chromosomal regions 1q31-32 and 17p13. Klin Padiatr 1997, 209:150-155