메뉴 건너뛰기




Volumn 96, Issue 4, 2005, Pages 728-740

E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis

Author keywords

Apoptosis; Calpain; Cell cycle; E2F1; Encephalitis; Lysosome; Necrosis; Neurodegeneration; Protease; SIV

Indexed keywords

CALPAIN; PROTEIN MDMX; PROTEIN P53; TRANSCRIPTION FACTOR E2F1;

EID: 27644472289     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20574     Document Type: Article
Times cited : (20)

References (63)
  • 2
    • 0028886612 scopus 로고
    • Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron
    • Amano T, Nakanishi H, Kondo T, Tanaka T, Oka M, Yamamoto K. 1995. Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron. Mech Ageing Dev 83:133-141.
    • (1995) Mech Ageing Dev , vol.83 , pp. 133-141
    • Amano, T.1    Nakanishi, H.2    Kondo, T.3    Tanaka, T.4    Oka, M.5    Yamamoto, K.6
  • 4
    • 0036830228 scopus 로고    scopus 로고
    • The neuropathogenic contributions of lysosomal dysfunction
    • Bahr BA, Bendiske J. 2002. The neuropathogenic contributions of lysosomal dysfunction. J Neurochem 83:481-489.
    • (2002) J Neurochem , vol.83 , pp. 481-489
    • Bahr, B.A.1    Bendiske, J.2
  • 5
    • 0043234207 scopus 로고    scopus 로고
    • Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
    • Bidere N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C, Senik A. 2003. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 278:31401-31411.
    • (2003) J Biol Chem , vol.278 , pp. 31401-31411
    • Bidere, N.1    Lorenzo, H.K.2    Carmona, S.3    Laforge, M.4    Harper, F.5    Dumont, C.6    Senik, A.7
  • 6
    • 0032881249 scopus 로고    scopus 로고
    • Regulation of E2F: A family of transcription factors involved in proliferation control
    • Black AR, Azizkhan-Clifford J. 1999. Regulation of E2F: A family of transcription factors involved in proliferation control. Gene 237:281-302.
    • (1999) Gene , vol.237 , pp. 281-302
    • Black, A.R.1    Azizkhan-Clifford, J.2
  • 7
    • 0030757986 scopus 로고    scopus 로고
    • Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
    • Brunk UT, Dalen H, Roberg K, Hellquist HB. 1997. Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic Biol Med 23:616-626.
    • (1997) Free Radic Biol Med , vol.23 , pp. 616-626
    • Brunk, U.T.1    Dalen, H.2    Roberg, K.3    Hellquist, H.B.4
  • 8
    • 0036478928 scopus 로고    scopus 로고
    • The Apaf-1 apoptosome: A large caspase-activating complex
    • Cain K, Bratton SB, Cohen GM. 2002. The Apaf-1 apoptosome: A large caspase-activating complex. Biochimie 84:203-214.
    • (2002) Biochimie , vol.84 , pp. 203-214
    • Cain, K.1    Bratton, S.B.2    Cohen, G.M.3
  • 9
    • 64049113022 scopus 로고    scopus 로고
    • Principles and Application of Fluorescence Microscopy
    • Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, editors. Hoboken: John Wiley & Sons, Inc.
    • Coling D, Kachar B. 2003. Principles and Application of Fluorescence Microscopy. In: Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, editors. Current Protocols in Molecular Biology. Hoboken: John Wiley & Sons, Inc. pp 14.10.
    • (2003) Current Protocols in Molecular Biology
    • Coling, D.1    Kachar, B.2
  • 12
    • 0037010122 scopus 로고    scopus 로고
    • E2F1 pathways to apoptosis
    • Ginsberg D. 2002. E2F1 pathways to apoptosis. FEBS Lett 529:122-125.
    • (2002) FEBS Lett , vol.529 , pp. 122-125
    • Ginsberg, D.1
  • 15
    • 0141814666 scopus 로고    scopus 로고
    • Specificity in the activation and control of transcription factor E2F-dependent apoptosis
    • Hallstrom TC, Nevins JR. 2003. Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci USA 100:10848-10853.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10848-10853
    • Hallstrom, T.C.1    Nevins, J.R.2
  • 16
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R, Tanaka H, Yasuda H. 1997. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 420:25-27.
    • (1997) FEBS Lett , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 17
    • 0035968092 scopus 로고    scopus 로고
    • Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons
    • Hou ST, Cowan E, Dostanic S, Rasquinha I, Comas T, Morley P, MacManus JP. 2001. Increased expression of the transcription factor E2F1 during dopamine-evoked, caspase-3-mediated apoptosis in rat cortical neurons. Neurosci Lett 306:153-156.
    • (2001) Neurosci Lett , vol.306 , pp. 153-156
    • Hou, S.T.1    Cowan, E.2    Dostanic, S.3    Rasquinha, I.4    Comas, T.5    Morley, P.6    MacManus, J.P.7
  • 18
    • 0034913318 scopus 로고    scopus 로고
    • The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation
    • Hou ST, Cowan E, Walker T, Ohan N, Dove M, Rasqinha I, MacManus JP. 2001. The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation. J Neurochem 78:287-297.
    • (2001) J Neurochem , vol.78 , pp. 287-297
    • Hou, S.T.1    Cowan, E.2    Walker, T.3    Ohan, N.4    Dove, M.5    Rasqinha, I.6    MacManus, J.P.7
  • 19
    • 0030850752 scopus 로고    scopus 로고
    • E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh JK, Fredersdorf S, Kouzarides T, Martin K, Lu X. 1997. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev 11:1840-1852.
    • (1997) Genes Dev , vol.11 , pp. 1840-1852
    • Hsieh, J.K.1    Fredersdorf, S.2    Kouzarides, T.3    Martin, K.4    Lu, X.5
  • 20
    • 0033832629 scopus 로고    scopus 로고
    • Noncaspase proteases in apoptosis
    • Johnson DE. 2000. Noncaspase proteases in apoptosis. Leukemia 14:1695-1703.
    • (2000) Leukemia , vol.14 , pp. 1695-1703
    • Johnson, D.E.1
  • 21
    • 0034724161 scopus 로고    scopus 로고
    • Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity
    • Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R. 2000a. Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. Biochemistry 39:3206-3215.
    • (2000) Biochemistry , vol.39 , pp. 3206-3215
    • Jordan-Sciutto, K.L.1    Dragich, J.M.2    Caltagarone, J.3    Hall, D.J.4    Bowser, R.5
  • 22
    • 0033888311 scopus 로고    scopus 로고
    • Induction of cell-cycle regulators in simian immunodeficiency virus encephalitis
    • Jordan-Sciutto KL, Wang G, Murphy-Corb M, Wiley CA. 2000b. Induction of cell-cycle regulators in simian immunodeficiency virus encephalitis. Am J Pathol 157:497-507.
    • (2000) Am J Pathol , vol.157 , pp. 497-507
    • Jordan-Sciutto, K.L.1    Wang, G.2    Murphy-Corb, M.3    Wiley, C.A.4
  • 23
    • 0034793625 scopus 로고    scopus 로고
    • Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease
    • Jordan-Sciutto K, Rhodes J, Bowser R. 2001. Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease. Mech Ageing Dev 123:11-20.
    • (2001) Mech Ageing Dev , vol.123 , pp. 11-20
    • Jordan-Sciutto, K.1    Rhodes, J.2    Bowser, R.3
  • 24
    • 0036201858 scopus 로고    scopus 로고
    • Altered distribution of cell cycle transcriptional regulators during Alzheimer disease
    • Jordan-Sciutto KL, Malaiyandi LM, Bowser R. 2002a. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. J Neuropathol Exp Neurol 61:358-367.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 358-367
    • Jordan-Sciutto, K.L.1    Malaiyandi, L.M.2    Bowser, R.3
  • 25
    • 0037088922 scopus 로고    scopus 로고
    • Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis
    • Jordan-Sciutto KL, Wang G, Murphey-Corb M, Wiley CA. 2002b. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. J Neurosci 22:2185-2195.
    • (2002) J Neurosci , vol.22 , pp. 2185-2195
    • Jordan-Sciutto, K.L.1    Wang, G.2    Murphey-Corb, M.3    Wiley, C.A.4
  • 26
    • 0035887215 scopus 로고    scopus 로고
    • Sphingosine-induced apoptosis is dependent on lysosomal proteases
    • Kagedal K, Zhao M, Svensson I, Brunk UT. 2001. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 359:335-343.
    • (2001) Biochem J , vol.359 , pp. 335-343
    • Kagedal, K.1    Zhao, M.2    Svensson, I.3    Brunk, U.T.4
  • 27
    • 0035940412 scopus 로고    scopus 로고
    • Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
    • Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M. 2001. Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci USA 98:12784-12789.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12784-12789
    • Kim, Y.J.1    Yi, Y.2    Sapp, E.3    Wang, Y.4    Cuiffo, B.5    Kegel, K.B.6    Qin, Z.H.7    Aronin, N.8    Difiglia, M.9
  • 28
    • 0035018119 scopus 로고    scopus 로고
    • Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: Implications for Parkinson's disease
    • Kulich SM, Chu CT. 2001. Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: Implications for Parkinson's disease. J Neurochem 77:1058-1066.
    • (2001) J Neurochem , vol.77 , pp. 1058-1066
    • Kulich, S.M.1    Chu, C.T.2
  • 30
    • 0344406759 scopus 로고    scopus 로고
    • Selective killing of cancer cells by beta-lapachone: Direct checkpoint activation as a strategy against cancer
    • Li Y, Sun X, LaMont JT, Pardee AB, Li CJ. 2003. Selective killing of cancer cells by beta-lapachone: Direct checkpoint activation as a strategy against cancer. Proc Natl Acad Sci USA 100:2674-2678.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2674-2678
    • Li, Y.1    Sun, X.2    LaMont, J.T.3    Pardee, A.B.4    Li, C.J.5
  • 31
    • 0035829650 scopus 로고    scopus 로고
    • Regulation of neuronal survival and death by E2F-dependent gene repression and derepression
    • Liu DX, Greene LA. 2001. Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 32:425-438.
    • (2001) Neuron , vol.32 , pp. 425-438
    • Liu, D.X.1    Greene, L.A.2
  • 32
    • 0030921323 scopus 로고    scopus 로고
    • Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease
    • McShea A, Harris PL, Webster KR, Wahl AF, Smith MA. 1997. Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease. Am J Pathol 150:1933-1939.
    • (1997) Am J Pathol , vol.150 , pp. 1933-1939
    • McShea, A.1    Harris, P.L.2    Webster, K.R.3    Wahl, A.F.4    Smith, M.A.5
  • 34
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael D, Oren M. 2003. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13:49-58.
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 36
    • 0039227088 scopus 로고    scopus 로고
    • Induction of S-phase entry by E2F transcription factors depends on their nuclear localization
    • Muller H, Moroni MC, Vigo E, Petersen BO, Bartek J, Helin K. 1997. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol Cell Biol 17:5508-5520.
    • (1997) Mol Cell Biol , vol.17 , pp. 5508-5520
    • Muller, H.1    Moroni, M.C.2    Vigo, E.3    Petersen, B.O.4    Bartek, J.5    Helin, K.6
  • 37
    • 0031022255 scopus 로고    scopus 로고
    • Increased expression of cathepsins e and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein
    • Nakanishi H, Amano T, Sastradipura DF, Yoshimine Y, Tsukuba T, Tanabe K, Hirotsu I, Ohono T, Yamamoto K. 1997. Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J Neurochem 68:739-749.
    • (1997) J Neurochem , vol.68 , pp. 739-749
    • Nakanishi, H.1    Amano, T.2    Sastradipura, D.F.3    Yoshimine, Y.4    Tsukuba, T.5    Tanabe, K.6    Hirotsu, I.7    Ohono, T.8    Yamamoto, K.9
  • 41
    • 0033231615 scopus 로고    scopus 로고
    • E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
    • Phillips AC, Ernst MK, Bates S, Rice NR, Vousden KH. 1999. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol Cell 4:771-781.
    • (1999) Mol Cell , vol.4 , pp. 771-781
    • Phillips, A.C.1    Ernst, M.K.2    Bates, S.3    Rice, N.R.4    Vousden, K.H.5
  • 42
    • 0037372292 scopus 로고    scopus 로고
    • Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis
    • Ranganathan S, Bowser R. 2003. Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis. Am J Pathol 162:823-835.
    • (2003) Am J Pathol , vol.162 , pp. 823-835
    • Ranganathan, S.1    Bowser, R.2
  • 43
    • 0028282502 scopus 로고
    • Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain
    • Roberts-Lewis JM, Savage MJ, Marcy VR, Pinsker LR, Siman R. 1994. Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J Neurosci 14:3934-3944.
    • (1994) J Neurosci , vol.14 , pp. 3934-3944
    • Roberts-Lewis, J.M.1    Savage, M.J.2    Marcy, V.R.3    Pinsker, L.R.4    Siman, R.5
  • 44
    • 0029880910 scopus 로고    scopus 로고
    • Immunolocalization and redistribution of the FAC1 protein in Alzheimer's disease
    • Schoonover S, Davies P, Bowser R. 1996. Immunolocalization and redistribution of the FAC1 protein in Alzheimer's disease. J Neuropathol Exp Neurol 55:444-455.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 444-455
    • Schoonover, S.1    Davies, P.2    Bowser, R.3
  • 47
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53-homologue p73 in E2F1-induced apoptosis
    • Stiewe T, Putzer BM. 2000. Role of the p53-homologue p73 in E2F1-induced apoptosis [see comment]. Nat Genet 26:464-469.
    • (2000) Nat Genet , vol.26 , pp. 464-469
    • Putzer Bm, S.T.1
  • 48
    • 0035824686 scopus 로고    scopus 로고
    • A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation
    • Strachan GD, Rallapalli R, Pucci B, Lafond TP, Hall DJ. 2001. A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation. J Biol Chem 276:45677-45685.
    • (2001) J Biol Chem , vol.276 , pp. 45677-45685
    • Strachan, G.D.1    Rallapalli, R.2    Pucci, B.3    Lafond, T.P.4    Hall, D.J.5
  • 49
    • 0037441475 scopus 로고    scopus 로고
    • The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
    • Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ. 2003. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. J Cell Biochem 88:557-568.
    • (2003) J Cell Biochem , vol.88 , pp. 557-568
    • Strachan, G.D.1    Jordan-Sciutto, K.L.2    Rallapalli, R.3    Tuan, R.S.4    Hall, D.J.5
  • 52
    • 0032531980 scopus 로고    scopus 로고
    • Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine
    • Takai N, Nakanishi H, Tanabe K, Nishioku T, Sugiyama T, Fujiwara M, Yamamoto K. 1998. Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine. J Neurosci Res 54:214-222.
    • (1998) J Neurosci Res , vol.54 , pp. 214-222
    • Takai, N.1    Nakanishi, H.2    Tanabe, K.3    Nishioku, T.4    Sugiyama, T.5    Fujiwara, M.6    Yamamoto, K.7
  • 55
    • 0035960074 scopus 로고    scopus 로고
    • Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum
    • Xu K, Tavernarakis N, Driscoll M. 2001. Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron 31:957-971.
    • (2001) Neuron , vol.31 , pp. 957-971
    • Xu, K.1    Tavernarakis, N.2    Driscoll, M.3
  • 56
    • 0031055112 scopus 로고    scopus 로고
    • Expression of activating transcription factor-2 (ATF-2), one of the cyclic AMP response element (CRE) binding proteins, in Alzheimer disease and non-neurological brain tissues
    • Yamada T, Yoshiyama Y, Kawaguchi N. 1997. Expression of activating transcription factor-2 (ATF-2), one of the cyclic AMP response element (CRE) binding proteins, in Alzheimer disease and non-neurological brain tissues. Brain Res 749:329-334.
    • (1997) Brain Res , vol.749 , pp. 329-334
    • Yamada, T.1    Yoshiyama, Y.2    Kawaguchi, N.3
  • 57
    • 0034739734 scopus 로고    scopus 로고
    • Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates
    • Yamashima T. 2000. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 62:273-295.
    • (2000) Prog Neurobiol , vol.62 , pp. 273-295
    • Yamashima, T.1
  • 58
    • 0242539781 scopus 로고    scopus 로고
    • Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates
    • Yamashima T, Tonchev AB, Tsukada T, Saido TC, Imajoh-Ohmi S, Momoi T, Kominami E. 2003. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus 13:791-800.
    • (2003) Hippocampus , vol.13 , pp. 791-800
    • Yamashima, T.1    Tonchev, A.B.2    Tsukada, T.3    Saido, T.C.4    Imajoh-Ohmi, S.5    Momoi, T.6    Kominami, E.7
  • 59
    • 0032526652 scopus 로고    scopus 로고
    • Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis
    • Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG. 1998. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis. J Neurosci Res 52:691-698.
    • (1998) J Neurosci Res , vol.52 , pp. 691-698
    • Yang, A.J.1    Chandswangbhuvana, D.2    Margol, L.3    Glabe, C.G.4
  • 60
    • 0344241479 scopus 로고    scopus 로고
    • Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    • Yang Y, Mufson EJ, Herrup K. 2003. Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J Neurosci 23:2557-2563.
    • (2003) J Neurosci , vol.23 , pp. 2557-2563
    • Yang, Y.1    Mufson, E.J.2    Herrup, K.3
  • 62
    • 0033450933 scopus 로고    scopus 로고
    • A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection
    • Zhu JW, DeRyckere D, Li FX, Wan YY, DeGregori J. 1999. A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection. Cell Growth Differ 10:829-838.
    • (1999) Cell Growth Differ , vol.10 , pp. 829-838
    • Zhu, J.W.1    DeRyckere, D.2    Li, F.X.3    Wan, Y.Y.4    DeGregori, J.5
  • 63
    • 0035142804 scopus 로고    scopus 로고
    • Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
    • Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA. 2001. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem 76:435-441.
    • (2001) J Neurochem , vol.76 , pp. 435-441
    • Zhu, X.1    Raina, A.K.2    Rottkamp, C.A.3    Aliev, G.4    Perry, G.5    Boux, H.6    Smith, M.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.