메뉴 건너뛰기




Volumn 108, Issue 2, 2001, Pages 189-201

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 40; CONNEXIN 43; DNA; HOMEODOMAIN PROTEIN; MUTANT PROTEIN; MYOSIN HEAVY CHAIN; PROTEIN CSX; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG;

EID: 0034947445     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12694     Document Type: Article
Times cited : (136)

References (45)
  • 1
    • 0027282774 scopus 로고
    • The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    • (1993) Development , vol.118 , pp. 719-729
    • Bodmer, R.1
  • 2
    • 0027237596 scopus 로고
    • Tinman and bagpipe: Two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
    • (1993) Genes Dev. , vol.7 , pp. 1325-1340
    • Azpiazu, N.1    Frasch, M.2
  • 7
  • 9
    • 0029972345 scopus 로고    scopus 로고
    • Molecular cloning and characterization of human cardiac homeobox gene CSX1
    • (1996) Circ. Res. , vol.79 , pp. 920-929
    • Shiojima, I.1
  • 10
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • (1998) Science , vol.281 , pp. 108-111
    • Schott, J.J.1
  • 11
    • 0033430230 scopus 로고    scopus 로고
    • Mutations in the cardiac transcription factor Nkx2-5 affect diverse cardiac developmental pathways
    • (1999) J. Clin. Invest. , vol.104 , pp. 1567-1573
    • Benson, W.1
  • 12
    • 0033912859 scopus 로고    scopus 로고
    • Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease
    • (2000) J. Clin. Invest. , vol.106 , pp. 299-308
    • Kasahara, H.1
  • 13
    • 0032380010 scopus 로고    scopus 로고
    • Tinman function is essential for vertebrate heart development: Elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkxc2-5
    • (1998) Dev. Biol. , vol.204 , pp. 187-196
    • Grow, M.W.1    Krieg, P.A.2
  • 14
    • 0035895925 scopus 로고    scopus 로고
    • Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein
    • (2001) J. Biol. Chem. , vol.20 , pp. 4570-4580
    • Kasahara, H.1
  • 26
    • 0032567957 scopus 로고    scopus 로고
    • Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
    • (1998) Curr. Biol. , vol.8 , pp. 299-302
    • Kirchhoff, S.1
  • 30
    • 0032959891 scopus 로고    scopus 로고
    • Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tissue-specifying homeobox gene product Csx/Nkx2.5
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 526-536
    • Kasahara, H.1    Izumo, S.2
  • 33
    • 0030772185 scopus 로고    scopus 로고
    • Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice
    • (1997) J. Clin. Invest. , vol.100 , pp. 1958-1968
    • Colbert, M.C.1
  • 36
    • 0028907907 scopus 로고
    • Cardiac malformation in neonatal mice lacking connexin43
    • (1995) Science , vol.267 , pp. 1831-1834
    • Reaume, A.G.1
  • 37
  • 38
    • 0032562189 scopus 로고    scopus 로고
    • Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: Evidence for chamber-specific molecular determinants of conduction
    • (1998) Circulation , vol.97 , pp. 686-691
    • Thomas, S.A.1
  • 39
    • 0029046714 scopus 로고
    • Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5
    • (1995) J. Biol. Chem. , vol.270 , pp. 15628-15633
    • Chen, C.Y.1    Schwartz, R.J.2
  • 44
    • 0033569865 scopus 로고    scopus 로고
    • Functional role of c-Src in gap junctions of the cardiomyopathic heart
    • (1999) Circ. Res. , vol.85 , pp. 672-681
    • Toyofuku, T.1
  • 45
    • 0035895649 scopus 로고    scopus 로고
    • Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
    • (2001) Circ. Res. , vol.88 , pp. 333-339
    • Gutstein, D.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.