Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function

Journal of Investigative Dermatology

Volumn 114, Issue 1, 2000, Pages 185-192

  Behne, Martin ^a,c   Uchida, Yoshikazu ^a,c   Seki, Taisuke ^a,c   Ortiz De Montellano, Paul ^b   Elias, Peter M ^a,c   Holleran, Walter M ^a,b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Dermatol Serv and Res U (190)   (United States)

Author keywords

Acylceramides; Ceramides; Cytochrome p450; Epidermal lipids; Omega hydroxylase; Permeability barrier; Stratum corneum

Indexed keywords

CERAMIDE DERIVATIVE; CYTOCHROME P450; OMEGA HYDROXYCERAMIDE; SKIN LIPID; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROXYLATION; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN PERMEABILITY; STRATUM CORNEUM; WATER LOSS;

EID: 0034081229     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00846.x     Document Type: Article

References (45)

1. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917, 1959
2. Bouwstra JA, Cheng K, Gooris GS, Weerheim A, Ponce M: The role of ceramides 1 and 2 in the stratum corneum lipid organisation, Biochim Biophys Acta 1300:177-186, 1996
3. Bouwstra JA, Gooris GS, Dubbelaar FE, Weerheim AM, Ijzerman AP, Ponec M: Role of ceramide 1 in the molecular organization of the stratum corneum lipids. J Lipid Res 39:186-196, 1998
4. Correia MA. Rat and human cytochrome P450. substrate and inhibitor specificities and functional markers. In: Ortiz de Montellano P (ed.). Cytochrome P45O Structure, Mechanism and Biochemistry. New York: Plenum Press, 1995. pp. 607-621
5. Dierks EA, Davis SC, Ortiz de Montellano PR: Glu-320 and Asp-323 are determinants of the CYP4A1 hydroxylation regiospecificity and resistance to inactivation by 1-aminobenzotriazole. Biochemistry 37:1839-1847, 1998
6. Doering T, Holleran WM, Potratz A, Vielhaber G, Elias PM, Suzuki K, Sandhoff K: Sphingolipid activator proteins are required for epidermal permeability barrier formation. J Biol Chem 274:11038-11045, 1999a
7. Doering T, Proia RL, Sandhoff K: Accumulation of protein-bound epidermal glucosylceramides in beta-glucocerebrosidase deficient type 2 Gaucher mice. FEBS Lett 447:167-170, 1999b
8. Downing DT: Lipid and protein structures in the permeability barrier of mammalian epidermis. J Lipid Res 33:301-313, 1992
9. Elias PM, Brown BE: The mammalian cutaneous permeability barrier: defective barrier function in essential fatty acid deficiency correlates with abnormal intercellular lipid deposition. Lab Invest 39:574-583, 1978
10. Elias PM, Menon GK: Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 24:1-26, 1991
11. Elias PM, Brown BE, Ziboh VA: The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function. J Invest Dermatol 74:230-233, 1980
12. Elias PM, Goerke J, Friend DS: Mammalian epidermal barrier layer lipids: composition and influence on structure. J Invest Dermatol 69:535-546, 1977
13. Grayson S, Johnson-Winegar AG, Wintroub BU, Isseroff RR, Epstein EH Jr, Elias PM: Lamellar body-enriched fractions from neonatal mice: preparative techniques and partial characterization. J Invest Dermatol 85:289-294, 1985
14. Holleran WM, Williams ML, Gao WN, Elias PM: Serine-palmitoyl transferable activity in cultured human keratinocytes. J Lipid Res 31:1655-1661, 1990
15. Holleran WM, Feingold KR, Man MQ, Gao WN, Lee JM, Elias PM: Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res 32:1151-1158, 1991a
16. Holleran WM, Man MQ, Gao WN, Menon GK, Elias PM, Feingold KR: Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. J Clin Invest 88:1338-1345, 1991b
17. Holleran WM, Takagi Y, Menon GK, Legler G, Feingold KR, Elias PM: Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest 91:1656-1664, 1993
18. Holleran WM, Ginns EI, Menon GK et al: Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest 93:1756-1764, 1994a
19. Holleran WM, Takagi Y, Menon GK, Jackson SM, Lee JM, Feingold KR, Elias PM: Permeability barrier requirements regulate epidermal beta-glucocerebrosidase. J Lipid Res 35:905-912, 1994b
20. Holleran WM, Gao WN, Feingold KR, Elias PM: Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity: alterations imposed by permeability barrier requirements. Arch Dermatol Res 287:254-258, 1995
21. Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM: Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. J Invest Dermatol 96:215-223, 1991
22. Madison KC, Howard EJ: Ceramides are transported through the Golgi apparatus in human keratinocytes in vitro. J Invest Dermatol 106:1030-1035, 1996
23. Madison KC, Swartzendruber DC, Wertz PW, Downing DT: Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum. J Invest Dermatol 88:714-718, 1987
24. Man MM, Feingold KR, Thornfeldt CR, Elias PM: Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 106:1096-1101, 1996
25. Marekov LN, Steinert PM: Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. J Biol Chem 273:17763-17770, 1998
26. Menon GK, Feingold KR, Moser AH, Brown BE, Elias PM: De novo sterologenesis in the skin. II. Regulation hy cutaneous barrier requirements. J Lipid Res 26:418-427, 1985
27. Motta S, Monti M, Sesana S, Caputo R, Carelli S, Ghidoni R: Ceramide composition of the psoriatic scale. Biochim Biophys Acta 1182:147-151, 1993
28. Nemes Z, Marekov LN, Fésüs L, Steinert PM: A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation. Proc Natl Acad Sci USA 96:8402-8407, 1999
29. Ortiz de Montellano P: Cytochrome P450. Structure, Mechanism, and Biochemistry, 2nd edn. New York: Plenum Press, 1995
30. Ortiz de Montellano PR, Chan WK, Tuck SF, Kaikaus RM, Bass NM, Peterson JA: Mechanism-based probes of the topology and function of fatty acid hydroxylases. FASEB J 6:695-699, 1992
31. Ortiz de Montellano PR, Correia MA: Inhibitors of cytochrome P450 enzymes. In: Ortiz de Montellano P (ed.). Cytochrome P450 Structure, Mechanism and Biochemistry. New York: Plenum Press, 1995, pp. 305-364
32. Pittelkow MR, Scott RE: New techniques for the in vitro culture of human skin keratinocytes and perspectives on their use for grafting of patients with extensive burns. Mayo Clinic Proceedings 61:771-777, 1986
33. Rheinwald JG, Green H: Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6:331-343, 1975
34. Robson KJ, Stewart ME, Michelsen S, Lazo ND, Downing DT: 6-Hydroxy-4-sphingenine in human epidermal ceramides. J Lipid Res 35:2060-2068, 1994
35. Su P, Kaushal KM, Kroetz DL: Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. Am J Physiol 275:R426-R438, 1998
36. Swartzendruber DC, Wertz PW, Madison KC, Downing DT: Evidence that the comeocyte has a chemically bound lipid envelope. J Invest Dematol 88:709-713, 1987
37. Wertz PW: The nature of the epidermal barrier: Biochemical aspects. Adv Drug Del Rev 18:283-294, 1996
38. Wertz PW, Downing DT: Ceramides of pig epidermis: structure determination. J Lipid Res 24:759-765, 1983
39. Wertz PW, Downing DT: Covalent attachment of omega-hydroxyacid derivatives to epidermal macromolecules: a preliminary characterization. Biochem Biophys Res Commun 137:992-997, 1986
40. Wertz PW, Downing DT: Covalently bound omega-hydroxyacylsphingosine in the stratum corneum. Biochim Biophys Acta 917:108-111, 1987
41. Wertz PW, Cho ES, Downing DT: Effect of essential fatty acid deficiency on the epidermal sphingolipids of the rat. Biochim Biophys Acta 753:350-355, 1983
42. Wertz PW, Downing DT, Freinkel RK, Traczyk TN: Sphingolipids of the stratum corneum and lamellar granules of fetal rat epidermis. J Invest Dermatol 83:193-195, 1984
43. Wertz PW, Miethke MC, Long SA, Strauss JS, Downing DT: The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol 84:410-412, 1985
44. Wertz PW, Madison KC, Downing DT: Covalently bound lipids of human stratum corneum. J Invest Dermatol 92:109-111. 1989a
45. Wertz PW, Swartzendruber DC, Kitko DJ, Madison KC, Downing DT: The role of the comeocyte lipid envelopes in cohesion of the stratum corneum. J Invest Dermatol 93:169-172, 1989b