-
1
-
-
0031937388
-
Proinflammatory and immunoregulatory functions of interleukin-12
-
Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int. Rev. Immunol. 16:1998;365-396.
-
(1998)
Int. Rev. Immunol.
, vol.16
, pp. 365-396
-
-
Trinchieri, G.1
-
2
-
-
0034763143
-
Regulation of interleukin-12 production in antigen-presenting cells
-
Ma X., Trinchieri G. Regulation of interleukin-12 production in antigen-presenting cells. Adv. Immunol. 79:2001;55-92.
-
(2001)
Adv. Immunol.
, vol.79
, pp. 55-92
-
-
Ma, X.1
Trinchieri, G.2
-
3
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B.et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:2000;715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
-
4
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
-
Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J.et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168:2002;5699-5708.
-
(2002)
J. Immunol.
, vol.168
, pp. 5699-5708
-
-
Parham, C.1
Chirica, M.2
Timans, J.3
Vaisberg, E.4
Travis, M.5
Cheung, J.6
-
5
-
-
0036604062
-
IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
-
Belladonna M.L., Renauld J.C., Bianchi R., Vacca C., Fallarino F., Orabona C.et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J. Immunol. 168:2002;5448-5454.
-
(2002)
J. Immunol.
, vol.168
, pp. 5448-5454
-
-
Belladonna, M.L.1
Renauld, J.C.2
Bianchi, R.3
Vacca, C.4
Fallarino, F.5
Orabona, C.6
-
6
-
-
0031943618
-
The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
-
Gately M.K., Renzetti L.M., Magram J., Stern A.S., Adorini L., Gubler U.et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:1998;495-521.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 495-521
-
-
Gately, M.K.1
Renzetti, L.M.2
Magram, J.3
Stern, A.S.4
Adorini, L.5
Gubler, U.6
-
7
-
-
0035179817
-
Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation
-
Taoufik Y., de Goer de Herve M.G., Giron-Michel J., Durali D., Cazes E., Tardieu M.et al. Human microglial cells express a functional IL-12 receptor and produce IL-12 following IL-12 stimulation. Eur. J. Immunol. 31:2001;3228-3239.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 3228-3239
-
-
Taoufik, Y.1
De Goer De Herve, M.G.2
Giron-Michel, J.3
Durali, D.4
Cazes, E.5
Tardieu, M.6
-
8
-
-
0029847274
-
Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
-
Becher B., Dodelet V., Fedorowicz V., Antel J.P. Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro. J. Clin. Invest. 98:1996;1539-1543.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1539-1543
-
-
Becher, B.1
Dodelet, V.2
Fedorowicz, V.3
Antel, J.P.4
-
9
-
-
0031571317
-
IL-12 production by central nervous system microglia is inhibited by astrocytes
-
Aloisi F., Penna G., Cerase J., Menendez Iglesias B., Adorini L. IL-12 production by central nervous system microglia is inhibited by astrocytes. J. Immunol. 159:1997;1604-1612.
-
(1997)
J. Immunol.
, vol.159
, pp. 1604-1612
-
-
Aloisi, F.1
Penna, G.2
Cerase, J.3
Menendez Iglesias, B.4
Adorini, L.5
-
11
-
-
0034651767
-
Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells
-
Aloisi F., De Simone R., Columba-Cabezas S., Penna G., Adorini L. Functional maturation of adult mouse resting microglia into an APC is promoted by granulocyte-macrophage colony-stimulating factor and interaction with Th1 cells. J. Immunol. 164:2000;1705-1712.
-
(2000)
J. Immunol.
, vol.164
, pp. 1705-1712
-
-
Aloisi, F.1
De Simone, R.2
Columba-Cabezas, S.3
Penna, G.4
Adorini, L.5
-
12
-
-
0030250932
-
Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia
-
Becher B., Antel J.P. Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia. Glia. 18:1996;1-10.
-
(1996)
Glia
, vol.18
, pp. 1-10
-
-
Becher, B.1
Antel, J.P.2
-
13
-
-
0028966091
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
-
Leonard J.P., Waldburger K.E., Goldman S.J. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:1995;381-386.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 381-386
-
-
Leonard, J.P.1
Waldburger, K.E.2
Goldman, S.J.3
-
14
-
-
0030944709
-
Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
-
Smith T., Hewson A.K., Kingsley C.I., Leonard J.P., Cuzner M.L. Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat. Am. J. Pathol. 150:1997;1909-1917.
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 1909-1917
-
-
Smith, T.1
Hewson, A.K.2
Kingsley, C.I.3
Leonard, J.P.4
Cuzner, M.L.5
-
15
-
-
0032536447
-
An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
-
Segal B.M., Dwyer B.K., Shevach E.M. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187:1998;537-546.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 537-546
-
-
Segal, B.M.1
Dwyer, B.K.2
Shevach, E.M.3
-
16
-
-
0036677420
-
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
-
Becher B., Durell B.G., Noelle R.J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 110:2002;493-497.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 493-497
-
-
Becher, B.1
Durell, B.G.2
Noelle, R.J.3
-
17
-
-
0037114150
-
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
-
Gran B., Zhang G.X., Yu S., Li J., Chen X.H., Ventura E.S.et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169:2002;7104-7110.
-
(2002)
J. Immunol.
, vol.169
, pp. 7104-7110
-
-
Gran, B.1
Zhang, G.X.2
Yu, S.3
Li, J.4
Chen, X.H.5
Ventura, E.S.6
-
18
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B.et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 421:2003;744-748.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
-
19
-
-
0033783588
-
T-cell activation and receptor downmodulation precede deletion induced by mucosally administered antigen
-
Benson J.M., Campbell K.A., Guan Z., Gienapp I.E., Stuckman S.S., Forsthuber T.et al. T-cell activation and receptor downmodulation precede deletion induced by mucosally administered antigen. J. Clin. Invest. 106:2000;1031-1038.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1031-1038
-
-
Benson, J.M.1
Campbell, K.A.2
Guan, Z.3
Gienapp, I.E.4
Stuckman, S.S.5
Forsthuber, T.6
-
20
-
-
0025900245
-
Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
-
Sedgwick J.D., Schwender S., Imrich H., Dorries R., Butcher G.W., ter Meulen V. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc. Natl. Acad. Sci. U. S. A. 88:1991;7438-7442.
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 7438-7442
-
-
Sedgwick, J.D.1
Schwender, S.2
Imrich, H.3
Dorries, R.4
Butcher, G.W.5
Ter Meulen, V.6
-
21
-
-
0029563373
-
Mouse microglia cell lines differing in constitutive and interferon-g-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells
-
Walker Mouse microglia cell lines differing in constitutive and interferon-g-inducible antigen-presenting activities for naive and memory CD4+ and CD8+ T cells. J. Neuroimmunol. 63:1995;163-174.
-
(1995)
J. Neuroimmunol.
, vol.63
, pp. 163-174
-
-
Walker1
-
22
-
-
0030064148
-
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
-
Ma X., Chow J.M., Gri G., Carra G., Gerosa F., Wolf S.F.et al. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J. Exp. Med. 183:1996;147-157.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 147-157
-
-
Ma, X.1
Chow, J.M.2
Gri, G.3
Carra, G.4
Gerosa, F.5
Wolf, S.F.6
-
23
-
-
16744366716
-
Production of interleukin-12 and expression of its receptors by murine microglia
-
Suzumura A., Sawada M., Takayanagi T. Production of interleukin-12 and expression of its receptors by murine microglia. Brain Res. 787:1998;139-142.
-
(1998)
Brain Res.
, vol.787
, pp. 139-142
-
-
Suzumura, A.1
Sawada, M.2
Takayanagi, T.3
-
24
-
-
0035892749
-
A protective and agonistic function of IL-12p40 in mycobacterial infection
-
Holscher C., Atkinson R.A., Arendse B., Brown N., Myburgh E., Alber G.et al. A protective and agonistic function of IL-12p40 in mycobacterial infection. J. Immunol. 167:2001;6957-6966.
-
(2001)
J. Immunol.
, vol.167
, pp. 6957-6966
-
-
Holscher, C.1
Atkinson, R.A.2
Arendse, B.3
Brown, N.4
Myburgh, E.5
Alber, G.6
-
25
-
-
0037442020
-
Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
-
Zhang G.X., Gran B., Yu S., Li J., Siglienti I., Chen X.et al. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J. Immunol. 170:2003;2153-2160.
-
(2003)
J. Immunol.
, vol.170
, pp. 2153-2160
-
-
Zhang, G.X.1
Gran, B.2
Yu, S.3
Li, J.4
Siglienti, I.5
Chen, X.6
-
26
-
-
0035865406
-
Brain dendritic cells and macrophages/microglia in central nervous system inflammation
-
Fischer H.G., Reichmann G. Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J. Immunol. 166:2001;2717-2726.
-
(2001)
J. Immunol.
, vol.166
, pp. 2717-2726
-
-
Fischer, H.G.1
Reichmann, G.2
-
27
-
-
0037313578
-
Interleukin-12 and the regulation of innate resistance and adaptive immunity
-
Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev., Immunol. 3:2003;133-146.
-
(2003)
Nat. Rev., Immunol.
, vol.3
, pp. 133-146
-
-
Trinchieri, G.1
-
28
-
-
0037111202
-
Regulation of virus-induced IL-12 and IL-23 expression in human macrophages
-
Pirhonen J., Matikainen S., Julkunen I. Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J. Immunol. 169:2002;5673-5678.
-
(2002)
J. Immunol.
, vol.169
, pp. 5673-5678
-
-
Pirhonen, J.1
Matikainen, S.2
Julkunen, I.3
-
29
-
-
0035886848
-
C-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription
-
Grumont R., Hochrein H., O'Keeffe M., Gugasyan R., White C., Caminschi I.et al. c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. J. Exp. Med. 194:2001;1021-1032.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1021-1032
-
-
Grumont, R.1
Hochrein, H.2
O'Keeffe, M.3
Gugasyan, R.4
White, C.5
Caminschi, I.6
-
30
-
-
0030064036
-
Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
-
Snijders A., Hilkens C.M., van der Pouw Kraan T.C., Engel M., Aarden L.A., Kapsenberg M.L. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit. J. Immunol. 156:1996;1207-1212.
-
(1996)
J. Immunol.
, vol.156
, pp. 1207-1212
-
-
Snijders, A.1
Hilkens, C.M.2
Van Der Pouw Kraan, T.C.3
Engel, M.4
Aarden, L.A.5
Kapsenberg, M.L.6
-
31
-
-
0032168336
-
IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production
-
Grohmann U., Belladonna M.L., Bianchi R., Orabona C., Ayroldi E., Fioretti M.C.et al. IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production. Immunity. 9:1998;315-323.
-
(1998)
Immunity
, vol.9
, pp. 315-323
-
-
Grohmann, U.1
Belladonna, M.L.2
Bianchi, R.3
Orabona, C.4
Ayroldi, E.5
Fioretti, M.C.6
-
32
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
-
Wiekowski M.T., Leach M.W., Evans E.W., Sullivan L., Chen S.C., Vassileva G.et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 166:2001;7563-7570.
-
(2001)
J. Immunol.
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
Sullivan, L.4
Chen, S.C.5
Vassileva, G.6
-
33
-
-
0034193032
-
Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
-
Pagenstecher A., Lassmann S., Carson M.J., Kincaid C.L., Stalder A.K., Campbell I.L. Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis. J. Immunol. 164:2000;4481-4492.
-
(2000)
J. Immunol.
, vol.164
, pp. 4481-4492
-
-
Pagenstecher, A.1
Lassmann, S.2
Carson, M.J.3
Kincaid, C.L.4
Stalder, A.K.5
Campbell, I.L.6
-
34
-
-
0032005162
-
Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis
-
Bright J.J., Musuro B.F., Du C., Sriram S. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis. J. Neuroimmunol. 82:1998;22-30.
-
(1998)
J. Neuroimmunol.
, vol.82
, pp. 22-30
-
-
Bright, J.J.1
Musuro, B.F.2
Du, C.3
Sriram, S.4
-
35
-
-
0032476702
-
Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat
-
Jander S., Stoll G. Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat. J. Neuroimmunol. 91:1998;93-99.
-
(1998)
J. Neuroimmunol.
, vol.91
, pp. 93-99
-
-
Jander, S.1
Stoll, G.2
-
36
-
-
0033636254
-
Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis
-
Serafini B., Columba-Cabezas S., Di Rosa F., Aloisi F. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am. J. Pathol. 157:2000;1991-2002.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1991-2002
-
-
Serafini, B.1
Columba-Cabezas, S.2
Di Rosa, F.3
Aloisi, F.4
-
37
-
-
0035933106
-
Developmental plasticity of CNS microglia
-
Santambrogio L., Belyanskaya S.L., Fischer F.R., Cipriani B., Brosnan C.F., Ricciardi-Castagnoli P.et al. Developmental plasticity of CNS microglia. Proc. Natl. Acad. Sci. U. S. A. 98:2001;6295-6300.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 6295-6300
-
-
Santambrogio, L.1
Belyanskaya, S.L.2
Fischer, F.R.3
Cipriani, B.4
Brosnan, C.F.5
Ricciardi-Castagnoli, P.6
-
38
-
-
0035710229
-
An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression
-
Giulietti A., Overbergh L., Valckx D., Decallonne B., Bouillon R., Mathieu C. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods. 25:2001;386-401.
-
(2001)
Methods
, vol.25
, pp. 386-401
-
-
Giulietti, A.1
Overbergh, L.2
Valckx, D.3
Decallonne, B.4
Bouillon, R.5
Mathieu, C.6
-
39
-
-
0034255735
-
The suppressive effect of TGF-beta on IL-12-mediated immune modulation specific to a peptide Ac1-11 of myelin basic protein (MBP): A mechanism involved in inhibition of both IL-12 receptor beta1 and beta2
-
Xu H., Zhang G.X., Wysocka M., Wu C.Y., Trinchieri G., Rostami A. The suppressive effect of TGF-beta on IL-12-mediated immune modulation specific to a peptide Ac1-11 of myelin basic protein (MBP): a mechanism involved in inhibition of both IL-12 receptor beta1 and beta2. J. Neuroimmunol. 108:2000;53-63.
-
(2000)
J. Neuroimmunol.
, vol.108
, pp. 53-63
-
-
Xu, H.1
Zhang, G.X.2
Wysocka, M.3
Wu, C.Y.4
Trinchieri, G.5
Rostami, A.6
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