The Objective Severity Assessment of Atopic Dermatitis Score: An Objective Measure Using Permeability Barrier Function and Stratum Corneum Hydration with Computer-Assisted Estimates for Extent of Disease

Archives of Dermatology

Volumn 139, Issue 11, 2003, Pages 1417-1422

  Sugarman, Jeffrey L ^a   Fluhr, Joachim W ^a,b,c   Fowler, Ashley J ^a   Bruckner, Thomas ^d   Diepgen, Thomas L ^d   Williams, Mary L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ALGORITHM; ANALYTIC METHOD; ARTICLE; ATOPIC DERMATITIS; BODY SURFACE; CHILD; CLINICAL ARTICLE; COMPUTER ASSISTED DIAGNOSIS; CONTROLLED STUDY; CORRELATION FUNCTION; DERMATOLOGY; DISEASE SEVERITY; ELECTRIC CAPACITANCE; FEMALE; HUMAN; HYDRATION; INFANT; INTERMETHOD COMPARISON; MALE; OUTCOMES RESEARCH; OUTPATIENT; PEDIATRIC HOSPITAL; PRIORITY JOURNAL; RATING SCALE; SKIN ELECTROPHYSIOLOGY; SKIN FUNCTION; SKIN WATER LOSS; STRATUM CORNEUM;

ADOLESCENT; BODY SURFACE AREA; BODY WATER; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; DIAGNOSIS, COMPUTER-ASSISTED; EPIDERMIS; FEMALE; HUMANS; INFANT; MALE; PERMEABILITY; PILOT PROJECTS; SEVERITY OF ILLNESS INDEX; WATER LOSS, INSENSIBLE;

EID: 0242576364     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.139.11.1417     Document Type: Article

References (26)

1. Leung DY. Pathogenesis of atopic dermatitis. J Allergy Clin Immunol. 1999;104(3, pt 2):S99-S108.
2. Uehara M. Clinical and histological features of dry skin in atopic dermatitis. Acta Derm Venereol Suppl (Stockh). 1985;114:82-86.
3. Werner Y. The water content of the stratum corneum in patients with atopic dermatitis: measurement with the Corneometer CM 420. Acta Derm Venereol. 1986;66:281-284.
4. Charman C, Williams H. Outcome measures of disease severity in atopic eczema. Arch Dermatol. 2000;136:763-769.
5. Severity scoring of atopic dermatitis: the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186:23-31.
6. Sprikkelman AB, Tupker RA, Burgerhof H, et al. Severity scoring of atopic dermatitis: a comparison of three scoring systems. Allergy. 1997;52:944-949.
7. Charman CR, Venn AJ, Williams HC. Measurement of body surface area involvement in atopic eczema: an impossible task? Br J Dermatol. 1999;140:109-111.
8. Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. Exp Dermatol. 2001;10:11-18.
9. Eberlein-Konig B, Schafer T, Huss-Marp J, et al. Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. Acta Derm Venereol. 2000;80:188-191.
10. Seidenari S, Giusti G. Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol. 1995;75:429-433.
11. Chamlin SL, Frieden IJ, Fowler A, et al. Ceramide-dominant, barrier-repair lipids improve childhood atopic dermatitis. Arch Dermatol. 2001;137:1110-1112.
12. Chamlin SL, Kao J, Frieden IJ, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol. 2002;47:198-208.
13. Di Nardo A, Wertz P, Giannetti A, Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol. 1998;78:27-30.
14. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol. 1991;96:523-526.
15. Yamamoto A, Serizawa S, Ito M, Sato Y. Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res. 1991;283:219-223.
16. Elias PM, Feingold KR. Does the tail wag the dog? role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications. Arch Dermatol. 2001;137:1079-1081.
17. Watanabe M, Tagami H, Horii I, Takahashi M, Kligman AM. Functional analyses of the superficial stratum corneum in atopic xerosis. Arch Dermatol. 1991;127:1689-1692.
18. Tanaka M, Okada M, Zhen YX, et al. Decreased hydration state of the stratum corneum and reduced amino acid content of the skin surface in patients with seasonal allergic rhinitis. Br J Dermatol. 1998;139:618-621.
19. Horii I, Nakayama Y, Obata M, Tagami H. Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol. 1989;121:587-592.
20. Pinnagoda J, Tupker RA, Agner T, Serup J. Guidelines for transepidermal water loss (TEWL) measurement: a report from the Standardization Group of the European Society of Contact Dermatitis. Contact Dermatitis. 1990;22:164-178.
21. Berardesca E. EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. Skin Res Technol. 1997;3:126-132.
22. Rogiers V. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol. 2001;14:117-128.
23. Fluhr JW, Pfisterer S, Gloor M. Direct comparison of skin physiology in children and adults with bioengineering methods. Pediatr Dermatol. 2000;17:436-439.
24. Finlay AY. Quality of life in atopic dermatitis. J Am Acad Dermatol. 2001;45 (suppl 1):S64-S66.
25. Lewis-Jones MS, Finlay AY, Dykes PJ. The Infants' Dermatitis Quality of Life Index. Br J Dermatol. 2001;144:104-110.
26. Gutgesell C, Frolich JC, Neumann C. Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores. Br J Dermatol. 2002;147:914-919.