Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHAND during murine heart development

Genes and Development

Volumn 11, Issue 11, 1997, Pages 1357-1369

  Biben, Christine ^a   Harvey, Richard P ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

bHLH; dHand; eHand; Heart development; Heart tube; Homeobox; Looping morphogenesis; NK genes; Nkx2 5; Tinman

Indexed keywords

HOMEODOMAIN PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FETUS; GENE CONTROL; HEART DEVELOPMENT; HOMEOBOX; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SITUS INVERSUS;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0030926451     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.11.1357     Document Type: Article

References (69)

1. Bodmer, R. 1993. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118: 719-729.
2. _. 1995. Heart development in Drosophila and its relationship to vertebrates. Trends Cardiovasc. Med. 5: 21-28.
3. Boterenbrood, E.C. and P.D. Nieuwkoop. 1973. The formation of the mesoderm in urodelan amphibians. Part 5: Its regional induction by the endoderm. Wilhelm Roux's Arch. Dev. Biol. 173: 319-332.
4. Bowers, P.N., M. Brueckner, and H.J. Yost. 1996. Laterality disturbances. Prog. Pedintr. Cardiol. 6: 53-62.
5. Burn, J. 1991. Disturbance of morphological laterality in humans. In Biological asymmetry and handedness (ed. G.R. Bock and J. Marsh), pp. 282-299. John Wiley and Sons, New York, NY.
6. Challice, C.E. and S. Viragh. 1973. The architectural development of the early mammalian heart. Tissue Cell 6: 447-462.
7. Chambers, A.E., S. Kotecha, N. Towers, and T.J. Mohun. 1992. Muscle-specific expression of SRF-related genes in the early embryos of Xenopus laevis. Development 118: 1095-1106.
8. Chen, C.Y. and R.J. Schwartz. 1995. Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, Nkx-2.5. J. Biol. Chem. 270: 15628-15633.
9. Chen, J.-N. and M.C. Fishman. 1996. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122: 3809-3816.
10. Cleaver, O.B., K.D. Patterson, and P.A. Krieg. 1996. Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development 122: 3549-3556.
11. Collignon, J., I. Varlet, and E.J. Robertson. 1996. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381: 155-158.
12. Cross, J.C., M.L. Flannery, M.A. Blanar, E. Steingrimsson, N.A. Jenkins, N.G. Copeland, W.J. Rutter, and Z. Werb. 1995. Htx encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development 121: 2513-2523.
13. Cserjesi, P., B. Brown, G.E. Lyons, and E.N. Olson. 1995. Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol. 170: 664-678.
14. de Vries, P.A. and C.M. Saunders. 1962. Development of the ventricles and spiral outflow tract in the human heart. Carnegie Inst. Wash. Contrib. Embryol. 37: 87-114.
15. DeHaan, R.L. 1965. Morphogenesis of the vertebrate heart. In Organogenesis (ed. R.L. DeHaan and H. Ursprung), pp. 377-419. Holt, Rinehart & Winston, New York, NY.
16. DeRuiter, M.C., R.E. Poelmann, I. VanderPlas-de Vries, M.M.T. Mentink, and A.C. Gittenberger-de Groot. 1992. The development of the myocardium and endocardium in mouse embryos. Anat. Embryol. 185: 461-473.
17. Downs, K.M. and T. Davies. 1993. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development 118: 1255-1266.
18. Edmondson, D.G., G.E. Lyons, J.F. Martin, and E.N. Olson. 1994. Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120: 1251-1263.
19. Evans, S., W. Yan, M.P. Murillo, J. Ponce, and N. Papalopulu. 1995. tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second homologue of tinman. Development 121: 3889-3899.
20. Frasch, M. 1995. Induction of visceral and cardiac mesoderm by ectopic Dpp in the early Drosophila embryo. Nature 374: 464-467.
21. Fu, Y. and S. Izumo. 1995. Cardiac myogenesis: Overexpression of XCsx2 or XMEF2A in whole Xenopus embryos induces the precocious expression of XMHCα gene. Roux's Arch. Dev. Biol. 205: 198-202.
22. Gonzalez-Sanchez, A. and D. Bader. 1990. In vitro analysis of cardiac progenitor cell differentiation. Dev. Biol. 139: 197-209.
23. Harvey, R.P. 1996. NK-2 homeobox genes and heart development. Dev. Biol. 178: 203-216.
24. Heikinheimo, M., J.M. Scandrett, and D.B. Wilson. 1994. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev. Biol. 164: 361-373.
25. Hollenberg, S.M., R. Sternglanz, P.F. Cheng, and H. Weintraub. 1995. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two hybrid system. Mol. Cell. Biol. 15: 3813-3822.
26. Hoyle, C., N.A. Brown, and L. Wolpert. 1992. Development of left/right handedness in the chick heart. Development 115: 1071-1078.
27. Hyatt, B.A., J.L. Lohr, and H.J. Yost. 1996. Initiation of vertebrate left-right axis formation by maternal Vgl. Nature 384: 62-65.
28. Icardo, J.M. 1984. The growing heart: An anatomical perspective. In Growth of the heart in health and disease (ed. R. Zak), pp. 41-79. Raven Press, New York, NY.
29. Isaac, A., M.G. Sargent, and J. Cooke. 1997. Control of vertebrate left-right asymmetry by a Snail-related zinc finger gene. Science 275: 1301-1304.
30. Itasaki, N., H. Nakamura, H. Sumida, and M. Yasuda. 1991. Actin bundles on the right side in the caudal part of the heart tube play a role in dextro-looping in the embryonic chick heart. Anat. Embryol. 183: 29-39.
31. Jacobson, A.G. and A.K. Sater. 1988. Features of embryonic induction. Development 104: 341-359.
32. Kaufman, M.H. and V. Navaratnam. 1981. Early differentiation of the heart in mouse embryos. J. Anat. 133: 235-246.
33. Kelly, R., S. Alonso, S. Tajbakhsh, G. Cossu, and M.E. Buckingham. 1995. Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in trasgenic mice J. Cell. Biol. 129: 383-396.
34. Komuro, I. and S. Izumo. 1993. Csx: A murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. 90: 8145-8149.
35. Laverrière, A.C., C. MacNeill, C. Mueller, R.E. Peolmann, J.B.E. Burch, and T. Evans. 1994. GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol. Chem. 269: 23177-23184.
36. Layton, W.M., M.D. Manasek, and D.M.D. Manasek. 1980. Cardiac looping in early iv/iv mouse embryos. In Etiology and morphogenesis of congenital heart disease (ed. R. Van Pragh), pp. 109-126. Futurs, Mount Kisco, NY.
37. Levin, M., R.L. Johnson, C.D. Stern, M. Kuehn, and C. Tabin. 1995. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell 82: 803-814.
38. Lints, T.J., L.M. Parsons, L. Hartley, I. Lyons, and R.P. Harvey. 1993. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119: 419-431.
39. Lowe, L.A., D.M. Supp, K. Sampath, T. Yokoyama, C.V.E. Wright, S.S. Potter, P. Overbeek, and M.R. Kuehn. 1996. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 381: 158-161.
40. Lyons, G.E. 1994. In situ analysis of the cardiac muscle gene program during embryogenesis. Trends Cardiovascular Med. 4: 70-77.
41. Lyons, I., L.M. Parsons, L. Hartley, R. Li, J.E. Andrews, L. Robb, and R.P. Harvey. 1995. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes & Dev. 9: 1654-1666.
42. Manasek, F.J. 1983. Control of early embryonic heart morphogenesis: A hypothesis. Ciba Found. Sym. 100: 4-19.
43. Manasek, F.J., B. Burnside, and R.E. Waterman. 1972. Myocardial cell shape change as a mechanism of embryonic heart looping. Dev. Biol. 29: 349-371.
44. Meno, C., Y. Saijoh, H. Fujii, M. Ikeda, T. Yokoyama, M. Yokoyama, Y. Toyada, and H. Hamada. 1996. Left-right asymmetric expression of the TGFβ-family member lefty in mouse embryos. Nature 381: 151-155.
45. Moessler, H., M. Mericskay, Z. Li, S. Nagl, D. Paulin, and J.V. Small. 1996. The SM 22 promoter directs tissue-specific expression in arterial but not in venous or visceral smooth muscle cells in transgenic mice. Development 122: 2415-2425.
46. Molkentin, J.D., A.B. Firulli, B.L. Black, J.F. Martin, C.M. Hustad, N. Copeland, N. Jenkins, G. Lyons, and E. Olson. 1996. MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol. 16: 3814-3824.
47. Montgomery, M.O., J. Litvin, A. Gonzalez-Sanchez, and D. Bader. 1994. Staging of commitment and differentiation of avian cardiac myocytes. Dev. Biol. 164: 63-71.
48. Nascone, N. and M. Mercola. 1995. An inductive role for the endoderm in Xenopus cardiogenesis. Development 121: 515-523.
49. Orts-Llorca, F. 1970. Curvature of the heart: Its first appearance and determination. Acta Anat. 77: 454-468.
50. Rawles, M.E. 1943. The heart forming area of the chick blastoderm. Physiol. Zool. 16: 22-41.
51. Robb, L., I. Lyons, R. Li, L. Hartley, F. Kontgen, R.P. Harvey, D. Metcalf, and C.G. Begley. 1995. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the Scl gene. Proc. Natl. Acad. Sci. 92: 7075-7079.
52. Rosenquist, G.C. 1966. A radioautographic study of labeled grafts in the chick blastoderm. Development from primitive streak stages to stage 12. Contrib. Embryol. Carnegie Inst. Washington 38: 71-110.
53. Ross, R.S., S. Navankasattusas, R.P. Harvey, and K.R. Chien. 1996. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and establishes an anterior-posterior gradient of expression via an Nkx2-5 independent pathway. Development 122: 1799-1809.
54. Schultheiss, T.M., S. Xydas, and A.B. Lassar. 1995. Induction of avian cardiac myogenesis by anterior endoderm. Development 121: 4203-4214.
55. Schultheiss, T.M., J.B.E. Burch, and A.B. Lassar. 1997. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes &. Dev. 11: 451-462.
56. Seo, J.W., N.A. Brown, S.Y. Ho, and R.H. Anderson. 1992. Abnormal laterality and congenital cardiac abnormalities. Relations of visceral and cardiac morphologies in the iv/iv mouse. Circulation 86: 642-650.
57. Smith, S.M., E.D. Dickman, R.P. Thompson, A.R. Sinning, A.M. Wunsch, and R.R. Markwald. 1997. Retinoic acid directs cardiac laterality and the expression of early markers of precardiac asymmetry. Dev. Biol. 182: 162-171.
58. Srivastava, D., P. Cserjesi, and E.N. Olson. 1995. A subclass of bHLH proteins required for cardiac morphogenesis. Science 270: 1995-1999.
59. Srivastava, D., T. Thomas, Q. Lin, D. Brown, and E.N. Olson. 1997. Regulation of cardiac msoderm and neural crest development by the bHLH transcription factor, dHAND. Nature Genet. (in press).
60. Stalsberg, H. 1969. The origin of heart asymmetry: Right and left contributions to the early chick embryo heart. Dev. Biol. 19: 109-129.
61. _. 1970. Mechanism of dextral looping of the embryonic heart. Am. J. Cardiol. 25: 265-271.
62. Stalsberg, H. and R.L. DeHaan. 1969. The precardiac areas and formation of the tubular heart in the chick. Dev. Biol. 19: 128-159.
63. Sugi, Y. and J. Lough. 1994. Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation in cells from the embryonic heart forming region. Dev. Dyn. 200: 155-162.
64. Tsuda, T., N. Philp, M.H. Zile, and K.K. Linask. 1996. Left-right asymmetric localization of flectin in the extracellular matrix during heart looping. Dev. Biol. 173: 39-50.
65. Wilkinson, D.G. 1992. Whole mount in situ hybridization of vertebrate embryos. In In situ hybridization: A practical approach (ed. D.G. Wilkinson), pp. 75-84. Oxford University Press, Oxford, UK.
66. Yokoyama, T., N.G. Copeland, N.A. Jenkins, C.A. Montgomery, F.F.B. Elder, and P.A. Overbeek. 1993. Reversal of left/ right asymmetry: A situs inversus mutant. Science 260: 679-682.
67. Yost, H.J. 1995. Vertebrate left-right development. Cell 82: 689-692.
68. Zeller, R., K.D. Bloch, R.S. Williams, R.J. Arceci, and C.E. Seidman. 1987. Localized expression of the atrial natriuretic factor gene during cardiac embryogenesis. Genes & Dev. 1: 693-698.
69. Zou, Y., S. Evans, J. Chen, H.-C. Kou, R.P. Harvey, and K.R. Chien. 1997. CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development 124: 793-804.