메뉴 건너뛰기




Volumn 11, Issue 14, 1997, Pages 1840-1852

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

Author keywords

Apoptosis; E2F1 overexpression; p53; Rb; Transactivation

Indexed keywords

DNA BINDING PROTEIN; PROTEIN P53;

EID: 0030850752     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.14.1840     Document Type: Article
Times cited : (263)

References (38)
  • 1
    • 0030023846 scopus 로고    scopus 로고
    • Cleavage of retinoblastoma protein during apoptosis: An interleukin lb-converting enzyme-like protease as candidate
    • An, B. and P.Q. Dou. 1996. Cleavage of retinoblastoma protein during apoptosis: An interleukin lb-converting enzyme-like protease as candidate. Cancer Res. 56: 438-442.
    • (1996) Cancer Res. , vol.56 , pp. 438-442
    • An, B.1    Dou, P.Q.2
  • 3
    • 0028033603 scopus 로고
    • Loss of APC protein expression by human colonic epithelial cells and the appearance of a specific lowmolecular-weight form is associated with apoptosis in vitro
    • Browne, S.J., A.C. Williams, A. Hague, A.J. Butt, and C. Paraskeva. 1994. Loss of APC protein expression by human colonic epithelial cells and the appearance of a specific lowmolecular-weight form is associated with apoptosis in vitro. Int. J. Cancer 59: 56-64.
    • (1994) Int. J. Cancer , vol.59 , pp. 56-64
    • Browne, S.J.1    Williams, A.C.2    Hague, A.3    Butt, A.J.4    Paraskeva, C.5
  • 5
    • 0029883399 scopus 로고    scopus 로고
    • The retinoblastoma gene product inhibits TGF-β1 induced apoptosis in primary rat hepatocytes and human HuH-7 hetatoma cells
    • Fan, G.-S., X.-M. Ma, B. Kren, and C.J. Steer. 1996. The retinoblastoma gene product inhibits TGF-β1 induced apoptosis in primary rat hepatocytes and human HuH-7 hetatoma cells. Oncogene 12: 1909-1919.
    • (1996) Oncogene , vol.12 , pp. 1909-1919
    • Fan, G.-S.1    Ma, X.-M.2    Kren, B.3    Steer, C.J.4
  • 8
    • 0027520469 scopus 로고
    • The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro
    • Hagemeier, C., A. Cook, and T. Kouzarides. 1993. The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res. 21: 4998-5004.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 4998-5004
    • Hagemeier, C.1    Cook, A.2    Kouzarides, T.3
  • 9
    • 0029797841 scopus 로고    scopus 로고
    • Degradation of E2F by the ubiquitinproteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
    • Hateboer, G., R.M. Kerkhoven, A. Shvarts, R, Bernards, and R,L. Beijersbergen, 1996. Degradation of E2F by the ubiquitinproteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes &. Dev. 10: 2960-2970.
    • (1996) Genes &. Dev. , vol.10 , pp. 2960-2970
    • Hateboer, G.1    Kerkhoven, R.M.2    Shvarts, A.3    Bernards, R.4    Beijersbergen, R.L.5
  • 10
    • 0028999429 scopus 로고
    • p53-mediated apoptosis in Hela cells can be overcome by excess pRb
    • Haupt, Y., S. Rowan, and M. Oren. 1995. p53-mediated apoptosis in Hela cells can be overcome by excess pRb. Oncogene 10: 1563-1571.
    • (1995) Oncogene , vol.10 , pp. 1563-1571
    • Haupt, Y.1    Rowan, S.2    Oren, M.3
  • 11
    • 0029985647 scopus 로고    scopus 로고
    • Cell type-specific inhibition of p53-mediated apoptosis by mdm2
    • Haupt, Y., Y. Barak, and M. Oren. 1996. Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J. 15: 1596-1606.
    • (1996) EMBO J. , vol.15 , pp. 1596-1606
    • Haupt, Y.1    Barak, Y.2    Oren, M.3
  • 14
    • 0029820095 scopus 로고    scopus 로고
    • The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteosome pathway
    • Hofmann, F., F. Martelli, D.M. Livingston, and Z. Wang. 1996. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteosome pathway. Genes & Dev. 10: 2949-2959.
    • (1996) Genes & Dev. , vol.10 , pp. 2949-2959
    • Hofmann, F.1    Martelli, F.2    Livingston, D.M.3    Wang, Z.4
  • 15
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D.G., J.K. Schwarz, W.D. Cress, and J.R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 17
    • 0028960617 scopus 로고
    • E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
    • Kowalik, T.F., J. DeGregori, J.K. Shwarz, and J. Nevins. 1995. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. Virology 69:2491-2500.
    • (1995) Virology , vol.69 , pp. 2491-2500
    • Kowalik, T.F.1    DeGregori, J.2    Shwarz, J.K.3    Nevins, J.4
  • 18
    • 0029559027 scopus 로고
    • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
    • Krek, W., G.-F. Xu, and D.M. Livingston. 1995. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83: 1149-1158.
    • (1995) Cell , vol.83 , pp. 1149-1158
    • Krek, W.1    Xu, G.-F.2    Livingston, D.M.3
  • 19
    • 0027986982 scopus 로고
    • DP and E2F proteins: Coordinating transcription with cell cycle progression
    • Lam, E.W.-F. and N.B. La Thangue. 1994. DP and E2F proteins: Coordinating transcription with cell cycle progression. Curr. Opin. Cell Biol. 6: 859-866.
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 859-866
    • Lam, E.W.-F.1    La Thangue, N.B.2
  • 21
    • 0031024991 scopus 로고    scopus 로고
    • E2F1 cooperates with topoisomerase II inhibitor and DNA damage to selectively agument p53-in-dependent apoptosis
    • Nip, J.S., D.K. Strom, B.E. Fee, G. Zambetti, J.L. Cleveland, and S.W. Hiebert. 1997. E2F1 cooperates with topoisomerase II inhibitor and DNA damage to selectively agument p53-in-dependent apoptosis. Mol. Cell Biol 17: 1049-1056.
    • (1997) Mol. Cell Biol , vol.17 , pp. 1049-1056
    • Nip, J.S.1    Strom, D.K.2    Fee, B.E.3    Zambetti, G.4    Cleveland, J.L.5    Hiebert, S.W.6
  • 22
    • 0029615315 scopus 로고
    • Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1
    • O'Connor, D.J., E.W.-F. Lam, S. Griffin, S. Zhong, L.C. Leighton, S.A. Burhidge, and X. Lu. 1995. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO J. 14: 6184-6192.
    • (1995) EMBO J. , vol.14 , pp. 6184-6192
    • O'Connor, D.J.1    Lam, E.W.-F.2    Griffin, S.3    Zhong, S.4    Leighton, L.C.5    Burhidge, S.A.6    Lu, X.7
  • 23
    • 0030739355 scopus 로고    scopus 로고
    • Induction of DNA synthesis and apoptosis are separable functions of E2F-1
    • this issuel
    • Phillips, A.C., S. Bates, K.M. Ryan, K. Helin, and K.H. Vousden. 1997. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes & Dev. (this issuel).
    • (1997) Genes & Dev.
    • Phillips, A.C.1    Bates, S.2    Ryan, K.M.3    Helin, K.4    Vousden, K.H.5
  • 24
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X.Q., D.M. Livingston, W.G.J. Kaelin, and P.D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. 91: 10918-10922.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin, W.G.J.3    Adams, P.D.4
  • 25
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cellcycle arrest function in a human tumour derived p53 mutant
    • Rowan, S., R.L. Ludwig, Y. Haupt, S. Bates, X. Lu, M. Oren, and K.H. Vousden. 1996. Specific loss of apoptotic but not cellcycle arrest function in a human tumour derived p53 mutant. EMBO J. 15: 827-838.
    • (1996) EMBO J. , vol.15 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 26
    • 0028948866 scopus 로고
    • E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phase of the cell cycle
    • Sardet, C., M. Vidai, D. Cobrinik, Y. Geng, C. Onufryk, and A. Chen. 1995. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phase of the cell cycle. Proc. Natl. Acad. Sci 92: 2403-2407.
    • (1995) Proc. Natl. Acad. Sci , vol.92 , pp. 2403-2407
    • Sardet, C.1    Vidai, M.2    Cobrinik, D.3    Geng, Y.4    Onufryk, C.5    Chen, A.6
  • 27
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B. and W.-H. Lee. 1994. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell. Biol. 14: 8166-8173.
    • (1994) Mol Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.-H.2
  • 28
    • 0030069682 scopus 로고    scopus 로고
    • Disruption of RB/ E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis
    • Shan, B., T. Durfee, and W.-H. Lee. 1996a. Disruption of RB/ E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. Proc. Natl. Acad. Sci. 93: 679-684.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 679-684
    • Shan, B.1    Durfee, T.2    Lee, W.-H.3
  • 29
    • 0029805888 scopus 로고    scopus 로고
    • The molecular basis of E2F-1/DP-1 induced S-phase entry and apoptosis
    • Shan, B., A.A. Farmer, and W.-H. Lee. 1996b. The molecular basis of E2F-1/DP-1 induced S-phase entry and apoptosis. Cell Growth Differ. 7: 689-697.
    • (1996) Cell Growth Differ. , vol.7 , pp. 689-697
    • Shan, B.1    Farmer, A.A.2    Lee, W.-H.3
  • 30
    • 0019801763 scopus 로고
    • Binding of dephosphorylated A protein to SV40 DNA
    • Shaw, S.B. and P. Tegtmeyer. 1981. Binding of dephosphorylated A protein to SV40 DNA. Virology 115: 88-96.
    • (1981) Virology , vol.115 , pp. 88-96
    • Shaw, S.B.1    Tegtmeyer, P.2
  • 31
    • 0028360766 scopus 로고
    • Overexpression of E2F1 in rat embryo fibroblasts leads to neoplastic transformation
    • Singh, C.J., S.H. Wong, and W. Hong. 1994. Overexpression of E2F1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J. 13: 3329-3338.
    • (1994) EMBO J. , vol.13 , pp. 3329-3338
    • Singh, C.J.1    Wong, S.H.2    Hong, W.3
  • 32
    • 0026636908 scopus 로고
    • Retinoblastoma protein switches the E2F site from positive to negative element
    • Weintraub, S.J., C.A. Prater, and D.C. Dean. 1992. Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358: 259-261.
    • (1992) Nature , vol.358 , pp. 259-261
    • Weintraub, S.J.1    Prater, C.A.2    Dean, D.C.3
  • 33
    • 0029043782 scopus 로고
    • Mechanism of active transcriptional repression by the retinoblastoma protein
    • Weintraub, S.J., K.N.B. Chow, R.X. Luo, S. Zhang, S. He, and D.C. Dean. 1995. Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375:812-815.
    • (1995) Nature , vol.375 , pp. 812-815
    • Weintraub, S.J.1    Chow, K.N.B.2    Luo, R.X.3    Zhang, S.4    He, S.5    Dean, D.C.6
  • 34
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X. and A.J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. 91: 3602-3606.
    • (1994) Proc. Natl. Acad. Sci. , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 37
    • 0029856734 scopus 로고    scopus 로고
    • Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product
    • Zacksenhaus, E., Z. Jiang, R.A. Phillips, and B. Gallie. 1996. Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product. EMBO J. 15: 5917-5927.
    • (1996) EMBO J. , vol.15 , pp. 5917-5927
    • Zacksenhaus, E.1    Jiang, Z.2    Phillips, R.A.3    Gallie, B.4
  • 38
    • 0029066888 scopus 로고
    • Cloning and characterization of human DP2, a novel dimerization partner of E2F
    • Zhang, Y. and S.P. Chellappan. 1995. Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogens 10: 2085-2093.
    • (1995) Oncogens , vol.10 , pp. 2085-2093
    • Zhang, Y.1    Chellappan, S.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.