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Volumn 8, Issue 22, 1998, Pages 3275-3280

Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA,ALPHA DIFLUOROSULFONATE; ALPHA,ALPHA DIFLUOROTETRAZOLE; ORGANOPHOSPHATE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0032542042     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00598-8     Document Type: Article
Times cited : (43)

References (25)
  • 15
    • 85038544708 scopus 로고    scopus 로고
    • note
    • 7. A detailed analysis and the scope of this reaction is in progress and will be reported in due course.
  • 16
    • 0026034405 scopus 로고
    • 8. NFSi has previously been used for preparing α,α,-difluorocarboxylic esters. For example see: Differding, E.; Ruegg, G. M.; Lang, R. W. Tetrahedron Lett. 1991, 32, 1779.
    • (1991) Tetrahedron Lett. , vol.32 , pp. 1779
    • Differding, E.1    Ruegg, G.M.2    Lang, R.W.3
  • 19
    • 0031036223 scopus 로고    scopus 로고
    • and references therein
    • 11. PTP1B is an intracellular PTP consisting of a single catalytic domain. There is now considerable evidence that this enzyme may be involved in the down-regulation of insulin signaling by dephosphorylating specific phosphotyrosine residues on the insulin receptor kinase. Thus, PTP1B is now being considered as a potential therapeutic target to help combat certain forms of diabetes. See: Bandyopadhyay, D.; Kusari, A.; Kenner, K. A.; Liu, F.; Chernoff, J.; Gustafson, T. A.; Kusari, J. J. Biol. Chem. 1997, 272, 1639 and references therein.
    • (1997) J. Biol. Chem. , vol.272 , pp. 1639
    • Bandyopadhyay, D.1    Kusari, A.2    Kenner, K.A.3    Liu, F.4    Chernoff, J.5    Gustafson, T.A.6    Kusari, J.7
  • 24
    • 85038554807 scopus 로고    scopus 로고
    • note
    • i'S were determined using the procedure outlined in reference 3d


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.