Alendronate mechanism of action: Geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 1, 1999, Pages 133-138

  Fisher, J E ^a   Rogers, M J ^b   Halasy, J M ^a   Luckman, S P ^b   Hughes, D E ^c   Masarachia, P J ^a   Wesolowski, G ^a   Russell, R G G ^c   Rodan, G A ^a   Reszka, A A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Bisphosphonate; Geranylgeranylation; Isoprenylation; Osteoporosis; Statin

Indexed keywords

ALENDRONIC ACID; CLODRONIC ACID; FARNESOL; GERANYLGERANIOL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; MEVINOLIN; PHOSPHOTRANSFERASE; SQUALENE;

ANIMAL CELL; ARTICLE; CALVARIA; CELL SURVIVAL; CHOLESTEROL SYNTHESIS; CYTOSKELETON; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; MEMBRANE FUSION; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRENYLATION; PRIORITY JOURNAL; RABBIT;

ALENDRONATE; ANIMALS; BONE RESORPTION; CELL DIFFERENTIATION; CELLS, CULTURED; CHOLESTEROL; CLODRONIC ACID; DITERPENES; ENZYME ACTIVATION; FARNESOL; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MEVALONIC ACID; MICE; OSTEOCLASTS; PROTEIN KINASES; RABBITS; SKULL; SQUALENE;

ANIMALIA; MURINAE; ORYCTOLAGUS CUNICULUS;

EID: 13044283050     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.1.133     Document Type: Article

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