Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence

Journal of Investigative Dermatology

Volumn 120, Issue 5, 2003, Pages 810-816

  Zaiou, Mohamed ^a   Nizet, Victor ^b   Gallo, Richard L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Infection; Innate immunity; Protease; Skin; Staphylococcus

Indexed keywords

CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CATHELIN; PROTEIN HCAP18; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; DIFFUSION; EFFECTOR CELL; ENZYME INHIBITION; EPITHELIUM CELL; ESCHERICHIA COLI; GENETIC RECOMBINATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNITY; LIQUID PHASE KILLING ASSAY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEINASE INHIBITION; SEQUENCE HOMOLOGY; SKIN CELL; SOLID PHASE RADIAL DIFFUSION; STRUCTURE ACTIVITY RELATION; TISSUE INJURY;

EID: 0037960231     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12132.x     Document Type: Article

References (54)

1. Abrahamson M, Ritonja A, Brown MA, Grubb A, Machleidt W, Barrett AJ: Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J Biol Chem 262:9688-9694, 1987
2. Agarwala KL, Kawabata S, Hirata M, Miyagi M, Tsunasawa S, Iwanaga S: A cysteine protease inhibitor stored in the large granules of horseshoe crab hemocytes: Purification, characterization, cDNA cloning and tissue localization. J Biochem (Tokyo) 119:85-94, 1996
3. Agerberth B, Gunne H, Odeberg J, Kogner P, Boman HG, Gudmundsson GH: FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proc Natl Acad Sci USA 92:195-199, 1995
4. Ashcroft GS, Lei K, Jin W, et al: Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 6:1147-1153, 2000
5. Bals R, Wang X, Zasloff M, Wilson JM: The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci USA 95:9541-9546, 1998
6. Bals R, Weiner DJ, Meegalla RL, Wilson JM: Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model. J Clin Invest 103:1113-1117, 1999a
7. Bals R, Weiner DJ, Moscioni AD, Meegalla RL, Wilson JM: Augmentation of innate host defense by expression of a cathelicidin antimicrobial peptide. Infect Immun 67:6084-6089, 1999b
8. Bjorck L, Akesson P, Bohus M,Trojnar J, Abrahamson M, Olafsson I, Grubb A: Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor. Nature 337:385-386, 1989
9. Blankenvoorde MF, van't Hof W, Walgreen-Weterings E, van Steenbergen TJ, Brand HS, Veerman EC, Nieuw Amerongen AV: Cystatin and cystatin-derived peptides have antibacterial activity against the pathogen Porphyromonas gingivalis. Biol Chem 379:1371-1375, 1998
10. Boman HG: Innate immunity and the normal microflora. Immunol Rev 173:5-16, 2000
11. Cole AM, Shi J, Ceccarelli A, Kim YH, Park A, Ganz T: Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds. Blood 97:297-304, 2001
12. Dorschner RA, Pestonjamasp VK, Tamakuwala S, et al: Cutaneous injury induces the release of cathelicidin anti-microbial peptides active against group A Streptococcus. J Invest Dermatol 117:91-97, 2001
13. Falla TJ, Karunaratne DN, Hancock RE: Mode of action of the antimicrobial peptide indolicidin. J Biol Chem 271:19298-19303, 1996
14. Frohm M, Agerberth B, Ahangari G, Stahle-Backdahl M, Liden S, Wigzell H, Gudmundsson GH: The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272:15258-15263, 1997
15. Gallo RL, Ono M, Povsic T, Page C, Eriksson E, Klagsbrun M, Bernfield M: Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proc Natl Acad Sci USA 91:11035-11039, 1994
16. Gallo RL, Kim KJ, Bernfield M, Kozak CA, Zanetti M, Merluzzi L, Gennaro R: Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse. J Biol Chem 272:13088-13093, 1997
17. Ganz T, Lehrer RI: Antimicrobial peptides of leukocytes. Curr Opin Hematol 4:53-58, 1997
18. Gennaro R, Zanetti M: Structural features and biological activities of the cathelicidin-derived antimicrobial peptides. Biopolymers 55:31-49, 2000
19. Gennaro R, Scocchi M, Merluzzi L, Zanetti M: Biological characterization of a novel mammalian antimicrobial peptide. Biochim Biophys Acta 1425:361-368, 1998
20. Gudmundsson GH, Agerberth B, Odeberg J, Bergman T, Olsson B, Salcedo R: The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. Eur J Biochem 238:325-332, 1996
21. Hancock RE: Peptide antibiotics. Lancet 349:418-422, 1997
22. Harder J, Bartels J, Christophers E, Schroder JM: A peptide antibiotic from human skin. Nature 387:861, 1997
23. Hoffmann JA, Kafatos FC, Janeway CA, Ezekowitz RA: Phylogenetic perspectives in innate immunity. Science 284:1313-1318, 1999
24. Islam D, Bandholtz L, Nilsson J, Wigzell H, Christensson B, Agerberth B, Gudmundsson G: Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 7:180-185, 2001
25. Kuboniwa M, Amano A, Shizukuishi S, Nakagawa I, Hamada S: Specific antibodies to Porphyromonas gingivalis Lys-gingipain by DNA vaccination inhibit bacterial binding to hemoglobin and protect mice from infection. Infect Immun 69:2972-2979, 2001
26. Lukomski S, Montgomery CA, Rurangirwa J, Geske RS, Barrish JP, Adams GJ, Musser JM: Extracellular cysteine protease produced by Streptococcus pyogenes participates in the pathogenesis of invasive skin infection and dissemination in mice. Infect Immun 67:1779-1788, 1999
27. Mason RW, Johnson DA, Barrett AJ, Chapman HA: Elastinolytic activity of human cathepsin L. Biochem J 233:925-927, 1986
28. Murakami M, Othake T, Dorshner R, Shittek B, Garbe C, Gallo RL: Cathelicidin antimicrobial peptide expression in sweat, an innate defense system for the skin. J Invest Dermatol, 119:1090-1095, 2002
29. Nizet V, Ohtake T, Lauth X, et al: Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414:454-457, 2001
30. Ong PY, Ohtake T, Brandt C, et al: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-1160, 2002
31. von Pawel-Rammingen U, Johansson BP, Bjorck L: IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. Embo J 21:1607-1615, 2002
32. Ramanathan B, Davis EG, Ross CR, Blecha F: Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity. Microbes Infect 4:361-372, 2002
33. + flux. Nature 416:291-297, 2002
34. Ritonja A, Kopitar M, Jerala R, Turk V: Primary structure of a new cysteine proteinase inhibitor from pig leucocytes. FEBS Lett 285:211-214, 1989
35. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: a Laboratory Manual. 2nd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 1989
36. Sanchez JF, Hoh F, Strub MP, Aumelas A, Dumas C: Structure of the cathelicidin motif of the protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein. Structure 10:1363-1370, 2002a
37. Sanchez JF, Wojcik F, Yang YS, et al: Overexpression and structural study of the cathelicidin motif of the protegrin-3 precursor. Biochemistry 41:21-30, 2002b
38. Schaller-Bals S, Schulze A, Bals R: Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am J Respir Crit Care Med 165:992-995, 2002
39. Scocchi M, Wang S, Zanetti M: Structural organization of the bovine cathelicidin gene family and identification of a novel member. FEBS Lett 417:311-315, 1997
40. Sorensen O, Arnljots K, Cowland JB, Bainton DF, Borregaard N: The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils. Blood 90:2796-2803, 1997
41. Sorensen OE, Follin P, Johnsen AH, Calafat J, Tjabringa GS, Hiemstra PS, Borregaard N: Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97:3951-3395, 2001
42. Steinberg DA, Lehrer RI: Designer assays for antimicrobial peptides. Disputing the one-size- fits-all' theory. Meth Mol Biol 78:169-186, 1997
43. Storici P, Tossi A, Lenarcic B, Romeo D: Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides. Eur J Biochem 238:769-776, 1996
44. Takahashi M, Tezuka T, Katunuma N: Inhibition of growth and cysteine proteinase activity of Staphylococcus aureus V8 by phosphorylated cystatin α in skin cornified envelope. FEBS Lett 335:275-278, 1994
45. Turner J, Cho Y, Dinh NN, Waring AJ, Lehrer R1: Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother 42:2206-2214, 1998
46. Valore EV, Martin E, Harwig SS, Ganz T: Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest 97:1624-1629, 1996
47. Verbanac D, Zanetti M, Romeo D: Chemotactic and protease-inhibiting activities of antibiotic peptide precursors. FEBS Lett 317:255-258, 1993
48. Westerhoff HV, Juretic D, Hendler RW, Zasloff M: Magainins and the disruption of membrane-linked free-energy transduction. Proc Natl Acad Sci USA 86:6597-6601, 1989
49. Zaiou M, Gallo RL: Cathelicidins, essential gene-encoded mammalian antibiotics. J Mol Med 80:549-561, 2002
50. Zanetti M, Litteri L, Gennaro R, Horstmann H, Romeo D: Bactenecins, defense polypeptides of bovine neutrophils, are generated from precursor molecules stored in the large granules. J Cell Biol 111:1363-1371, 1990
51. Zanetti M, Litteri L, Griffiths G, Gennaro R, Romeo D: Stimulus-induced maturation of probactenecins, precursors of neutrophil antimicrobial polypeptides. J Immunol 146:4295-4300, 1991
52. Zarember KA, Katz SS, Tack BF, Doukhan L, Weiss J, Elsbach P: Host defense functions of proteolytically processed and parent (unprocessed) cathelicidins of rabbit granulocytes. Infect Immun 70:569-576, 2002
53. Zasloff M: Antimicrobial peptides of multicellular organisms. Nature 415:389-395, 2002
54. Zhang Z, Wang L, Seydel KB, Li E, Ankri S, Mirelman D, Stanley SL Jr: Entamoeba histolytica cysteine proteinases with interleukin-1 β converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis. Mol Microbiol 37:542-548, 2000