메뉴 건너뛰기




Volumn 107, Issue 2, 2005, Pages 252-268

Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases

Author keywords

Cardiac development; Cardiac hypertrophy; Cardioprotection; Congenital heart disease; Homeobox; Transcriptional regulation

Indexed keywords

HOMEODOMAIN PROTEIN; PROTEIN; PROTEIN CSX; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

EID: 21344435944     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.03.005     Document Type: Review
Times cited : (180)

References (158)
  • 1
    • 0038390128 scopus 로고    scopus 로고
    • Roles of cardiac transcription factors in cardiac hypertrophy
    • H. Akazawa, and I. Komuro Roles of cardiac transcription factors in cardiac hypertrophy Circ Res 92 2003 1079 1088
    • (2003) Circ Res , vol.92 , pp. 1079-1088
    • Akazawa, H.1    Komuro, I.2
  • 2
    • 0037348192 scopus 로고    scopus 로고
    • Too much Csx/Nkx2-5 is as bad as too little?
    • H. Akazawa, and I. Komuro Too much Csx/Nkx2-5 is as bad as too little? J Mol Cell Cardiol 35 2003 227 229
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 227-229
    • Akazawa, H.1    Komuro, I.2
  • 3
    • 0842288224 scopus 로고    scopus 로고
    • A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5
    • H. Akazawa, S. Kudoh, N. Mochizuki, N. Takekoshi, H. Takano, and T. Nagai A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5 J Cell Biol 164 2004 395 405
    • (2004) J Cell Biol , vol.164 , pp. 395-405
    • Akazawa, H.1    Kudoh, S.2    Mochizuki, N.3    Takekoshi, N.4    Takano, H.5    Nagai, T.6
  • 4
    • 0036333532 scopus 로고    scopus 로고
    • Regulation of avian cardiogenesis by Fgf8 signaling
    • B.H. Alsan, and T.M. Schultheiss Regulation of avian cardiogenesis by Fgf8 signaling Development 129 2002 1935 1943
    • (2002) Development , vol.129 , pp. 1935-1943
    • Alsan, B.H.1    Schultheiss, T.M.2
  • 5
    • 0033597114 scopus 로고    scopus 로고
    • Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site
    • B.A. Amendt, L.B. Sutherland, and A.F. Russo Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site J Biol Chem 274 1999 11635 11642
    • (1999) J Biol Chem , vol.274 , pp. 11635-11642
    • Amendt, B.A.1    Sutherland, L.B.2    Russo, A.F.3
  • 7
    • 0027237596 scopus 로고
    • Tinman and bagpipe: Two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
    • N. Azpiazu, and M. Frasch tinman and bagpipe: Two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila Genes Dev 7 1993 1325 1340
    • (1993) Genes Dev , vol.7 , pp. 1325-1340
    • Azpiazu, N.1    Frasch, M.2
  • 8
    • 0030636780 scopus 로고    scopus 로고
    • Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome
    • C.T. Basson, D.R. Bachinsky, R.C. Lin, T. Levi, J.A. Elkins, and J. Soults Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome Nat Genet 15 1997 30 35
    • (1997) Nat Genet , vol.15 , pp. 30-35
    • Basson, C.T.1    Bachinsky, D.R.2    Lin, R.C.3    Levi, T.4    Elkins, J.A.5    Soults, J.6
  • 9
    • 0033430230 scopus 로고    scopus 로고
    • Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
    • D.W. Benson, G.M. Silberbach, A. Kavanaugh-McHugh, C. Cottrill, Y. Zhang, and S. Riggs Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways J Clin Invest 104 1999 1567 1573
    • (1999) J Clin Invest , vol.104 , pp. 1567-1573
    • Benson, D.W.1    Silberbach, G.M.2    Kavanaugh-Mchugh, A.3    Cottrill, C.4    Zhang, Y.5    Riggs, S.6
  • 10
    • 0030926451 scopus 로고    scopus 로고
    • Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development
    • C. Biben, and R.P. Harvey Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development Genes Dev 11 1997 1357 1369
    • (1997) Genes Dev , vol.11 , pp. 1357-1369
    • Biben, C.1    Harvey, R.P.2
  • 11
    • 0031959594 scopus 로고    scopus 로고
    • Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart
    • C. Biben, T. Hatzistavrou, and R.P. Harvey Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart Mech Dev 73 1998 125 127
    • (1998) Mech Dev , vol.73 , pp. 125-127
    • Biben, C.1    Hatzistavrou, T.2    Harvey, R.P.3
  • 12
    • 0034634279 scopus 로고    scopus 로고
    • Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5
    • C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, and D.A. Elliott Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5 Circ Res 87 2000 888 895
    • (2000) Circ Res , vol.87 , pp. 888-895
    • Biben, C.1    Weber, R.2    Kesteven, S.3    Stanley, E.4    McDonald, L.5    Elliott, D.A.6
  • 13
    • 0027282774 scopus 로고
    • The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    • R. Bodmer The gene tinman is required for specification of the heart and visceral muscles in Drosophila Development 118 1993 719 729
    • (1993) Development , vol.118 , pp. 719-729
    • Bodmer, R.1
  • 14
    • 0025201511 scopus 로고
    • A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila
    • R. Bodmer, L.Y. Jan, and Y.N. Jan A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila Development 110 1990 661 669
    • (1990) Development , vol.110 , pp. 661-669
    • Bodmer, R.1    Jan, L.Y.2    Jan, Y.N.3
  • 15
    • 0030746215 scopus 로고    scopus 로고
    • Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development
    • T. Brand, B. Andree, A. Schneider, A. Buchberger, and H.H. Arnold Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development Mech Dev 64 1997 53 59
    • (1997) Mech Dev , vol.64 , pp. 53-59
    • Brand, T.1    Andree, B.2    Schneider, A.3    Buchberger, A.4    Arnold, H.H.5
  • 16
    • 1642402120 scopus 로고    scopus 로고
    • The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
    • C.O. Brown III, X. Chi, E. Garcia-Gras, M. Shirai, X.H. Feng, and R.J. Schwartz The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer J Biol Chem 279 2004 10659 10669
    • (2004) J Biol Chem , vol.279 , pp. 10659-10669
    • Brown III, C.O.1    Chi, X.2    Garcia-Gras, E.3    Shirai, M.4    Feng, X.H.5    Schwartz, R.J.6
  • 17
    • 0037155776 scopus 로고    scopus 로고
    • Transcriptional regulation of vertebrate cardiac morphogenesis
    • B.G. Bruneau Transcriptional regulation of vertebrate cardiac morphogenesis Circ Res 90 2002 509 519
    • (2002) Circ Res , vol.90 , pp. 509-519
    • Bruneau, B.G.1
  • 18
    • 0034650311 scopus 로고    scopus 로고
    • Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand
    • B.G. Bruneau, Z.Z. Bao, M. Tanaka, J.J. Schott, S. Izumo, and C.L. Cepko Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand Dev Biol 217 2000 266 277
    • (2000) Dev Biol , vol.217 , pp. 266-277
    • Bruneau, B.G.1    Bao, Z.Z.2    Tanaka, M.3    Schott, J.J.4    Izumo, S.5    Cepko, C.L.6
  • 19
    • 17944378083 scopus 로고    scopus 로고
    • A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    • B.G. Bruneau, G. Nemer, J.P. Schmitt, F. Charron, L. Robitaille, S. Caron, and D.A. Conner A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease Cell 106 2001 709 721
    • (2001) Cell , vol.106 , pp. 709-721
    • Bruneau, B.G.1    Nemer, G.2    Schmitt, J.P.3    Charron, F.4    Robitaille, L.5    Caron, S.6    Conner, D.A.7
  • 20
    • 0029984771 scopus 로고    scopus 로고
    • Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: Differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development
    • A. Buchberger, O. Pabst, T. Brand, K. Seidl, and H.H. Arnold Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development Mech Dev 56 1996 151 163
    • (1996) Mech Dev , vol.56 , pp. 151-163
    • Buchberger, A.1    Pabst, O.2    Brand, T.3    Seidl, K.4    Arnold, H.H.5
  • 21
    • 20444448850 scopus 로고    scopus 로고
    • Myocardial-cell: The science, the clinic and the future
    • N.M. Caplice, and A. Deb Myocardial-cell: the science, the clinic and the future Nat Clinic Pract Cardiovasc Med 1 2004 90 95
    • (2004) Nat Clinic Pract Cardiovasc Med , vol.1 , pp. 90-95
    • Caplice, N.M.1    Deb, A.2
  • 22
    • 0030465318 scopus 로고    scopus 로고
    • Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation
    • J.N. Chen, and M.C. Fishman Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation Development 122 1996 3809 3816
    • (1996) Development , vol.122 , pp. 3809-3816
    • Chen, J.N.1    Fishman, M.C.2
  • 23
    • 0029046714 scopus 로고
    • Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5
    • C.Y. Chen, and R.J. Schwartz Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5 J Biol Chem 270 1995 15628 15633
    • (1995) J Biol Chem , vol.270 , pp. 15628-15633
    • Chen, C.Y.1    Schwartz, R.J.2
  • 24
    • 0000634381 scopus 로고    scopus 로고
    • Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription
    • C.Y. Chen, and R.J. Schwartz Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription Mol Cell Biol 16 1996 6372 6384
    • (1996) Mol Cell Biol , vol.16 , pp. 6372-6384
    • Chen, C.Y.1    Schwartz, R.J.2
  • 25
    • 18644374460 scopus 로고    scopus 로고
    • Hop is an unusual homeobox gene that modulates cardiac development
    • F. Chen, H. Kook, R. Milewski, A.D. Gitler, M.M. Lu, and J. Li Hop is an unusual homeobox gene that modulates cardiac development Cell 110 2002 713 723
    • (2002) Cell , vol.110 , pp. 713-723
    • Chen, F.1    Kook, H.2    Milewski, R.3    Gitler, A.D.4    Lu, M.M.5    Li, J.6
  • 26
    • 0029955134 scopus 로고    scopus 로고
    • Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia
    • O.B. Cleaver, K.D. Patterson, and P.A. Krieg Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia Development 122 1996 3549 3556
    • (1996) Development , vol.122 , pp. 3549-3556
    • Cleaver, O.B.1    Patterson, K.D.2    Krieg, P.A.3
  • 27
    • 0029779002 scopus 로고    scopus 로고
    • The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium
    • D. Durocher, C.Y. Chen, A. Ardati, R.J. Schwartz, and M. Nemer The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium Mol Cell Biol 16 1996 4648 4655
    • (1996) Mol Cell Biol , vol.16 , pp. 4648-4655
    • Durocher, D.1    Chen, C.Y.2    Ardati, A.3    Schwartz, R.J.4    Nemer, M.5
  • 28
    • 0030799792 scopus 로고    scopus 로고
    • The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
    • D. Durocher, F. Charron, R. Warren, R.J. Schwartz, and M. Nemer The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors EMBO J 16 1997 5687 5696
    • (1997) EMBO J , vol.16 , pp. 5687-5696
    • Durocher, D.1    Charron, F.2    Warren, R.3    Schwartz, R.J.4    Nemer, M.5
  • 29
    • 0032860232 scopus 로고    scopus 로고
    • WNT11 promotes cardiac tissue formation of early mesoderm
    • C.A. Eisenberg, and L.M. Eisenberg WNT11 promotes cardiac tissue formation of early mesoderm Dev Dyn 216 1999 45 58
    • (1999) Dev Dyn , vol.216 , pp. 45-58
    • Eisenberg, C.A.1    Eisenberg, L.M.2
  • 30
    • 0031057963 scopus 로고    scopus 로고
    • Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6
    • C.A. Eisenberg, R.G. Gourdie, and L.M. Eisenberg Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6 Development 124 1997 525 536
    • (1997) Development , vol.124 , pp. 525-536
    • Eisenberg, C.A.1    Gourdie, R.G.2    Eisenberg, L.M.3
  • 31
    • 0037975739 scopus 로고    scopus 로고
    • Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: Associations with atrial septal defect and hypoplastic left heart syndrome
    • D.A. Elliott, E.P. Kirk, T. Yeoh, S. Chandar, F. McKenzie, and P. Taylor Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome J Am Coll Cardiol 41 2003 2072 2076
    • (2003) J Am Coll Cardiol , vol.41 , pp. 2072-2076
    • Elliott, D.A.1    Kirk, E.P.2    Yeoh, T.3    Chandar, S.4    McKenzie, F.5    Taylor, P.6
  • 32
    • 0028863326 scopus 로고
    • Tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman
    • S.M. Evans, W. Yan, M.P. Murillo, J. Ponce, and N. Papalopulu tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman Development 121 1995 3889 3899
    • (1995) Development , vol.121 , pp. 3889-3899
    • Evans, S.M.1    Yan, W.2    Murillo, M.P.3    Ponce, J.4    Papalopulu, N.5
  • 33
    • 0031882143 scopus 로고    scopus 로고
    • Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1
    • A.B. Firulli, D.G. McFadden, Q. Lin, D. Srivastava, and E.N. Olson Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1 Nat Genet 18 1998 266 270
    • (1998) Nat Genet , vol.18 , pp. 266-270
    • Firulli, A.B.1    McFadden, D.G.2    Lin, Q.3    Srivastava, D.4    Olson, E.N.5
  • 34
    • 0030664296 scopus 로고    scopus 로고
    • Parsing the heart: Genetic modules for organ assembly
    • M.C. Fishman, and E.N. Olson Parsing the heart: genetic modules for organ assembly Cell 91 1997 153 156
    • (1997) Cell , vol.91 , pp. 153-156
    • Fishman, M.C.1    Olson, E.N.2
  • 35
    • 0028903248 scopus 로고
    • Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo
    • M. Frasch Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo Nature 374 1995 464 467
    • (1995) Nature , vol.374 , pp. 464-467
    • Frasch, M.1
  • 36
    • 0031647381 scopus 로고    scopus 로고
    • Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner
    • Y. Fu, W. Yan, T.J. Mohun, and S.M. Evans Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner Development 125 1998 4439 4449
    • (1998) Development , vol.125 , pp. 4439-4449
    • Fu, Y.1    Yan, W.2    Mohun, T.J.3    Evans, S.M.4
  • 37
    • 0041703018 scopus 로고    scopus 로고
    • Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5
    • H. Funke-Kaiser, J. Lemmer, C.V. Langsdorff, A. Thomas, S.D. Kovacevic, and M. Strasdat Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5 FASEB J 17 2003 1487 1489
    • (2003) FASEB J , vol.17 , pp. 1487-1489
    • Funke-Kaiser, H.1    Lemmer, J.2    Langsdorff, C.V.3    Thomas, A.4    Kovacevic, S.D.5    Strasdat, M.6
  • 38
    • 0035923555 scopus 로고    scopus 로고
    • NKX2.5 mutations in patients with tetralogy of fallot
    • E. Goldmuntz, E. Geiger, and D.W. Benson NKX2.5 mutations in patients with tetralogy of fallot Circulation 104 2001 2565 2568
    • (2001) Circulation , vol.104 , pp. 2565-2568
    • Goldmuntz, E.1    Geiger, E.2    Benson, D.W.3
  • 39
    • 0032380010 scopus 로고    scopus 로고
    • Tinman function is essential for vertebrate heart development: Elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5
    • M.W. Grow, and P.A. Krieg Tinman function is essential for vertebrate heart development: elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5 Dev Biol 204 1998 187 196
    • (1998) Dev Biol , vol.204 , pp. 187-196
    • Grow, M.W.1    Krieg, P.A.2
  • 40
    • 0035951807 scopus 로고    scopus 로고
    • COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development
    • L. Guo, J. Lynch, K. Nakamura, L. Fliegel, H. Kasahara, and S. Izumo COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development J Biol Chem 276 2001 2797 2801
    • (2001) J Biol Chem , vol.276 , pp. 2797-2801
    • Guo, L.1    Lynch, J.2    Nakamura, K.3    Fliegel, L.4    Kasahara, H.5    Izumo, S.6
  • 41
    • 0037093383 scopus 로고    scopus 로고
    • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation
    • P.E. Habets, A.F. Moorman, D.E. Clout, M.A. van Roon, M. Lingbeek, and M. van Lohuizen Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation Genes Dev 16 2002 1234 1246
    • (2002) Genes Dev , vol.16 , pp. 1234-1246
    • Habets, P.E.1    Moorman, A.F.2    Clout, D.E.3    Van Roon, M.A.4    Lingbeek, M.5    Van Lohuizen, M.6
  • 42
    • 0030587603 scopus 로고    scopus 로고
    • NK-2 homeobox genes and heart development
    • R.P. Harvey NK-2 homeobox genes and heart development Dev Biol 178 1996 203 216
    • (1996) Dev Biol , vol.178 , pp. 203-216
    • Harvey, R.P.1
  • 43
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • C.H. Heldin, K. Miyazono, and P. ten Dijke TGF-beta signalling from cell membrane to nucleus through SMAD proteins Nature 390 1997 465 471
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 44
    • 0034931034 scopus 로고    scopus 로고
    • Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
    • Y. Hiroi, S. Kudoh, K. Monzen, Y. Ikeda, Y. Yazaki, and R. Nagai Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation Nat Genet 28 2001 276 280
    • (2001) Nat Genet , vol.28 , pp. 276-280
    • Hiroi, Y.1    Kudoh, S.2    Monzen, K.3    Ikeda, Y.4    Yazaki, Y.5    Nagai, R.6
  • 45
    • 0033574574 scopus 로고    scopus 로고
    • Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress
    • H. Hirota, J. Chen, U.A. Betz, K. Rajewsky, Y. Gu, and J. Ross Jr. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress Cell 97 1999 189 198
    • (1999) Cell , vol.97 , pp. 189-198
    • Hirota, H.1    Chen, J.2    Betz, U.A.3    Rajewsky, K.4    Gu, Y.5    Ross Jr., J.6
  • 46
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • B.L. Hogan Bone morphogenetic proteins: multifunctional regulators of vertebrate development Genes Dev 10 1996 1580 1594
    • (1996) Genes Dev , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 47
    • 0032975539 scopus 로고    scopus 로고
    • Familial atrial septal defect and atrioventricular conduction disturbance associated with a point mutation in the cardiac homeobox gene CSX/NKX2-5 in a Japanese patient
    • T. Hosoda, I. Komuro, I. Shiojima, Y. Hiroi, M. Harada, and Y. Murakawa Familial atrial septal defect and atrioventricular conduction disturbance associated with a point mutation in the cardiac homeobox gene CSX/NKX2-5 in a Japanese patient Jpn Circ J 63 1999 425 426
    • (1999) Jpn Circ J , vol.63 , pp. 425-426
    • Hosoda, T.1    Komuro, I.2    Shiojima, I.3    Hiroi, Y.4    Harada, M.5    Murakawa, Y.6
  • 48
    • 0036306830 scopus 로고    scopus 로고
    • Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease
    • Y. Ikeda, Y. Hiroi, T. Hosoda, T. Utsunomiya, S. Matsuo, and T. Ito Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease Circ J 66 2002 561 563
    • (2002) Circ J , vol.66 , pp. 561-563
    • Ikeda, Y.1    Hiroi, Y.2    Hosoda, T.3    Utsunomiya, T.4    Matsuo, S.5    Ito, T.6
  • 49
    • 0035976861 scopus 로고    scopus 로고
    • BMP signaling regulates Nkx2-5 activity during cardiomyogenesis
    • M. Jamali, C. Karamboulas, P.J. Rogerson, and I.S. Skerjanc BMP signaling regulates Nkx2-5 activity during cardiomyogenesis FEBS Lett 509 2001 126 130
    • (2001) FEBS Lett , vol.509 , pp. 126-130
    • Jamali, M.1    Karamboulas, C.2    Rogerson, P.J.3    Skerjanc, I.S.4
  • 50
  • 52
    • 8444240109 scopus 로고    scopus 로고
    • The LIM domain: From the cytoskeleton to the nucleus
    • J.L. Kadrmas, and M.C. Beckerle The LIM domain: from the cytoskeleton to the nucleus Nat Rev Mol Cell Biol 5 2004 920 931
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 920-931
    • Kadrmas, J.L.1    Beckerle, M.C.2
  • 53
    • 0032959891 scopus 로고    scopus 로고
    • Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tissue-specifying homeobox gene product Csx/Nkx2.5
    • H. Kasahara, and S. Izumo Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tissue-specifying homeobox gene product Csx/Nkx2.5 Mol Cell Biol 19 1999 526 536
    • (1999) Mol Cell Biol , vol.19 , pp. 526-536
    • Kasahara, H.1    Izumo, S.2
  • 54
    • 0032543267 scopus 로고    scopus 로고
    • Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein
    • H. Kasahara, S. Bartunkova, M. Schinke, M. Tanaka, and S. Izumo Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein Circ Res 82 1998 936 946
    • (1998) Circ Res , vol.82 , pp. 936-946
    • Kasahara, H.1    Bartunkova, S.2    Schinke, M.3    Tanaka, M.4    Izumo, S.5
  • 55
    • 0033912859 scopus 로고    scopus 로고
    • Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease
    • H. Kasahara, B. Lee, J.J. Schott, D.W. Benson, J.G. Seidman, and C.E. Seidman Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease J Clin Invest 106 2000 299 308
    • (2000) J Clin Invest , vol.106 , pp. 299-308
    • Kasahara, H.1    Lee, B.2    Schott, J.J.3    Benson, D.W.4    Seidman, J.G.5    Seidman, C.E.6
  • 56
    • 0035895925 scopus 로고    scopus 로고
    • Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein
    • H. Kasahara, A. Usheva, T. Ueyama, H. Aoki, N. Horikoshi, and S. Izumo Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein J Biol Chem 276 2001 4570 4580
    • (2001) J Biol Chem , vol.276 , pp. 4570-4580
    • Kasahara, H.1    Usheva, A.2    Ueyama, T.3    Aoki, H.4    Horikoshi, N.5    Izumo, S.6
  • 57
    • 0034947445 scopus 로고    scopus 로고
    • Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein
    • H. Kasahara, H. Wakimoto, M. Liu, C.T. Maguire, K.L. Converso, and T. Shioi Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein J Clin Invest 108 2001 189 201
    • (2001) J Clin Invest , vol.108 , pp. 189-201
    • Kasahara, H.1    Wakimoto, H.2    Liu, M.3    Maguire, C.T.4    Converso, K.L.5    Shioi, T.6
  • 58
    • 0037350193 scopus 로고    scopus 로고
    • Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes
    • H. Kasahara, T. Ueyama, H. Wakimoto, M.K. Liu, C.T. Maguire, and K.L. Converso Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes J Mol Cell Cardiol 35 2003 243 256
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 243-256
    • Kasahara, H.1    Ueyama, T.2    Wakimoto, H.3    Liu, M.K.4    Maguire, C.T.5    Converso, K.L.6
  • 59
    • 0036534107 scopus 로고    scopus 로고
    • The anterior heart-forming field: Voyage to the arterial pole of the heart
    • R.G. Kelly, and M.E. Buckingham The anterior heart-forming field: voyage to the arterial pole of the heart Trends Genet 18 2002 210 216
    • (2002) Trends Genet , vol.18 , pp. 210-216
    • Kelly, R.G.1    Buckingham, M.E.2
  • 61
    • 0032567957 scopus 로고    scopus 로고
    • Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
    • S. Kirchhoff, E. Nelles, A. Hagendorff, O. Kruger, O. Traub, and K. Willecke Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice Curr Biol 8 1998 299 302
    • (1998) Curr Biol , vol.8 , pp. 299-302
    • Kirchhoff, S.1    Nelles, E.2    Hagendorff, A.3    Kruger, O.4    Traub, O.5    Willecke, K.6
  • 62
    • 0027184211 scopus 로고
    • Csx: A murine homeobox-containing gene specifically expressed in the developing heart
    • I. Komuro, and S. Izumo Csx: a murine homeobox-containing gene specifically expressed in the developing heart Proc Natl Acad Sci U S A 90 1993 8145 8149
    • (1993) Proc Natl Acad Sci U S a , vol.90 , pp. 8145-8149
    • Komuro, I.1    Izumo, S.2
  • 63
    • 0027460744 scopus 로고
    • Control of cardiac gene expression by mechanical stress
    • I. Komuro, and Y. Yazaki Control of cardiac gene expression by mechanical stress Annu Rev Physiol 55 1993 55 75
    • (1993) Annu Rev Physiol , vol.55 , pp. 55-75
    • Komuro, I.1    Yazaki, Y.2
  • 64
    • 0030916211 scopus 로고    scopus 로고
    • GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
    • C.T. Kuo, E.E. Morrisey, R. Anandappa, K. Sigrist, M.M. Lu, and M.S. Parmacek GATA4 transcription factor is required for ventral morphogenesis and heart tube formation Genes Dev 11 1997 1048 1060
    • (1997) Genes Dev , vol.11 , pp. 1048-1060
    • Kuo, C.T.1    Morrisey, E.E.2    Anandappa, R.3    Sigrist, K.4    Lu, M.M.5    Parmacek, M.S.6
  • 65
    • 0030589617 scopus 로고    scopus 로고
    • A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm
    • K.H. Lee, Q. Xu, and R.E. Breitbart A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm Dev Biol 180 1996 722 731
    • (1996) Dev Biol , vol.180 , pp. 722-731
    • Lee, K.H.1    Xu, Q.2    Breitbart, R.E.3
  • 66
    • 0031844382 scopus 로고    scopus 로고
    • The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression
    • Y. Lee, T. Shioi, H. Kasahara, S.M. Jobe, R.J. Wiese, and B.E. Markham The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression Mol Cell Biol 18 1998 3120 3129
    • (1998) Mol Cell Biol , vol.18 , pp. 3120-3129
    • Lee, Y.1    Shioi, T.2    Kasahara, H.3    Jobe, S.M.4    Wiese, R.J.5    Markham, B.E.6
  • 67
    • 7244255984 scopus 로고    scopus 로고
    • SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer
    • K.H. Lee, S. Evans, T.Y. Ruan, and A.B. Lassar SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer Development 131 2004 4709 4723
    • (2004) Development , vol.131 , pp. 4709-4723
    • Lee, K.H.1    Evans, S.2    Ruan, T.Y.3    Lassar, A.B.4
  • 68
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
    • D. Levy, R.J. Garrison, D.D. Savage, W.B. Kannel, and W.P. Castelli Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study N Engl J Med 322 1990 1561 1566
    • (1990) N Engl J Med , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3    Kannel, W.B.4    Castelli, W.P.5
  • 69
    • 1842413728 scopus 로고    scopus 로고
    • Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
    • Q.Y. Li, R.A. Newbury-Ecob, J.A. Terrett, D.I. Wilson, A.R. Curtis, and C.H. Yi Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family Nat Genet 15 1997 21 29
    • (1997) Nat Genet , vol.15 , pp. 21-29
    • Li, Q.Y.1    Newbury-Ecob, R.A.2    Terrett, J.A.3    Wilson, D.I.4    Curtis, A.R.5    Yi, C.H.6
  • 70
    • 0037091085 scopus 로고    scopus 로고
    • Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region
    • C.M. Liberatore, R.D. Searcy-Schrick, E.B. Vincent, and K.E. Yutzey Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region Dev Biol 244 2002 243 256
    • (2002) Dev Biol , vol.244 , pp. 243-256
    • Liberatore, C.M.1    Searcy-Schrick, R.D.2    Vincent, E.B.3    Yutzey, K.E.4
  • 71
    • 0032937224 scopus 로고    scopus 로고
    • Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer
    • C.L. Lien, C. Wu, B. Mercer, R. Webb, J.A. Richardson, and E.N. Olson Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer Development 126 1999 75 84
    • (1999) Development , vol.126 , pp. 75-84
    • Lien, C.L.1    Wu, C.2    Mercer, B.3    Webb, R.4    Richardson, J.A.5    Olson, E.N.6
  • 72
    • 0037090906 scopus 로고    scopus 로고
    • Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site
    • C.L. Lien, J. McAnally, J.A. Richardson, and E.N. Olson Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site Dev Biol 244 2002 257 266
    • (2002) Dev Biol , vol.244 , pp. 257-266
    • Lien, C.L.1    McAnally, J.2    Richardson, J.A.3    Olson, E.N.4
  • 73
    • 0027383023 scopus 로고
    • Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
    • T.J. Lints, L.M. Parsons, L. Hartley, I. Lyons, and R.P. Harvey Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants Development 119 1993 419 431
    • (1993) Development , vol.119 , pp. 419-431
    • Lints, T.J.1    Parsons, L.M.2    Hartley, L.3    Lyons, I.4    Harvey, R.P.5
  • 74
    • 0034713820 scopus 로고    scopus 로고
    • Left ventricular hypertrophy: Pathogenesis, detection, and prognosis
    • B.H. Lorell, and B.A. Carabello Left ventricular hypertrophy: pathogenesis, detection, and prognosis Circulation 102 2000 470 479
    • (2000) Circulation , vol.102 , pp. 470-479
    • Lorell, B.H.1    Carabello, B.A.2
  • 75
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    • I. Lyons, L.M. Parsons, L. Hartley, R. Li, J.E. Andrews, and L. Robb Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5 Genes Dev 9 1995 1654 1666
    • (1995) Genes Dev , vol.9 , pp. 1654-1666
    • Lyons, I.1    Parsons, L.M.2    Hartley, L.3    Li, R.4    Andrews, J.E.5    Robb, L.6
  • 76
    • 0035252357 scopus 로고    scopus 로고
    • Inhibition of Wnt activity induces heart formation from posterior mesoderm
    • M.J. Marvin, G. Di Rocco, A. Gardiner, S.M. Bush, and A.B. Lassar Inhibition of Wnt activity induces heart formation from posterior mesoderm Genes Dev 15 2001 316 327
    • (2001) Genes Dev , vol.15 , pp. 316-327
    • Marvin, M.J.1    Di Rocco, G.2    Gardiner, A.3    Bush, S.M.4    Lassar, A.B.5
  • 77
    • 3142554538 scopus 로고    scopus 로고
    • Stem cells and repair of the heart
    • A. Mathur, and J.F. Martin Stem cells and repair of the heart Lancet 364 2004 183 192
    • (2004) Lancet , vol.364 , pp. 183-192
    • Mathur, A.1    Martin, J.F.2
  • 78
    • 12144287908 scopus 로고    scopus 로고
    • Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes
    • K. Matsuura, T. Nagai, N. Nishigaki, T. Oyama, J. Nishi, and H. Wada Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes J Biol Chem 279 2004 11384 11391
    • (2004) J Biol Chem , vol.279 , pp. 11384-11391
    • Matsuura, K.1    Nagai, T.2    Nishigaki, N.3    Oyama, T.4    Nishi, J.5    Wada, H.6
  • 80
    • 0029740603 scopus 로고    scopus 로고
    • BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein mix 1
    • P.E. Mead, I.H. Brivanlou, C.M. Kelley, and L.I. Zon BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein mix 1 Nature 382 1996 357 360
    • (1996) Nature , vol.382 , pp. 357-360
    • Mead, P.E.1    Brivanlou, I.H.2    Kelley, C.M.3    Zon, L.I.4
  • 81
    • 0034671733 scopus 로고    scopus 로고
    • The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression
    • J.D. Molkentin The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression J Biol Chem 275 2000 38949 38952
    • (2000) J Biol Chem , vol.275 , pp. 38949-38952
    • Molkentin, J.D.1
  • 82
    • 0032850596 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4
    • K. Monzen, I. Shiojima, Y. Hiroi, S. Kudoh, T. Oka, and E. Takimoto Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4 Mol Cell Biol 19 1999 7096 7105
    • (1999) Mol Cell Biol , vol.19 , pp. 7096-7105
    • Monzen, K.1    Shiojima, I.2    Hiroi, Y.3    Kudoh, S.4    Oka, T.5    Takimoto, E.6
  • 83
    • 0035858884 scopus 로고    scopus 로고
    • Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation
    • K. Monzen, Y. Hiroi, S. Kudoh, H. Akazawa, T. Oka, and E. Takimoto Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation J Cell Biol 153 2001 687 698
    • (2001) J Cell Biol , vol.153 , pp. 687-698
    • Monzen, K.1    Hiroi, Y.2    Kudoh, S.3    Akazawa, H.4    Oka, T.5    Takimoto, E.6
  • 85
    • 0036660872 scopus 로고    scopus 로고
    • Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor
    • J.G. Muller, J.T. Thompson, A.M. Edmonson, M.S. Rackley, H. Kasahara, and S. Izumo Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor J Mol Cell Cardiol 34 2002 807 821
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 807-821
    • Muller, J.G.1    Thompson, J.T.2    Edmonson, A.M.3    Rackley, M.S.4    Kasahara, H.5    Izumo, S.6
  • 86
    • 0242270619 scopus 로고    scopus 로고
    • Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002
    • A.T. Naito, A. Tominaga, M. Oyamada, Y. Oyamada, I. Shiraishi, and K. Monzen Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002 Exp Cell Res 291 2003 56 69
    • (2003) Exp Cell Res , vol.291 , pp. 56-69
    • Naito, A.T.1    Tominaga, A.2    Oyamada, M.3    Oyamada, Y.4    Shiraishi, I.5    Monzen, K.6
  • 87
    • 0037947766 scopus 로고    scopus 로고
    • A Wnt- and beta-catenin-dependent pathway for mammalian cardiac myogenesis
    • T. Nakamura, M. Sano, Z. Songyang, and M.D. Schneider A Wnt- and beta-catenin-dependent pathway for mammalian cardiac myogenesis Proc Natl Acad Sci U S A 100 2003 5834 5839
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 5834-5839
    • Nakamura, T.1    Sano, M.2    Songyang, Z.3    Schneider, M.D.4
  • 88
    • 0031835362 scopus 로고    scopus 로고
    • Tinman-related genes expressed during heart development in Xenopus
    • C.S. Newman, and P.A. Krieg Tinman-related genes expressed during heart development in Xenopus Dev Genet 22 1998 230 238
    • (1998) Dev Genet , vol.22 , pp. 230-238
    • Newman, C.S.1    Krieg, P.A.2
  • 89
    • 0033994198 scopus 로고    scopus 로고
    • Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10
    • C.S. Newman, J. Reecy, M.W. Grow, K. Ni, T. Boettger, and M. Kessel Transient cardiac expression of the tinman-family homeobox gene, XNkx2-10 Mech Dev 91 2000 369 373
    • (2000) Mech Dev , vol.91 , pp. 369-373
    • Newman, C.S.1    Reecy, J.2    Grow, M.W.3    Ni, K.4    Boettger, T.5    Kessel, M.6
  • 90
    • 0142027772 scopus 로고    scopus 로고
    • Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
    • H. Oh, S.B. Bradfute, T.D. Gallardo, T. Nakamura, V. Gaussin, and Y. Mishina Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction Proc Natl Acad Sci U S A 100 2003 12313 12318
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 12313-12318
    • Oh, H.1    Bradfute, S.B.2    Gallardo, T.D.3    Nakamura, T.4    Gaussin, V.5    Mishina, Y.6
  • 91
    • 0030043669 scopus 로고    scopus 로고
    • Molecular pathways controlling heart development
    • E.N. Olson, and D. Srivastava Molecular pathways controlling heart development Science 272 1996 671 676
    • (1996) Science , vol.272 , pp. 671-676
    • Olson, E.N.1    Srivastava, D.2
  • 92
    • 0031812546 scopus 로고    scopus 로고
    • Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm
    • D. Onichtchouk, A. Glinka, and C. Niehrs Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm Development 125 1998 1447 1456
    • (1998) Development , vol.125 , pp. 1447-1456
    • Onichtchouk, D.1    Glinka, A.2    Niehrs, C.3
  • 93
    • 0037043688 scopus 로고    scopus 로고
    • Wnt-11 activation of a noncanonical Wnt signalling pathway is required for cardiogenesis
    • P. Pandur, M. Lasche, L.M. Eisenberg, and M. Kuhl Wnt-11 activation of a noncanonical Wnt signalling pathway is required for cardiogenesis Nature 418 2002 636 641
    • (2002) Nature , vol.418 , pp. 636-641
    • Pandur, P.1    Lasche, M.2    Eisenberg, L.M.3    Kuhl, M.4
  • 95
    • 0030578428 scopus 로고    scopus 로고
    • The wingless signaling pathway is directly involved in Drosophila heart development
    • M. Park, X. Wu, K. Golden, J.D. Axelrod, and R. Bodmer The wingless signaling pathway is directly involved in Drosophila heart development Dev Biol 177 1996 104 116
    • (1996) Dev Biol , vol.177 , pp. 104-116
    • Park, M.1    Wu, X.2    Golden, K.3    Axelrod, J.D.4    Bodmer, R.5
  • 96
    • 13144257684 scopus 로고    scopus 로고
    • Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes
    • M. Park, C. Lewis, D. Turbay, A. Chung, J.N. Chen, and S. Evans Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes Proc Natl Acad Sci U S A 95 1998 9366 9371
    • (1998) Proc Natl Acad Sci U S a , vol.95 , pp. 9366-9371
    • Park, M.1    Lewis, C.2    Turbay, D.3    Chung, A.4    Chen, J.N.5    Evans, S.6
  • 97
    • 0031833737 scopus 로고    scopus 로고
    • Dual role for the zeste-white3/shaggyencoded kinase in mesoderm and heart development of Drosophila
    • M. Park, T.V. Venkatesh, and R. Bodmer Dual role for the zeste-white3/shaggyencoded kinase in mesoderm and heart development of Drosophila Dev Genet 22 1998 201 211
    • (1998) Dev Genet , vol.22 , pp. 201-211
    • Park, M.1    Venkatesh, T.V.2    Bodmer, R.3
  • 98
    • 11144357335 scopus 로고    scopus 로고
    • Nkx2-5 pathways and congenital heart disease; Loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block
    • M. Pashmforoush, J.T. Lu, H. Chen, T.S. Amand, R. Kondo, and S. Pradervand Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block Cell 117 2004 373 386
    • (2004) Cell , vol.117 , pp. 373-386
    • Pashmforoush, M.1    Lu, J.T.2    Chen, H.3    Amand, T.S.4    Kondo, R.5    Pradervand, S.6
  • 99
    • 0042466555 scopus 로고    scopus 로고
    • GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation
    • T. Peterkin, A. Gibson, and R. Patient GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation EMBO J 22 2003 4260 4273
    • (2003) EMBO J , vol.22 , pp. 4260-4273
    • Peterkin, T.1    Gibson, A.2    Patient, R.3
  • 100
    • 0031685432 scopus 로고    scopus 로고
    • Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice
    • G. Ranganayakulu, D.A. Elliott, R.P. Harvey, and E.N. Olson Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice Development 125 1998 3037 3048
    • (1998) Development , vol.125 , pp. 3037-3048
    • Ranganayakulu, G.1    Elliott, D.A.2    Harvey, R.P.3    Olson, E.N.4
  • 101
    • 4444298928 scopus 로고    scopus 로고
    • Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease
    • S.M. Reamon-Buettner, and J. Borlak Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease J Med Genet 41 2004 684 690
    • (2004) J Med Genet , vol.41 , pp. 684-690
    • Reamon-Buettner, S.M.1    Borlak, J.2
  • 103
    • 0031571635 scopus 로고    scopus 로고
    • Chicken Nkx-2.8: A novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm
    • J.M. Reecy, M. Yamada, K. Cummings, D. Sosic, C.Y. Chen, and G. Eichele Chicken Nkx-2.8: a novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm Dev Biol 188 1997 295 311
    • (1997) Dev Biol , vol.188 , pp. 295-311
    • Reecy, J.M.1    Yamada, M.2    Cummings, K.3    Sosic, D.4    Chen, C.Y.5    Eichele, G.6
  • 104
    • 0033013018 scopus 로고    scopus 로고
    • Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5
    • J.M. Reecy, X. Li, M. Yamada, F.J. DeMayo, C.S. Newman, and R.P. Harvey Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5 Development 126 1999 839 849
    • (1999) Development , vol.126 , pp. 839-849
    • Reecy, J.M.1    Li, X.2    Yamada, M.3    Demayo, F.J.4    Newman, C.S.5    Harvey, R.P.6
  • 105
    • 0031882249 scopus 로고    scopus 로고
    • The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis
    • P. Riley, L. Anson-Cartwright, and J.C. Cross The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis Nat Genet 18 1998 271 275
    • (1998) Nat Genet , vol.18 , pp. 271-275
    • Riley, P.1    Anson-Cartwright, L.2    Cross, J.C.3
  • 106
    • 0034329539 scopus 로고    scopus 로고
    • Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos
    • P.R. Riley, M. Gertsenstein, K. Dawson, and J.C. Cross Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos Dev Biol 227 2000 156 168
    • (2000) Dev Biol , vol.227 , pp. 156-168
    • Riley, P.R.1    Gertsenstein, M.2    Dawson, K.3    Cross, J.C.4
  • 107
    • 0033553573 scopus 로고    scopus 로고
    • Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5
    • S.A. Rivkees, M. Chen, J. Kulkarni, J. Browne, and Z. Zhao Characterization of the murine A1 adenosine receptor promoter, potent regulation by GATA-4 and Nkx2.5 J Biol Chem 274 1999 14204 14209
    • (1999) J Biol Chem , vol.274 , pp. 14204-14209
    • Rivkees, S.A.1    Chen, M.2    Kulkarni, J.3    Browne, J.4    Zhao, Z.5
  • 108
    • 0032809986 scopus 로고    scopus 로고
    • Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice
    • N. Saadane, L. Alpert, and L.E. Chalifour Expression of immediate early genes, GATA-4, and Nkx-2.5 in adrenergic-induced cardiac hypertrophy and during regression in adult mice Br J Pharmacol 127 1999 1165 1176
    • (1999) Br J Pharmacol , vol.127 , pp. 1165-1176
    • Saadane, N.1    Alpert, L.2    Chalifour, L.E.3
  • 109
    • 0030969371 scopus 로고    scopus 로고
    • The cellular and molecular response of cardiac myocytes to mechanical stress
    • J. Sadoshima, and S. Izumo The cellular and molecular response of cardiac myocytes to mechanical stress Annu Rev Physiol 59 1997 551 571
    • (1997) Annu Rev Physiol , vol.59 , pp. 551-571
    • Sadoshima, J.1    Izumo, S.2
  • 110
    • 0035252543 scopus 로고    scopus 로고
    • Wnt antagonism initiates cardiogenesis in Xenopus laevis
    • V.A. Schneider, and M. Mercola Wnt antagonism initiates cardiogenesis in Xenopus laevis Genes Dev 15 2001 304 315
    • (2001) Genes Dev , vol.15 , pp. 304-315
    • Schneider, V.A.1    Mercola, M.2
  • 111
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • J.J. Schott, D.W. Benson, C.T. Basson, W. Pease, G.M. Silberbach, and J.P. Moak Congenital heart disease caused by mutations in the transcription factor NKX2-5 Science 281 1998 108 111
    • (1998) Science , vol.281 , pp. 108-111
    • Schott, J.J.1    Benson, D.W.2    Basson, C.T.3    Pease, W.4    Silberbach, G.M.5    Moak, J.P.6
  • 112
    • 0029583152 scopus 로고
    • Induction of avian cardiac myogenesis by anterior endoderm
    • T.M. Schultheiss, S. Xydas, and A.B. Lassar Induction of avian cardiac myogenesis by anterior endoderm Development 121 1995 4203 4214
    • (1995) Development , vol.121 , pp. 4203-4214
    • Schultheiss, T.M.1    Xydas, S.2    Lassar, A.B.3
  • 113
    • 0031018002 scopus 로고    scopus 로고
    • A role for bone morphogenetic proteins in the induction of cardiac myogenesis
    • T.M. Schultheiss, J.B. Burch, and A.B. Lassar A role for bone morphogenetic proteins in the induction of cardiac myogenesis Genes Dev 11 1997 451 462
    • (1997) Genes Dev , vol.11 , pp. 451-462
    • Schultheiss, T.M.1    Burch, J.B.2    Lassar, A.B.3
  • 114
    • 0032727374 scopus 로고    scopus 로고
    • Building the heart piece by piece: Modularity of cis-elements regulating Nkx2-5 transcription
    • R.J. Schwartz, and E.N. Olson Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription Development 126 1999 4187 4192
    • (1999) Development , vol.126 , pp. 4187-4192
    • Schwartz, R.J.1    Olson, E.N.2
  • 115
    • 0031647382 scopus 로고    scopus 로고
    • A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice
    • R.D. Searcy, E.B. Vincent, C.M. Liberatore, and K.E. Yutzey A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice Development 125 1998 4461 4470
    • (1998) Development , vol.125 , pp. 4461-4470
    • Searcy, R.D.1    Vincent, E.B.2    Liberatore, C.M.3    Yutzey, K.E.4
  • 116
    • 0031815073 scopus 로고    scopus 로고
    • GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: Role for regulating early cardiac gene expression
    • J.L. Sepulveda, N. Belaguli, V. Nigam, C.Y. Chen, M. Nemer, and R.J. Schwartz GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression Mol Cell Biol 18 1998 3405 3415
    • (1998) Mol Cell Biol , vol.18 , pp. 3405-3415
    • Sepulveda, J.L.1    Belaguli, N.2    Nigam, V.3    Chen, C.Y.4    Nemer, M.5    Schwartz, R.J.6
  • 117
    • 0034663217 scopus 로고    scopus 로고
    • BMP signaling is required for heart formation in vertebrates
    • Y. Shi, S. Katsev, C. Cai, and S. Evans BMP signaling is required for heart formation in vertebrates Dev Biol 224 2000 226 237
    • (2000) Dev Biol , vol.224 , pp. 226-237
    • Shi, Y.1    Katsev, S.2    Cai, C.3    Evans, S.4
  • 118
    • 18644364557 scopus 로고    scopus 로고
    • Modulation of cardiac growth and development by HOP, an unusual homeodomain protein
    • C.H. Shin, Z.P. Liu, R. Passier, C.L. Zhang, D.Z. Wang, and T.M. Harris Modulation of cardiac growth and development by HOP, an unusual homeodomain protein Cell 110 2002 725 735
    • (2002) Cell , vol.110 , pp. 725-735
    • Shin, C.H.1    Liu, Z.P.2    Passier, R.3    Zhang, C.L.4    Wang, D.Z.5    Harris, T.M.6
  • 120
    • 0029972345 scopus 로고    scopus 로고
    • Molecular cloning and characterization of human cardiac homeobox gene CSX1
    • I. Shiojima, I. Komuro, T. Mizuno, R. Aikawa, H. Akazawa, and T. Oka Molecular cloning and characterization of human cardiac homeobox gene CSX1 Circ Res 79 1996 920 929
    • (1996) Circ Res , vol.79 , pp. 920-929
    • Shiojima, I.1    Komuro, I.2    Mizuno, T.3    Aikawa, R.4    Akazawa, H.5    Oka, T.6
  • 121
    • 0033583178 scopus 로고    scopus 로고
    • Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx- 2.5 and GATA-4
    • I. Shiojima, I. Komuro, T. Oka, Y. Hiroi, T. Mizuno, and E. Takimoto Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx- 2.5 and GATA-4 J Biol Chem 274 1999 8231 8239
    • (1999) J Biol Chem , vol.274 , pp. 8231-8239
    • Shiojima, I.1    Komuro, I.2    Oka, T.3    Hiroi, Y.4    Mizuno, T.5    Takimoto, E.6
  • 123
    • 0036073842 scopus 로고    scopus 로고
    • The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis
    • M. Shirai, T. Osugi, H. Koga, Y. Kaji, E. Takimoto, and I. Komuro The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis J Clin Invest 110 2002 177 184
    • (2002) J Clin Invest , vol.110 , pp. 177-184
    • Shirai, M.1    Osugi, T.2    Koga, H.3    Kaji, Y.4    Takimoto, E.5    Komuro, I.6
  • 124
    • 17744364498 scopus 로고    scopus 로고
    • Two-step regulation of left-right asymmetric expression of Pitx2: Initiation by nodal signaling and maintenance by Nkx2
    • H. Shiratori, R. Sakuma, M. Watanabe, H. Hashiguchi, K. Mochida, and Y. Sakai Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2 Mol Cell 7 2001 137 149
    • (2001) Mol Cell , vol.7 , pp. 137-149
    • Shiratori, H.1    Sakuma, R.2    Watanabe, M.3    Hashiguchi, H.4    Mochida, K.5    Sakai, Y.6
  • 125
    • 0032567887 scopus 로고    scopus 로고
    • Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
    • A.M. Simon, D.A. Goodenough, and D.L. Paul Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block Curr Biol 8 1998 295 298
    • (1998) Curr Biol , vol.8 , pp. 295-298
    • Simon, A.M.1    Goodenough, D.A.2    Paul, D.L.3
  • 126
    • 0033119649 scopus 로고    scopus 로고
    • T-box genes: What they do and how they do it
    • J. Smith T-box genes: what they do and how they do it Trends Genet 15 1999 154 158
    • (1999) Trends Genet , vol.15 , pp. 154-158
    • Smith, J.1
  • 127
    • 0033000465 scopus 로고    scopus 로고
    • HAND proteins: Molecular mediators of cardiac development and congenital heart disease
    • D. Srivastava HAND proteins: molecular mediators of cardiac development and congenital heart disease Trends Cardiovasc Med 9 1999 11 18
    • (1999) Trends Cardiovasc Med , vol.9 , pp. 11-18
    • Srivastava, D.1
  • 128
    • 0034648772 scopus 로고    scopus 로고
    • A genetic blueprint for cardiac development
    • D. Srivastava, and E.N. Olson A genetic blueprint for cardiac development Nature 407 2000 221 226
    • (2000) Nature , vol.407 , pp. 221-226
    • Srivastava, D.1    Olson, E.N.2
  • 129
    • 0030903857 scopus 로고    scopus 로고
    • Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND
    • D. Srivastava, T. Thomas, Q. Lin, M.L. Kirby, D. Brown, and E.N. Olson Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND Nat Genet 16 1997 154 160
    • (1997) Nat Genet , vol.16 , pp. 154-160
    • Srivastava, D.1    Thomas, T.2    Lin, Q.3    Kirby, M.L.4    Brown, D.5    Olson, E.N.6
  • 131
    • 0036362978 scopus 로고    scopus 로고
    • Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3′UTR-ires-Cre allele of the homeobox gene Nkx2-5
    • E.G. Stanley, C. Biben, A. Elefanty, L. Barnett, F. Koentgen, and L. Robb Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3′UTR-ires-Cre allele of the homeobox gene Nkx2-5 Int J Dev Biol 46 2002 431 439
    • (2002) Int J Dev Biol , vol.46 , pp. 431-439
    • Stanley, E.G.1    Biben, C.2    Elefanty, A.3    Barnett, L.4    Koentgen, F.5    Robb, L.6
  • 132
    • 0141615095 scopus 로고    scopus 로고
    • Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart
    • F.A. Stennard, M.W. Costa, D.A. Elliott, S. Rankin, S.J. Haast, and D. Lai Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart Dev Biol 262 2003 206 224
    • (2003) Dev Biol , vol.262 , pp. 206-224
    • Stennard, F.A.1    Costa, M.W.2    Elliott, D.A.3    Rankin, S.4    Haast, S.J.5    Lai, D.6
  • 134
    • 0032907924 scopus 로고    scopus 로고
    • The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
    • M. Tanaka, Z. Chen, S. Bartunkova, N. Yamasaki, and S. Izumo The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development Development 126 1999 1269 1280
    • (1999) Development , vol.126 , pp. 1269-1280
    • Tanaka, M.1    Chen, Z.2    Bartunkova, S.3    Yamasaki, N.4    Izumo, S.5
  • 135
    • 0344428124 scopus 로고    scopus 로고
    • Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5
    • M. Tanaka, S.B. Wechsler, I.W. Lee, N. Yamasaki, J.A. Lawitts, and S. Izumo Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5 Development 126 1999 1439 1450
    • (1999) Development , vol.126 , pp. 1439-1450
    • Tanaka, M.1    Wechsler, S.B.2    Lee, I.W.3    Yamasaki, N.4    Lawitts, J.A.5    Izumo, S.6
  • 136
    • 0034115494 scopus 로고    scopus 로고
    • Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting
    • M. Tanaka, N. Yamasaki, and S. Izumo Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting Mol Cell Biol 20 2000 2874 2879
    • (2000) Mol Cell Biol , vol.20 , pp. 2874-2879
    • Tanaka, M.1    Yamasaki, N.2    Izumo, S.3
  • 137
    • 0034967610 scopus 로고    scopus 로고
    • Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx
    • M. Tanaka, M. Schinke, H.S. Liao, N. Yamasaki, and S. Izumo Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx Mol Cell Biol 21 2001 4391 4398
    • (2001) Mol Cell Biol , vol.21 , pp. 4391-4398
    • Tanaka, M.1    Schinke, M.2    Liao, H.S.3    Yamasaki, N.4    Izumo, S.5
  • 138
    • 8444238887 scopus 로고    scopus 로고
    • Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes
    • H. Terami, K. Hidaka, T. Katsumata, A. Iio, and T. Morisaki Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes Biochem Biophys Res Commun 325 2004 968 975
    • (2004) Biochem Biophys Res Commun , vol.325 , pp. 968-975
    • Terami, H.1    Hidaka, K.2    Katsumata, T.3    Iio, A.4    Morisaki, T.5
  • 139
    • 0036773644 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene
    • B.D. Thattaliyath, B.A. Firulli, and A.B. Firulli The basic helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene J Mol Cell Cardiol 34 2002 1335 1344
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1335-1344
    • Thattaliyath, B.D.1    Firulli, B.A.2    Firulli, A.B.3
  • 141
    • 0031861927 scopus 로고    scopus 로고
    • Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload
    • J.T. Thompson, M.S. Rackley, and T.X. O'Brien Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload Am J Physiol 274 1998 H1569 H1573
    • (1998) Am J Physiol , vol.274
    • Thompson, J.T.1    Rackley, M.S.2    O'Brien, T.X.3
  • 142
    • 0037025368 scopus 로고    scopus 로고
    • Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart
    • H. Toko, W. Zhu, E. Takimoto, I. Shiojima, Y. Hiroi, and Y. Zou Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart J Biol Chem 277 2002 24735 24743
    • (2002) J Biol Chem , vol.277 , pp. 24735-24743
    • Toko, H.1    Zhu, W.2    Takimoto, E.3    Shiojima, I.4    Hiroi, Y.5    Zou, Y.6
  • 143
    • 0028294694 scopus 로고
    • XNkx- 2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development
    • K.F. Tonissen, T.A. Drysdale, T.J. Lints, R.P. Harvey, and P.A. Krieg XNkx- 2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development Dev Biol 162 1994 325 328
    • (1994) Dev Biol , vol.162 , pp. 325-328
    • Tonissen, K.F.1    Drysdale, T.A.2    Lints, T.J.3    Harvey, R.P.4    Krieg, P.A.5
  • 144
    • 0029669183 scopus 로고    scopus 로고
    • Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx
    • D. Turbay, S.B. Wechsler, K.M. Blanchard, and S. Izumo Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx Mol Med 2 1996 86 96
    • (1996) Mol Med , vol.2 , pp. 86-96
    • Turbay, D.1    Wechsler, S.B.2    Blanchard, K.M.3    Izumo, S.4
  • 145
    • 0035252105 scopus 로고    scopus 로고
    • Wnt signals from the neural tube block ectopic cardiogenesis
    • E. Tzahor, and A.B. Lassar Wnt signals from the neural tube block ectopic cardiogenesis Genes Dev 15 2001 255 260
    • (2001) Genes Dev , vol.15 , pp. 255-260
    • Tzahor, E.1    Lassar, A.B.2
  • 146
    • 0345060044 scopus 로고    scopus 로고
    • Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis
    • T. Ueyama, H. Kasahara, T. Ishiwata, Q. Nie, and S. Izumo Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis Mol Cell Biol 23 2003 9222 9232
    • (2003) Mol Cell Biol , vol.23 , pp. 9222-9232
    • Ueyama, T.1    Kasahara, H.2    Ishiwata, T.3    Nie, Q.4    Izumo, S.5
  • 147
    • 0041706297 scopus 로고    scopus 로고
    • Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart
    • T. Ueyama, H. Kasahara, T. Ishiwata, N. Yamasaki, and S. Izumo Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart J Biol Chem 278 2003 28750 28757
    • (2003) J Biol Chem , vol.278 , pp. 28750-28757
    • Ueyama, T.1    Kasahara, H.2    Ishiwata, T.3    Yamasaki, N.4    Izumo, S.5
  • 148
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • M.T. Veeman, J.D. Axelrod, and R.T. Moon A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling Dev Cell 5 2003 367 377
    • (2003) Dev Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 150
    • 0036848609 scopus 로고    scopus 로고
    • Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD
    • Y. Watanabe, D.W. Benson, S. Yano, T. Akagi, M. Yoshino, and J.C. Murray Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD J Med Genet 39 2002 807 811
    • (2002) J Med Genet , vol.39 , pp. 807-811
    • Watanabe, Y.1    Benson, D.W.2    Yano, S.3    Akagi, T.4    Yoshino, M.5    Murray, J.C.6
  • 151
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • G. Winnier, M. Blessing, P.A. Labosky, and B.L. Hogan Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse Genes Dev 9 1995 2105 2116
    • (1995) Genes Dev , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 152
    • 0029000929 scopus 로고
    • Heart development in Drosophila requires the segment polarity gene wingless
    • X. Wu, K. Golden, and R. Bodmer Heart development in Drosophila requires the segment polarity gene wingless Dev Biol 169 1995 619 628
    • (1995) Dev Biol , vol.169 , pp. 619-628
    • Wu, X.1    Golden, K.2    Bodmer, R.3
  • 153
    • 0032145411 scopus 로고    scopus 로고
    • Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
    • X. Xu, Z. Yin, J.B. Hudson, E.L. Ferguson, and M. Frasch Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm Genes Dev 12 1998 2354 2370
    • (1998) Genes Dev , vol.12 , pp. 2354-2370
    • Xu, X.1    Yin, Z.2    Hudson, J.B.3    Ferguson, E.L.4    Frasch, M.5
  • 154
    • 0035891429 scopus 로고    scopus 로고
    • The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation
    • H. Yamagishi, C. Yamagishi, O. Nakagawa, R.P. Harvey, E.N. Olson, and D. Srivastava The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation Dev Biol 239 2001 190 203
    • (2001) Dev Biol , vol.239 , pp. 190-203
    • Yamagishi, H.1    Yamagishi, C.2    Nakagawa, O.3    Harvey, R.P.4    Olson, E.N.5    Srivastava, D.6
  • 155
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
    • K. Yamaguchi, K. Shirakabe, H. Shibuya, K. Irie, I. Oishi, and N. Ueno Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction Science 270 1995 2008 2011
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.1    Shirakabe, K.2    Shibuya, H.3    Irie, K.4    Oishi, I.5    Ueno, N.6
  • 156
    • 0029850112 scopus 로고    scopus 로고
    • Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development
    • H. Zhang, and A. Bradley Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development Development 122 1996 2977 2986
    • (1996) Development , vol.122 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 157
    • 0034634624 scopus 로고    scopus 로고
    • Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease
    • W. Zhu, I. Shiojima, Y. Hiroi, Y. Zou, H. Akazawa, and M. Mizukami Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease J Biol Chem 275 2000 35291 35296
    • (2000) J Biol Chem , vol.275 , pp. 35291-35296
    • Zhu, W.1    Shiojima, I.2    Hiroi, Y.3    Zou, Y.4    Akazawa, H.5    Mizukami, M.6
  • 158
    • 0031029447 scopus 로고    scopus 로고
    • CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway
    • Y. Zou, S. Evans, J. Chen, H.C. Kuo, R.P. Harvey, and K.R. Chien CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway Development 124 1997 793 804
    • (1997) Development , vol.124 , pp. 793-804
    • Zou, Y.1    Evans, S.2    Chen, J.3    Kuo, H.C.4    Harvey, R.P.5    Chien, K.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.