The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

Molecular and Cellular Biology

Volumn 24, Issue 23, 2004, Pages 10381-10389

  Shima, Naoko ^a,b   Munroe, Robert J ^a,b   Schimenti, John C ^a,b  

^a JACKSON LABORATORY   (United States)

^b Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CHROMOSOME PROTEIN; DNA POLYMERASE; PROTEIN CHAOS 1; PROTEIN POLQ; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DISEASE COURSE; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GENE INTERACTION; GENE MUTATION; GENE TARGETING; GENETIC COMPLEMENTATION; GROWTH RETARDATION; LIFESPAN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THYMUS LYMPHOMA;

ALLELES; ANIMALS; BLOTTING, NORTHERN; CELL CYCLE PROTEINS; CELL PROLIFERATION; CHROMOSOMES; CROSSES, GENETIC; DNA DAMAGE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; ERYTHROCYTES; FEMALE; FIBROBLASTS; GENETIC COMPLEMENTATION TEST; HOMOZYGOTE; LYMPH NODES; LYMPHOMA; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MICRONUCLEUS TESTS; MITOMYCIN; MODELS, GENETIC; MUTATION; MUTATION, MISSENSE; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX FACTORS; TESTIS; THYMUS NEOPLASMS; TIME FACTORS; TISSUE DISTRIBUTION; TRANSGENES; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS); RODENTIA;

EID: 8644233355     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.23.10381-10389.2004     Document Type: Article

References (45)

1. Abraham, R. T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
2. Alizadeh, A. A., M. B. Eisen, R. E. Davis, C. Ma, I. S. Lossos, A. Rosenwald, J. C. Boldrick, H. Sabet, T. Tran, X. Yu, J. I. Powell, L. Yang, G. E. Marti, T. Moore, J. J. Hudson, L. Lu, D. B. Lewis, R. Tibshirani, G. Sherlock, W. C. Chan, T. C. Greiner, D. D. Weisenburger, J. O. Armitage, R. Warnke, R. Levy, W. Wilson, M. R. Grever, J. C. Byrd, D. Botstein, P. O. Brown, and L. M. Staudt. 2000. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403:503-511.
3. Balling, R. 2001. ENU mutagenesis: analyzing gene function in mice. Annu. Rev. Genomics Hum. Genet. 2:463-492.
4. Barlow, C., S. Hirotsune, R. Paylor, M. Liyanage, M. Eckhaus, F. Collins, Y. Shiloh, J. N. Crawley, T. Ried, D. Tagle, and A. Wynshaw-Boris. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86:159-171.
5. Boyd, J. B., K. Sakaguchi, and P. V. Harris. 1990. mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease. Genetics 125:813-819.
6. Dertinger, S. D., D. K. Torous, and K. R. Tometsko. 1996. Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer. Mutat. Res. 371:283-292.
7. Friedberg, E. C., R. Wagner, and M. Radman. 2002. Specialized DNA polymerases, cellular survival, and the genesis of mutations. Science 296:1627-1630.
8. Golding, S. E., E. Rosenberg, A. Khalil, A. McEwen, M. Holmes, S. Neill, L. F. Povirk, and K. Valerie. 2004. Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. J. Biol. Chem. 279:15402-15410.
9. Gurley, K. E., and C. J. Kemp. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr. Biol. 11:191-194.
10. Harris, P. V., O. M. Mazina, E. A. Leonhardt, R. B. Case, J. B. Boyd, and K. C. Burtis. 1996. Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes. Mol. Cell. Biol. 16:5764-5771.
11. Heddle, J. A. 1973. A rapid in vivo test for chromosomal damage. Mutat. Res. 18:187-190.
12. Heyer, B. S., A. MacAuley, O. Behrendtsen, and Z. Werb. 2000. Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development. Genes Dev. 14:2072-2084.
13. Hitotsumachi, S., D. A. Carpenter, and W. L. Russell. 1985. Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia. Proc. Natl. Acad. Sci. USA 82:6619-6621.
14. Hoeijmakers, J. H. 2001. Genome maintenance mechanisms for preventing cancer. Nature 411:366-374.
15. Hubscher, U., G. Maga, and S. Spadari. 2002. Eukaryotic DNA polymerases. Annu. Rev. Biochem. 71:133-163.
16. Kanaar, R., J. H. Hoeijmakers, and D. C. van Gent. 1998. Molecular mechanisms of DNA double strand break repair. Trends Cell Biol. 8:483-489.
17. Kawamura, K., R. Bahar, M. Seimiya, M. Chiyo, A. Wada, S. Okada, M. Hatano, T. Tokuhisa, H. Kimura, S. Watanabe, I. Honda, S. Sakiyama, M. Tagawa, and J. O. Wang. 2004. DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers. Int. J. Cancer 109:9-16.
18. Khanna, K. K., and S. P. Jackson. 2001. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27:247-254.
19. Laurencon, A., C. M. Orme, H. K. Peters, C. L. Boulton, E. K. Vladar, S. A. Langley, E. P. Bakis, D. T. Harris, N. J. Harris, S. M. Wayson, R. S. Hawley, and K. C. Burtis. 2004. A large-scale screen for mutagen-sensitive Loci in Drosophila. Genetics 167:217-231.
20. Lees-Miller, S. P., and K. Meek. 2003. Repair of DNA double strand breaks by non-homologous end joining. Biochimie 85:1161-1173.
21. Leonhardt, E. A., D. S. Henderson, J. E. Rinehart, and J. B. Boyd. 1993. Characterization of the mus308 gene in Drosophila melanogaster. Genetics 133:87-96.
22. Maga, G., I. Shevelev, K. Ramadan, S. Spadari, and U. Hubscher. 2002. DNA polymerase theta purified from human cells is a high-fidelity enzyme. J. Mol. Biol. 319:359-369.
23. Marini, F., N. Kim, A. Schuffert, and R. D. Wood. 2003. POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308. J. Biol. Chem. 278:32014-32019.
24. Marini, F., and R. D. Wood. 2002. A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. J. Biol. Chem. 277:8716-8723.
25. Masutani, M., H. Nakagama, and T. Sugimura. 2003. Poly(ADP-ribose) and carcinogenesis. Genes Chromosomes Cancer 38:339-348.
26. Menisser-de Murcia, J., M. Mark, O. Wendling, A. Wynshaw-Boris, and G. de Murcia. 2001. Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development. Mol. Cell. Biol. 21:1828-1832.
27. Morita, T., N. Asano, T. Awogi, Y. F. Sasaki, S. Sato, H. Shimada, S. Sutou, T. Suzuki, A. Wakata, T. Sofuni, M. Hayashi, et al. 1997. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B): the summary report of the 6th collaborative study by CSGMT/JEMS MMS. Mutat. Res. 389:3-122.
28. Morrison, C., E. Sonoda, N. Takao, A. Shinohara, K. Yamamoto, and S. Takeda. 2000. The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J. 19:463-471.
29. Nusse, M., B. M. Miller, S. Viaggi, and J. Grawe. 1996. Analysis of the DNA content distribution of micronuclei using flow sorting and fluorescent in situ hybridization with a centromeric DNA probe. Mutagenesis 11:405-413.
30. Petiniot, L. K., Z. Weaver, C. Barlow, R. Shen, M. Eckhaus, S. M. Steinberg, T. Ried, A. Wynshaw-Boris, and R. J. Hodes. 2000. Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Proc. Natl. Acad. Sci. USA 97:6664-6669.
31. Petiniot, L. K., Z. Weaver, M. Vacchio, R. Shen, D. Wangsa, C. Barlow, M. Eckhaus, S. M. Steinberg, A. Wynshaw-Boris, T. Ried, and R. J. Hodes. 2002. RAG-mediated V(D)J. recombination is not essential for tumorigenesis in Atm-deficient mice. Mol. Cell. Biol. 22:3174-3317.
32. Prakash, S., and L. Prakash. 2002. Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair. Genes Dev. 16:1872-1883.
33. Rattray, A. J., and J. N. Strathern. 2003. Error-prone DNA polymerases: when making a mistake is the only way to get ahead. Annu. Rev. Genet. 37: 31-66.
34. Seki, M., F. Marini, and R. D. Wood. 2003. POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells. Nucleic Acids Res. 31:6117-6126.
35. Sekiguchi, J., D. O. Ferguson, H. T. Chen, E. M. Yang, J. Earle, K. Frank, S. Whitlow, Y. Gu, X. Y., A. Nussenzweig, and F. W. Alt. 2001. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc. Natl. Acad. Sci. USA 98:3243-3248.
36. Shcherbakova, P. V., K. Bebenek, and T. A. Kunkel. 2003. Functions of eukaryotic DNA polymerases. Sci. Aging Knowledge Environ. 2003:RE3.
37. Shima, N., S. A. Hartford, T. Duffy, L. A. Wilson, K. J. Schimenti, and J. C. Schimenti. 2003. Phenotype-based identification of mouse chromosome instability mutants. Genetics 163:1031-1040.
38. Thompson, L. H., and D. Schild. 1999. The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81:87-105.
39. Thompson, L. H., and D. Schild. 2001. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat. Res. 477:131-153.
40. Treuner, K., R. Helton, and C. Barlow. 2004. Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice. Oncogene 23: 4655-4661.
41. Valerie, K., and L. F. Povirk. 2003. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22:5792-5812.
42. Wang, H., X. Wang, G. Iliakis, and Y. Wang. 2003. Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing. Radiat. Res. 159:420-425.
43. Wang, X., H. Wang, G. Iliakis, and Y. Wang. 2003. Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks. Radiat. Res. 159:426-432.
44. Wang, Y. A., A. Elson, and P. Leder. 1997. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc. Natl. Acad. Sci. USA 94:14590-14595.
45. Woo, R. A., and R. Y. Poon. 2004. Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev. 18:1317-1330.