Bisphosphonates Are Potent Inhibitors of Trypanosoma cruzi Farnesyl Pyrophosphate Synthase

Journal of Biological Chemistry

Volumn 276, Issue 36, 2001, Pages 33930-33937

  Montalvetti, Andrea ^a   Bailey, Brian N ^a   Martin, Michael B ^a   Severin, Gregory W ^a   Oldfield, Eric ^a   Docampo, Roberto ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONING; GENES; NITROGEN; PHOSPHORUS COMPOUNDS; PROTEINS;

MOLECULAR MASS;

BIOCHEMISTRY;

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; ETIDRONIC ACID; FARNESYL DIPHOSPHATE; GERANYLTRANSFERASE; PAMIDRONIC ACID; RISEDRONIC ACID; AMINO ACID; CALCIUM CHANNEL BLOCKING AGENT; CATION; DRUG DERIVATIVE; GERANYL PYROPHOSPHATE; ISOPRENOID PHOSPHATE; RECOMBINANT PROTEIN; TRANSFERASE;

APOPTOSIS; ARTICLE; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE INSERTION; GENE ISOLATION; GENE SEQUENCE; GROWTH INHIBITION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTOZOAL INFECTION; TRYPANOSOMA CRUZI; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; BIRD; CELL CULTURE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; DOSE RESPONSE; DRUG ANTAGONISM; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; MOLECULAR GENETICS; NORTHERN BLOTTING; PH; PROTEIN BINDING; PROTEIN MOTIF; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; INSERTION SEQUENCES; OTHER SEQUENCES; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ALKYL AND ARYL TRANSFERASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BINDING SITES; BIRDS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CALCIUM CHANNEL BLOCKERS; CATIONS; CELLS, CULTURED; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHONATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; ETIDRONIC ACID; GERANYLTRANSTRANSFERASE; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA CRUZI;

EID: 0035823604     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103950200     Document Type: Article

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