Lamellar granule biogenesis: A role for ceramide glucosyltransferase, lysosomal enzyme transport, and the Golgi

Journal of Investigative Dermatology Symposium Proceedings

Volumn 3, Issue 2, 1998, Pages 80-86

  Madison, Kathi C ^a,c   Sando, Gloria N ^a   Howard, Elizabeth J ^a   True, Cheryl A ^a   Gilbert, Delon ^a   Swartzendruber, Donald C ^b   Wertz, Philip W ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Acid lipase; Epidermis; Glucocerebrosidase; Keratinocyte; Permeability barrier

Indexed keywords

ACID LIPASE; CERAMIDE GLUCOSYLTRANSFERASE; GLUCOSYLCERAMIDASE; GLUCOSYLCERAMIDE; GLUCOSYLTRANSFERASE; LIPID; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; RETINOIC ACID; SPHINGOMYELIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL DIFFERENTIATION; CELL GRANULE; ENZYME INDUCTION; ENZYME RELEASE; EPIDERMIS; GOLGI COMPLEX; HUMAN; HUMAN CELL; KERATINOCYTE; LAMELLAR BODY; MEMBRANE VESICLE; NEWBORN; NONHUMAN; PERMEABILITY BARRIER; PREPUCE; SWINE;

EID: 0032459304     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/jidsymp.1998.19     Document Type: Article

References (50)

1. Aerts JMFG, Schram AW, Strijland A, et al: Glucocerebrosidase, a lysosomal enzyme that does not undergo oligosaccharide phosphorylation. Biochim Biophys Acta 964:303-308, 1988
2. Amers D, Merkel M, Eckerskorn C, Greten H: Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase. Eur J Biochim 219:905-914, 1994
3. Anderson RA, Sando GN: Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. J Biol Chem 266:22479-22484, 1991
4. Burkhardt JK, Hester S, Lapham CK, Argon Y: The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments. J Cell Biol 111:2327-2340, 1990
5. Chen C-SJ, Lavker RM, Rodeck U, Risse B, Jensen PJ: Use of a serum-free epidermal culture model to show deleterious effects of epidermal growth factor on morphogenesis and differentiation. J Invest Dermatol 104:107-112, 1995
6. Diment S, Eidelman M, Rodriguez GM, Orlow SJ: Lysosomal hydrolases are present in melanosomes and are elevated in melanizing cells. J Biol Chem 270:4213-4215, 1995
7. Dinur T, Grabowski GA, Desnick RJ, Gatt S: Synthesis of a fluorescent derivative of glucosylceramide for the sensitive determination of glucocerebrosidase activity. Anal Biochem 136:223-234, 1984
8. Freinkel RK, Traczyk TN: A method for partial purification of lamellar granules from fetal rat epidermis. J Invest Dermatol 77:478-482, 1981
9. Freinkel RK, Traczyk TN: Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis. J Invest Dermatol 85:295-298, 1985
10. Fuchs E: Epidermal differentiation: The bare essentials. J Cell Biol 111:2807-2814, 1990
11. Futerman AH, Pagano RE: Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver. Biochem J 280:295-302, 1991
12. Grace ME, Graves PN, Smith FI, Grabowski GA: Analyses of catalytic activity and inhibitor binding of human acid β-glucosidase by site-directed mutagenesis. J Biol Chem 265:6827-6835, 1990
13. Grayson S, Johnson-Winegar AG, Wintroub BU, Isseroff RR, Epstein EH, Elias PM: Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization. J Invest Dermatol 85:289-294, 1985
14. Hanley K, Rassner U, Elias PM, Williams ML, Feingold KR: Glucosylceramide metabolism is regulated during normal and hormonally stimulated epidermal barrier development in the rat. J Lipid Res 38:576-854, 1997
15. Hedberg CL, Wertz PW, Downing DT: The nonpolar lipids of pig epidermis. J Invest Dermatol 90:225-229, 1988
16. Holleran WM, Ginns EI, Menon GK, et al: Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest 93:1756-1764, 1994
17. Ichikawa S, Sakiyama H, Suzuki G, Hidari KI-PJ, Hirabayashi Y: Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis. PNAS 93:4638-4643, 1996
18. Jeckel D, Karrenbauer A, Burger KNJ, van Meer G, Wieland F: Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. J Cell Biol 117:259-267, 1992
19. Jetten AM: Multi-stage program of differentiation in human epidermal keratinocytes; regulation by retinoids. J Invest Dermatol 95:44S-46S, 1990
20. Jetten AM, George MA, Rearick JI: Down-regulation of squamous cell-specific markers by retinoids: Transglutaminase Type 1 and cholesterol sulfotransferase. Meth Enzymol 190:42-49, 1990
21. Kornfeld S, Mellman I: The biogenesis of lysosomes. Ann Rev Cell Biol 5:488-525, 1989
22. Klausner RD, Donaldson JG, Lippincott-Schwartz J, Brefelden A: Insights into the control of membrane traffic and organelle structure. J Cell Biol 116:1071-1080, 1992
23. Labarca C, Paigen K: A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344-352, 1980
24. Ladinsky MS, Howell KE: The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A. Eur J Cell Biol 59:92-105, 1992
25. Ladinsky MS, Kremer JR, Furcinitti PS, McIntosh JR, Howell KE: HVEM tomography of the trans-Golgi network: Structural insights and identification of a lace-like vesicle coat. J Cell Biol 127:29-38, 1994
26. Landmann L: The epidermal permeability barrier. Anat Embryol 178:1-13, 1988
27. Lippincott-Schwartz J, Yuan L, Tipper C, Amherdt M, Orci L, Klausner RD: Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67:601-616, 1991
28. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275, 1951
29. Madison KC, Howard EJ: Ceramides are transported through the Golgi apparatus in human keratinocytes in vitro. J Invest Dermatol 106:1030-1035, 1996
30. Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. J Invest Dermatol 93:10-17, 1989
31. Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Sphingolipid metabolism in organotypic mouse keratinocyte cultures. J Invest Dermatol 95:657-664, 1990
32. Matsuo N, Nomura T, Imokawa G: A rapid and simple assay method for UDP-glucose:ceramide glucosyltransferase. Biochim Biophys Acta 111:97-103, 1992
33. Mellman I, Simons K: The Golgi complex: in vitro veritis? Cell 68:829-840, 1992
34. Menon GK, Grayson S, Elias PM: Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis. J Invest Dermatol 86:591-597, 1986
35. Menon GK, Ghadially R, Williams ML, Elias PM: Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation. Br J Dermatol 126:337-345, 1992
36. Miller SG, Moore H-P: Regulated secretion. Curr Opin Cell Biol 2:642-647, 1990
37. 1 domains, secretory granules and exocytosis. Cell Calcium 22:1-4, 1997
38. Pfeffer SR: Targeting of proteins to the lysosome. Curr Topics Microbiol Immunol 170:43-65, 1991
39. Robson KJ, Stewart ME, Michelsen S, Lazo ND, Downing DT: 6-hydroxy 4-sphinganine in human epidermal ceramides. J Lipid Res 35:2060-2068, 1994
40. 2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol 137:93-104, 1997
41. Rothman JE: The protein machinery of vesicle budding and fusion. Protein Sci 5:185-194, 1996
42. Sando GN, Rosenbaum LM: Human lysosomal acid lipase/cholesteryl ester hydrolase. Purification and properties of the form secreted by fibroblasts in microcarrier culture. J Biol Chem 260:15186-15193, 1985
43. Sando GN, Ma G-P, Lindsley KA, Wei Y-P: Intercellular transport of lysosomal acid lipase mediates lipoprotein cholesteryl ester metabolism in a human vascular endothelial cell- fibroblast coculture system. Cell Reg 1:661-674, 1990
44. Sando GN, Howard EJ, Madison KC: Induction of ceramide glucosyltransferase activity in cultured human keratinocytes: Correlation with culture differentiation. J Biol Chem 271:22044-22051, 1996
45. Swartzendruber DC, Burnett IH, Wertz PW, Madison KC, Squier CA: Osmium tetroxide and ruthenium tetroxide are complementary reagents for the preparation of epidermal samples for transmission electron microscopy. J Invest Dermatol 104:417-420, 1995
46. Teitelbaum SL, Tondravi MM, Ross FP: Osteoclasts, macrophages, and the molecular mechanisms of bone resorption. J Leukocyte Biol 61:381-388, 1997
47. Wertz PW, Downing DT, Freinkel RK, Traczyk TN: Sphingolipids of stratum corneum and lamellar granules of fetal rat epidermis. J Invest Dermatol 83:193-195, 1984
48. von Figura K: Molecular recognition and targeting of lysosomal proteins. Curr Opin Cell Biol 3:642-646, 1991
49. von Figura K, Hastlik A: Lysosomal enzymes and their receptors. Ann Rev Biochem 55:167-193, 1986
50. Wertz PW, Cox PS, Squier CA, Downing DT: Lipids of epidermis and keratinized and nonkeratinized oral epithelia. Comp Biochem Biophys 83B:529-531, 1986