The interleukin-12 family of cytokines: Therapeutic targets for inflammatory disease mediation

Clinical and Applied Immunology Reviews

Volumn 5, Issue 4, 2005, Pages 225-240

  Barrie III, Arthur M ^a   Plevy, Scott E ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Crohn's disease; IL 12; IL 23; Multiple sclerosis; Psoriasis; Rheumatoid arthritis

Indexed keywords

ABT 874; BETA INTERFERON; CNTO 1275; CYCLOPHOSPHAMIDE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12P40; INTERLEUKIN 12P40 ANTIBODY; INTERLEUKIN 23; METHYLPREDNISOLONE; PLACEBO; STA 5326; TUMOR NECROSIS FACTOR ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; CLINICAL TRIAL; CROHN DISEASE; DRUG PULSE THERAPY; DRUG TARGETING; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; INFECTION; INFLAMMATORY DISEASE; INJECTION SITE REACTION; INNATE IMMUNITY; INTERFERON PRODUCTION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PSORIASIS VULGARIS; REVIEW; RHEUMATOID ARTHRITIS; SAFETY;

EID: 26944437427     PISSN: 15291049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cair.2005.06.003     Document Type: Review

References (97)

1. M. Feldmann M.J. Elliott J.N. Woody R.N. Maini Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis Adv Immunol 64 1997 283-350
2. G. Krueger K. Callis Potential of tumor necrosis factor inhibitors in psoriasis and psoriatic arthritis Arch Dermatol 140 2004 218-225
3. F.C. Victor A.B. Gottlieb A. Menter Changing paradigms in dermatology: tumor necrosis factor alpha (TNF-alpha) blockade in psoriasis and psoriatic arthritis Clin Dermatol 21 2003 392-397
4. D. Kane O. FitzGerald Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: A clinical, genetic, and histopathologic perspective Curr Rheumatol Rep 6 2004 292-298
5. P.J. Mannon I.J. Fuss L. Mayer C.O. Elson W.J. Sandborn D. Present et al. Anti-interleukin-12 antibody for active Crohn's disease N Engl J Med 351 2004 2069-2079
6. S. Ganesan S.P. Travis T. Ahmad R. Jazrawi Therapeutic inhibitors of tumor necrosis factor in Crohn's disease Curr Opin Investig Drugs 3 2002 1301-1306
7. W.J. Sandborn Strategies targeting tumor necrosis factor in Crohn's disease Acta Gastroenterol Belg 64 2001 170-172
8. M.H. Buch S.J. Bingham Y. Seto D. McGonagle V. Bejarano J. White et al. Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor alpha blockade Arthritis Rheum 50 2004 725-728
9. C.W. Thomas Jr. B.G. Weinshenker W.J. Sandborn Demyelination during anti-tumor necrosis factor alpha therapy with infliximab for Crohn's disease Inflamm Bowel Dis 10 2004 28-31
10. S. Vermeire M. Noman G. Van Assche F. Baert K. Van Steen N. Esters et al. Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease: A prospective cohort study Gastroenterology 125 2003 32-39
11. L. Guillevin L. Mouthon Tumor necrosis factor-alpha blockade and the risk of vasculitis J Rheumatol 31 2004 1885-1887
12. K. Vandenbroeck I. Alloza M. Gadina P. Matthys Inhibiting cytokines of the interleukin-12 family: Recent advances and novel challenges J Pharm Pharmacol 56 2004 145-160
13. R. Cordoba-Rodriguez D.M. Frucht IL-23 and IL-27: New members of the growing family of IL-12-related cytokines with important implications for therapeutics Expert Opin Biol Ther 3 2003 715-723
14. F. Brombacher R.A. Kastelein G. Alber Novel IL-12 family members shed light on the orchestration of Th1 responses Trends Immunol 24 2003 207-212
15. G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 3 2003 133-146
16. K. Hong A. Chu B.R. Ludviksson E.L. Berg R.O. Ehrhardt IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder J Immunol 162 1999 7480-7491
17. D.J. Najarian A.B. Gottlieb Connections between psoriasis and Crohn's disease J Am Acad Dermatol 48 2003 805-821 quiz 22-4
18. G.L. Costa M.R. Sandora A. Nakajima E.V. Nguyen C. Taylor-Edwards A.J. Slavin et al. Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit J Immunol 167 2001 2379-2387
19. A.A. Byrnes J.C. McArthur C.L. Karp Interferon-beta therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production Ann Neurol 51 2002 165-174
20. M. Comabella K. Balashov S. Issazadeh D. Smith H.L. Weiner S.J. Khoury Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy J Clin Invest 102 1998 671-678
21. S.S. Soldan A.I. Alvarez Retuerto N.L. Sicotte R.R. Voskuhl Dysregulation of IL-10 and IL-12 p40 in secondary progressive multiple sclerosis J Neuroimmunol 146 2004 209-215
22. D.K. Podolsky Inflammatory bowel disease N Engl J Med 347 2002 417-429
23. K. Tozawa H. Hanai K. Sugimoto S. Baba H. Sugimura T. Aoshi et al. Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice J Gastroenterol Hepatol 18 2003 578-587
24. M.K. Gately L.M. Renzetti J. Magram A.S. Stern L. Adorini U. Gubler et al. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses Annu Rev Immunol 16 1998 495-521
25. S. Pflanz J.C. Timans J. Cheung R. Rosales H. Kanzler J. Gilbert et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells Immunity 16 2002 779-790
26. F. Larousserie S. Pflanz A. Coulomb-L'Hermine N. Brousse R. Kastelein O. Devergne Expression of IL-27 in human Th1-associated granulomatous diseases J Pathol 202 2004 164-171
27. R. Salcedo J.K. Stauffer E. Lincoln T.C. Back J.A. Hixon C. Hahn et al. IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: Role for CD8+ T cells J Immunol 173 2004 7170-7182
28. M. Chiyo O. Shimozato L. Yu K. Kawamura T. Iizasa T. Fujisawa et al. Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals Int J Cancer 2005
29. J. Scheller B. Schuster C. Holscher T. Yoshimoto S. Rose-John No inhibition of IL-27 signaling by soluble gp130 Biochem Biophys Res Commun 326 2005 724-728
30. J.E. Pearl S.A. Khader A. Solache L. Gilmartin N. Ghilardi F. deSauvage et al. IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice J Immunol 173 2004 7490-7496
31. C.A. Hunter A. Villarino D. Artis P. Scott The role of IL-27 in the development of T-cell responses during parasitic infections Immunol Rev 202 2004 106-114
32. R. Goldberg G. Wildbaum Y. Zohar G. Maor N. Karin Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27 J Immunol 173 2004 1171-1178
33. E.E. Nieuwenhuis M.F. Neurath N. Corazza H. Iijima J. Trgovcich S. Wirtz et al. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice Proc Natl Acad Sci U S A 99 2002 16951-16956
34. C.L. Kauffman N. Aria E. Toichi T.S. McCormick K.D. Cooper A.B. Gottlieb et al. A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis J Invest Dermatol 123 2004 1037-1044
35. M.T. Wiekowski M.W. Leach E.W. Evans L. Sullivan S.C. Chen G. Vassileva et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death J Immunol 166 2001 7563-7570
36. C. Holscher The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases Med Microbiol Immunol (Berl) 193 2004 1-17
37. C.S. Lankford D.M. Frucht A unique role for IL-23 in promoting cellular immunity J Leukoc Biol 73 2003 49-56
38. C. Parham M. Chirica J. Timans E. Vaisberg M. Travis J. Cheung et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R J Immunol 168 2002 5699-5708
39. G. Trinchieri F. Gerosa Immunoregulation by interleukin-12 J Leukoc Biol 59 1996 505-511
40. W.T. Watford M. Moriguchi A. Morinobu J.J. O'Shea The biology of IL-12: coordinating innate and adaptive immune responses Cytokine Growth Factor Rev 14 2003 361-368
41. B. Oppmann R. Lesley B. Blom J.C. Timans Y. Xu B. Hunte et al. Novel p19 protein engages IL-12 p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 2000 715-725
42. D.M. Frucht IL-23: A cytokine that acts on memory T cells Sci STKE 2002 2002 PE1
43. S.J. Ha D.J. Kim K.H. Baek Y.D. Yun Y.C. Sung IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization J Immunol 172 2004 525-531
44. M.L. Belladonna J.C. Renauld R. Bianchi C. Vacca F. Fallarino C. Orabona et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells J Immunol 168 2002 5448-5454
45. S. Aggarwal N. Ghilardi M.H. Xie F.J. de Sauvage A.L. Gurney Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 J Biol Chem 278 2003 1910-1914
46. S. Aggarwal A.L. Gurney IL-17: Prototype member of an emerging cytokine family J Leukoc Biol 71 2002 1-8
47. Z. Yao W.C. Fanslow M.F. Seldin A.M. Rousseau S.L. Painter M.R. Comeau et al. Herpes virus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor Immunity 3 1995 811-821
48. J. Kennedy D.L. Rossi S.M. Zurawski F. Vega Jr. R.A. Kastelein J.L. Wagner et al. Mouse IL-17: A cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells J Interferon Cytokine Res 16 1996 611-617
49. F. Fossiez O. Djossou P. Chomarat L. Flores-Romo S. Ait-Yahia C. Maat et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines J Exp Med 183 1996 2593-2603
50. A. Linden H. Hoshino M. Laan Airway neutrophils and interleukin-17 Eur Respir J 15 2000 973-977
51. X.Y. Cai C.P. Gommoll Jr. L. Justice S.K. Narula J.S. Fine Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17 Immunol Lett 62 1998 51-58
52. M. Laan Z.H. Cui H. Hoshino J. Lotvall M. Sjostrand D.C. Gruenert et al. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways J Immunol 162 1999 2347-2352
53. D.V. Jovanovic J.A. Di Battista J. Martel-Pelletier F.C. Jolicoeur Y. He M. Zhang et al. IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages J Immunol 160 1998 3513-3521
54. M. Chabaud F. Fossiez J.L. Taupin P. Miossec Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines J Immunol 161 1998 409-414
55. S. Kotake N. Udagawa N. Takahashi K. Matsuzaki K. Itoh S. Ishiyama et al. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis J Clin Invest 103 1999 1345-1352
56. M. Chabaud J.M. Durand N. Buchs F. Fossiez G. Page L. Frappart et al. Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium Arthritis Rheum 42 1999 963-970
57. M.A. Antonysamy W.C. Fanslow F. Fu W. Li S. Qian A.B. Troutt et al. Evidence for a role of IL-17 in alloimmunity: A novel IL-17 antagonist promotes heart graft survival Transplant Proc 31 1999 93
58. M.A. Antonysamy W.C. Fanslow F. Fu W. Li S. Qian A.B. Troutt et al. Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors J Immunol 162 1999 577-584
59. C.C. Loong C.Y. Lin W.Y. Lui Expression of interleukin-17 as a predictive parameter in acute renal allograft rejection Transplant Proc 32 2000 1773
60. H.G. Hsieh C.C. Loong W.Y. Lui A. Chen C.Y. Lin IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection Transpl Int 14 2001 287-298
61. K. Kurasawa K. Hirose H. Sano H. Endo H. Shinkai Y. Nawata et al. Increased interleukin-17 production in patients with systemic sclerosis Arthritis Rheum 43 2000 2455-2463
62. C. Albanesi C. Scarponi A. Cavani M. Federici F. Nasorri G. Girolomoni Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes J Invest Dermatol 115 2000 81-87
63. B. Homey M.C. Dieu-Nosjean A. Wiesenborn C. Massacrier J.J. Pin E. Oldham et al. Up-regulation of macrophage inflammatory protein-3 alpha/ CCL20 and CC chemokine receptor 6 in psoriasis J Immunol 164 2000 6621-6632
64. M.B. Teunissen C.W. Koomen R. de Waal Malefyt E.A. Wierenga J.D. Bos Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes J Invest Dermatol 111 1998 645-649
65. C.A. Murphy C.L. Langrish Y. Chen W. Blumenschein T. McClanahan R.A. Kastelein et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J Exp Med 198 2003 1951-1957
66. S. Nakae A. Nambu K. Sudo Y. Iwakura Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice J Immunol 171 2003 6173-6177
67. X.T. Ma X.J. Zhang B. Zhang Y.Q. Geng Y.M. Lin G. Li et al. Expression and regulation of interleukin-23 subunits in human peripheral blood mononuclear cells and hematopoietic cell lines in response to various inducers Cell Biol Int 28 2004 689-697
68. J. Li B. Gran G.X. Zhang E.S. Ventura I. Siglienti A. Rostami et al. Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia J Neurol Sci 215 2003 95-103
69. C. Becker S. Wirtz M. Blessing J. Pirhonen D. Strand O. Bechthold et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells J Clin Invest 112 2003 693-706
70. J. Pirhonen S. Matikainen I. Julkunen Regulation of virus-induced IL-12 and IL-23 expression in human macrophages J Immunol 169 2002 5673-5678
71. G. Carra F. Gerosa G. Trinchieri Biosynthesis and posttranslational regulation of human IL-12 J Immunol 164 2000 4752-4761
72. S. Gillessen D. Carvajal P. Ling F.J. Podlaski D.L. Stremlo P.C. Familletti et al. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist Eur J Immunol 25 1995 200-206
73. F.P. Heinzel A.M. Hujer F.N. Ahmed R.M. Rerko In vivo production and function of IL-12 p40 homodimers J Immunol 158 1997 4381-4388
74. N. Yawalkar S. Karlen R. Hunger C.U. Brand L.R. Braathen Expression of interleukin-12 is increased in psoriatic skin J Invest Dermatol 111 1998 1053-1057
75. E. Lee W.L. Trepicchio J.L. Oestreicher D. Pittman F. Wang F. Chamian et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris J Exp Med 199 2004 125-130
76. J. Cheng Y. Tu J. Li C. Huang Z. Liu D. Liu A study on the expression of interleukin (IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions J Tongji Med Univ 21 2001 86-88
77. R. Joshi Immunopathogenesis of psoriasis Indian J Dermatol Venereol Leprol 70 2004 10-12
78. L. Camoglio N.P. Juffermans M. Peppelenbosch A.A. te Velde F.J. ten Kate S.J. van Deventer et al. Contrasting roles of IL-12 p40 and IL-12p35 in the development of hapten-induced colitis Eur J Immunol 32 2002 261-269
79. G. Trinchieri M. Wysocka A. D'Andrea M. Rengaraju M. Aste-Amezaga M. Kubin et al. Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation Prog Growth Factor Res 4 1992 355-368
80. D.J. Cua J. Sherlock Y. Chen C.A. Murphy B. Joyce B. Seymour et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744-748
81. H.P. Brok M. van Meurs E. Blezer A. Schantz D. Peritt G. Treacy et al. Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12 p40 monoclonal antibody J Immunol 169 2002 6554-6563
82. National Multiple Sclerosis Society Clinical Trials Recruiting Patients 2005 National Multiple Sclerosis Society New York . Accessed 02.20.05
83. P. Parronchi P. Romagnani F. Annunziato S. Sampognaro A. Becchio L. Giannarini et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease Am J Pathol 150 1997 823-832
84. G. Monteleone L. Biancone R. Marasco G. Morrone O. Marasco F. Luzza et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells Gastroenterology 112 1997 1169-1178
85. J.R. Piccotti K. Li S.Y. Chan J. Ferrante J. Magram E.J. Eichwald et al. Alloantigen-reactive Th1 development in IL-12-deficient mice J Immunol 160 1998 1132-1138
86. A. Stallmach T. Marth B. Weiss B.M. Wittig A. Hombach C. Schmidt et al. An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: Anti-inflammatory activity in Crohn's disease and experimental colitis in vivo Gut 53 2004 339-345
87. G. Bouma A. Kaushiva W. Strober Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses Gastroenterology 123 2002 554-565
88. M.F. Neurath I. Fuss B.L. Kelsall E. Stuber W. Strober Antibodies to interleukin 12 abrogate established experimental colitis in mice J Exp Med 182 1995 1281-1290
89. Y. Morita M. Yamamura K. Nishida S. Harada H. Okamoto H. Inoue et al. Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis Arthritis Rheum 41 1998 306-314
90. A. Spadaro T. Rinaldi V. Riccieri G. Valesini E. Taccari Interleukin 13 in synovial fluid and serum of patients with psoriatic arthritis Ann Rheum Dis 61 2002 174-176
91. K. Sullivan TNF and TNF alpha inhibitors: Mechanisms of action Pediatr Rheumatol Online J 2 2004 7-22
92. K. Ishihara T. Hirano IL-6 in autoimmune disease and chronic inflammatory proliferative disease Cytokine Growth Factor Rev 13 2002 357-368
93. D.M. Butler A.M. Malfait R.N. Maini F.M. Brennan M. Feldmann Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis Eur J Immunol 29 1999 2205-2212
94. A.M. Malfait D.M. Butler D.H. Presky R.N. Maini F.M. Brennan M. Feldmann Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis Clin Exp Immunol 111 1998 377-383
95. C.E. Verhagen T. de Boer H.H. Smits F.A. Verreck E.A. Wierenga M. Kurimoto et al. Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor beta1 (IL-12Rbeta1): Evidence for an IL-12Rbeta1-independent pathway of IL-12 responsiveness in human T cells J Exp Med 192 2000 517-528
96. R. de Jong F. Altare I.A. Haagen D.G. Elferink T. Boer P.J. van Breda Vriesman et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients Science 280 1998 1435-1438
97. D. Lilic I. Gravenor N. Robson D.A. Lammas P. Drysdale J.E. Calvert et al. Deregulated production of protective cytokines in response to Candida albicans infection in patients with chronic mucocutaneous candidiasis Infect Immun 71 2003 5690-5699