Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier

Journal of Clinical Investigation

Volumn 104, Issue 12, 1999, Pages 1761-1770

  Jensen, Jens Michael ^a,b   Schütze, Stefan ^a   Förl, Michael ^a   Krönke, Martin ^a,c   Proksch, Ehrhardt ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; IMIPRAMINE; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; EPIDERMIS CELL; LAMELLAR BODY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN PERMEABILITY; WOUND HEALING;

EID: 0343415084     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5307     Document Type: Article

References (59)

1. Elias, P.M. 1983. Epidermal lipids, barrier function, and desquamation. J. Invest. Dermatol. 80(Suppl.):44S-49S.
2. Schürer, N.Y., and Elias, P.M. 1991. The biochemistry and function of stratum corneum lipids. In Advances in lipid research (skin lipids). P.M. Elias, editor. Academic Press Inc. San Diego, CA. 27-56.
3. Wilhelm, K.P., Surber, C., and Maibach, H.I. 1991. Effect of sodium lauryl sulfate-induced skin irritation on in vivo percutaneous penetration of four drugs. J. Invest. Dermatol. 97:927-932.
4. Di Nardo, A., Wertz, P., Giannetti, A., and Seidenari, S. 1998. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm. Venereol. 78:2-30.
5. Grice, K., Sattar, H., Baker, H., and Sharratt, M. 1975. The relationship of transepidermal water loss to skin temperature in psoriasis and eczema. J. Invest. Dermatol. 64:313-315.
6. Suetake T., Sasai, S., Zhen, Y.X., Ohi, T., and Tagami, H. 1996. Functional analyses of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars, and atrophic scars. Arch Dermatol. 132:1453-1458.
7. Holleran, WM., et al. 1992. β-glucocerebrosidase activity in murine epidermis: characterization and localisation in relationship to differentiation. J. Lipid Res. 33:1201-1209.
8. Tagaki, Y., Kriehuber, E., Imokawa, G., Elias, P.M., and Holleran, W.M. 1999. β-glucocerebrosidase activity in mammalian stratum corneum. J. Lipid Res. 40:861-869.
9. Menon, G.K., Grayson, S., and Elias, P.M. 1986. Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis. J. Invest. Dermatol. 86:591-597.
10. Freinkel, R.K., and Traczyk, T.N. 1983. Acid hydrolases of the epidermis: subcellular localization and relationship to cornification. J. Invest. Dermatol. 80:441-446.
11. Freinkel, R.K., and Traczyk, T.N. 1985. Lipid composition and acid hydrolase content of lamellar granules of fetal rat epidermis. J. Invest. Dermatol. 85:295-298.
12. Wiegmann, K., Schudie;tze, S., Machleidt, T., Witte, D., and Krönke, M. 1994. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell. 78:1005-1015.
13. Hannun, Y.A., and Linardic, C.M. 1993. Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim. Biophys. Acta. 1154:223-236.
14. Kolesnick, R.N., and Golde, D.W. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell. 77:325-328.
15. Heller, R.A., and Krönke, M. 1994. Tumor necrosis factor receptor-mediated signaling pathways. J. Cell Biol. 126:5-9.
16. Kolesnick, R.N., and Krönke, M. 1998. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60:643-665.
17. Cifone, M.G., et al. 1995. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J. 14:5859-5868.
18. Santana, P., et al. 1996. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell. 86:189-199.
19. Herr, I., Wilhelm, D., Bohler, T., Angel, P., and Debatin, K.M. 1997. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16:6200-6208.
20. De Maria, R., and Testi, R. 1998. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunol. Today. 19:121-125.
21. Grubauer, G., Feingold, K.R., and Elias, P.M. 1987. Relationship of epidermal lipogenesis to cutaneous barrier function. J. Lipid Res. 28:746-752.
22. Proksch, E., Elias, P.M., and Feingold, K.R. 1990. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis: modulation of enzyme content and activation state by barrier requirement. J. Clin. Invest. 85:874-882.
23. Holleran, W.M., et al. 1991. Regulation of epidermal sphingolipid synthesis by permeability barrier function. J. Lipid Res. 32:1151-1158.
24. Ottey, K.A., Wood, L.C., Grunfeld, C., Elias, P.M., and Feingold, K.R. 1995. Cutaneous permeability barrier disruption increases fatty acid synthetic enzyme activity in the epidermis of hairless mice. J. Invest. Dermatot. 104:401-404.
25. Proksch, E., Feingold, K.R., and Elias, P.M. 1991. Barrier function regulates epidermal DNA-synthesis. J. Clin. Invest. 87:1668-1673.
26. Ekanayake-Mudiyanselage, S., et al. 1998. Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption. J. Invest. Dermatol. 111:517-523.
27. Lee, S.H., et al. 1992. Calcium and potassium are important regulators of barrier homeostasis in murine epidermis. J. Clin. Invest. 89:530-538.
28. Wood, L.C., Jackson, S.M., Elias, P.M., Grufeld, C., and Feingold, K.R. 1992. Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J. Clin. Invest. 90:482-487.
29. Nickoloff, B.J., and Naidu, Y. 1994. Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J. Am. Acad. Dermatol. 30:535-546.
30. Hübner, G., et al. 1996. Differential regulation of pro-inflammatory cytokines during wound healing in normal and glucocorticoid-treated mice. Cytokine. 8:548-556.
31. Tsai, J.C., et al. 1994. Permeability barrier disruption alters the localization and expression of TNF-protein in the epidermis. Arch. Dermatol. Res. 286:242-248.
32. Pfeffer, K., et al. 1993. Mice deficient for the p55kD tumor necrosis factor receptor are resistant for endotoxic shock, yet succumb to L. monocytogenes infection. Cell. 73:457-467.
33. Peschon, J.J., et al. 1998. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J. Immunol. 160:943-952.
34. Elias, P.M., Fritsch, P., Tappeiner, G., Mittermayer, H., and Wolff, K. 1974. Experimental staphylococcal toxic epidermal necrolysis (TEN) in adult humans and mice. J. Lab. Clin. Med. 84:414-424.
35. Proksch, E., Elias, P.M., and Feingold, K.R. 1991. Localization and regulation of epidermal 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity by barrier requirements. Biochim. Biophys. Acta. 1083:71-79.
36. Bligh, E., and Dyer, W.J. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physio. 37:911-917.
37. Madison, K.C., Swartzendruber, D.C., Wertz, P.W., and Downing, D.T. 1990. Sphingolipid metabolism in organotypic mouse keratinocyte cultures. J. Invest. Dermatol. 95:657-664.
38. Vicanova, J., et al. 1998. Stratum corneum lipid composition and structure in cultured skin substitutes is restored to normal after grafting onto athymic mice. J. Investig Dermatol. Symp. Proc. 3:114-120.
39. Doering, T., et al. 1999. Sphingolipid activator proteins are required for epidermal permeability barrier formation. J. Biol. Chem. 274:11038-11045.
40. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:248-254.
41. Albouz, S., et al. 1981.Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures. Biomedicine. 35:218-220.
42. Hurwitz, R., Ferlinz, K., and Sandhoff, K. 1994. The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol. Chem. Hoppe Seyler. 375:447-450.
43. Ballou, L.R. 1992. Sphingolipids and cell function. Immunol. Today. 13:339-341.
44. Ballou, L.R., Laulederkind, S.J., Rosloniec, E.F., and Raghow, R. 1996. Ceramide signaling and the immune response. Biochim. Biophys. Acta. 1301:273-287.
45. Jensen, J.M., Kupper, T.S., and Proksch, E. 1998. Il-1/Il-1 receptor over-expression and knockout constructs in permeability barrier repair of transgenic mice. J Invest. Dermatol. 110:499a. (Abstr.)
46. Schütze, S., Pothoff, K., Machleidt, T., Berkovic, D., Wiegmann, K., and Krönke, M. 1992. TNF activates NF-B by phosphatidylcholine-specific sphingomyelin breakdown. Cell 71:765-776.
47. Hannun, Y.A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science. 274:1855-1859.
48. Hertvig, E., Nilsson, A., Nyberg, L., and Duan, R.D. 1997. Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer. 79:448-453.
49. Adam-Klages, S., et al. 1996. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. Cell 86:937-947.
50. Kreder, D., et al. 1999. Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice. EMBO J. 18:2472-2479.
51. Bowser, P.A., and Gray, P.M. 1978. Sphingomyelinase in pig and human epidermis. J. Invest. Dermatol. 70:331-335.
52. Elias, P.M., Menon, G.K., Grayson, S., and Brown, B.E. 1988. Membrane structural alterations in murine stratum corneum: relationship to the localization of polar lipids and phospholipases. J. Invest. Dermatol. 91:3-10.
53. Robson, K.J., Stewart, M.E., Michelsen, S., Lazo, N.D., and Downing, D.T. 1994. 6-Hydroxy-4-sphingenine in human epidermal ceramides. J. Lipid Res. 35:2060-2068.
54. Yano, M., Kishida, E., Muneyuki, Y., and Masuzawa, Y. 1998. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. J. Lipid Res. 39:2091-2098.
55. Holleran, WM., et al. 1994 Permeability barrier requirements regulate epidermal β-glucocerebrosidase. J. Lipid Res. 35:905-912.
56. Holleran, W.M., et al. 1993. Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J. Clin. Invest. 91:1656-1664.
57. Holleran, W.M., et al. 1994. Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J. Clin. Invest. 93:1756-1764.
58. Levade, T., Salvayre, R., and Douste-Blazy, L. 1986. Sphingomyelinases and Niemann-Pick disease. J. Clin. Chem. Clin. Biochem. 24:205-220.
59. Schmuth, M., Weber, F., Paschke, E., Sepp, N., and Fritsch, P. 1999. Delayed epidermal barrier repair in patients with Sphingomyelinase deficiency (Niemann Pick Disease). J. Invest. Dermatol. 112:542a. (Abstr.)