Synthesis of [difluoro-(3-alkenylphenyl)-methyl]-phosphonic acids on non-crosslinked polystyrene and their evaluation as inhibitors of PTP1B

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 23, 2002, Pages 3471-3474

  Hum, Gabriel ^a   Lee, Jason ^a   Taylor, Scott D ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ESTER DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; ESTER; POLYSTYRENE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; CROSS LINKING; DRUG SCREENING; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; BINDING COMPETITION; CHEMISTRY; DRUG ANTAGONISM; IC 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BINDING, COMPETITIVE; ENZYME INHIBITORS; ESTERS; INHIBITORY CONCENTRATION 50; PHOSPHONIC ACIDS; POLYSTYRENES; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036888691     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00768-0     Document Type: Article

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