Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design

Biochemistry

Volumn 35, Issue 50, 1996, Pages 15989-15996

  Burke Jr , Terrence R ^a   Ye, Bin ^a   Yan, Xinjian ^a   Wang, Shaomeng ^a   Jia, Zongchao ^b   Chen, Li ^c   Zhang, Zhong Yin ^c   Barford, David ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NAPHTHALENE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; COMPLEX FORMATION; ENZYME ACTIVE SITE; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CALORIMETRY; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; NAPHTHALENES; PHOSPHONIC ACIDS; PHOSPHOTYROSINE; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; SERINE;

EID: 0030467887     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961256d     Document Type: Article

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