-
1
-
-
0028884033
-
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi D. R., Cuenda A., Cohen P., Dudley D. T. and Saltiel A. R. (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem 270, 27489-27494.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
2
-
-
0016652087
-
Brain peroxidase and catalase in Parkinson disease
-
Ambani L. M., Van Woert M. H. and Murphy S. (1975) Brain peroxidase and catalase in Parkinson disease. Arch. Neurol. 32, 114-118.
-
(1975)
Arch. Neurol.
, vol.32
, pp. 114-118
-
-
Ambani, L.M.1
Van Woert, M.H.2
Murphy, S.3
-
3
-
-
0027331917
-
The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls
-
Andrew R., Watson D. G., Best S. A., Midgley J. M., Wenlong H. and Petty R. K. H. (1993) The determination of hydroxydopamines and other trace amines in the urine of Parkinsonian patients and normal controls. Neurochem. Res. 18, 1175-1177.
-
(1993)
Neurochem. Res.
, vol.18
, pp. 1175-1177
-
-
Andrew, R.1
Watson, D.G.2
Best, S.A.3
Midgley, J.M.4
Wenlong, H.5
Petty, R.K.H.6
-
4
-
-
0031946038
-
Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice
-
Asanuma M., Hirata H. and Cadet J. L. (1998) Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice. Neuroscience 85, 907-917.
-
(1998)
Neuroscience
, vol.85
, pp. 907-917
-
-
Asanuma, M.1
Hirata, H.2
Cadet, J.L.3
-
5
-
-
0029125857
-
Aging, energy, and oxidative stress in neurodegenerative diseases
-
Beal M. F. (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366.
-
(1995)
Ann. Neurol.
, vol.38
, pp. 357-366
-
-
Beal, M.F.1
-
6
-
-
0032921811
-
2 activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: Role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death
-
2 activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J. Neurochem. 72, 112-119.
-
(1999)
J. Neurochem.
, vol.72
, pp. 112-119
-
-
Bhat, N.R.1
Zhang, P.2
-
7
-
-
0034161438
-
2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats
-
2 dopamine receptor stimulation in unilateral 6-hydroxydopamine-lesioned rats. J. Neurosci. 20, 1849-1857.
-
(2000)
J. Neurosci.
, vol.20
, pp. 1849-1857
-
-
Cai, G.1
Zhen, X.2
Uryu, K.3
Friedman, E.4
-
8
-
-
0033168508
-
Two distinct mechanisms are involved in 6-hydroxydopamine-and MPP+-induced dopaminergic neuronal cell death: Role of caspases, ROS, and JNK
-
Choi W. S., Yoon S. Y., Oh T. H., Choi E. J., O'Malley K. L. and Oh Y. J. (1999) Two distinct mechanisms are involved in 6-hydroxydopamine-and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK. J. Neurosci. Res. 57, 86-94.
-
(1999)
J. Neurosci. Res.
, vol.57
, pp. 86-94
-
-
Choi, W.S.1
Yoon, S.Y.2
Oh, T.H.3
Choi, E.J.4
O'Malley, K.L.5
Oh, Y.J.6
-
9
-
-
0031019795
-
Dopaminergic neurons protected from degeneration by GDNFgene therapy
-
Choi-Lundberg D., Lin Q., Chang Y., Chiang Y., Hay C., Mohajeri H., Davidson B. and Bohn M. (1997) Dopaminergic neurons protected from degeneration by GDNFgene therapy. Science 275, 838-841.
-
(1997)
Science
, vol.275
, pp. 838-841
-
-
Choi-Lundberg, D.1
Lin, Q.2
Chang, Y.3
Chiang, Y.4
Hay, C.5
Mohajeri, H.6
Davidson, B.7
Bohn, M.8
-
10
-
-
0027499466
-
Receptor-mediated antigen delivery into macrophages: Complexing antigen to α2-macroglobulin enhances presentation to T-cells
-
Chu C. T. and Pizzo S. V. (1993) Receptor-mediated antigen delivery into macrophages: Complexing antigen to α2-macroglobulin enhances presentation to T-cells. J. Immunol. 150, 48-58.
-
(1993)
J. Immunol.
, vol.150
, pp. 48-58
-
-
Chu, C.T.1
Pizzo, S.V.2
-
11
-
-
0030787340
-
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
-
Chu C. T., Everiss K. D., Batra S., Wikstrand C. J., Kung H.-J. and Bigner D. D. (1997) Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem. J. 324, 855-861.
-
(1997)
Biochem. J.
, vol.324
, pp. 855-861
-
-
Chu, C.T.1
Everiss, K.D.2
Batra, S.3
Wikstrand, C.J.4
Kung, H.-J.5
Bigner, D.D.6
-
12
-
-
0016378870
-
The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents
-
Cohen G. and Heikkila R. E. (1974) The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem. 249, 2447-2452.
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 2447-2452
-
-
Cohen, G.1
Heikkila, R.E.2
-
13
-
-
0033575432
-
Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro
-
Eggert K., Schlegel J., Oertel W., Wurz C., Krieg J. C. and Vedder H. (1999) Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro. Neurosci. Lett. 269, 178-182.
-
(1999)
Neurosci. Lett.
, vol.269
, pp. 178-182
-
-
Eggert, K.1
Schlegel, J.2
Oertel, W.3
Wurz, C.4
Krieg, J.C.5
Vedder, H.6
-
14
-
-
0028276809
-
Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat
-
Frim D., Uhler T., Galpern W., Beal M., Breakefield X. and Isacson O. (1994) Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Natl. Acad. Sci. USA 91, 5104-5108.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5104-5108
-
-
Frim, D.1
Uhler, T.2
Galpern, W.3
Beal, M.4
Breakefield, X.5
Isacson, O.6
-
15
-
-
0028918841
-
Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine
-
Glinka Y. Y. and Youdim M. B. (1995) Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. Eur J. Pharmacol. 292, 329-332.
-
(1995)
Eur J. Pharmacol.
, vol.292
, pp. 329-332
-
-
Glinka, Y.Y.1
Youdim, M.B.2
-
16
-
-
0033961816
-
Delayed and sustained activation of p42/p44 mitogen-activated protein kinase induced by proteasome inhibitors through p21 (ras) in PC12 cells
-
Hashimoto K., Guroff G. and Katagiri Y. (2000) Delayed and sustained activation of p42/p44 mitogen-activated protein kinase induced by proteasome inhibitors through p21 (ras) in PC12 cells. J. Neurochem. 74, 92-98.
-
(2000)
J. Neurochem.
, vol.74
, pp. 92-98
-
-
Hashimoto, K.1
Guroff, G.2
Katagiri, Y.3
-
17
-
-
0029933450
-
Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections
-
Hastings T. G., Lewis D. A. and Zigmond M. J. (1996) Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections. Proc. Natl. Acad. Sci. USA 93, 1956-1961.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1956-1961
-
-
Hastings, T.G.1
Lewis, D.A.2
Zigmond, M.J.3
-
18
-
-
0026034279
-
Iron and aluminum increase in the substantia nigra of patients with parkinson's disease: An X-ray microanalysis
-
Hirsch E.C., Brandel J. P., Galle P., Javoy-Agid F. and Agid Y. (1991) Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem. 56, 446-451.
-
(1991)
J. Neurochem.
, vol.56
, pp. 446-451
-
-
Hirsch, E.C.1
Brandel, J.P.2
Galle, P.3
Javoy-Agid, F.4
Agid, Y.5
-
19
-
-
0032521027
-
Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling
-
Holmström T. H., Chow S. C., Elo I., Coffey E. T., Orrenius S., Sistonen L. and Eriksson J. E. (1998) Suppression of Fas/APO-1-mediated apoptosis by mitogen-activated kinase signaling. J. Immunol. 160, 2626-2636.
-
(1998)
J. Immunol.
, vol.160
, pp. 2626-2636
-
-
Holmström, T.H.1
Chow, S.C.2
Elo, I.3
Coffey, E.T.4
Orrenius, S.5
Sistonen, L.6
Eriksson, J.E.7
-
20
-
-
0033954661
-
Hyperexpression and activation of extracellular signal-regulated kinases (ERK 1/2) in atherosclerotic lesions of cholesterol-fed rabbits
-
Hu Y., Dietrich H., Metzler B., Wick G. and Xu Q. (2000) Hyperexpression and activation of extracellular signal-regulated kinases (ERK 1/2) in atherosclerotic lesions of cholesterol-fed rabbits. Arterioscler. Thromb. Vasc. Biol. 20, 18-26.
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 18-26
-
-
Hu, Y.1
Dietrich, H.2
Metzler, B.3
Wick, G.4
Xu, Q.5
-
21
-
-
0033517719
-
Dual potential of extracellular signal-regulated kinase for the control of cell survival
-
Ishikawa Y. and Kitamura M. (1999) Dual potential of extracellular signal-regulated kinase for the control of cell survival. Biochem. Biophys. Res. Commun 264, 696-701.
-
(1999)
Biochem. Biophys. Res. Commun
, vol.264
, pp. 696-701
-
-
Ishikawa, Y.1
Kitamura, M.2
-
22
-
-
0002608401
-
6-Hydroxydopamine. Dopamine, and ferritin: A cycle of reactions sustaining parkinson's disease?
-
Poli G., Cadenas E. and Packer L., eds, Marcel Dekker, Inc., New York
-
Jameson, G. N. L. and Linert, W. (2000) 6-Hydroxydopamine. dopamine, and ferritin: a cycle of reactions sustaining parkinson's disease?, in Free Radicals in Brain Pathophysiology (Poli G., Cadenas E. and Packer L., eds), pp. 247-272. Marcel Dekker, Inc., New York.
-
(2000)
Free Radicals in Brain Pathophysiology
, pp. 247-272
-
-
Jameson, G.N.L.1
Linert, W.2
-
23
-
-
0022415447
-
Glutathione peroxidase activity in Parkinson's disease brain
-
Kish S. J., Morito C. and Hornykiewicz O. (1985) Glutathione peroxidase activity in Parkinson's disease brain. Neurosci. Lett. 58, 343-346.
-
(1985)
Neurosci. Lett.
, vol.58
, pp. 343-346
-
-
Kish, S.J.1
Morito, C.2
Hornykiewicz, O.3
-
24
-
-
0033121096
-
Modulation of protein kinases and protein phosphatases by reactive oxygen species: Implications for hippocampal synaptic plasticity
-
Klann E. and Thiels E. (1999) Modulation of protein kinases and protein phosphatases by reactive oxygen species: implications for hippocampal synaptic plasticity. Prog. Neuropsychopharmacol. Biol. Psychiatry 23, 359-376.
-
(1999)
Prog. Neuropsychopharmacol. Biol. Psychiatry
, vol.23
, pp. 359-376
-
-
Klann, E.1
Thiels, E.2
-
25
-
-
0031054520
-
A molecular redox switch on p21 (ras). Structural basis for the nitric oxide-p21 (ras) interaction
-
Lander H. M., Hajjar D. P., Hempstead B. L., Mirza U. A., Chait B. T., Campbell S. and Quilliam L. A. (1997) A molecular redox switch on p21 (ras). Structural basis for the nitric oxide-p21 (ras) interaction. J. Biol. Chem. 272, 4323-4326.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4323-4326
-
-
Lander, H.M.1
Hajjar, D.P.2
Hempstead, B.L.3
Mirza, U.A.4
Chait, B.T.5
Campbell, S.6
Quilliam, L.A.7
-
26
-
-
0032497504
-
Parkinson's disease. First of two parts
-
Lang A. E. and Lozano A. M. (1998) Parkinson's disease. First of two parts. N. Engl. J. Med. 339, 1044-1053.
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 1044-1053
-
-
Lang, A.E.1
Lozano, A.M.2
-
27
-
-
0033557640
-
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
-
Lotharius J., Dugan L. L. and O'Malley K. L. (1999) Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19, 1284-1293.
-
(1999)
J. Neurosci.
, vol.19
, pp. 1284-1293
-
-
Lotharius, J.1
Dugan, L.L.2
O'Malley, K.L.3
-
28
-
-
0032488992
-
Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
-
Luo Y., Umegaki H., Xiantao W., Abe R. and Roth G. S. (1998) Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J. Biol. Chem. 273, 3756-3764.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3756-3764
-
-
Luo, Y.1
Umegaki, H.2
Xiantao, W.3
Abe, R.4
Roth, G.S.5
-
29
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall C. J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
30
-
-
0028338865
-
Prevalence of movement disorders in elderly community residents
-
Moghal S., Rajput A. H., D'Arcy C. and Rajput R. (1994) Prevalence of movement disorders in elderly community residents. Neuroepidemiology 13, 175-178.
-
(1994)
Neuroepidemiology
, vol.13
, pp. 175-178
-
-
Moghal, S.1
Rajput, A.H.2
D'Arcy, C.3
Rajput, R.4
-
31
-
-
0033600821
-
Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells
-
Oh-hashi K., Maruyama W., Yi H., Takahashi T., Naoi M. and Isobe K. (1999) Mitogen-activated protein kinase pathway mediates peroxynitrite-induced apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells. Biochem. Biophys. Res. Commun. 263, 504-509.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.263
, pp. 504-509
-
-
Oh-Hashi, K.1
Maruyama, W.2
Yi, H.3
Takahashi, T.4
Naoi, M.5
Isobe, K.6
-
32
-
-
0033516947
-
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation
-
Perry G., Roder H., Nunomura A., Takeda A., Friedlich A. L., Zhu X., Raina A. K., Holbrook N., Siedlak S. L., Harris P. L. and Smith M. A. (1999) Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. Neuroreport 10, 2411-2415.
-
(1999)
Neuroreport
, vol.10
, pp. 2411-2415
-
-
Perry, G.1
Roder, H.2
Nunomura, A.3
Takeda, A.4
Friedlich, A.L.5
Zhu, X.6
Raina, A.K.7
Holbrook, N.8
Siedlak, S.L.9
Harris, P.L.10
Smith, M.A.11
-
33
-
-
0032530577
-
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism
-
Runden E., Seglen P. O., Haug F. M., Ottersen O. P., Wieloch T., Shamloo M. and Laake J. H. (1998) Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J. Neurosci. 18, 7296-7305.
-
(1998)
J. Neurosci.
, vol.18
, pp. 7296-7305
-
-
Runden, E.1
Seglen, P.O.2
Haug, F.M.3
Ottersen, O.P.4
Wieloch, T.5
Shamloo, M.6
Laake, J.H.7
-
34
-
-
0016358141
-
Clonal cell lines from the rat central nervous system
-
Schubert D., Heinemann S., Carlisle W., Tarikas H., Kimes B., Patrick J. and Steinback J. H. (1974) Clonal cell lines from the rat central nervous system. Nature 249, 224-227.
-
(1974)
Nature
, vol.249
, pp. 224-227
-
-
Schubert, D.1
Heinemann, S.2
Carlisle, W.3
Tarikas, H.4
Kimes, B.5
Patrick, J.6
Steinback, J.H.7
-
35
-
-
0029925683
-
Intracellular signaling pathways activated by neurotrophic factors
-
Segal R. A. and Greenberg M. E. (1996) Intracellular signaling pathways activated by neurotrophic factors. Ann. Rev. Neurosci. 19, 463-489.
-
(1996)
Ann. Rev. Neurosci.
, vol.19
, pp. 463-489
-
-
Segal, R.A.1
Greenberg, M.E.2
-
36
-
-
0034697364
-
Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures
-
Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., Reynolds I., Klann E., Angiolieri M., Johnson J. and Defranco D. B. (2000) Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 275, 12200-12206.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12200-12206
-
-
Stanciu, M.1
Wang, Y.2
Kentor, R.3
Burke, N.4
Watkins, S.5
Kress, G.6
Reynolds, I.7
Klann, E.8
Angiolieri, M.9
Johnson, J.10
Defranco, D.B.11
-
37
-
-
0030722559
-
The tetrazolium dyes MTS and XTT provide new quantitative assays for superoxide and superoxide dismutase
-
Sutherland M. W. and Learmonth B. A. (1997) The tetrazolium dyes MTS and XTT provide new quantitative assays for superoxide and superoxide dismutase. Free Radic. Res. 27, 283-289.
-
(1997)
Free Radic. Res.
, vol.27
, pp. 283-289
-
-
Sutherland, M.W.1
Learmonth, B.A.2
-
39
-
-
0032521642
-
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
-
Tombes R. M., Auer K. L., Mikkelsen R., Valerie K., Wymann M. P., Marshall C. J., Mcmahon M. and Dent P. (1998) The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem. J. 330, 1451-1460.
-
(1998)
Biochem. J.
, vol.330
, pp. 1451-1460
-
-
Tombes, R.M.1
Auer, K.L.2
Mikkelsen, R.3
Valerie, K.4
Wymann, M.P.5
Marshall, C.J.6
McMahon, M.7
Dent, P.8
-
40
-
-
0026486878
-
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC 12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
-
Traverse S., Gomez N., Paterson H., Marshall C. and Cohen P. (1992) Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC 12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288, 351-355.
-
(1992)
Biochem. J.
, vol.288
, pp. 351-355
-
-
Traverse, S.1
Gomez, N.2
Paterson, H.3
Marshall, C.4
Cohen, P.5
-
41
-
-
0014376793
-
6-Hydroxy-dopamine induced degeneration of central monoamine neurons
-
Ungerstedt U. (1968) 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur J. Pharmacol. 5, 107-110.
-
(1968)
Eur J. Pharmacol.
, vol.5
, pp. 107-110
-
-
Ungerstedt, U.1
-
43
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z., Dickens M., Raingeaud J., Davis R. J. and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
|