Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002

Experimental Cell Research

Volumn 291, Issue 1, 2003, Pages 56-69

  Naito, Atsuhiko T ^a   Tominaga, Aki ^a   Oyamada, Masahito ^a,c   Oyamada, Yumiko ^a   Shiraishi, Isao ^a   Monzen, Koshiro ^b   Komuro, Issei ^a   Takamatsu, Tetsuro ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Akt; Cardiomyocyte differentiation; Csx Nkx 2.5; GATA 4; LY294002; P19CL6 cells; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CONTRACTILE PROTEIN; MYOSIN HEAVY CHAIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CSX; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; HEART MUSCLE CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SARCOMERE;

EID: 0242270619     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00378-1     Document Type: Article

References (40)

1. Charron F., Nemer M. GATA transcription factors and cardiac development. Semin. Cell Dev. Biol. 10:1999;85-91.
2. Bruneau B.G. Transcriptional regulation of vertebrate cardiac morphogenesis. Circ. Res. 90:2002;509-519.
3. Zaffran S., Frasch M. Early signals in cardiac development. Circ. Res. 91:2002;457-469.
4. Schultheiss T.M., Burch J.B., Lassar A.B. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev. 11:1997;451-462.
5. Alsan B.H., Schultheiss T.M. Regulation of avian cardiogenesis by Fgf8 signaling. Development. 129:2002;1935-1943.
6. Vanhaesebroeck B., Waterfield M.D. Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell Res. 253:1999;239-254.
7. Katso R., Okkenhaug K., Ahmadi K., White S., Timms J., Waterfield M.D. Cellular function of phosphoinositide 3-kinases implications for development, homeostasis, and cancer . Annu. Rev. Cell Dev. Biol. 17:2001;615-675.
8. Cantley L.C. The phosphoinositide 3-kinase pathway. Science. 296:2002;1655-1657.
9. Toker A., Cantley L.C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature. 387:1997;673-676.
10. Kaliman P., Vinals F., Testar X., Palacin M., Zorzano A. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. J. Biol. Chem. 271:1996;19146-19151.
11. Jiang B.H., Zheng J.Z., Vogt P.K. An essential role of phosphatidylinositol 3-kinase in myogenic differentiation. Proc. Natl. Acad. Sci. USA. 95:1998;14179-14183.
12. Tamir Y., Bengal E. Phosphoinositide 3-kinase induces the transcriptional activity of MEF2 proteins during muscle differentiation. J. Biol. Chem. 275:2000;34424-34432.
13. Sakaue H., Ogawa W., Matsumoto M., Kuroda S., Takata M., Sugimoto T., Spiegelman B.M., Kasuga M. Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase. J. Biol. Chem. 273:1998;28945-28952.
14. Xia X., Serrero G. Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors. J. Cell. Physiol. 178:1999;9-16.
15. Ai Z., Misra S., Susa M., Varticovski L., Cohen C.M. Phosphatidylinositol 3-kinase activity in murine erythroleukemia cells during DMSO-induced differentiation. Exp. Cell Res. 219:1995;454-460.
16. Aikawa R., Nawano M., Gu Y., Katagiri H., Asano T., Zhu W., Nagai R., Komuro I. Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation. 102:2000;2873-2879.
17. Shioi T., Kang P.M., Douglas P.S., Hampe J., Yballe C.M., Lawitts J., Cantley L.C., Izumo S. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19:2000;2537-2548.
18. Klinz F., Bloch W., Addicks K., Hescheler J. Inhibition of phosphatidylinositol-3-kinase blocks development of functional embryonic cardiomyocytes. Exp. Cell Res. 247:1999;79-83.
19. Sauer H., Rahimi G., Hescheler J., Wartenberg M. Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells. FEBS Lett. 476:2000;218-223.
20. Habara-Ohkubo A. Differentiation of beating cardiac muscle cells from a derivative of P19 embryonal carcinoma cells. Cell Struct. Funct. 21:1996;101-110.
21. Monzen K., Shiojima I., Hiroi Y., Kudoh S., Oka T., Takimoto E., Hayashi D., Hosoda T., Habara-Ohkubo A., Nakaoka T., Fujita T., Yazaki Y., Komuro I. Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4. Mol. Cell. Biol. 19:1999;7096-7105.
22. Monzen K., Hiroi Y., Kudoh S., Akazawa H., Oka T., Takimoto E., Hayashi D., Hosoda T., Kawabata M., Miyazono K., Ishii S., Yazaki Y., Nagai R., Komuro I. Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J. Cell Biol. 153:2001;687-698.
23. Monzen K., Zhu W., Kasai H., Hiroi Y., Hosoda T., Akazawa H., Zou Y., Hayashi D., Yamazaki T., Nagai R., Komuro I. Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes. Biochem. Biophys. Res. Commun. 298:2002;493-500.
24. Skerjanc I.S. Cardiac and skeletal muscle development in P19 embryonal carcinoma cells. Trends Cardiovasc. Med. 9:1999;139-143.
25. Oyamada Y., Komatsu K., Kimura H., Mori M., Oyamada M. Differential regulation of gap junction protein (connexin) genes during cardiomyocytic differentiation of mouse embryonic stem cells in vitro. Exp. Cell Res. 229:1996;318-326.
26. Thorsteinsdottir S., Roelen B.A., Goumans M.J., Ward-van Oostwaard D., Gaspar A.C., Mummery C.L. Expression of the alpha 6A integrin splice variant in developing mouse embryonic stem cell aggregates and correlation with cardiac muscle differentiation. Differentiation. 64:1999;173-184.
27. Vlahos C.J., Matter W.F., Hui K.Y., Brown R.F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269:1994;5241-5248.
28. Arcaro A., Wymann M.P. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses . Biochem. J. 296:1993;297-301.
29. Alessi D.R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., Hemmings B.A. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15:1996;6541-6551.
30. Andjelkovic M., Maira S.M., Cron P., Parker P.J., Hemmings B.A. Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol. Cell. Biol. 19:1999;5061-5072.
31. Peng C.F., Wei Y., Levsky J.M., McDonald T.V., Childs G., Kitsis R.N. Microarray analysis of global changes in gene expression during cardiac myocyte differentiation. Physiol. Genom. 9:2002;145-155.
32. Monzen K., Nagai R., Komuro I. A role for bone morphogenetic protein signaling in cardiomyocyte differentiation. Trends Cardiovasc. Med. 12:2002;263-269.
33. Ghosh-Choudhury N., Abboud S.L., Nishimura R., Celeste A., Mahimainathan L., Choudhury G.G. Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription. J. Biol. Chem. 277:2002;33361-33368.
34. Jamali M., Rogerson P.J., Wilton S., Skerjanc I.S. Nkx2-5 activity is essential for cardiomyogenesis. J. Biol. Chem. 276:2001;42252-42258.
35. Lien C.L., Wu C., Mercer B., Webb R., Richardson J.A., Olson E.N. Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development. 126:1999;75-84.
36. Gajewski K., Zhang Q., Choi C.Y., Fossett N., Dang A., Kim Y.H., Kim Y., Schulz R.A. Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis. Dev. Biol. 233:2001;425-436.
37. Morisco C., Seta K., Hardt S.E., Lee Y., Vatner S.F., Sadoshima J. Glycogen synthase kinase 3b regulates GATA4 in cardiac myocytes. J. Biol. Chem. 276:2001;28586-28597.
38. Carballada R., Yasuo H., Lemaire P. Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction. Development. 128:2001;35-44.
39. Hidai C., Masako O., Ikeda H., Nagashima H., Matsuoka R., Quertermous T., Kasanuki H., Kokubun S., Kawana M. FGF-1 enhanced cardiogenesis in differentiating embryonal carcinoma cell cultures, which was opposite to the effect of FGF-2. J. Mol. Cell. Cardiol. 35:2003;421-425.
40. Paquin J., Danalache B.A., Jankowski M., McCann S.M., Gutkowska J. Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes. Proc. Natl. Acad. Sci. USA. 99:2002;9550-9555.