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Volumn 125, Issue 2, 2005, Pages 183-200

Stratum corneum defensive functions: An integrated view

Author keywords

Barrier function; Corneodesmosomes; Cytokines; Desquamation; Hydration; Lamellar bodies; Lamellar body; pH; Psychological stress; Stratum corneum

Indexed keywords

CATHEPSIN G; CYSTEINE PROTEINASE; CYTOKINE; GROWTH FACTOR; PROTEINASE INHIBITOR; SERINE PROTEINASE; LIPID;

EID: 24344448276     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23668.x     Document Type: Review
Times cited : (576)

References (242)
  • 1
    • 0027936162 scopus 로고
    • SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes
    • Alkemade JA, Molhuizen HO, Ponec M, et al: SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes. J Cell Sci 107 (Part 8):2335-2342, 1994
    • (1994) J Cell Sci , vol.107 , Issue.PART 8 , pp. 2335-2342
    • Alkemade, J.A.1    Molhuizen, H.O.2    Ponec, M.3
  • 3
    • 0018237599 scopus 로고
    • Effect of prolonged occlusion on the microbial flora, pH, carbon dioxide and transepidermal water loss on human skin
    • Aly R, Shirley C, Cunico B, Maibach HI: Effect of prolonged occlusion on the microbial flora, pH, carbon dioxide and transepidermal water loss on human skin. J Invest Dermatol 71:378-381, 1978
    • (1978) J Invest Dermatol , vol.71 , pp. 378-381
    • Aly, R.1    Shirley, C.2    Cunico, B.3    Maibach, H.I.4
  • 4
    • 0004575385 scopus 로고
    • The pH of the skin surface of children with seborrhoeic dermatitis compared with unaffected children
    • Beare JM, Cheeseman EA, Gailey AA, Neill DW: The pH of the skin surface of children with seborrhoeic dermatitis compared with unaffected children. Br J Dermatol 70:233-241, 1958
    • (1958) Br J Dermatol , vol.70 , pp. 233-241
    • Beare, J.M.1    Cheeseman, E.A.2    Gailey, A.A.3    Neill, D.W.4
  • 5
    • 27844572281 scopus 로고    scopus 로고
    • The antiporter NHE1 influences the function of the SC pH gradient
    • Behne M, Elias PM, Mauro T: The antiporter NHE1 influences the function of the SC pH gradient. J Skin Barrier Res 3:3-10, 2001
    • (2001) J Skin Barrier Res , vol.3 , pp. 3-10
    • Behne, M.1    Elias, P.M.2    Mauro, T.3
  • 6
    • 0034081229 scopus 로고    scopus 로고
    • Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function
    • Behne M, Uchida Y, Seki T, de Montellano PO, Elias PM, Holleran WM: Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J Invest Dermatol 114:185-192, 2000
    • (2000) J Invest Dermatol , vol.114 , pp. 185-192
    • Behne, M.1    Uchida, Y.2    Seki, T.3    De Montellano, P.O.4    Elias, P.M.5    Holleran, W.M.6
  • 7
    • 0038806397 scopus 로고    scopus 로고
    • Neonatal development of the stratum corneum pH gradient: Localization and mechanisms leading to emergence of optimal barrier function
    • Behne MJ, Barry NP, Hanson KM, et al: Neonatal development of the stratum corneum pH gradient: Localization and mechanisms leading to emergence of optimal barrier function. J Invest Dermatol 120:998-1006, 2003
    • (2003) J Invest Dermatol , vol.120 , pp. 998-1006
    • Behne, M.J.1    Barry, N.P.2    Hanson, K.M.3
  • 8
    • 0346668341 scopus 로고    scopus 로고
    • NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging
    • Behne MJ, Meyer JW, Hanson KM, et al: NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem 277:47399-47406, 2002
    • (2002) J Biol Chem , vol.277 , pp. 47399-47406
    • Behne, M.J.1    Meyer, J.W.2    Hanson, K.M.3
  • 9
    • 0037379365 scopus 로고    scopus 로고
    • Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin L2
    • Bernard D, Mehul B, Thomas-Collignon A, Simonetti L, Remy V, Bernard MA, Schmidt R: Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin L2. J Invest Dermatol 120:592-600, 2003
    • (2003) J Invest Dermatol , vol.120 , pp. 592-600
    • Bernard, D.1    Mehul, B.2    Thomas-Collignon, A.3    Simonetti, L.4    Remy, V.5    Bernard, M.A.6    Schmidt, R.7
  • 11
    • 0028912665 scopus 로고
    • Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development
    • Bickenbach JR, Greer JM, Bundman DS, Rothnagel JA, Roop DR: Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol 104:405-410, 1995
    • (1995) J Invest Dermatol , vol.104 , pp. 405-410
    • Bickenbach, J.R.1    Greer, J.M.2    Bundman, D.S.3    Rothnagel, J.A.4    Roop, D.R.5
  • 12
    • 0036174691 scopus 로고    scopus 로고
    • Netherton syndrome: Disease expression and spectrum of SPINK5 mutations in 21 families
    • Bitoun E, Chavanas S, Irvine AD, et al: Netherton syndrome: Disease expression and spectrum of SPINK5 mutations in 21 families. J Invest Dermatol 118:352-361, 2002
    • (2002) J Invest Dermatol , vol.118 , pp. 352-361
    • Bitoun, E.1    Chavanas, S.2    Irvine, A.D.3
  • 16
    • 12944265408 scopus 로고    scopus 로고
    • Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies
    • Braff MH, Di Nardo A, Gallo RL: Keratinocytes store the antimicrobial peptide cathelicidin in lamellar bodies. J Invest Dermatol 124:394-400, 2005
    • (2005) J Invest Dermatol , vol.124 , pp. 394-400
    • Braff, M.H.1    Di Nardo, A.2    Gallo, R.L.3
  • 17
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
    • Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137: 354-366, 1996
    • (1996) Endocrinology , vol.137 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 18
    • 0031788318 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development
    • Braissant O, Wahli W: Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 139:2748-2754, 1998
    • (1998) Endocrinology , vol.139 , pp. 2748-2754
    • Braissant, O.1    Wahli, W.2
  • 19
    • 0033569724 scopus 로고    scopus 로고
    • Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation
    • Brattsand M, Egelrud T: Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J Biol Chem 274:30033-30040, 1999
    • (1999) J Biol Chem , vol.274 , pp. 30033-30040
    • Brattsand, M.1    Egelrud, T.2
  • 20
    • 0031965513 scopus 로고    scopus 로고
    • Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake
    • discussion S54-S75
    • Brown MS, Goldstein JL: Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake. Nutr Rev 56:1-S3, 1998, discussion S54-S75
    • (1998) Nutr Rev , vol.56
    • Brown, M.S.1    Goldstein, J.L.2
  • 21
    • 0032478181 scopus 로고    scopus 로고
    • A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases
    • Candi E, Tarcsa E, Digiovanna JJ, Compton JG, Elias PM, Marekov LN, Steinert PM: A highly conserved lysine residue on the head domain of type II keratins is essential for the attachment of keratin intermediate filaments to the cornified cell envelope through isopeptide crosslinking by transglutaminases. Proc Natl Acad Sci USA 95:2067-2072, 1998
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2067-2072
    • Candi, E.1    Tarcsa, E.2    Digiovanna, J.J.3    Compton, J.G.4    Elias, P.M.5    Marekov, L.N.6    Steinert, P.M.7
  • 22
    • 2442428082 scopus 로고    scopus 로고
    • Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    • Caubet C, Jonca N, Brattsand M et al: Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J Invest Dermatol 122:1235-1244, 2004
    • (2004) J Invest Dermatol , vol.122 , pp. 1235-1244
    • Caubet, C.1    Jonca, N.2    Brattsand, M.3
  • 23
    • 0024570089 scopus 로고
    • Acylation of keratinocyte transglutaminase by palmitic and myristic acids in the membrane anchorage region
    • Chakravarty R, Rice RH: Acylation of keratinocyte transglutaminase by palmitic and myristic acids in the membrane anchorage region. J Biol Chem 264:625-629, 1989
    • (1989) J Biol Chem , vol.264 , pp. 625-629
    • Chakravarty, R.1    Rice, R.H.2
  • 24
    • 0036696327 scopus 로고    scopus 로고
    • Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity
    • Chamlin SL, Kao J, Frieden IJ, et al: Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 47:198-208, 2002
    • (2002) J Am Acad Dermatol , vol.47 , pp. 198-208
    • Chamlin, S.L.1    Kao, J.2    Frieden, I.J.3
  • 26
    • 0034120666 scopus 로고    scopus 로고
    • Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
    • Chavanas S, Bodemer C, Rochat A, et al: Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 25:141-142, 2000
    • (2000) Nat Genet , vol.25 , pp. 141-142
    • Chavanas, S.1    Bodemer, C.2    Rochat, A.3
  • 28
    • 0029906097 scopus 로고    scopus 로고
    • Corrective gene transfer in the human skin disorder lamellar ichthyosis
    • Choate KA, Medalie DA, Morgan JR, Khavari PA: Corrective gene transfer in the human skin disorder lamellar ichthyosis. Nat Med 2:1263-1267, 1996b
    • (1996) Nat Med , vol.2 , pp. 1263-1267
    • Choate, K.A.1    Medalie, D.A.2    Morgan, J.R.3    Khavari, P.A.4
  • 29
    • 0031918432 scopus 로고    scopus 로고
    • Transglutaminase 1 expression in a patient with features of harlequin ichthyosis: Case report
    • Choate KA, Williams ML, Elias PM, Khavari PA: Transglutaminase 1 expression in a patient with features of harlequin ichthyosis: Case report. J Am Acad Dermatol 38:325-329, 1998
    • (1998) J Am Acad Dermatol , vol.38 , pp. 325-329
    • Choate, K.A.1    Williams, M.L.2    Elias, P.M.3    Khavari, P.A.4
  • 30
    • 0001364006 scopus 로고
    • Visualization of the cell layers of the stratum corneum
    • Christophers E, Kligman AM: Visualization of the cell layers of the stratum corneum. J Invest Dermatol 42:407-409, 1964
    • (1964) J Invest Dermatol , vol.42 , pp. 407-409
    • Christophers, E.1    Kligman, A.M.2
  • 31
    • 0031888257 scopus 로고    scopus 로고
    • Glucosylceramide synthase activity in murine epidermis: Quantitation, localization, regulation, and requirement for barrier homeostasis
    • Chujor CS, Feingold KR, Elias PM, Holleran WM: Glucosylceramide synthase activity in murine epidermis: Quantitation, localization, regulation, and requirement for barrier homeostasis. J Lipid Res 39:277-285, 1998
    • (1998) J Lipid Res , vol.39 , pp. 277-285
    • Chujor, C.S.1    Feingold, K.R.2    Elias, P.M.3    Holleran, W.M.4
  • 32
    • 0030455978 scopus 로고    scopus 로고
    • Human keratin diseases: Hereditary fragility of specific epithelial tissues
    • Corden LD, McLean WH: Human keratin diseases: Hereditary fragility of specific epithelial tissues. Exp Dermatol 5:297-307, 1996
    • (1996) Exp Dermatol , vol.5 , pp. 297-307
    • Corden, L.D.1    McLean, W.H.2
  • 33
    • 0031030244 scopus 로고    scopus 로고
    • Transient expression of epidermal filaggrin in cultured cells causes collapse of intermediate filament networks with alteration of cell shape and nuclear integrity
    • Dale BA, Presland RB, Lewis SP, Underwood RA, Fleckman P: Transient expression of epidermal filaggrin in cultured cells causes collapse of intermediate filament networks with alteration of cell shape and nuclear integrity. J Invest Dermatol 108:179-187, 1997
    • (1997) J Invest Dermatol , vol.108 , pp. 179-187
    • Dale, B.A.1    Presland, R.B.2    Lewis, S.P.3    Underwood, R.A.4    Fleckman, P.5
  • 34
    • 0031738525 scopus 로고    scopus 로고
    • Exposure to a dry environment enhances epidermal permeability barrier function
    • Denda M, Sato J, Masuda Y, et al: Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol 111:858-863, 1998
    • (1998) J Invest Dermatol , vol.111 , pp. 858-863
    • Denda, M.1    Sato, J.2    Masuda, Y.3
  • 36
    • 0029985932 scopus 로고    scopus 로고
    • The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss
    • Denda M, Wood LC, Emami S, Calhoun C, Brown BE, Elias PM, Feingold KR: The epidermal hyperplasia associated with repeated barrier disruption by acetone treatment or tape stripping cannot be attributed to increased water loss. Arch Dermatol Res 288:230-238, 1996
    • (1996) Arch Dermatol Res , vol.288 , pp. 230-238
    • Denda, M.1    Wood, L.C.2    Emami, S.3    Calhoun, C.4    Brown, B.E.5    Elias, P.M.6    Feingold, K.R.7
  • 40
    • 0036709899 scopus 로고    scopus 로고
    • Is there a single mechanism for fatty acid regulation of gene transcription?
    • Duplus E, Forest C: Is there a single mechanism for fatty acid regulation of gene transcription? Biochem Pharmacol 64:893-901, 2002
    • (2002) Biochem Pharmacol , vol.64 , pp. 893-901
    • Duplus, E.1    Forest, C.2
  • 41
    • 0030935565 scopus 로고    scopus 로고
    • The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation
    • Eckert RL, Crish JF, Robinson NA: The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 77:397-424, 1997
    • (1997) Physiol Rev , vol.77 , pp. 397-424
    • Eckert, R.L.1    Crish, J.F.2    Robinson, N.A.3
  • 42
    • 3042552896 scopus 로고    scopus 로고
    • Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation
    • Egberts F, Heinrich M, Jensen JM, et al: Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci 117: 2295-2307, 2004
    • (2004) J Cell Sci , vol.117 , pp. 2295-2307
    • Egberts, F.1    Heinrich, M.2    Jensen, J.M.3
  • 44
    • 0034128648 scopus 로고    scopus 로고
    • Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process?
    • Ekholm IE, Brattsand M, Egelrud T: Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process? J Invest Dermatol 114:56-63, 2000
    • (2000) J Invest Dermatol , vol.114 , pp. 56-63
    • Ekholm, I.E.1    Brattsand, M.2    Egelrud, T.3
  • 45
    • 0036915960 scopus 로고    scopus 로고
    • Origin of the epidermal calcium gradient: Regulation by barrier status and role of active vs passive mechanisms
    • Elias P, Ahn S, Brown B, Crumrine D, Feingold KR: Origin of the epidermal calcium gradient: Regulation by barrier status and role of active vs passive mechanisms. J Invest Dermatol 119:1269-1274, 2002a
    • (2002) J Invest Dermatol , vol.119 , pp. 1269-1274
    • Elias, P.1    Ahn, S.2    Brown, B.3    Crumrine, D.4    Feingold, K.R.5
  • 46
    • 0036445564 scopus 로고    scopus 로고
    • Modulations in epidermal calcium regulate the expression of differentiation-specific markers
    • Elias PM, Ahn SK, Denda M, et al: Modulations in epidermal calcium regulate the expression of differentiation-specific markers. J Invest Dermatol 119:1128-1136, 2002b
    • (2002) J Invest Dermatol , vol.119 , pp. 1128-1136
    • Elias, P.M.1    Ahn, S.K.2    Denda, M.3
  • 47
    • 0018216654 scopus 로고
    • The mammalian cutaneous permeability barrier: Defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition
    • Elias PM, Brown BE: The mammalian cutaneous permeability barrier: Defective barrier function is essential fatty acid deficiency correlates with abnormal intercellular lipid deposition. Lab Invest 39:574-583, 1978
    • (1978) Lab Invest , vol.39 , pp. 574-583
    • Elias, P.M.1    Brown, B.E.2
  • 48
    • 0018964343 scopus 로고
    • The permeability barrier in essential fatty acid deficiency: Evidence for a direct role for linoleic acid in barrier function
    • Elias PM, Brown BE, Ziboh VA: The permeability barrier in essential fatty acid deficiency: Evidence for a direct role for linoleic acid in barrier function. J Invest Dermatol 74:230-233, 1980
    • (1980) J Invest Dermatol , vol.74 , pp. 230-233
    • Elias, P.M.1    Brown, B.E.2    Ziboh, V.A.3
  • 49
    • 10744223838 scopus 로고    scopus 로고
    • Basis for abnormal desquamation and permeability barrier dysfunction in RXLI
    • Elias PM, Crumrine D, Rassner U, et al: Basis for abnormal desquamation and permeability barrier dysfunction in RXLI. J Invest Dermatol 122:314-319, 2004
    • (2004) J Invest Dermatol , vol.122 , pp. 314-319
    • Elias, P.M.1    Crumrine, D.2    Rassner, U.3
  • 51
    • 0033781690 scopus 로고    scopus 로고
    • Origin of the corneocyte lipid envelope (CLE): Observations in harlequin ichthyosis and cultured human keratinocytes
    • Elias PM, Fartasch M, Crumrine D, Behne M, Uchida Y, Holleran WM: Origin of the corneocyte lipid envelope (CLE): Observations in harlequin ichthyosis and cultured human keratinocytes. J Invest Dermatol 115:765-769, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 765-769
    • Elias, P.M.1    Fartasch, M.2    Crumrine, D.3    Behne, M.4    Uchida, Y.5    Holleran, W.M.6
  • 52
    • 0026693975 scopus 로고
    • Lipids and the epidermal water barrier: Metabolism, regulation, and pathophysiology
    • Elias PM, Feingold KR: Lipids and the epidermal water barrier: Metabolism, regulation, and pathophysiology. Semin Dermatol 11:176-182, 1992
    • (1992) Semin Dermatol , vol.11 , pp. 176-182
    • Elias, P.M.1    Feingold, K.R.2
  • 53
    • 0345237479 scopus 로고    scopus 로고
    • Skin as an organ of protection
    • Freedberg I, et al: (ed). Philadelphia: McGraw-Hill
    • Elias PM, Feingold KR: Skin as an organ of protection. In: Freedberg I, et al: (ed). Fitzpatrick's Dermatology in General Medicine. Philadelphia: McGraw-Hill, 1999; p 164-174
    • (1999) Fitzpatrick's Dermatology in General Medicine , pp. 164-174
    • Elias, P.M.1    Feingold, K.R.2
  • 54
    • 0034871785 scopus 로고    scopus 로고
    • Does the tail wag the dog? Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications
    • Elias PM, Feingold KR: Does the tail wag the dog? Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications. Arch Dermatol 137:1079-1081, 2001
    • (2001) Arch Dermatol , vol.137 , pp. 1079-1081
    • Elias, P.M.1    Feingold, K.R.2
  • 55
    • 0345237479 scopus 로고    scopus 로고
    • Skin as an organ of protection
    • Freedberg I, et al: (ed). Philadelphia: McGraw-Hill
    • Elias PM, Feingold KR: Skin as an organ of protection. In: Freedberg I, et al: (ed). Fitzpatrick's Dermatology in General Medicine. Philadelphia: McGraw-Hill, 2003; p 164-174
    • (2003) Fitzpatrick's Dermatology in General Medicine , pp. 164-174
    • Elias, P.M.1    Feingold, K.R.2
  • 56
    • 0036141548 scopus 로고    scopus 로고
    • The aged epidermal permeability barrier: Basis for functional abnormalities
    • Elias PM, Ghadially R: The aged epidermal permeability barrier: Basis for functional abnormalities. Clin Geriatr Med 18:103-120, 2002
    • (2002) Clin Geriatr Med , vol.18 , pp. 103-120
    • Elias, P.M.1    Ghadially, R.2
  • 57
    • 0017700678 scopus 로고
    • Mammalian epidermal barrier layer lipids: Composition and influence on structure
    • Elias PM, Goerke J, Friend DS: Mammalian epidermal barrier layer lipids: Composition and influence on structure. J Invest Dermatol 69:535-546, 1977a
    • (1977) J Invest Dermatol , vol.69 , pp. 535-546
    • Elias, P.M.1    Goerke, J.2    Friend, D.S.3
  • 58
    • 0017763391 scopus 로고
    • Membrane alterations during cornification of mammalian squamous epithelia: A freeze-fracture, tracer, and thin-section study
    • Elias PM, McNutt NS, Friend DS: Membrane alterations during cornification of mammalian squamous epithelia: A freeze-fracture, tracer, and thin-section study. Anat Rec 189:577-594, 1977b
    • (1977) Anat Rec , vol.189 , pp. 577-594
    • Elias, P.M.1    McNutt, N.S.2    Friend, D.S.3
  • 59
    • 0026265525 scopus 로고
    • Structural and lipid biochemical correlates of the epidermal permeability barrier
    • Elias PM, Menon GK: Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 24:1-26, 1991
    • (1991) Adv Lipid Res , vol.24 , pp. 1-26
    • Elias, P.M.1    Menon, G.K.2
  • 60
    • 45449121762 scopus 로고
    • Membrane structural alterations in murine stratum corneum: Relationship to the localization of polar lipids and phospholipases
    • Elias PM, Menon GK, Grayson S, Brown BE: Membrane structural alterations in murine stratum corneum: Relationship to the localization of polar lipids and phospholipases. J Invest Dermatol 91:3-10, 1988
    • (1988) J Invest Dermatol , vol.91 , pp. 3-10
    • Elias, P.M.1    Menon, G.K.2    Grayson, S.3    Brown, B.E.4
  • 61
    • 0036617684 scopus 로고    scopus 로고
    • Basis for the permeability barrier abnormality in lamellar ichthyosis
    • Elias PM, Schmuth M, Uchida Y, et al: Basis for the permeability barrier abnormality in lamellar ichthyosis. Exp Dermatol 11:248-256, 2002c
    • (2002) Exp Dermatol , vol.11 , pp. 248-256
    • Elias, P.M.1    Schmuth, M.2    Uchida, Y.3
  • 63
    • 0034030527 scopus 로고    scopus 로고
    • Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation
    • Ellis CN, Varani J, Fisher GJ, et al: Troglitazone improves psoriasis and normalizes models of proliferative skin disease: Ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 136:609-616, 2000
    • (2000) Arch Dermatol , vol.136 , pp. 609-616
    • Ellis, C.N.1    Varani, J.2    Fisher, G.J.3
  • 65
    • 0032588114 scopus 로고    scopus 로고
    • Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: Differentiation from other infantile erythrodermas and pathogenic implications
    • Fartasch M, Williams ML, Elias PM: Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: Differentiation from other infantile erythrodermas and pathogenic implications. Arch Dermatol 135:823-832, 1999
    • (1999) Arch Dermatol , vol.135 , pp. 823-832
    • Fartasch, M.1    Williams, M.L.2    Elias, P.M.3
  • 66
    • 0026284989 scopus 로고
    • The regulation and role of epidermal lipid synthesis
    • Feingold KR: The regulation and role of epidermal lipid synthesis. Adv Lipid Res 24:57-82, 1991
    • (1991) Adv Lipid Res , vol.24 , pp. 57-82
    • Feingold, K.R.1
  • 71
    • 0032501136 scopus 로고    scopus 로고
    • Photoprotection: Sunscreens and the immunomodulatory effects of UV irradiation
    • Finlay-Jones JJ, Hart PH: Photoprotection: Sunscreens and the immunomodulatory effects of UV irradiation. Mutat Res 422:155-159, 1998
    • (1998) Mutat Res , vol.422 , pp. 155-159
    • Finlay-Jones, J.J.1    Hart, P.H.2
  • 72
    • 0036012793 scopus 로고    scopus 로고
    • Nuclear hormone receptors and cholesterol trafficking: The orphans find a new home
    • Fitzgerald ML, Moore KJ, Freeman MW: Nuclear hormone receptors and cholesterol trafficking: The orphans find a new home. J Mol Med 80:271-281, 2002
    • (2002) J Mol Med , vol.80 , pp. 271-281
    • Fitzgerald, M.L.1    Moore, K.J.2    Freeman, M.W.3
  • 73
    • 0022407324 scopus 로고
    • Profilaggrin, a high-molecular-weight precursor of filaggrin in human epidermis and cultured keratinocytes
    • Fleckman P, Dale BA, Holbrook KA: Profilaggrin, a high-molecular-weight precursor of filaggrin in human epidermis and cultured keratinocytes. J Invest Dermatol 85:507-512, 1985
    • (1985) J Invest Dermatol , vol.85 , pp. 507-512
    • Fleckman, P.1    Dale, B.A.2    Holbrook, K.A.3
  • 74
    • 1442348108 scopus 로고    scopus 로고
    • Stratum corneum acidification in neonatal skin: Secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum
    • Fluhr JW, Behne MJ, Brown BE, et al: Stratum corneum acidification in neonatal skin: Secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. J Invest Dermatol 122:320-329, 2004
    • (2004) J Invest Dermatol , vol.122 , pp. 320-329
    • Fluhr, J.W.1    Behne, M.J.2    Brown, B.E.3
  • 75
    • 0034932649 scopus 로고    scopus 로고
    • Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity
    • Fluhr JW, Kao J, Jain M, Ahn SK, Feingold KR, Elias PM: Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. J Invest Dermatol 117:44-51, 2001
    • (2001) J Invest Dermatol , vol.117 , pp. 44-51
    • Fluhr, J.W.1    Kao, J.2    Jain, M.3    Ahn, S.K.4    Feingold, K.R.5    Elias, P.M.6
  • 76
    • 0037960303 scopus 로고    scopus 로고
    • Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice
    • Fluhr JW, Mao-Qiang M, Brown BE, et al: Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol 120:728-737, 2003
    • (2003) J Invest Dermatol , vol.120 , pp. 728-737
    • Fluhr, J.W.1    Mao-Qiang, M.2    Brown, B.E.3
  • 77
    • 0037289786 scopus 로고    scopus 로고
    • Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: Liver-X-receptor-specific inhibition of inflammation and primary cytokine production
    • Fowler AJ, Sheu MY, Schmuth M, et al: Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: Liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120:246-255, 2003
    • (2003) J Invest Dermatol , vol.120 , pp. 246-255
    • Fowler, A.J.1    Sheu, M.Y.2    Schmuth, M.3
  • 78
    • 0020581259 scopus 로고
    • Acid hydrolases of the epidermis: Subcellular localization and relationship to cornification
    • Freinkel RK, Traczyk TN: Acid hydrolases of the epidermis: Subcellular localization and relationship to cornification. J Invest Dermatol 80:441-446, 1983
    • (1983) J Invest Dermatol , vol.80 , pp. 441-446
    • Freinkel, R.K.1    Traczyk, T.N.2
  • 79
    • 0028287112 scopus 로고
    • Intermediate filaments and disease: Mutations that cripple cell strength
    • Fuchs E: Intermediate filaments and disease: Mutations that cripple cell strength. J Cell Biol 125:511-516, 1994
    • (1994) J Cell Biol , vol.125 , pp. 511-516
    • Fuchs, E.1
  • 80
    • 0028283501 scopus 로고
    • Intermediate filaments: Structure, dynamics, function, and disease
    • Fuchs E, Weber K: Intermediate filaments: Structure, dynamics, function, and disease. Annu Rev Biochem 63:345-382, 1994
    • (1994) Annu Rev Biochem , vol.63 , pp. 345-382
    • Fuchs, E.1    Weber, K.2
  • 81
    • 0142058024 scopus 로고    scopus 로고
    • Endogenous production of antimicrobial peptides in innate immunity and human disease
    • Gallo RL, Nizet V: Endogenous production of antimicrobial peptides in innate immunity and human disease. Curr Allergy Asthma Rep 3:402-409, 2003
    • (2003) Curr Allergy Asthma Rep , vol.3 , pp. 402-409
    • Gallo, R.L.1    Nizet, V.2
  • 82
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • Ganz T: Defensins: Antimicrobial peptides of innate immunity. Nat Rev Immunol 3:710-720, 2003
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-720
    • Ganz, T.1
  • 83
    • 0035144999 scopus 로고    scopus 로고
    • Psychological stress perturbs epidermal permeability barrier homeostasis: Implications for the pathogenesis of stress-associated skin disorders
    • Garg A, Chren MM, Sands LP, Matsui MS, Marenus KD, Feingold KR, Elias PM: Psychological stress perturbs epidermal permeability barrier homeostasis: Implications for the pathogenesis of stress-associated skin disorders. Arch Dermatol 137:53-59, 2001
    • (2001) Arch Dermatol , vol.137 , pp. 53-59
    • Garg, A.1    Chren, M.M.2    Sands, L.P.3    Matsui, M.S.4    Marenus, K.D.5    Feingold, K.R.6    Elias, P.M.7
  • 85
    • 0028960479 scopus 로고
    • The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model
    • Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM: The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 95:2281-2290, 1995
    • (1995) J Clin Invest , vol.95 , pp. 2281-2290
    • Ghadially, R.1    Brown, B.E.2    Sequeira-Martin, S.M.3    Feingold, K.R.4    Elias, P.M.5
  • 86
    • 0026528052 scopus 로고
    • Effects of petrolatum on stratum corneum structure and function
    • Ghadially R, Halkier-Sorensen L, Elias PM: Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol 26:387-396, 1992a
    • (1992) J Am Acad Dermatol , vol.26 , pp. 387-396
    • Ghadially, R.1    Halkier-Sorensen, L.2    Elias, P.M.3
  • 87
    • 0029820503 scopus 로고    scopus 로고
    • Stratum corneum structure and function correlates with phenotype in psoriasis
    • Ghadially R, Reed JT, Elias PM: Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol 107:558-564, 1996b
    • (1996) J Invest Dermatol , vol.107 , pp. 558-564
    • Ghadially, R.1    Reed, J.T.2    Elias, P.M.3
  • 88
    • 0026683842 scopus 로고
    • Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses
    • Ghadially R, Williams ML, Hou SY, Elias PM: Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses. J Invest Dermatol 99:755-763, 1992b
    • (1992) J Invest Dermatol , vol.99 , pp. 755-763
    • Ghadially, R.1    Williams, M.L.2    Hou, S.Y.3    Elias, P.M.4
  • 89
    • 0035013520 scopus 로고    scopus 로고
    • Skin barrier, hydration, and pH of the skin of infants under 2 years of age
    • Giusti F, Martella A, Bertoni L, Seidenari S: Skin barrier, hydration, and pH of the skin of infants under 2 years of age. Pediatr Dermatol 18:93-96, 2001
    • (2001) Pediatr Dermatol , vol.18 , pp. 93-96
    • Giusti, F.1    Martella, A.2    Bertoni, L.3    Seidenari, S.4
  • 92
    • 0024565913 scopus 로고
    • Transepidermal water loss: The signal for recovery of barrier structure and function
    • Grubauer G, Elias PM, Feingold KR: Transepidermal water loss: The signal for recovery of barrier structure and function. J Lipid Res 30:323-333, 1989
    • (1989) J Lipid Res , vol.30 , pp. 323-333
    • Grubauer, G.1    Elias, P.M.2    Feingold, K.R.3
  • 93
    • 0023268984 scopus 로고
    • Relationship of epidermal lipogenesis to cutaneous barrier function
    • Grubauer G, Feingold KR, Elias PM: Relationship of epidermal lipogenesis to cutaneous barrier function. J Lipid Res 28:746-752, 1987
    • (1987) J Lipid Res , vol.28 , pp. 746-752
    • Grubauer, G.1    Feingold, K.R.2    Elias, P.M.3
  • 94
    • 0041621569 scopus 로고    scopus 로고
    • pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion
    • Hachem JP, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM: pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 121:345-353, 2003
    • (2003) J Invest Dermatol , vol.121 , pp. 345-353
    • Hachem, J.P.1    Crumrine, D.2    Fluhr, J.3    Brown, B.E.4    Feingold, K.R.5    Elias, P.M.6
  • 95
    • 0029794965 scopus 로고    scopus 로고
    • A longitudinal study of a harlequin infant presenting clinically as non-bullous congenital ichthyosiform erythroderma
    • Haftek M, Cambazard F, Dhouailly D, et al: A longitudinal study of a harlequin infant presenting clinically as non-bullous congenital ichthyosiform erythroderma. Br J Dermatol 135:448-453, 1996
    • (1996) Br J Dermatol , vol.135 , pp. 448-453
    • Haftek, M.1    Cambazard, F.2    Dhouailly, D.3
  • 97
    • 0030835838 scopus 로고    scopus 로고
    • Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier
    • Hanley K, Jiang Y, Crumrine D, et al: Activators of the nuclear hormone receptors PPARalpha and FXR accelerate the development of the fetal epidermal permeability barrier. J Clin Invest 100:705-712, 1997
    • (1997) J Clin Invest , vol.100 , pp. 705-712
    • Hanley, K.1    Jiang, Y.2    Crumrine, D.3
  • 98
    • 0032725472 scopus 로고    scopus 로고
    • Fetal epidermal differentiation and barrier development in vivo is accelerated by nuclear hormone receptor activators
    • Hanley K, Komuves LG, Bass NM, et al: Fetal epidermal differentiation and barrier development in vivo is accelerated by nuclear hormone receptor activators. J Invest Dermatol 113:788-795, 1999
    • (1999) J Invest Dermatol , vol.113 , pp. 788-795
    • Hanley, K.1    Komuves, L.G.2    Bass, N.M.3
  • 99
    • 0040952982 scopus 로고    scopus 로고
    • Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha
    • Hanley K, Komuves LG, Ng DC, et al: Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. J Biol Chem 275:11484-11491, 2000a
    • (2000) J Biol Chem , vol.275 , pp. 11484-11491
    • Hanley, K.1    Komuves, L.G.2    Ng, D.C.3
  • 100
    • 0034126633 scopus 로고    scopus 로고
    • Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription
    • Hanley K, Ng DC, He SS, et al: Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J Invest Dermatol 114:545-553, 2000b
    • (2000) J Invest Dermatol , vol.114 , pp. 545-553
    • Hanley, K.1    Ng, D.C.2    He, S.S.3
  • 101
    • 0030004831 scopus 로고    scopus 로고
    • Epidermal barrier ontogenesis: Maturation in serum-free media and acceleration by glucocorticoids and thyroid hormone but not selected growth factors
    • Hanley K, Rassner U, Elias PM, Williams ML, Feingold KR: Epidermal barrier ontogenesis: Maturation in serum-free media and acceleration by glucocorticoids and thyroid hormone but not selected growth factors. J Invest Dermatol 106:404-411, 1996a
    • (1996) J Invest Dermatol , vol.106 , pp. 404-411
    • Hanley, K.1    Rassner, U.2    Elias, P.M.3    Williams, M.L.4    Feingold, K.R.5
  • 102
    • 0029949786 scopus 로고    scopus 로고
    • Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone
    • Hanley K, Rassner U, Jiang Y, et al: Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone. J Clin Invest 97:2576-2584, 1996b
    • (1996) J Clin Invest , vol.97 , pp. 2576-2584
    • Hanley, K.1    Rassner, U.2    Jiang, Y.3
  • 103
  • 104
    • 0027956112 scopus 로고
    • Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase
    • Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A, Egelrud T: Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J Biol Chem 269:19420-19426, 1994
    • (1994) J Biol Chem , vol.269 , pp. 19420-19426
    • Hansson, L.1    Stromqvist, M.2    Backman, A.3    Wallbrandt, P.4    Carlstein, A.5    Egelrud, T.6
  • 105
    • 0033828399 scopus 로고    scopus 로고
    • High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis
    • Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G: High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 115:406-413, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 406-413
    • Hara, J.1    Higuchi, K.2    Okamoto, R.3    Kawashima, M.4    Imokawa, G.5
  • 106
    • 0037195896 scopus 로고    scopus 로고
    • RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin
    • Harder J, Schröder JM: RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 277:46779-46784, 2002
    • (2002) J Biol Chem , vol.277 , pp. 46779-46784
    • Harder, J.1    Schröder, J.M.2
  • 107
    • 16844370194 scopus 로고    scopus 로고
    • Psoriatic scales: A promising source for the isolation of human skin-derived antimicrobial proteins
    • Harder J, Schröder JM: Psoriatic scales: A promising source for the isolation of human skin-derived antimicrobial proteins. J Leukoc Biol 77:476-486, 2005
    • (2005) J Leukoc Biol , vol.77 , pp. 476-486
    • Harder, J.1    Schröder, J.M.2
  • 109
    • 0031465070 scopus 로고    scopus 로고
    • Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis
    • Harris IR, Farrell AM, Grunfeld C, Holleran WM, Elias PM, Feingold KR: Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J Invest Dermatol 109:783-787, 1997
    • (1997) J Invest Dermatol , vol.109 , pp. 783-787
    • Harris, I.R.1    Farrell, A.M.2    Grunfeld, C.3    Holleran, W.M.4    Elias, P.M.5    Feingold, K.R.6
  • 110
    • 0031935804 scopus 로고    scopus 로고
    • Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis
    • Harris IR, Farrell AM, Holleran WM, Jackson S, Grunfeld C, Elias PM, Feingold KR: Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis. J Lipid Res 39:412-422, 1998
    • (1998) J Lipid Res , vol.39 , pp. 412-422
    • Harris, I.R.1    Farrell, A.M.2    Holleran, W.M.3    Jackson, S.4    Grunfeld, C.5    Elias, P.M.6    Feingold, K.R.7
  • 111
    • 0019891490 scopus 로고
    • Calcium induction of transglutaminase and the formation of epsilon (gamma-glutamyl) lysine cross-links in cultured mouse epidermal cells
    • Hennings H, Steinert P, Buxman MM: Calcium induction of transglutaminase and the formation of epsilon (gamma-glutamyl) lysine cross-links in cultured mouse epidermal cells. Biochem Biophys Res Commun 102:739-745, 1981
    • (1981) Biochem Biophys Res Commun , vol.102 , pp. 739-745
    • Hennings, H.1    Steinert, P.2    Buxman, M.M.3
  • 112
    • 0025338188 scopus 로고
    • Cornified cell envelope
    • Hohl D: Cornified cell envelope. Dermatologica 180:201-211, 1990
    • (1990) Dermatologica , vol.180 , pp. 201-211
    • Hohl, D.1
  • 113
    • 0027180934 scopus 로고
    • Analysis of the cornified cell envelope in lamellar ichthyosis
    • Hohl D, Huber M, Frenk E: Analysis of the cornified cell envelope in lamellar ichthyosis. Arch Dermatol 129:618-624, 1993
    • (1993) Arch Dermatol , vol.129 , pp. 618-624
    • Hohl, D.1    Huber, M.2    Frenk, E.3
  • 114
    • 0025811645 scopus 로고
    • Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins
    • Hohl D, Mehrel T, Lichti U, Turner ML, Roop DR, Steinert PM: Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins. J Biol Chem 266:6626-6636, 1991
    • (1991) J Biol Chem , vol.266 , pp. 6626-6636
    • Hohl, D.1    Mehrel, T.2    Lichti, U.3    Turner, M.L.4    Roop, D.R.5    Steinert, P.M.6
  • 116
    • 0025955624 scopus 로고
    • Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation
    • Holleran WM, Man MQ, Gao WN, Menon GK, Elias PM, Feingold KR: Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. J Clin Invest 88:1338-1345, 1991b
    • (1991) J Clin Invest , vol.88 , pp. 1338-1345
    • Holleran, W.M.1    Man, M.Q.2    Gao, W.N.3    Menon, G.K.4    Elias, P.M.5    Feingold, K.R.6
  • 117
    • 0032468737 scopus 로고    scopus 로고
    • Isoforms of cathepsin D and human epidermal differentiation
    • Horikoshi T, Arany I, Rajaraman S, et al: Isoforms of cathepsin D and human epidermal differentiation. Biochimie 80:605-612, 1998
    • (1998) Biochimie , vol.80 , pp. 605-612
    • Horikoshi, T.1    Arany, I.2    Rajaraman, S.3
  • 118
    • 0032849966 scopus 로고    scopus 로고
    • Role of endogenous cathepsin D-like and chymotrypsin-like proteolysis in human epidermal desquamation
    • Horikoshi T, Igarashi S, Uchiwa H, Brysk H, Brysk MM: Role of endogenous cathepsin D-like and chymotrypsin-like proteolysis in human epidermal desquamation. Br J Dermatol 141:453-459, 1999
    • (1999) Br J Dermatol , vol.141 , pp. 453-459
    • Horikoshi, T.1    Igarashi, S.2    Uchiwa, H.3    Brysk, H.4    Brysk, M.M.5
  • 120
    • 0028947560 scopus 로고
    • Mutations of keratinocyte transglutaminase in lamellar ichthyosis
    • Huber M, Rettler I, Bernasconi K, et al: Mutations of keratinocyte transglutaminase in lamellar ichthyosis. Science 267:525-528, 1995
    • (1995) Science , vol.267 , pp. 525-528
    • Huber, M.1    Rettler, I.2    Bernasconi, K.3
  • 121
    • 0036460781 scopus 로고    scopus 로고
    • Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin
    • Huh WK, Oono T, Shirafuji Y, et al: Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin. J Mol Med 80:678-684, 2002
    • (2002) J Mol Med , vol.80 , pp. 678-684
    • Huh, W.K.1    Oono, T.2    Shirafuji, Y.3
  • 122
  • 123
    • 0025819102 scopus 로고
    • Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?
    • Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A: Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin? J Invest Dermatol 96:523-526, 1991
    • (1991) J Invest Dermatol , vol.96 , pp. 523-526
    • Imokawa, G.1    Abe, A.2    Jin, K.3    Higaki, Y.4    Kawashima, M.5    Hidano, A.6
  • 124
    • 0031882479 scopus 로고    scopus 로고
    • Structural organization of cornified cell envelopes and alterations in inherited skin disorders
    • Ishida-Yamamoto A, Iizuka H: Structural organization of cornified cell envelopes and alterations in inherited skin disorders. Exp Dermatol 7:1-10, 1998
    • (1998) Exp Dermatol , vol.7 , pp. 1-10
    • Ishida-Yamamoto, A.1    Iizuka, H.2
  • 125
    • 0343415084 scopus 로고    scopus 로고
    • Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier
    • Jensen JM, Schutze S, Forl M, Kronke M, Proksch E: Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier. J Clin Invest 104:1761-1770, 1999
    • (1999) J Clin Invest , vol.104 , pp. 1761-1770
    • Jensen, J.M.1    Schutze, S.2    Forl, M.3    Kronke, M.4    Proksch, E.5
  • 126
    • 0037085257 scopus 로고    scopus 로고
    • Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties
    • Jonca N, Guerrin M, Hadjiolova K, Caubet C, Gallinaro H, Simon M, Serre G: Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties. J Biol Chem 277:5024-5029, 2002
    • (2002) J Biol Chem , vol.277 , pp. 5024-5029
    • Jonca, N.1    Guerrin, M.2    Hadjiolova, K.3    Caubet, C.4    Gallinaro, H.5    Simon, M.6    Serre, G.7
  • 127
    • 0036715005 scopus 로고    scopus 로고
    • Epithelial barrier function: Assembly and structural features of the cornified cell envelope
    • Kalinin AE, Kajava AV, Steinert PM: Epithelial barrier function: Assembly and structural features of the cornified cell envelope. Bioessays 24:789-800, 2002
    • (2002) Bioessays , vol.24 , pp. 789-800
    • Kalinin, A.E.1    Kajava, A.V.2    Steinert, P.M.3
  • 128
    • 0037335167 scopus 로고    scopus 로고
    • Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: Inhibition of epidermal lipid synthesis accounts for functional abnormalities
    • Kao JS, Fluhr JW, Man MQ, et al: Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: Inhibition of epidermal lipid synthesis accounts for functional abnormalities. J Invest Dermatol 120:456-464, 2003
    • (2003) J Invest Dermatol , vol.120 , pp. 456-464
    • Kao, J.S.1    Fluhr, J.W.2    Man, M.Q.3
  • 131
    • 0036125197 scopus 로고    scopus 로고
    • Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides
    • Komatsu N, Takata M, Otsuki N, Ohka R, Amano O, Takehara K, Saijoh K: Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J Invest Dermatol 118:436-443, 2002
    • (2002) J Invest Dermatol , vol.118 , pp. 436-443
    • Komatsu, N.1    Takata, M.2    Otsuki, N.3    Ohka, R.4    Amano, O.5    Takehara, K.6    Saijoh, K.7
  • 132
    • 0031657806 scopus 로고    scopus 로고
    • Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development
    • Komuves LG, Hanley K, Jiang Y, Elias PM, Williams ML, Feingold KR: Ligands and activators of nuclear hormone receptors regulate epidermal differentiation during fetal rat skin development. J Invest Dermatol 111: 429-433, 1998
    • (1998) J Invest Dermatol , vol.111 , pp. 429-433
    • Komuves, L.G.1    Hanley, K.2    Jiang, Y.3    Elias, P.M.4    Williams, M.L.5    Feingold, K.R.6
  • 133
    • 0033832034 scopus 로고    scopus 로고
    • Keratinocyte differentiation in hyperproliferative epidermis: Topical application of PPARalpha activators restores tissue homeostasis
    • Komuves LG, Hanley K, Man MQ, Elias PM, Williams ML, Feingold KR: Keratinocyte differentiation in hyperproliferative epidermis: Topical application of PPARalpha activators restores tissue homeostasis. J Invest Dermatol 115:361-367, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 361-367
    • Komuves, L.G.1    Hanley, K.2    Man, M.Q.3    Elias, P.M.4    Williams, M.L.5    Feingold, K.R.6
  • 134
    • 0025184575 scopus 로고
    • Differences in the skin surface pH and bacterial microflora due to the long-term application of synthetic detergent preparations of pH 5.5 and pH 7.0. Results of a crossover trial in healthy volunteers
    • Korting HC, Hubner K, Greiner K, Hamm G, Braun-Falco O: Differences in the skin surface pH and bacterial microflora due to the long-term application of synthetic detergent preparations of pH 5.5 and pH 7.0. Results of a crossover trial in healthy volunteers. Acta Derm Venereol 70:429-431, 1990
    • (1990) Acta Derm Venereol , vol.70 , pp. 429-431
    • Korting, H.C.1    Hubner, K.2    Greiner, K.3    Hamm, G.4    Braun-Falco, O.5
  • 135
    • 0033522399 scopus 로고    scopus 로고
    • Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice
    • Kreder D, Krut O, Adam-Klages S, et al: Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J 18:2472-2479, 1999
    • (1999) EMBO J , vol.18 , pp. 2472-2479
    • Kreder, D.1    Krut, O.2    Adam-Klages, S.3
  • 136
    • 0033832585 scopus 로고    scopus 로고
    • Evidence for the existence of a self-regulated enzymatic process within human stratum corneum - An unexpected role for urocanic acid
    • Krien P, Kermici M: Evidence for the existence of a self-regulated enzymatic process within human stratum corneum-an unexpected role for urocanic acid. J Invest Dermatol 115:414-420, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 414-420
    • Krien, P.1    Kermici, M.2
  • 137
    • 0025637676 scopus 로고
    • Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations
    • Kupper TS: Immune and inflammatory processes in cutaneous tissues. Mechanisms and speculations. J Clin Invest 86:1783-1789, 1990
    • (1990) J Clin Invest , vol.86 , pp. 1783-1789
    • Kupper, T.S.1
  • 139
    • 0023949069 scopus 로고
    • The epidermal permeability barrier
    • Landmann L: The epidermal permeability barrier. Anat Embryol (Berl) 178:1-13, 1988
    • (1988) Anat Embryol (Berl) , vol.178 , pp. 1-13
    • Landmann, L.1
  • 140
    • 0028881058 scopus 로고
    • Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis
    • Lavrijsen AP, Bouwstra JA, Gooris GS, Weerheim A, Bodde HE, Ponec M: Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis. J Invest Dermatol 105: 619-624, 1995
    • (1995) J Invest Dermatol , vol.105 , pp. 619-624
    • Lavrijsen, A.P.1    Bouwstra, J.A.2    Gooris, G.S.3    Weerheim, A.4    Bodde, H.E.5    Ponec, M.6
  • 142
    • 0018576597 scopus 로고
    • Updated in vivo methods for evaluating topical antimicrobial agents on human skin
    • Leyden JJ, Stewart R, Kligman AM: Updated in vivo methods for evaluating topical antimicrobial agents on human skin. J Invest Dermatol 72: 165-170, 1979
    • (1979) J Invest Dermatol , vol.72 , pp. 165-170
    • Leyden, J.J.1    Stewart, R.2    Kligman, A.M.3
  • 143
    • 0031022561 scopus 로고    scopus 로고
    • Amphiregulin and nerve growth factor expression are regulated by barrier status in murine epidermis
    • Liou A, Elias PM, Grunfeld C, Feingold KR, Wood LC: Amphiregulin and nerve growth factor expression are regulated by barrier status in murine epidermis. J Invest Dermatol 108:73-77, 1997
    • (1997) J Invest Dermatol , vol.108 , pp. 73-77
    • Liou, A.1    Elias, P.M.2    Grunfeld, C.3    Feingold, K.R.4    Wood, L.C.5
  • 144
    • 0036178642 scopus 로고    scopus 로고
    • Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation
    • Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T: Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 118:275-281, 2002
    • (2002) J Invest Dermatol , vol.118 , pp. 275-281
    • Liu, A.Y.1    Destoumieux, D.2    Wong, A.V.3    Park, C.H.4    Valore, E.V.5    Liu, L.6    Ganz, T.7
  • 145
    • 0037137346 scopus 로고    scopus 로고
    • Cholesterol homeostasis: Not until the SCAP lady INSIGs
    • Loewen CJ, Levine TP: Cholesterol homeostasis: Not until the SCAP lady INSIGs. Curr Biol 12:R779-R781, 2002
    • (2002) Curr Biol , vol.12
    • Loewen, C.J.1    Levine, T.P.2
  • 146
    • 0027991839 scopus 로고
    • Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation
    • Lundstrom A, Serre G, Haftek M, Egelrud T: Evidence for a role of corneodesmosin, a protein which may serve to modify desmosomes during cornification, in stratum corneum cell cohesion and desquamation. Arch Dermatol Res 286:369-375, 1994
    • (1994) Arch Dermatol Res , vol.286 , pp. 369-375
    • Lundstrom, A.1    Serre, G.2    Haftek, M.3    Egelrud, T.4
  • 148
    • 15844391073 scopus 로고    scopus 로고
    • A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome
    • Maestrini E, Monaco AP, McGrath JA, et al: A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome. Nat Genet 13:70-77, 1996
    • (1996) Nat Genet , vol.13 , pp. 70-77
    • Maestrini, E.1    Monaco, A.P.2    McGrath, J.A.3
  • 150
    • 0027312467 scopus 로고
    • Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin
    • Man MQ, Feingold KR, Elias PM: Exogenous lipids influence permeability barrier recovery in acetone-treated murine skin. Arch Dermatol 129:728-738, 1993
    • (1993) Arch Dermatol , vol.129 , pp. 728-738
    • Man, M.Q.1    Feingold, K.R.2    Elias, P.M.3
  • 151
    • 0029039602 scopus 로고
    • Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction
    • Mao-Qiang M, Brown BE, Wu-Pong S, Feingold KR, Elias PM: Exogenous nonphysiologic vs physiologic lipids. Divergent mechanisms for correction of permeability barrier dysfunction. Arch Dermatol 131:809-816, 1995a
    • (1995) Arch Dermatol , vol.131 , pp. 809-816
    • Mao-Qiang, M.1    Brown, B.E.2    Wu-Pong, S.3    Feingold, K.R.4    Elias, P.M.5
  • 152
    • 0027242298 scopus 로고
    • Fatty acids are required for epidermal permeability barrier function
    • Mao-Qiang M, Elias PM, Feingold KR: Fatty acids are required for epidermal permeability barrier function. J Clin Invest 92:791-798, 1993a
    • (1993) J Clin Invest , vol.92 , pp. 791-798
    • Mao-Qiang, M.1    Elias, P.M.2    Feingold, K.R.3
  • 153
    • 0029090027 scopus 로고
    • Extracellular processing of phospholipids is required for permeability barrier homeostasis
    • Mao-Qiang M, Feingold KR, Jain M, Elias PM: Extracellular processing of phospholipids is required for permeability barrier homeostasis. J Lipid Res 36:1925-1935, 1995b
    • (1995) J Lipid Res , vol.36 , pp. 1925-1935
    • Mao-Qiang, M.1    Feingold, K.R.2    Jain, M.3    Elias, P.M.4
  • 154
    • 0029670641 scopus 로고    scopus 로고
    • Secretory phospholipase A2 activity is required for permeability barrier homeostasis
    • Mao-Qiang M, Jain M, Feingold KR, Elias PM: Secretory phospholipase A2 activity is required for permeability barrier homeostasis. J Invest Dermatol 106:57-63, 1996
    • (1996) J Invest Dermatol , vol.106 , pp. 57-63
    • Mao-Qiang, M.1    Jain, M.2    Feingold, K.R.3    Elias, P.M.4
  • 155
    • 0032504164 scopus 로고    scopus 로고
    • Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope
    • Marekov LN, Steinert PM: Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. J Biol Chem 273: 17763-17770, 1998
    • (1998) J Biol Chem , vol.273 , pp. 17763-17770
    • Marekov, L.N.1    Steinert, P.M.2
  • 156
    • 0031744403 scopus 로고    scopus 로고
    • Barrier recovery is impeded at neutral pH, independent of ionic effects: Implications for extracellular lipid processing
    • Mauro T, Holleran WM, Grayson S, et al: Barrier recovery is impeded at neutral pH, independent of ionic effects: Implications for extracellular lipid processing. Arch Dermatol Res 290:215-222, 1998
    • (1998) Arch Dermatol Res , vol.290 , pp. 215-222
    • Mauro, T.1    Holleran, W.M.2    Grayson, S.3
  • 157
    • 0034022802 scopus 로고    scopus 로고
    • Identification of two secreted phospholipases A2 in human epidermis
    • Maury E, Prevost MC, Simon MF, et al: Identification of two secreted phospholipases A2 in human epidermis. J Invest Dermatol 114:960-966, 2000
    • (2000) J Invest Dermatol , vol.114 , pp. 960-966
    • Maury, E.1    Prevost, M.C.2    Simon, M.F.3
  • 158
    • 0034114362 scopus 로고    scopus 로고
    • Identification of pancreatic type I secreted phospholipase A2 in human epidermis and its determination by tape stripping
    • Mazereeuw-Hautier J, Redoules D, Tarroux R, et al: Identification of pancreatic type I secreted phospholipase A2 in human epidermis and its determination by tape stripping. Br J Dermatol 142:424-431, 2000
    • (2000) Br J Dermatol , vol.142 , pp. 424-431
    • Mazereeuw-Hautier, J.1    Redoules, D.2    Tarroux, R.3
  • 159
    • 0031436110 scopus 로고    scopus 로고
    • Morphologic basis for a pore-pathway in mammalian stratum corneum
    • Menon GK, Elias PM: Morphologic basis for a pore-pathway in mammalian stratum corneum. Skin Pharmacol 10:235-246, 1997
    • (1997) Skin Pharmacol , vol.10 , pp. 235-246
    • Menon, G.K.1    Elias, P.M.2
  • 160
    • 0028307892 scopus 로고
    • Integrity of the permeability barrier is crucial for maintenance of the epidermal calcium gradient
    • Menon GK, Elias PM, Feingold KR: Integrity of the permeability barrier is crucial for maintenance of the epidermal calcium gradient. Br J Dermatol 130: 139-147, 1994a
    • (1994) Br J Dermatol , vol.130 , pp. 139-147
    • Menon, G.K.1    Elias, P.M.2    Feingold, K.R.3
  • 161
    • 0026560393 scopus 로고
    • Lamellar body secretory response to barrier disruption
    • Menon GK, Feingold KR, Elias PM: Lamellar body secretory response to barrier disruption. J Invest Dermatol 98:279-289, 1992
    • (1992) J Invest Dermatol , vol.98 , pp. 279-289
    • Menon, G.K.1    Feingold, K.R.2    Elias, P.M.3
  • 162
    • 0021942128 scopus 로고
    • De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements
    • Menon GK, Feingold KR, Moser AH, Brown BE, Elias PM: De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J Lipid Res 26:418-427, 1985a
    • (1985) J Lipid Res , vol.26 , pp. 418-427
    • Menon, G.K.1    Feingold, K.R.2    Moser, A.H.3    Brown, B.E.4    Elias, P.M.5
  • 163
    • 0021796108 scopus 로고
    • Ionic calcium reservoirs in mammalian epidermis: Ultrastructural localization by ion-capture cytochemistry
    • Menon GK, Grayson S, Elias PM: Ionic calcium reservoirs in mammalian epidermis: Ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508-512, 1985b
    • (1985) J Invest Dermatol , vol.84 , pp. 508-512
    • Menon, G.K.1    Grayson, S.2    Elias, P.M.3
  • 164
    • 0028280029 scopus 로고
    • Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion
    • Menon GK, Price LF, Bommannan B, Elias PM, Feingold KR: Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion. J Invest Dermatol 102:789-795, 1994b
    • (1994) J Invest Dermatol , vol.102 , pp. 789-795
    • Menon, G.K.1    Price, L.F.2    Bommannan, B.3    Elias, P.M.4    Feingold, K.R.5
  • 165
    • 0015067051 scopus 로고
    • Structure and organization of mammalian stratum corneum
    • Menton DN, Eisen AZ: Structure and organization of mammalian stratum corneum. J Ultrastruct Res 35:247-264, 1971
    • (1971) J Ultrastruct Res , vol.35 , pp. 247-264
    • Menton, D.N.1    Eisen, A.Z.2
  • 166
    • 0023857815 scopus 로고
    • In vitro and in vivo antistaphylococcal activity of human stratum corneum lipids
    • Miller SJ, Aly R, Shinefeld HR, Elias PM: In vitro and in vivo antistaphylococcal activity of human stratum corneum lipids. Arch Dermatol 124:209-215, 1988
    • (1988) Arch Dermatol , vol.124 , pp. 209-215
    • Miller, S.J.1    Aly, R.2    Shinefeld, H.R.3    Elias, P.M.4
  • 167
    • 0027173236 scopus 로고
    • SKALP/elafin: An elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase crosslinking
    • Molhuizen HO, Alkemade HA, Zeeuwen PL, de Jongh GJ, Wieringa B, Schalkwijk J: SKALP/elafin: An elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase crosslinking. J Biol Chem 268:12028-12032, 1993
    • (1993) J Biol Chem , vol.268 , pp. 12028-12032
    • Molhuizen, H.O.1    Alkemade, H.A.2    Zeeuwen, P.L.3    De Jongh, G.J.4    Wieringa, B.5    Schalkwijk, J.6
  • 168
    • 85030730467 scopus 로고    scopus 로고
    • Pathophysiological basis for growth failure in children with ichthyosis: An evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure
    • in press
    • Moskowitz DG, Fowler AJ, Heyman MB, Cohen SP, Crumrine D, Elias PM, Williams ML: Pathophysiological basis for growth failure in children with ichthyosis: An evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure. J Pediatr, in press
    • J Pediatr
    • Moskowitz, D.G.1    Fowler, A.J.2    Heyman, M.B.3    Cohen, S.P.4    Crumrine, D.5    Elias, P.M.6    Williams, M.L.7
  • 169
    • 0036329082 scopus 로고    scopus 로고
    • Lipid metabolism: Regulation of lipid metabolism gene expression by peroxisome proliferator-activated receptor alpha and sterol regulatory element binding proteins
    • Narce M, Poisson JP: Lipid metabolism: Regulation of lipid metabolism gene expression by peroxisome proliferator-activated receptor alpha and sterol regulatory element binding proteins. Curr Opin Lipidol 13:445-447, 2002
    • (2002) Curr Opin Lipidol , vol.13 , pp. 445-447
    • Narce, M.1    Poisson, J.P.2
  • 170
    • 0028295190 scopus 로고
    • Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin
    • Nickoloff BJ, Naidu Y: Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J Am Acad Dermatol 30:535-546, 1994
    • (1994) J Am Acad Dermatol , vol.30 , pp. 535-546
    • Nickoloff, B.J.1    Naidu, Y.2
  • 171
    • 0035936156 scopus 로고    scopus 로고
    • Innate antimicrobial peptide protects the skin from invasive bacterial infection
    • Nizet V, Ohtake T, Lauth X, et al: Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457, 2001
    • (2001) Nature , vol.414 , pp. 454-457
    • Nizet, V.1    Ohtake, T.2    Lauth, X.3
  • 172
    • 0026650941 scopus 로고
    • Immunosuppression by ultraviolet B radiation: Initiation by urocanic acid
    • Noonan FP, De Fabo EC: Immunosuppression by ultraviolet B radiation: Initiation by urocanic acid. Immunol Today 13:250-254, 1992
    • (1992) Immunol Today , vol.13 , pp. 250-254
    • Noonan, F.P.1    De Fabo, E.C.2
  • 173
    • 0034783382 scopus 로고    scopus 로고
    • Skin barrier formation: The membrane folding model
    • Norlen L: Skin barrier formation: The membrane folding model. J Invest Dermatol 117:823-829, 2001a
    • (2001) J Invest Dermatol , vol.117 , pp. 823-829
    • Norlen, L.1
  • 174
    • 0034778702 scopus 로고    scopus 로고
    • Skin barrier structure and function: The single gel phase model
    • Norlen L: Skin barrier structure and function: The single gel phase model. J Invest Dermatol 117:830-836, 2001b
    • (2001) J Invest Dermatol , vol.117 , pp. 830-836
    • Norlen, L.1
  • 176
    • 0028094570 scopus 로고
    • In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis
    • Ohman H, Vahlquist A: In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis. Acta Derm Venereol 74:375-379, 1994
    • (1994) Acta Derm Venereol , vol.74 , pp. 375-379
    • Ohman, H.1    Vahlquist, A.2
  • 177
    • 0037057645 scopus 로고    scopus 로고
    • Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    • Ong PY, Ohtake T, Brandt C, et al: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-1160, 2002
    • (2002) N Engl J Med , vol.347 , pp. 1151-1160
    • Ong, P.Y.1    Ohtake, T.2    Brandt, C.3
  • 178
    • 0037388020 scopus 로고    scopus 로고
    • In human epidermis, beta-defensin 2 is packaged in lamellar bodies
    • Oren A, Ganz T, Liu L, Meerloo T: In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp Mol Pathol 74:180-182, 2003
    • (2003) Exp Mol Pathol , vol.74 , pp. 180-182
    • Oren, A.1    Ganz, T.2    Liu, L.3    Meerloo, T.4
  • 179
    • 0030984026 scopus 로고    scopus 로고
    • Na+/H+ exchangers of mammalian cells
    • Orlowski J, Grinstein S: Na+/H+ exchangers of mammalian cells. J Biol Chem 272:22373-22376, 1997
    • (1997) J Biol Chem , vol.272 , pp. 22373-22376
    • Orlowski, J.1    Grinstein, S.2
  • 180
    • 0028909356 scopus 로고
    • Cutaneous permeability barrier disruption increases fatty acid synthetic enzyme activity in the epidermis of hairless mice
    • Ottey KA, Wood LC, Grunfeld C, Elias PM, Feingold KR: Cutaneous permeability barrier disruption increases fatty acid synthetic enzyme activity in the epidermis of hairless mice. J Invest Dermatol 104:401-404, 1995
    • (1995) J Invest Dermatol , vol.104 , pp. 401-404
    • Ottey, K.A.1    Wood, L.C.2    Grunfeld, C.3    Elias, P.M.4    Feingold, K.R.5
  • 181
    • 0025372245 scopus 로고
    • Lipid biophysics of water loss through the skin
    • Potts RO, Francoeur ML: Lipid biophysics of water loss through the skin. Proc Natl Acad Sci USA 87:3871-3873, 1990
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3871-3873
    • Potts, R.O.1    Francoeur, M.L.2
  • 182
    • 0025248718 scopus 로고
    • Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements
    • Proksch E, Elias PM, Feingold KR: Regulation of 3-hydroxy-3- methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements. J Clin Invest 85:874-882, 1990
    • (1990) J Clin Invest , vol.85 , pp. 874-882
    • Proksch, E.1    Elias, P.M.2    Feingold, K.R.3
  • 183
    • 0037357652 scopus 로고    scopus 로고
    • Skin lipids and epidermal differentiation in atopic dermatitis
    • Proksch E, Jensen JM, Elias PM: Skin lipids and epidermal differentiation in atopic dermatitis. Clin Dermatol 21:134-144, 2003
    • (2003) Clin Dermatol , vol.21 , pp. 134-144
    • Proksch, E.1    Jensen, J.M.2    Elias, P.M.3
  • 184
    • 0043172415 scopus 로고    scopus 로고
    • The SREBP pathway-insights from Insigs and insects
    • Rawson RB: The SREBP pathway-insights from Insigs and insects. Nat Rev Mol Cell Biol 4:631-640, 2003
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 631-640
    • Rawson, R.B.1
  • 185
    • 0032797223 scopus 로고    scopus 로고
    • Characterisation and assay of five enzymatic activities in the stratum corneum using tape-strippings
    • Redoules D, Tarroux R, Assalit MF, Peri JJ: Characterisation and assay of five enzymatic activities in the stratum corneum using tape-strippings. Skin Pharmacol Appl Skin Physiol 12:182-192, 1999
    • (1999) Skin Pharmacol Appl Skin Physiol , vol.12 , pp. 182-192
    • Redoules, D.1    Tarroux, R.2    Assalit, M.F.3    Peri, J.J.4
  • 187
    • 0031727899 scopus 로고    scopus 로고
    • Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2)
    • Risse BC, Brown H, Lavker RM, Pearson JM, Baker MS, Ginsburg D, Jensen PJ: Differentiating cells of murine stratified squamous epithelia constitutively express plasminogen activator inhibitor type 2 (PAI-2). Histochem Cell Biol 110:559-569, 1998
    • (1998) Histochem Cell Biol , vol.110 , pp. 559-569
    • Risse, B.C.1    Brown, H.2    Lavker, R.M.3    Pearson, J.M.4    Baker, M.S.5    Ginsburg, D.6    Jensen, P.J.7
  • 188
    • 0033975473 scopus 로고    scopus 로고
    • Evidence for intracellular cleavage of plasminogen activator inhibitor type 2 (PAI-2) in normal epidermal keratinocytes
    • Risse BC, Chung NM, Baker MS, Jensen PJ: Evidence for intracellular cleavage of plasminogen activator inhibitor type 2 (PAI-2) in normal epidermal keratinocytes. J Cell Physiol 182:281-289, 2000
    • (2000) J Cell Physiol , vol.182 , pp. 281-289
    • Risse, B.C.1    Chung, N.M.2    Baker, M.S.3    Jensen, P.J.4
  • 189
    • 0034004910 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model
    • Rivier M, Castiel I, Safonova I, Ailhaud G, Michel S: Peroxisome proliferator-activated receptor-alpha enhances lipid metabolism in a skin equivalent model. J Invest Dermatol 114:681-687, 2000
    • (2000) J Invest Dermatol , vol.114 , pp. 681-687
    • Rivier, M.1    Castiel, I.2    Safonova, I.3    Ailhaud, G.4    Michel, S.5
  • 190
    • 0026781694 scopus 로고
    • Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis
    • Rothnagel JA, Dominey AM, Dempsey LD, et al: Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis. Science 257:1128-1130, 1992
    • (1992) Science , vol.257 , pp. 1128-1130
    • Rothnagel, J.A.1    Dominey, A.M.2    Dempsey, L.D.3
  • 191
    • 0141922040 scopus 로고    scopus 로고
    • Inhibition of IgE-production by peroxisome proliferator-activated receptor ligands
    • Ruhl R, Dahten A, Schweigert FJ, Herz U, Worm M: Inhibition of IgE-production by peroxisome proliferator-activated receptor ligands. J Invest Dermatol 121:757-764, 2003
    • (2003) J Invest Dermatol , vol.121 , pp. 757-764
    • Ruhl, R.1    Dahten, A.2    Schweigert, F.J.3    Herz, U.4    Worm, M.5
  • 192
    • 0035831171 scopus 로고    scopus 로고
    • Molecular and functional characterization of sodium-hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes
    • Sarangarajan R, Shumaker H, Soleimani M, Le Poole C, Boissy RE: Molecular and functional characterization of sodium-hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes. Biochim Biophys Acta 1511:181-192, 2001
    • (2001) Biochim Biophys Acta , vol.1511 , pp. 181-192
    • Sarangarajan, R.1    Shumaker, H.2    Soleimani, M.3    Le Poole, C.4    Boissy, R.E.5
  • 193
    • 0036428659 scopus 로고    scopus 로고
    • Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis
    • Sato J, Denda M, Chang S, Elias PM, Feingold KR: Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol 119:900-904, 2002
    • (2002) J Invest Dermatol , vol.119 , pp. 900-904
    • Sato, J.1    Denda, M.2    Chang, S.3    Elias, P.M.4    Feingold, K.R.5
  • 194
    • 0035135395 scopus 로고    scopus 로고
    • Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA
    • Schadow A, Scholz-Pedretti K, Lambeau G, Gelb MH, Furstenberger G, Pfeilschifter J, Kaszkin M: Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA. J Invest Dermatol 116:31-39, 2001
    • (2001) J Invest Dermatol , vol.116 , pp. 31-39
    • Schadow, A.1    Scholz-Pedretti, K.2    Lambeau, G.3    Gelb, M.H.4    Furstenberger, G.5    Pfeilschifter, J.6    Kaszkin, M.7
  • 196
    • 3042684719 scopus 로고    scopus 로고
    • The effect of LXR activators on AP-1 proteins in keratinocytes
    • Schmuth M, Elias PM, Hanley K, et al: The effect of LXR activators on AP-1 proteins in keratinocytes. J Invest Dermatol 123:41-48, 2004a
    • (2004) J Invest Dermatol , vol.123 , pp. 41-48
    • Schmuth, M.1    Elias, P.M.2    Hanley, K.3
  • 197
    • 2342637194 scopus 로고    scopus 로고
    • Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis)
    • Schmuth M, Fluhr JW, Crumrine DC, et al: Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis). J Invest Dermatol 122:909-922, 2004b
    • (2004) J Invest Dermatol , vol.122 , pp. 909-922
    • Schmuth, M.1    Fluhr, J.W.2    Crumrine, D.C.3
  • 198
    • 2342579597 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    • Schmuth M, Haqq CM, Cairns WJ, et al: Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-983, 2004c
    • (2004) J Invest Dermatol , vol.122 , pp. 971-983
    • Schmuth, M.1    Haqq, C.M.2    Cairns, W.J.3
  • 199
    • 0034783306 scopus 로고    scopus 로고
    • Pathogenesis of the permeability barrier abnormality in epidermolytic hyperkeratosis
    • Schmuth M, Yosipovitch G, Williams ML, et al: Pathogenesis of the permeability barrier abnormality in epidermolytic hyperkeratosis. J Invest Dermatol 117:837-847, 2001b
    • (2001) J Invest Dermatol , vol.117 , pp. 837-847
    • Schmuth, M.1    Yosipovitch, G.2    Williams, M.L.3
  • 200
    • 0026279967 scopus 로고
    • The biochemistry and function of stratum corneum lipids
    • Schurer NY, Elias PM: The biochemistry and function of stratum corneum lipids. Adv Lipid Res 24:27-56, 1991
    • (1991) Adv Lipid Res , vol.24 , pp. 27-56
    • Schurer, N.Y.1    Elias, P.M.2
  • 201
    • 0019420574 scopus 로고
    • Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid
    • Scott IR: Factors controlling the expressed activity of histidine ammonia-lyase in the epidermis and the resulting accumulation of urocanic acid. Biochem J 194:829-838, 1981
    • (1981) Biochem J , vol.194 , pp. 829-838
    • Scott, I.R.1
  • 202
    • 0022585350 scopus 로고
    • Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment
    • Scott IR, Harding CR: Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol 115:84-92, 1986
    • (1986) Dev Biol , vol.115 , pp. 84-92
    • Scott, I.R.1    Harding, C.R.2
  • 203
    • 0026052977 scopus 로고
    • Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope
    • Serre G, Mils V, Haftek M, et al: Identification of late differentiation antigens of human cornified epithelia, expressed in re-organized desmosomes and bound to cross-linked envelope. J Invest Dermatol 97:1061-1072, 1991
    • (1991) J Invest Dermatol , vol.97 , pp. 1061-1072
    • Serre, G.1    Mils, V.2    Haftek, M.3
  • 204
    • 0036153739 scopus 로고    scopus 로고
    • Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    • Sheu MY, Fowler AJ, Kao J, et al: Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol 118:94-101, 2002
    • (2002) J Invest Dermatol , vol.118 , pp. 94-101
    • Sheu, M.Y.1    Fowler, A.J.2    Kao, J.3
  • 205
    • 0035827559 scopus 로고    scopus 로고
    • Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation
    • Simon M, Jonca N, Guerrin M, et al: Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation. J Biol Chem 276:20292-20299, 2001
    • (2001) J Biol Chem , vol.276 , pp. 20292-20299
    • Simon, M.1    Jonca, N.2    Guerrin, M.3
  • 206
    • 0031465982 scopus 로고    scopus 로고
    • Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes
    • Simon M, Montezin M, Guerrin M, Durieux JJ, Serre G: Characterization and purification of human corneodesmosin, an epidermal basic glycoprotein associated with corneocyte-specific modified desmosomes. J Biol Chem 272:31770-31776, 1997
    • (1997) J Biol Chem , vol.272 , pp. 31770-31776
    • Simon, M.1    Montezin, M.2    Guerrin, M.3    Durieux, J.J.4    Serre, G.5
  • 207
    • 0024203810 scopus 로고
    • Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase
    • Smith JR, Osborne TF, Brown MS, Goldstein JL, Gil G: Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Biol Chem 263:18480-18487, 1988
    • (1988) J Biol Chem , vol.263 , pp. 18480-18487
    • Smith, J.R.1    Osborne, T.F.2    Brown, M.S.3    Goldstein, J.L.4    Gil, G.5
  • 208
    • 0028348639 scopus 로고
    • Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: Evidence of a proteinase specifically expressed in keratinizing squamous epithelia
    • Sondell B, Thornell LE, Stigbrand T, Egelrud T: Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: Evidence of a proteinase specifically expressed in keratinizing squamous epithelia. J Histochem Cytochem 42:459-465, 1994
    • (1994) J Histochem Cytochem , vol.42 , pp. 459-465
    • Sondell, B.1    Thornell, L.E.2    Stigbrand, T.3    Egelrud, T.4
  • 209
    • 0032752533 scopus 로고    scopus 로고
    • Cutaneous pH in children affected by atopic dermatitis and in healthy children: A multicenter study
    • Sparavigna A, Setaro M, Gualandri V: Cutaneous pH in children affected by atopic dermatitis and in healthy children: A multicenter study. Skin Res Technol 5:221-227, 1999
    • (1999) Skin Res Technol , vol.5 , pp. 221-227
    • Sparavigna, A.1    Setaro, M.2    Gualandri, V.3
  • 210
    • 0031037715 scopus 로고    scopus 로고
    • Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified envelope
    • Steinert PM, Marekov LN: Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified envelope. J Biol Chem 17:2021-2030, 1997
    • (1997) J Biol Chem , vol.17 , pp. 2021-2030
    • Steinert, P.M.1    Marekov, L.N.2
  • 211
    • 0242576364 scopus 로고    scopus 로고
    • The objective severity assessment of atopic dermatitis score: An objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease
    • Sugarman JL, Fluhr JW, Fowler AJ, Bruckner T, Diepgen TL, Williams ML: The objective severity assessment of atopic dermatitis score: An objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease. Arch Dermatol 139:1417-1422, 2003
    • (2003) Arch Dermatol , vol.139 , pp. 1417-1422
    • Sugarman, J.L.1    Fluhr, J.W.2    Fowler, A.J.3    Bruckner, T.4    Diepgen, T.L.5    Williams, M.L.6
  • 212
    • 0029925303 scopus 로고    scopus 로고
    • The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1 and their reduced activity in the skin of ichthyotic patients
    • Suzuki Y, Koyama J, Moro O, Horii I, Kikuchi K, Tanida M, Tagami H: The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1 and their reduced activity in the skin of ichthyotic patients. Br J Dermatol 134:460-464, 1996
    • (1996) Br J Dermatol , vol.134 , pp. 460-464
    • Suzuki, Y.1    Koyama, J.2    Moro, O.3    Horii, I.4    Kikuchi, K.5    Tanida, M.6    Tagami, H.7
  • 213
    • 0027303045 scopus 로고
    • Detection and characterization of endogenous protease associated with desquamation of stratum corneum
    • Suzuki Y, Nomura J, Hori J, Koyama J, Takahashi M, Horii I: Detection and characterization of endogenous protease associated with desquamation of stratum corneum. Arch Dermatol Res 285:372-377, 1993
    • (1993) Arch Dermatol Res , vol.285 , pp. 372-377
    • Suzuki, Y.1    Nomura, J.2    Hori, J.3    Koyama, J.4    Takahashi, M.5    Horii, I.6
  • 215
    • 0030012757 scopus 로고    scopus 로고
    • Filaggrin linker segment peptide and cystatin alpha are parts of a complex of the cornified envelope of epidermis
    • Takahashi M, Tezuka T, Katunuma N: Filaggrin linker segment peptide and cystatin alpha are parts of a complex of the cornified envelope of epidermis. Arch Biochem Biophys 329:123-126, 1996
    • (1996) Arch Biochem Biophys , vol.329 , pp. 123-126
    • Takahashi, M.1    Tezuka, T.2    Katunuma, N.3
  • 216
    • 0012030796 scopus 로고
    • Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase
    • Thompson RC, Ohlsson K: Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase. Proc Natl Acad Sci USA 83:6692-6696, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 6692-6696
    • Thompson, R.C.1    Ohlsson, K.2
  • 217
    • 0023789153 scopus 로고
    • The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients
    • Thune P, Nilsen T, Hanstad IK, Gustavsen T, Lovig Dahl H: The water barrier function of the skin in relation to the water content of stratum corneum, pH and skin lipids. The effect of alkaline soap and syndet on dry skin in elderly, non-atopic patients. Acta Derm Venereol 68:277-283, 1988
    • (1988) Acta Derm Venereol , vol.68 , pp. 277-283
    • Thune, P.1    Nilsen, T.2    Hanstad, I.K.3    Gustavsen, T.4    Lovig Dahl, H.5
  • 219
    • 0034526215 scopus 로고    scopus 로고
    • Epidermal sphingomyelins are precursors for selected stratum corneum ceramides
    • Uchida Y, Hara M, Nishio H, et al: Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 41:2071-2082, 2000
    • (2000) J Lipid Res , vol.41 , pp. 2071-2082
    • Uchida, Y.1    Hara, M.2    Nishio, H.3
  • 220
    • 0011176887 scopus 로고    scopus 로고
    • A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase gene
    • Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methyl- glutaryl coenzyme A reductase gene. J Biol Chem 271:12247-12253, 1996
    • (1996) J Biol Chem , vol.271 , pp. 12247-12253
    • Vallett, S.M.1    Sanchez, H.B.2    Rosenfeld, J.M.3    Osborne, T.F.4
  • 221
    • 0031426588 scopus 로고    scopus 로고
    • Demonstration of an Na+/H+ exchanger in mouse keratinocytes measured by the novel pH-sensitive fluorochrome SNARF-calcein
    • van Hooijdonk CA, Colbers RM, Piek J, van Erp PE: Demonstration of an Na+/H+ exchanger in mouse keratinocytes measured by the novel pH-sensitive fluorochrome SNARF-calcein. Cell Prolif 30:351-363, 1997
    • (1997) Cell Prolif , vol.30 , pp. 351-363
    • Van Hooijdonk, C.A.1    Colbers, R.M.2    Piek, J.3    Van Erp, P.E.4
  • 223
    • 0034750572 scopus 로고    scopus 로고
    • Water modulation of stratum corneum chymotryptic enzyme activity and desquamation
    • Watkinson A, Harding C, Moore A, Coan P: Water modulation of stratum corneum chymotryptic enzyme activity and desquamation. Arch Dermatol Res 293:470-476, 2001
    • (2001) Arch Dermatol Res , vol.293 , pp. 470-476
    • Watkinson, A.1    Harding, C.2    Moore, A.3    Coan, P.4
  • 224
    • 0021242315 scopus 로고
    • Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis
    • Wertz PW, Downing DT, Freinkel RK, Traczyk TN: Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis. J Invest Dermatol 83:193-195, 1984
    • (1984) J Invest Dermatol , vol.83 , pp. 193-195
    • Wertz, P.W.1    Downing, D.T.2    Freinkel, R.K.3    Traczyk, T.N.4
  • 226
    • 0025168332 scopus 로고
    • Elafin: An elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence
    • Wiedow O, Schroder JM, Gregory H, Young JA, Christophers E: Elafin: An elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence. J Biol Chem 256:14791-14795, 1990
    • (1990) J Biol Chem , vol.256 , pp. 14791-14795
    • Wiedow, O.1    Schroder, J.M.2    Gregory, H.3    Young, J.A.4    Christophers, E.5
  • 228
    • 0027180936 scopus 로고
    • From basket weave to barrier. Unifying concepts for the pathogenesis of the disorders of cornification
    • Williams ML, Elias PM: From basket weave to barrier. Unifying concepts for the pathogenesis of the disorders of cornification. Arch Dermatol 129: 626-629, 1993
    • (1993) Arch Dermatol , vol.129 , pp. 626-629
    • Williams, M.L.1    Elias, P.M.2
  • 229
    • 0142156000 scopus 로고    scopus 로고
    • Enlightened therapy of the disorders of cornification
    • Williams ML, Elias PM: Enlightened therapy of the disorders of cornification. Clin Dermatol 21:269-273, 2003
    • (2003) Clin Dermatol , vol.21 , pp. 269-273
    • Williams, M.L.1    Elias, P.M.2
  • 230
    • 0029883952 scopus 로고    scopus 로고
    • Barrier disruption stimulates interleukin-1 alpha expression and release from a preformed pool in murine epidermis
    • Wood LC, Elias PM, Calhoun C, Tsai JC, Grunfeld C, Feingold KR: Barrier disruption stimulates interleukin-1 alpha expression and release from a preformed pool in murine epidermis. J Invest Dermatol 106:397-403, 1996
    • (1996) J Invest Dermatol , vol.106 , pp. 397-403
    • Wood, L.C.1    Elias, P.M.2    Calhoun, C.3    Tsai, J.C.4    Grunfeld, C.5    Feingold, K.R.6
  • 231
    • 0028593915 scopus 로고
    • Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption
    • Wood LC, Elias PM, Sequeira-Martin SM, Grunfeld C, Feingold KR: Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption. J Invest Dermatol 103:834-838, 1994a
    • (1994) J Invest Dermatol , vol.103 , pp. 834-838
    • Wood, L.C.1    Elias, P.M.2    Sequeira-Martin, S.M.3    Grunfeld, C.4    Feingold, K.R.5
  • 232
    • 0028340841 scopus 로고
    • Barrier function coordinately regulates epidermal IL-1 and IL-1 receptor antagonist mRNA levels
    • Wood LC, Feingold KR, Sequeira-Martin SM, Elias PM, Grunfeld C: Barrier function coordinately regulates epidermal IL-1 and IL-1 receptor antagonist mRNA levels. Exp Dermatol 3:56-60, 1994b
    • (1994) Exp Dermatol , vol.3 , pp. 56-60
    • Wood, L.C.1    Feingold, K.R.2    Sequeira-Martin, S.M.3    Elias, P.M.4    Grunfeld, C.5
  • 233
    • 0026706275 scopus 로고
    • Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice
    • Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR: Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90:482-487, 1992
    • (1992) J Clin Invest , vol.90 , pp. 482-487
    • Wood, L.C.1    Jackson, S.M.2    Elias, P.M.3    Grunfeld, C.4    Feingold, K.R.5
  • 235
    • 0036615233 scopus 로고    scopus 로고
    • Alterations in cytokine regulation in aged epidermis: Implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family
    • Ye J, Garg A, Calhoun C, Feingold KR, Elias PM, Ghadially R: Alterations in cytokine regulation in aged epidermis: Implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family. Exp Dermatol 11:209-216, 2002
    • (2002) Exp Dermatol , vol.11 , pp. 209-216
    • Ye, J.1    Garg, A.2    Calhoun, C.3    Feingold, K.R.4    Elias, P.M.5    Ghadially, R.6
  • 236
    • 0027478348 scopus 로고
    • Skin surface pH in intertriginous areas in NIDDM patients. Possible correlation to candidal intertrigo
    • Yosipovitch G, Tur E, Cohen O, Rusecki Y: Skin surface pH in intertriginous areas in NIDDM patients. Possible correlation to candidal intertrigo. Diabetes Care 16:560-563, 1993
    • (1993) Diabetes Care , vol.16 , pp. 560-563
    • Yosipovitch, G.1    Tur, E.2    Cohen, O.3    Rusecki, Y.4
  • 237
    • 0036379140 scopus 로고    scopus 로고
    • Cathelicidins, essential gene-encoded mammalian antibiotics
    • Zaiou M, Gallo RL: Cathelicidins, essential gene-encoded mammalian antibiotics. J Mol Med 80:549-561, 2002
    • (2002) J Mol Med , vol.80 , pp. 549-561
    • Zaiou, M.1    Gallo, R.L.2
  • 238
    • 0037960231 scopus 로고    scopus 로고
    • Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence
    • Zaiou M, Nizet V, Gallo RL: Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol 120:810-816, 2003
    • (2003) J Invest Dermatol , vol.120 , pp. 810-816
    • Zaiou, M.1    Nizet, V.2    Gallo, R.L.3
  • 239
    • 0041842712 scopus 로고    scopus 로고
    • The human cystatin M/E gene (CST6): Exclusion candidate gene for harlequin ichthyosis
    • Zeeuwen PL, Dale BA, de Jongh GJ, et al: The human cystatin M/E gene (CST6): Exclusion candidate gene for harlequin ichthyosis. J Invest Dermatol 121:65-68, 2003
    • (2003) J Invest Dermatol , vol.121 , pp. 65-68
    • Zeeuwen, P.L.1    Dale, B.A.2    De Jongh, G.J.3
  • 240
    • 0035018513 scopus 로고    scopus 로고
    • Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: A new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase
    • Zeeuwen PL, Van Vlijmen-Willems IM, Jansen BJ, et al: Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: A new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. J Invest Dermatol 116:693-701, 2001
    • (2001) J Invest Dermatol , vol.116 , pp. 693-701
    • Zeeuwen, P.L.1    Van Vlijmen-Willems, I.M.2    Jansen, B.J.3
  • 241
    • 0031737359 scopus 로고    scopus 로고
    • Recessive x-linked ichthyosis: Role of cholesterol-sulfate accumulation in the barrier abnormality
    • Zettersten E, Man MQ, Sato J, et al: Recessive x-linked ichthyosis: Role of cholesterol-sulfate accumulation in the barrier abnormality. J Invest Dermatol 111:784-790, 1998
    • (1998) J Invest Dermatol , vol.111 , pp. 784-790
    • Zettersten, E.1    Man, M.Q.2    Sato, J.3
  • 242
    • 0030930733 scopus 로고    scopus 로고
    • Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin
    • Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM: Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol 37:403-408, 1997
    • (1997) J Am Acad Dermatol , vol.37 , pp. 403-408
    • Zettersten, E.M.1    Ghadially, R.2    Feingold, K.R.3    Crumrine, D.4    Elias, P.M.5


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