Genomic amplification of orthodenticle homologue 2 in medulloblastomas

Cancer Research

Volumn 65, Issue 3, 2005, Pages 703-707

  Boon, Kathy ^a   Eberhart, Charles G ^a   Riggins, Gregory J ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Center Tower ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; MYC PROTEIN; TRANSCRIPTION FACTOR OTX2;

AMPLICON; ARTICLE; BRAIN DEVELOPMENT; CANCER CELL; CHROMOSOME 14Q; CHROMOSOME 17Q; CONTROLLED STUDY; DNA FLANKING REGION; EMBRYO; EMBRYO CELL; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; HOMEOBOX; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOCHROMOSOME; KARYOTYPING; MEDULLOBLASTOMA; NEUROECTODERM; OPEN READING FRAME; PREDICTION; PRIORITY JOURNAL; PROTEIN FUNCTION; STEM CELL;

BRAIN NEOPLASMS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 14; DNA, NEOPLASM; GENE AMPLIFICATION; GENE DOSAGE; GENOME, HUMAN; HOMEODOMAIN PROTEINS; HUMANS; KARYOTYPING; MEDULLOBLASTOMA; NERVE TISSUE PROTEINS; OTX TRANSCRIPTION FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 13444249487     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Kleihues P, Burger PC, Plate KH, et al. Pathology & Genetics: Tumours of the Nervous System. Lyon: IARC; 2000.
2. Raffel C, Jenkins RB, Frederick L, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res 1997;57:842-5.
3. Zurawel RH, Chiappa SA, Allen C, et al. Sporadic meduiloblastomas contain oncogenic β-catenin mutations. Cancer Res 1998;58:896-9.
4. Bigner SH, Friedman HS, Vogelstein B, et al. Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Res 1990;50:2347-50.
5. Tong C, Hui A, Yin X, et al. Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization. J Neurosurg Spine 2004;100:187-93.
6. Saha S, Sparks A, Rago C, et al. Using the transcriptome to annotate the genome. Nat Biotechnol 2002;20:508-12.
7. Wang T-L, Maierhofer C, Speicher MR, et al. Digital karyotyping. Proc Natl Acad Sci 2002;99:16156-61.
8. Wang TL, Diaz LA Jr, Romans K, et al. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci U S A 2004;101:3089-94.
9. Kurokawa D, Kiyonari H, Nakayama R, et al. Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 2004;131:3319-31.
10. Friedman H, Burger P, Bigner S, et al. Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283. Med. J Neuropathol Exp Neurol 1985;44:592-605.
11. Pietsch T, Scharmann T, Fonatsch C, et al. Characterization of five new cell lines derived from human primitive neuroectodermal tumors of the central nervous system. Cancer Res 1994;54:3278-87.
12. Boon K, Edwards J, Siu I, et al. Comparison of medulloblastoma and normal neural transcriptomes identifies a restricted set of activated genes. Oncogene 2003;22:7687-94.
13. Siu IM, Lal A, Blankenship JR, et al. c-Myc promoter activation in medulloblastoma Cancer Res 2003;63:4773-6.
14. Bigner SH, McLendon RE, Fuchs M, et al. Chromosomal characteristics of childhood brain tumors. Cancer Genet Cytogenet 1997;97:125-34.
15. Aldosari N, Wiltshire RN, Dutra A, et al. Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft Neuro-oncol 2002;4:75-85.
16. Boon K, Osorio EC, Greenhut SF, et al. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci 2002;99:11287-92.
17. Michiels EM, Oussoren E, Van Groenigen M, et al. Genes differentially expressed in medulloblastoma and fetal brain. Physiol Genomics 1999;1:83-91.
18. Yokota N, Mainprize T, Taylor M, et al. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 2004;23:3444-53.
19. Simeone A, Puelles E, Acampora D. The Otx family. Curr Opin Genet Dev 2002;12:409-15.
20. Puelles E, Acampora D, Lacroix E, et al. Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci 2003;6:453-60.
21. Broccoli V, Boncinelli E, Wurst W. The caudal limit of Otx2 expression positions the isthmic organizer. Nature 1999;401:164-8.
22. Nedelec S, Foucher I, Brunet I, et al. Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc Natl Acad Sci 2004;101:10815-20.