Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid

Cancer Research

Volumn 65, Issue 3, 2005, Pages 919-924

  Di, Chunhui ^a   Liao, Shaoxi ^a   Adamson, David C ^a   Parrett, Timothy J ^a   Broderick, Daniel K ^a   Shi, Qun ^a   Lengauer, Christoph ^b   Cummins, Jordan M ^b   Velculescu, Victor E ^b   Fults, Daniel W ^c   McLendon, Roger E ^a   Bigner, Darell D ^a   Yan, Hai ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR OTX2;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CONCENTRATION RESPONSE; GENE AMPLIFICATION; GENE EXPRESSION; GENE IDENTIFICATION; HISTOPATHOLOGY; KARYOTYPE; MEDULLOBLASTOMA; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; GENE AMPLIFICATION; HOMEODOMAIN PROTEINS; HUMANS; MEDULLOBLASTOMA; NERVE TISSUE PROTEINS; ONCOGENES; OTX TRANSCRIPTION FACTORS; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRETINOIN;

EID: 13444279877     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Kleihues P, Cavenee WK, editors. Pathology and genetics of tumours of the nervous system: WHO classification of tumors. Lyon France: IARC Press; 2000.
2. Gajjar A, Hernan R, Kocak M, et al. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol 2004;22:984-93.
3. Wang TL, Maierhofer C, Speicher MR, et al. Digital karyotyping. Proc Natl Acad Sci U S A 2002;99:16156-61.
4. Pinkel D, Segraves R, Sudar D, et al. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet 1998;20:207-11.
5. Wang TL, Diaz LA Jr, Romans K, et al. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci U S A 2004;101:3089-94.
6. Aldosari N, Wiltshire RN, Dutra A, et al. Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft. Neuro-oncol 2002;4:75-85.
7. Boncinelli E, Morgan R. Downstream of Otx2, or how to get a head. Trends Genet 2001;17:633-6.
8. Simeone A. Otx1 and Otx2 in the development and evolution of the mammalian brain. EMBO J 1998;17:6790-8.
9. Frantz GD, Weimann JM, Levin ME, McConnell SK. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J Neurosci 1994;14:5725-40.
10. Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev 1995;9:2646-58.
11. Broccoli V, Boncinelli E, Wurst W. The caudal limit of Otx2 expression positions the isthmic organizer. Nature 1999;401:164-8.
12. Michiels EM, Oussoren E, Van Groenigen M, et al. Genes differentially expressed in medulloblastoma and fetal brain. Physiol Genomics 1999;1:83-91.
13. Yokota N, Mainprize TG, Taylor MD, et al. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 2004;23:3444-53.
14. Boon K, Osorio EC, Greenhut SF, et al. An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A 2002;99:11287-92.
15. Eberhart CG, Kepner JL, Goldthwaite PT, et al. Histopathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002;94:552-60.
16. Clotman F, van Maele-Fabry G, Chu-Wu L, Picard JJ. Structural and gene expression abnormalities induced by retinoic acid in the forebrain. Reprod Toxicol 1998;12:169-76.
17. Simeone A, Avantaggiato V, Moroni MC, et al. Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system. Mech Dev 1995;51:83-98.
18. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789-99.
19. Gumireddy K, Sutton LN, Phillips PC, Reddy CD. All-trans-retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3/poly(ADP-ribose) polymerase 1 pathway. Clin Cancer Res 2003;9:4052-9.
20. Hallahan AR, Pritchard JI, Chandraratna RA, et al. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat Med 2003;9:1033-8.
21. Evans TR, Kaye SB. Retinoids: present role and future potential. Br J Cancer 1999;80:1-8.