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Volumn 355, Issue 1405, 2001, Pages 67-72

Evolution and the molecular basis of somatic hypermutation of antigen receptor genes

Author keywords

DNA polymerase zeta (Pol ); Evolution of somatic hypermutation; Gene conversion; Nurse shark antigen receptor; Pattern of mutation; Translesion synthesis

Indexed keywords

DNA DIRECTED DNA POLYMERASE; FUNGAL PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; NURSE SHARK ANTIGEN RECEPTOR; REV7 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

EID: 0035966781     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (22)

References (70)
  • 2
    • 0025046393 scopus 로고
    • Somatic mutation in antibodies expressed by germinal centre B cells early after primary immunization
    • (1990) Int. Immunol. , vol.2 , pp. 813-819
    • Apel, M.1    Berek, C.2
  • 16
    • 0032911308 scopus 로고    scopus 로고
    • Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: The translesion synthesis model of somatic hypermutation
    • (1999) Int. Immunol. , vol.11 , pp. 825-833
    • Diaz, M.1    Velez, J.2    Singh, M.3    Cerny, J.4    Flajnik, M.F.5
  • 22
    • 0028006250 scopus 로고
    • Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: Implications for the location of cis-acting elements required for somatic mutation
    • (1994) J. Exp. Med. , vol.179 , pp. 235-248
    • Giusti, A.M.1    Manser, T.2
  • 29
    • 0032101017 scopus 로고    scopus 로고
    • Hypermutation of immunoglobulin genes in memory B-cells of DNA repair-deficient mice
    • (1998) J. Exp. Med. , vol.187 , pp. 1735-1743
    • Jacobs, H.1
  • 31
    • 0032100485 scopus 로고    scopus 로고
    • The role of DNA repair in somatic hypermutation of immunoglobulin genes
    • (1998) J. Exp. Med. , vol.187 , pp. 1729-1733
    • Kim, N.1    Storb, U.2
  • 32
    • 0033526760 scopus 로고    scopus 로고
    • Different mismatch repair deficiencies all have the same effects on somatic hypermutation: Intact primary mechanism accompanied by secondary modifications
    • (1999) J. Exp. Med. , vol.190 , pp. 21-30
    • Kim, N.1    Bozek, G.2    Lo, J.C.3    Storb, U.4
  • 35
    • 0021872030 scopus 로고
    • The mutational specificity of DNA polymerase-β during in vitro DNA synthesis. Production of frameshift, base substitution and deletion mutations
    • (1985) J. Biochem. , vol.260 , pp. 5787-5796
    • Kunkel, T.A.1
  • 42
    • 0024551797 scopus 로고
    • Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?
    • (1989) Trends Genet. , vol.5 , pp. 4-8
    • Maizels, N.1
  • 43
    • 0006379753 scopus 로고    scopus 로고
    • Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
    • (1996) Nature , vol.382 , pp. 462-466
    • Matsumoto, M.1
  • 49
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 56
    • 0029065847 scopus 로고
    • Specificities of the Saccharomyces cerevisiae rad6, rad18 & rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase
    • (1995) Genetics , vol.140 , pp. 443-456
    • Roche, H.1    Gietz, R.D.2    Kunz, B.A.3
  • 58
    • 0032435650 scopus 로고    scopus 로고
    • TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
    • (1998) Immunity , vol.9 , pp. 859-869
    • Sale, J.E.1    Neuberger, M.S.2
  • 62
    • 0023652303 scopus 로고
    • Somatic diversification of the chicken immunoglobulin gene is limited to the rearranged variable gene segment
    • (1987) Cell , vol.48 , pp. 369-378
    • Thompson, C.B.1    Neiman, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.