Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo

Biochemical and Biophysical Research Communications

Volumn 255, Issue 2, 1999, Pages 491-494

  Van Beek, Ermond ^a   Pieterman, Elsbet ^b   Cohen, Louis ^b   Löwik, Clemens ^a   Papapoulos, Socrates ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; FARNESYL TRANS TRANSFERASE; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; NITROGEN; OLPADRONIC ACID;

ARTICLE; ENZYME INHIBITION; PRIORITY JOURNAL;

EID: 0033573882     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1999.0224     Document Type: Article

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