Testosterone perturbs epidermal permeability barrier homeostasis

Journal of Investigative Dermatology

Volumn 116, Issue 3, 2001, Pages 443-451

  Kao, J S ^a   Garg, A ^a   Mao Qiang, M ^a   Crumrine, D ^a   Ghadially, R ^a   Feingold, K R ^a   Elias, P M ^a  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Androgens; Epidermal lipid synthesis; Epidermal ultrastructure; Lamellar bodies; Permeability barrier; Testosterone; Transepidermal water loss

Indexed keywords

FLUTAMIDE; TESTOSTERONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASE REPORT; CASTRATION; CONTROLLED STUDY; EPIDERMIS; HUMAN; HYPOGONADISM; LAMELLAR BODY; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL;

EID: 0035089985     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01281.x     Document Type: Article

References (49)

1. The limit of viability - Neonatal outcome of infants born at 22-25 weeks' gestation
2. The metabolism of testosterone by human male scalp skin
3. Location of androgen receptor in human skin
4. Androgen receptor in human foreskin. II. Characterization of the receptor from hypospadiac tissue
5. The epidemiology of occupational contact dermatitis
6. In vivo effects of steroid hormones on the testosterone 5alpha-reductase in skin
7. The antagonistic relatonship between testosterone and thyroxine in maintaining the epidermis of the male rat
8. The action of testosterone on the sebaceous glands and epidermis in castrated and hypophysectomized male rats
9. Immunohistochemical evidence for differential distribution of 5 alpha-reductase isoenzymes in human skin
10. Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers
11. Lipids and the epidermal water barrier: Metabolism, regulation, and pathophysiology
12. Structural and lipid biochemical correlates of the epidermal permeability barrier
13. The secretory granular cell: The outermost granular cell as a specialized secretory cell
14. De novo sterologenesis in intact primates
15. Localization of de novo sterologenesis in mammalian skin
16. The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model
17. Skin irritability to sodium lauryl sulphate - As measured by skin water vapour loss-by sex and race
18. Relationship of epidermal lipogenesis to cutaneous barrier function
19. Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone
20. Sphingolipids are required for mammalian barrier function: Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation
21. Membrane structures in normal and essential fatty acid-deficient stratum corneum: Characterization by ruthenium tetroxide staining and x-ray diffraction
22. Factors affecting the sex differential in neonatal mortality: The role of respiratory distress syndrome
23. Regulation of intracellular ceramide content in B16 melanoma cells: Biological implications of ceramide glycosylation
24. Outcome of infants weighing less than 800 grams at birth: 15 Years' experience
25. Irritant reactivity in males and females
26. The prevalence of atopic dermatitis in oregon schoolchildren
27. The effects of a nonsteroid antiandrogen, flutamide, on sebaceous gland activity
28. Characterization, expression, and immunohistochemical localization of 5 alpha-reductase in human skin
29. Lamellar granule biogenesis: A role for ceramide glucosyltransferase, lysosomal enzyme transport, and the golgi
30. Fatty acids are required for epidermal permeability barrier function
31. Ionic calcium reservoirs in mammalian epidermis: Ultrastructural, localization by ion-capture cytochemistry
32. Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion
33. Localization of sites of lipid biosynthesis in mammalian epidermis
34. Mitotic activity in the epidermis of the rabbit stimulated with local applications of testosterone propionate
35. Androgen receptor in human skin cytosol
36. Concentrations of circulating steroids in normal prepubertal and adult male and female humans, chimpanzees, rhesus monkeys, rats, mice, and hamsters: A literature survey
37. Is the metabolism of testosterone to 5 alpha-dihydrotestosterone required for androgen action in the skin?
38. Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies
39. A comparative study of pediatric onset psoriasis with adult onset psoriasis
40. Skin type, but neither race nor gender, influence epidermal permeability barrier function
41. Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin - A possible pathogenic factor in ache
42. Activity of testosterone 5 alpha-reductase in various tissues of human skin
43. Effects of sex steroids on human skin in organ culture
44. Morphometric analysis of human epidermis treated with testosterone and dehydroepiandrosterone in organ culture
45. Activity of the type 1, 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin
46. Ontogeny of the epidermal permeability barrier
47. Dihydrotestosterone formation in fetal tissues of the rabbit and rat
48. The conversion of testosterone to 5 alpha-androstan-17 beta-ol-3-one (dihydrotestosterone) by skin slices of man
49. Effect of prolonged administration of testosterone on the epidermis of female rats