Synthesis and biological evaluation of α,α-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 4, 1999, Pages 529-532

  Yokomatsu, Tsutomu ^a   Murano, Tetsuo ^a   Umesue, Ikuko ^b   Soeda, Shinji ^b   Shimeno, Hiroshi ^b   Shibuya, Shiroshi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

Enzyme inhibitors; Isosteres; Mimetics; Phosphonic acids and derivs; Substituent effects

Indexed keywords

PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; DEPHOSPHORYLATION; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ENZYME INHIBITORS; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 0033593914     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00027-X     Document Type: Article

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