메뉴 건너뛰기




Volumn 102, Issue 4, 1998, Pages 671-678

Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy

Author keywords

Cyclophosphamide; Interleukin 12; Intracellular immunofluorescence; Multiple sclerosis; Th2; Th3

Indexed keywords

CYCLOPHOSPHAMIDE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 5; METHOTREXATE; METHYLPREDNISOLONE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032528896     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3125     Document Type: Article
Times cited : (197)

References (49)
  • 1
    • 0002776223 scopus 로고    scopus 로고
    • Immunological mechanisms in multiple sclerosis
    • S.D. Cook, editor. Marcell Dekker Inc., New York
    • Khoury, S.J., H.L. Weiner, and D.A. Hafler. 1996. Immunological mechanisms in multiple sclerosis. In Handbook of Multiple Sclerosis. S.D. Cook, editor. Marcell Dekker Inc., New York. 145-155.
    • (1996) Handbook of Multiple Sclerosis , pp. 145-155
    • Khoury, S.J.1    Weiner, H.L.2    Hafler, D.A.3
  • 2
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 3
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen, Y., V.K. Kuchroo, J.-I. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.-I.3    Hafler, D.A.4    Weiner, H.L.5
  • 4
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner, H.L. 1997. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol. Today. 18:335-343.
    • (1997) Immunol. Today , vol.18 , pp. 335-343
    • Weiner, H.L.1
  • 5
    • 0024368359 scopus 로고
    • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
    • Ando, D.G., J. Clayton, D. Kono, J.L. Urban, and E.E. Sercarz. 1989. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 124:132-143.
    • (1989) Cell. Immunol. , vol.124 , pp. 132-143
    • Ando, D.G.1    Clayton, J.2    Kono, D.3    Urban, J.L.4    Sercarz, E.E.5
  • 7
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin e expression in the brain
    • Khoury, S.J., W.W. Hancock, and H.L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176:1355-1364.
    • (1992) J. Exp. Med. , vol.176 , pp. 1355-1364
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 8
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
    • Kennedy, M.K., D.S. Torrance, K.S. Picha, and K.M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496-2505.
    • (1992) J. Immunol. , vol.149 , pp. 2496-2505
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3    Mohler, K.M.4
  • 9
    • 0028806468 scopus 로고
    • Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: Dynamics of mRNA expression for interleukin 10, interleukin 12, cytolysin, tumor necrosis factor-a and tumor necrosis factor-b
    • Issazadeh, S., A. Ljungdahl, B. Hojeberg, M. Mustafa, and T. Olsson. 1995. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin 10, interleukin 12, cytolysin, tumor necrosis factor-a and tumor necrosis factor-b. J. Neuroimmunol. 61:205-212.
    • (1995) J. Neuroimmunol. , vol.61 , pp. 205-212
    • Issazadeh, S.1    Ljungdahl, A.2    Hojeberg, B.3    Mustafa, M.4    Olsson, T.5
  • 10
    • 0031891953 scopus 로고    scopus 로고
    • Mechanisms of recovery from experimental allergic encephalomyelitis: T cell deletion and immune deviation in myelin basic protein receptor transgenic mice
    • Chen, Y., W.W. Hancock, R. Marks, P.A. Gonnella, and H.L. Weiner. 1998. Mechanisms of recovery from experimental allergic encephalomyelitis: T cell deletion and immune deviation in myelin basic protein receptor transgenic mice. J. Neuroimmunol. 82:149-159.
    • (1998) J. Neuroimmunol. , vol.82 , pp. 149-159
    • Chen, Y.1    Hancock, W.W.2    Marks, R.3    Gonnella, P.A.4    Weiner, H.L.5
  • 11
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti, R., P. Parronchi, M.G. Giudizi, M.P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
    • (1993) J. Exp. Med. , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 12
    • 0028265155 scopus 로고
    • Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones
    • Manetti, R., F. Gerosa, M.G. Giudizi, R. Biagiotti, P. Parronchi, M.P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, G. Trinchieri, et al. 1994. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J. Exp. Med. 179:1273-1283.
    • (1994) J. Exp. Med. , vol.179 , pp. 1273-1283
    • Manetti, R.1    Gerosa, F.2    Giudizi, M.G.3    Biagiotti, R.4    Parronchi, P.5    Piccinni, M.P.6    Sampognaro, S.7    Maggi, E.8    Romagnani, S.9    Trinchieri, G.10
  • 13
    • 0027491655 scopus 로고
    • Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
    • Seder, R.A., R. Gazzinelli, A. Sher, and W.E. Paul. 1993. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 14
    • 0027336689 scopus 로고
    • Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • Hsieh, C.S., S.E. Macatonia, C.S. Tripp, S.F. Wolf, A. O'Garra, and K.M. Murphy. 1993. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:547-549.
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 15
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard, J.P., K.E. Waldburger, and S.J. Goldman. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181:381-386.
    • (1995) J. Exp. Med. , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 16
    • 0031027581 scopus 로고    scopus 로고
    • Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand
    • Balashov, K.E., D.R. Smith, S.J. Khoury, D.A. Hafler, and H.L. Weiner. 1997. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc. Natl. Acad. Sci. USA. 94:599-603.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 599-603
    • Balashov, K.E.1    Smith, D.R.2    Khoury, S.J.3    Hafler, D.A.4    Weiner, H.L.5
  • 18
    • 0014640881 scopus 로고
    • Cyclophosphamide inhibition ot experimental allergic encephalomyelitis and cellular transfer of the disease in Lewis rats
    • Paterson, P.Y., and M.A. Hanson. 1969. Cyclophosphamide inhibition ot experimental allergic encephalomyelitis and cellular transfer of the disease in Lewis rats. J. Immunol. 103:1311-1316.
    • (1969) J. Immunol. , vol.103 , pp. 1311-1316
    • Paterson, P.Y.1    Hanson, M.A.2
  • 19
    • 0014671660 scopus 로고
    • Cyclophosphamide: Effect on experimental allergic encephalomyelitis in Lewis rats
    • Paterson, P.Y., and D.G. Drobish. 1969. Cyclophosphamide: effect on experimental allergic encephalomyelitis in Lewis rats. Science. 165:191-192.
    • (1969) Science , vol.165 , pp. 191-192
    • Paterson, P.Y.1    Drobish, D.G.2
  • 20
    • 0021330932 scopus 로고
    • The effect of cyclophosphamide on T lymphocytes and T lymphocyte subsets in patients with chronic progressive multiple sclerosis
    • Brinkman, C.J., W.M. Nillesen, and O.R. Hommes. 1984. The effect of cyclophosphamide on T lymphocytes and T lymphocyte subsets in patients with chronic progressive multiple sclerosis. Acta Neurol. Scand. 69:90-96.
    • (1984) Acta Neurol. Scand. , vol.69 , pp. 90-96
    • Brinkman, C.J.1    Nillesen, W.M.2    Hommes, O.R.3
  • 21
    • 0023103639 scopus 로고
    • Administration of monthly pulses of Cyclophosphamide in multiple sclerosis patients. Delayed recovery of several immune parameters following discontinuation of long-term cyclophosphamide treatment
    • Moody, D.J., J.L. Fahey, E. Grable, G.W. Ellison, and L.W. Myers. 1987. Administration of monthly pulses of Cyclophosphamide in multiple sclerosis patients. Delayed recovery of several immune parameters following discontinuation of long-term cyclophosphamide treatment. J. Neuroimmunol. 14: 175-182.
    • (1987) J. Neuroimmunol. , vol.14 , pp. 175-182
    • Moody, D.J.1    Fahey, J.L.2    Grable, E.3    Ellison, G.W.4    Myers, L.W.5
  • 22
    • 0023788471 scopus 로고
    • The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis
    • Lamers, K.J., B.M. Uitdehaag, O.R. Hommes, W. Doeshurg, R.A. Wevers, and W.J. von Geel. 1988. The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 51:1334-1337.
    • (1988) J. Neurol. Neurosurg. Psychiatry , vol.51 , pp. 1334-1337
    • Lamers, K.J.1    Uitdehaag, B.M.2    Hommes, O.R.3    Doeshurg, W.4    Wevers, R.A.5    Von Geel, W.J.6
  • 23
    • 0025904767 scopus 로고
    • Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis
    • Hafler, D.A., J. Orav, R. Gertz, L. Stazzone, and H.L. Weiner. 1991. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. J. Neuroimmunol. 32:149-158.
    • (1991) J. Neuroimmunol. , vol.32 , pp. 149-158
    • Hafler, D.A.1    Orav, J.2    Gertz, R.3    Stazzone, L.4    Weiner, H.L.5
  • 24
    • 0020683886 scopus 로고
    • Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH
    • Hauser, S.L., D.M. Dawson, J.R. Lehrich, M.F. Beal, S.V. Kevy, R.D. Propper, J.A. Mills, and H.L. Weiner. 1983. Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N. Engl. J. Med. 308:173-180.
    • (1983) N. Engl. J. Med. , vol.308 , pp. 173-180
    • Hauser, S.L.1    Dawson, D.M.2    Lehrich, J.R.3    Beal, M.F.4    Kevy, S.V.5    Propper, R.D.6    Mills, J.A.7    Weiner, H.L.8
  • 25
    • 0027196941 scopus 로고
    • Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: Final report of the Northeast Cooperative Multiple Sclerosis Treatment Group
    • Weiner, H.L., G.A. Mackin, E.J. Orav, D.A. Hafler, D.M. Dawson, Y. LaPierre, R. Herndon, J.R. Lehrich, S.L. Hauser, A. Turel, et al. 1993. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology. 43:910-918.
    • (1993) Neurology , vol.43 , pp. 910-918
    • Weiner, H.L.1    Mackin, G.A.2    Orav, E.J.3    Hafler, D.A.4    Dawson, D.M.5    Lapierre, Y.6    Herndon, R.7    Lehrich, J.R.8    Hauser, S.L.9    Turel, A.10
  • 26
    • 0025967752 scopus 로고
    • The Canadian Cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis
    • Group., T.C.C.M.S.S. 1991. The Canadian Cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. Lancet. 337:442-446.
    • (1991) Lancet , vol.337 , pp. 442-446
  • 27
    • 0030767497 scopus 로고    scopus 로고
    • Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin-4 production and associated eosinophilia
    • Smith, D.R., K.E. Balashov, D.A. Hafler, S.J. Khoury, and H.L. Weiner. 1997. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann. Neurol. 42:313-318.
    • (1997) Ann. Neurol. , vol.42 , pp. 313-318
    • Smith, D.R.1    Balashov, K.E.2    Hafler, D.A.3    Khoury, S.J.4    Weiner, H.L.5
  • 28
    • 0031828331 scopus 로고    scopus 로고
    • Pulse cyclophosphamide plus methylprednisolone induces myelin antigen specific IL-4 secreting T cells in multiple sclerosis patients
    • Takashima, H., D. Smith, H. Fukaura, S. Khoury, D. Hafler, and H. Weiner. 1998. Pulse cyclophosphamide plus methylprednisolone induces myelin antigen specific IL-4 secreting T cells in multiple sclerosis patients. Clin. Immunol. Immunopathol. 88:28-34.
    • (1998) Clin. Immunol. Immunopathol. , vol.88 , pp. 28-34
    • Takashima, H.1    Smith, D.2    Fukaura, H.3    Khoury, S.4    Hafler, D.5    Weiner, H.6
  • 29
    • 0026164714 scopus 로고
    • Detecting cytokine production at the single-cell level
    • Lewis, C.E. 1991. Detecting cytokine production at the single-cell level. Cytokine. 3:184-188.
    • (1991) Cytokine , vol.3 , pp. 184-188
    • Lewis, C.E.1
  • 30
    • 0030962527 scopus 로고    scopus 로고
    • Cytokine flow cytometry: Understanding cytokine biology at the single-cell level
    • Prussin, C. 1997. Cytokine flow cytometry: understanding cytokine biology at the single-cell level. J. Clin. Immunol. 17:195-204.
    • (1997) J. Clin. Immunol. , vol.17 , pp. 195-204
    • Prussin, C.1
  • 32
    • 0028095562 scopus 로고
    • Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis
    • Link, J., M. Soderstrom, T. Olsson, B. Hojeberg, A. Ljungdahl, and H. Link. 1994. Increased transforming growth factor-beta, interleukin-4, and interferon-gamma in multiple sclerosis. Ann. Neurol. 36:379-386.
    • (1994) Ann. Neurol. , vol.36 , pp. 379-386
    • Link, J.1    Soderstrom, M.2    Olsson, T.3    Hojeberg, B.4    Ljungdahl, A.5    Link, H.6
  • 33
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch, H.S., R.L. Hirsch, A.S. Haley, and K.P. Johnson. 1987. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1:893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, H.S.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 34
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestations in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck, J., P. Rondot, L. Catinot, E. Falcoff, H. Kirchner, and J. Wietzerbin. 1988. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestations in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol. Scand. 78:318-323.
    • (1988) Acta Neurol. Scand. , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3    Falcoff, E.4    Kirchner, H.5    Wietzerbin, J.6
  • 36
    • 0031570475 scopus 로고    scopus 로고
    • Corticosteroids inhibit H.-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes
    • Blotta, M.H., R.H. DeKruyff, and D.T. Umetsu. 1997. Corticosteroids inhibit H.-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J. Immunol. 158:5589-5595.
    • (1997) J. Immunol. , vol.158 , pp. 5589-5595
    • Blotta, M.H.1    Dekruyff, R.H.2    Umetsu, D.T.3
  • 37
    • 0029999942 scopus 로고    scopus 로고
    • Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection hy flow cytometry and surface marker analysis
    • Crucian, B., P. Dunne, H. Friedman, R. Ragsdale, S. Pross, and R. Widen. 1996. Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection hy flow cytometry and surface marker analysis. Clin. Diagn. Lab. Immunol. 3:411-416.
    • (1996) Clin. Diagn. Lab. Immunol. , vol.3 , pp. 411-416
    • Crucian, B.1    Dunne, P.2    Friedman, H.3    Ragsdale, R.4    Pross, S.5    Widen, R.6
  • 38
    • 0028879819 scopus 로고
    • Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
    • Scheinman, R.I., P.C. Cogswell, A.K. Lofquist, and A.J. Baldwin. 1995. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science. 270:283-286.
    • (1995) Science , vol.270 , pp. 283-286
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin, A.J.4
  • 39
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • Auphan, N., J.A. DiDonato, C. Rosette, A. Helmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 270:286-290.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    Didonato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 40
    • 0029925751 scopus 로고    scopus 로고
    • Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro
    • Ramirez, F., D.J. Fowell, M. Puklavec, S. Simmonds, and D. Mason. 1996. Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro. J. Immunol. 156:2406-2412.
    • (1996) J. Immunol. , vol.156 , pp. 2406-2412
    • Ramirez, F.1    Fowell, D.J.2    Puklavec, M.3    Simmonds, S.4    Mason, D.5
  • 42
    • 0025892475 scopus 로고
    • Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1
    • Racke, M.K., S. Dhib-Jalbut, P.S. Cannella, P.S. Albert, and D.E. McFarlin. 1991. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1. J. Immunol. 146:3012-3017.
    • (1991) J. Immunol. , vol.146 , pp. 3012-3017
    • Racke, M.K.1    Dhib-Jalbut, S.2    Cannella, P.S.3    Albert, P.S.4    McFarlin, D.E.5
  • 43
    • 0026006736 scopus 로고
    • Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-β1
    • Johns, L., K. Flanders, G. Ranges, and S. Sriram. 1991. Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-β1. J. Immunol. 147:1792-1796.
    • (1991) J. Immunol. , vol.147 , pp. 1792-1796
    • Johns, L.1    Flanders, K.2    Ranges, G.3    Sriram, S.4
  • 44
    • 0028990468 scopus 로고
    • Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Olsson, T. 1995. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol. Rev. 144:245-268.
    • (1995) Immunol. Rev. , vol.144 , pp. 245-268
    • Olsson, T.1
  • 45
    • 0030938148 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-beta production by interleukin-12
    • Marth, T., W. Strober, R.A. Seder, and B.L. Kelsall. 1997. Regulation of transforming growth factor-beta production by interleukin-12. Eur. J. Immunol. 27:1213-1220.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1213-1220
    • Marth, T.1    Strober, W.2    Seder, R.A.3    Kelsall, B.L.4
  • 46
    • 0019505298 scopus 로고
    • Direct in vitro evidence for different susceptibilities to 4-hydroperoxycyclophosphamide of antigen-primed T cells regulating humoral and cell-mediated immune responses to sheep erythrocytes: A possible explanation for the inverse action of cyclophosphamide on humoral and cell-mediated immune responses
    • Diamantstein, T., M. Klos, H. Hahn, and S.H. Kaufmann. 1981. Direct in vitro evidence for different susceptibilities to 4-hydroperoxycyclophosphamide of antigen-primed T cells regulating humoral and cell-mediated immune responses to sheep erythrocytes: a possible explanation for the inverse action of cyclophosphamide on humoral and cell-mediated immune responses. J. Immunol. 126:1717-1719.
    • (1981) J. Immunol. , vol.126 , pp. 1717-1719
    • Diamantstein, T.1    Klos, M.2    Hahn, H.3    Kaufmann, S.H.4
  • 47
    • 0018818370 scopus 로고
    • Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4-hydroperoxycyclophosphamide
    • Kaufmann, S.H., H. Hahn, and T. Diamantstein. 1980. Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4-hydroperoxycyclophosphamide. J. Immunol. 125:1104-1108.
    • (1980) J. Immunol. , vol.125 , pp. 1104-1108
    • Kaufmann, S.H.1    Hahn, H.2    Diamantstein, T.3
  • 48
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella, M., D. Scheidegger, L.K. Palmer, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747-752.
    • (1996) J. Exp. Med. , vol.184 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer, L.K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 49
    • 0030639620 scopus 로고    scopus 로고
    • Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40
    • DeKruyff, R.H., R.S. Gieni, and D.T. Umetsu. 1997. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 158:359-366.
    • (1997) J. Immunol. , vol.158 , pp. 359-366
    • Dekruyff, R.H.1    Gieni, R.S.2    Umetsu, D.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.