Computer-aided analysis and design of phosphonic and phosphinic enzyme inhibitors as potential drugs and agrochemicals

Current Organic Chemistry

Volumn 9, Issue 18, 2005, Pages 1829-1850

  Berlicki, Łukasz ^a   Kafarski, Paweł ^a  

^a WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL CHEMICALS; BIOACTIVITY; COMPUTER AIDED ANALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; LEAD COMPOUNDS;

COMPUTER-AIDED ANALYSIS; COMPUTER-AIDED DESIGN; ENZYME INHIBITORS; MODERN DRUG DEVELOPMENT; PHOSPHONIC; POTENT INHIBITOR; POTENTIAL DRUG; SELECTIVE INHIBITORS; STRUCTURAL FEATURE; STRUCTURE-BASED;

COMPUTER AIDED DESIGN;

AGRICULTURAL CHEMICAL; AMINO ACID DERIVATIVE; ANTIINFECTIVE AGENT; ASPARTATE SEMIALDEHYDE DEHYDROGENASE; ASTACIN; BETA LACTAMASE INHIBITOR; BISPHOSPHONIC ACID DERIVATIVE; CATHEPSIN G; CHOLINESTERASE INHIBITOR; CYTOSOL AMINOPEPTIDASE; ENZYME INHIBITOR; HERBICIDE; LEUCINE; LIGAND; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; NEW DRUG; NITROGEN DERIVATIVE; ORGANOPHOSPHATE; ORGANOPHOSPHORUS COMPOUND; PHOSPHINIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; SERINE PROTEINASE INHIBITOR; SOMAN; THERMOLYSIN; TRYPSIN; UNINDEXED DRUG; ZINC;

CHEMICAL BOND; COMPUTER AIDED DESIGN; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; INFECTION; NONHUMAN; PATHOGENESIS; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 27944467415     PISSN: 13852728     EISSN: None     Source Type: Journal    
DOI: 10.2174/138527205774913088     Document Type: Review

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