Inhibition of human α-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate

Journal of Molecular Biology

Volumn 311, Issue 3, 2001, Pages 549-555

  Skordalakes, Emmanuel ^a,b   Dodson, Guy G ^b   Green, Donovan St Clair ^c   Goodwin, Christopher A ^a   Scully, Michael F ^a   Hudson, Harry R ^c   Kakkar, Vijay V ^a   Deadman, John J ^a  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c LONDON METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

Complex; Human thrombin; Pentacovalent phosphorus; Transition state; Tripeptide phosphonate

Indexed keywords

PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS DERIVATIVE; THROMBIN; TRIPEPTIDE;

ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DEACYLATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HEMOSTASIS; HUMAN; HUMAN CELL; HYDROLYSIS; LIGAND BINDING; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION INHIBITION; X RAY CRYSTALLOGRAPHY;

EID: 0035902769     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4872     Document Type: Article

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