Evidence for the critical role of interleukin-12 but not interferon-γ in the pathogenesis of experimental colitis in mice

Journal of Gastroenterology and Hepatology (Australia)

Volumn 18, Issue 5, 2003, Pages 578-587

  Tozawa, Kotaro ^a   Hanai, Hiroyuki ^a   Sugimoto, Ken ^a   Baba, Satoshi ^a   Sugimura, Haruhiko ^a   Aoshi, Taiki ^a   Uchijima, Masato ^a   Nagata, Toshi ^a   Koide, Yukio ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Interferon ; Interleukin 12, 2, 4, 6 trinitrobenzene sulfonic acid induced colitis

Indexed keywords

ALCOHOL; CD4 ANTIGEN; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; IMMUNOGLOBULIN G; INTERLEUKIN 12; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; RNA; TRINITROBENZENESULFONIC ACID;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON DISEASE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0038054271     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.2003.03024.x     Document Type: Article

References (30)

1. + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 1996; 157: 1261-70.
2. Powrie F. T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995; 3: 171-4.
3. Braegger CP, MacDonald TT. Immune mechanisms in chronic inflammatory bowel disease. Ann. Allergy 1994; 72: 135-41.
4. Monteleone G, Biancone L, Marasco R et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997; 112: 1169-78.
5. Parronchi P, Romagnani P, Annunziato F et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 1997; 150: 823-32.
6. Neurath MF, Fuss I, Kelsall BL, Stüber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995; 182: 1281-90.
7. Sadlack B, Merz H, Schorle A, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75: 253-61.
8. Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993; 75: 263-74.
9. Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993; 75: 275-82.
10. Turk JL. Delayed Hypersensitivity. Amsterdam: North Holland Publishing Co., 1975.
11. Billiau A. Interferon-gamma: biology and role in pathogenesis. Adv. Immunol. 1996; 62: 61-130.
12. + Th1-like responses. J. Clin. Invest. 1996; 98: 1010-20.
13. -/- mice: an overview. J. Leukoc. Biol. 1997; 61: 389-96.
14. + T cells. Immunity 1994; 1: 553-62.
15. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84: 4008-27.
16. Magram J, Connaughton SE, Warrier RR et al. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 1996; 4: 471-81.
17. Duchmann R, Schmitt E, Knolle P, Meyer zum Büschenfelde K-H, Neurath M. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12. Eur. J. Immunol. 1996; 26: 934-8.
18. Ehrhardt RO, Lúdvíksson BR, Gray B, Neurath M, Strober W. Induction and prevention of colonic inflammation in IL-2-deficient mice. J. Immunol. 1997; 158: 566-73.
19. Koide Y, Yoshida A. The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression. Infect. Immun. 1994; 62: 948-55.
20. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 1987; 162: 156-9.
21. Fuss IJ, Marth T, Neurath MF, Pearlstein GR, Jain A, Strober W. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology 1999; 117: 1078-88.
22. Dohi T, Fujihashi K, Rennert PD, Iwatani K, Kiyono H, McGhee JR. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J. Exp. Med. 1999; 189: 1169-79.
23. Kopf M, Brombacher F, Köhler G et al. IL-4-deficient Balb/c mice resist infection with Leishmania major. J. Exp. Med. 1996; 184: 1127-36.
24. + T cell response. J. Exp. Med. 1995; 181: 961-71.
25. Dohi T, Fujihashi K, Kiyono H, Elson CO, McGhee JR. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology 2000; 119: 724-33.
26. Camoglio L, te Velde AA, de Boer A, ten Kate FJ, Kopf M, van Deventer SJ. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-γ receptor-deficient mice. Eur. J. Immunol. 2000; 30: 1486-95.
27. + T cells and IFN-γ by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenes. Vaccine 2001; 19: 4297-306.
28. Neurath MF, Fuss I, Pasparakis M et al. Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice. Eur. J. Immunol. 1997; 27: 1743-50.
29. Trinchieri G, Gerosa F. Immunoregulation by interleukin-12. J. Leukoc. Biol. 1996; 59: 505-11.
30. Davidson NJ, Hudak SA, Lesley RE, Menon S, Leach MW, Rennick DM. IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 1998; 161: 3143-9.