Peroxisome proliferator-activated receptor-α enhances lipid metabolism in a skin equivalent model

Journal of Investigative Dermatology

Volumn 114, Issue 4, 2000, Pages 681-687

  Rivier, Michel ^a   Castiel, Isabelle ^b   Safonova, Irina ^a   Ailhaud, Gérard ^c   Michel, Serge ^a  

^a Galderma R and D   (France)

^b L ORÉAL RECHERCHE   (France)

^c CENTRE DE BIOCHIMIE   (France)

Author keywords

Keratinocytes; Lipids; Peroxisome proliferator activated receptor

Indexed keywords

CERAMIDE; CHOLESTEROL DERIVATIVE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DERMOEPIDERMAL JUNCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPID METABOLISM; LIPOGENESIS; MODEL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PSORIASIS; REGULATORY MECHANISM; SKIN; SKIN PERMEABILITY; STRATUM CORNEUM;

EID: 0034004910     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00939.x     Document Type: Article

References (37)

1. Asselineau D, Bernard BA, Bailly C, Darmon M: Epidermal morphogenesis and induction of 67 kD keratin polypeptide by culture at the air liquid interface. Exp Cell Res 159:536-539, 1985
2. Asselineau D, Bernard BA, Bailly C, Darmon M: Retinoic acid improve epidermal morphogenesis. Dev Biol 133:322-335, 1989
3. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917, 1959
4. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator-activated receptor (PPAR): tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology 137:354-366, 1996
5. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
6. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812, 1995
7. Grubauer G, Feingold KR, Elias PM: Relationship of epidermal lipogenesis to cutaneous barrier function. J Lipid Res 28:746-752, 1987
8. Hanley K, Jiang Y, Crumrine D, et al: Activators of the nuclear hormone receptors PPARα and FXR accelerate the development of the fetal epidermal permeability barrier. J Clin Invest 100:705-712, 1997
9. Hanley K, Jiang Y, He SS, et al: Keratinocyte differentiation is stimulated by activators of the nuclear receptor PPARα. J Invest Dermatol 110:368-375, 1998
10. Harris IR, Farrell AM, Holleran WM, Jackson S, Grunfeld C, Elias PM, Feingold KR: Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis. J Lipid Res 39:412-422, 1998
11. Holleran WM, Williams ML, Gao WN, Elias PM: Serine-palmitoyl transferase activity in cultured human keratinocytes. J Lipid Res 31:1655-1661, 1990
12. Holleran WH, Feingold KR, Man MQ, Gao WN, Lee JM, Elias PM: Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res 32:1151-1158, 1991
13. Holleran WM, Takagi Y, Imokawa G, Jackson S, Lee JM, Elis PM: β-glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation. J Lipid Res 33:1201-1209, 1992
14. Imaoka S, Ogawa H, Kimura S, Gonzalez FJ: Complete cDNA sequence and cDNA-directed expression of CIP4A11, a fatty acid omega-hydroxylase expressed in human kidney. DNA Cell Biol 12:893-899, 1993
15. Issemann I, Green S: Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:647-650, 1990
16. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM: Convergence of 9-cis and peroxisome signalling pathways through heterodimer formation of their receptors. Nature 358:771-774, 1992
17. Kliewer SA, Forman BM, Blumberg B, et al: Differential expression and activation of a family of murine peroxisome proliferator-activated receptor. Proc Natl Acad Sci USA 91:7355-7359, 1994
18. 2 metabolite binds peroxisome proliferator activated receptor γ and promotes adipocyte differentiation. Cell 83:813-819, 1995
19. Lampe MA, Williams ML, Elias PM: Human epidermal lipids: characterization and modulations during differentiation. J Lipid Res 24:131-140, 1983
20. Lanzmann L: Epidermal permeability barrier: transformation of lamellar-granule disks into intercellular sheets by a membrane-fusion process, a freeze-fracture study. J Invest Dermatol 87:202-209, 1986
21. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkinson WO, Wilson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptors γ (PPARγ). J Biol Chem 270:12953-12956, 1995
22. Lemberger T, Desvergne B, Wahli W: Peroxisome Proliferator-Activated Receptors: A nuclear receptor signaling pathway in lipid physiology. In: Spudish JA, Gerhart J, Mcknight SL, Schekman R (eds). Annual Review in Cell and Development Biology. Palo Alto CA: Annual Reviews Inc., 1996, 12, pp 335-363
23. Long SA, Wertz PW, Strauss JS, Downing DT: Human stratum corneum polar lipids and desquamation. Arch Dermatol Res 277:284-287, 1985
24. Motta S, Monti M, Sesana S, Mellesi L, Ghidoni R, Caputo R: Abnormality of water barrier function in psoriasis. Role of ceramide fractions. Arch Dermatol 130:452-456, 1994
25. O'Guin W, Manabe M, Sun T: T: association of a 25K protein with membrane coating granules of human epidermis. J Cell Biol 109:2313-2321, 1989
26. Ponec M. Lipid metabolism in cultured keratinocyte. In: Elias P (ed.) Skin Lipids, Advances in Lipid Research. San Diego: Academic Press, 1991, 24, pp 83-117
27. Ponec M, Weerheim A, Kempenaar J, Mommaas AM, Nugteren DH: Lipid composition of cultured human keratinocytes in relation to their differentiation. J Lipid Res 29:949-961, 1988
28. Ponec M, Kempenaar J, de Weerheim A, Lannoy L, Kalkman I, Jansen H: Triglyceride metabolism in human keratinocytes cultured at the air-liquid interface. Arch Dermatol Res 287:723-730, 1995
29. Ponec M, Weerheim A, Kempenaar J, Mulder A, Gooris GS, Bouwstra J: The formation of competent barrier lipids in reconstructed human epidermis requires the presence of vitamin C. J Invest Dermatol 109:348-355, 1997
30. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK: The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79-82, 1998
31. Rivier M, Safonova I, Lebrun P, Griffiths CEM, Ailhaud G, Michel S: Differential expression of peroxisome proliferator-activated receptor subtypes during the course of keratinocyte differentiation. J Invest Dermatol 111:1116-1121, 1998
32. Schäfer L, Kragballe K: Abnormalities in epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol 96:10-15, 1991
33. Schurer NY, Elias PM. The biochemistry and function of stratum corneum lipids. In: Elias P (ed.). Skin Lipids, Advances in Lipid Research. San Diego: Academic Press, 1991, 24, pp 27-56
34. Spanjaard RA, Ikeda M, Lee PJ, Charpentier B, Chin WW, Eberlein TJ: Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells. J Biol Chem 272:18990-18999, 1997
35. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM: mPPARγ2. tissue-specific regulator of an adipocyte enhancer. Genes Dev 8:1224-1234, 1994
36. Wertz PW, Downing DT. Epidermal lipids. In: Golsmith LA (ed.). Physiology, Biochemistry and Molecular Biology of the Skin. New York: Oxford University Press, 1991:pp 205-236
37. Williams ML, Brown BE, Monger DJ, Grayson S, Elias PM: Lipid content and metabolism of human keratinocyte cultures grown at the air-medium interface. J Cell Physiol 136:103-110, 1988