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Volumn 204, Issue 1, 1998, Pages 187-196

Tinman function is essential for vertebrate heart development: Elimination of cardiac differentiation by dominant inhibitory mutants of the tinman-related genes, XNkx2-3 and XNkx2-5

Author keywords

Cardiac development; Homeobox; Homeodomain; NK2; Tinman; Xenopus

Indexed keywords

HOMEODOMAIN PROTEIN; MESSENGER RNA;

EID: 0032380010     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1998.9080     Document Type: Article
Times cited : (106)

References (45)
  • 1
    • 0027237596 scopus 로고
    • Tinman and bagpipe: Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila
    • Azpiazu, N., and Frasch, M. (1993). tinman and bagpipe: Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 1, 1325-1340.
    • (1993) Genes Dev. , vol.1 , pp. 1325-1340
    • Azpiazu, N.1    Frasch, M.2
  • 2
    • 0030926451 scopus 로고    scopus 로고
    • Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development
    • Biben, C., and Harvey, R. P. (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 11, 1357-1369.
    • (1997) Genes Dev. , vol.11 , pp. 1357-1369
    • Biben, C.1    Harvey, R.P.2
  • 3
    • 0031959594 scopus 로고    scopus 로고
    • Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart
    • Biben, C., Hatzistavrou, T., and Harvey, R. P. (1998). Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech. Dev. 73, 125-127.
    • (1998) Mech. Dev. , vol.73 , pp. 125-127
    • Biben, C.1    Hatzistavrou, T.2    Harvey, R.P.3
  • 4
    • 0027282774 scopus 로고
    • The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    • Bodmer, R. (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719-729.
    • (1993) Development , vol.118 , pp. 719-729
    • Bodmer, R.1
  • 5
    • 0030915332 scopus 로고    scopus 로고
    • The chicken Nkx2-8 homeobox gene: A novel member of the NK-2 gene family
    • Boettger, T., Stein, S., and Kessel, M. (1997). The chicken Nkx2-8 homeobox gene: A novel member of the NK-2 gene family. Dev. Genes Evol. 207, 65-70.
    • (1997) Dev. Genes Evol. , vol.207 , pp. 65-70
    • Boettger, T.1    Stein, S.2    Kessel, M.3
  • 6
    • 0030746215 scopus 로고    scopus 로고
    • Chicken Nkx2-8, a novel gene expressed during early heart and forgut development
    • Brand, T., Andree, B., Schneider, A., Buchberger, A., and Arnold, H-H. (1997). Chicken Nkx2-8, a novel gene expressed during early heart and forgut development. Mech. Dev. 64, 53-59.
    • (1997) Mech. Dev. , vol.64 , pp. 53-59
    • Brand, T.1    Andree, B.2    Schneider, A.3    Buchberger, A.4    Arnold, H.-H.5
  • 7
    • 0029984771 scopus 로고    scopus 로고
    • Chick Nkx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: Differential expression of cNkx-2.3 and cNkx-2.5 during heart and gut development
    • Buchberger, A., Pabst, O., Brand, T., Seidl, K., and Arnold, H-H. (1996). Chick Nkx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: Differential expression of cNkx-2.3 and cNkx-2.5 during heart and gut development. Mech. Dev. 56, 151-163.
    • (1996) Mech. Dev. , vol.56 , pp. 151-163
    • Buchberger, A.1    Pabst, O.2    Brand, T.3    Seidl, K.4    Arnold, H.-H.5
  • 8
    • 0028260440 scopus 로고
    • The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos
    • Chambers, A. E., Logan, M., Kotecha, S., Towers, N., Sparrow, D., and Mohun, T. J. (1994). The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos. Genes Dev. 8, 1324-1334.
    • (1994) Genes Dev. , vol.8 , pp. 1324-1334
    • Chambers, A.E.1    Logan, M.2    Kotecha, S.3    Towers, N.4    Sparrow, D.5    Mohun, T.J.6
  • 9
    • 0000634381 scopus 로고    scopus 로고
    • Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription
    • Chen, C. Y., and Schwartz, R. J. (1996). Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription. Mol. Cell Biol. 16, 6372-6384.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 6372-6384
    • Chen, C.Y.1    Schwartz, R.J.2
  • 10
    • 0030465318 scopus 로고    scopus 로고
    • Zebrafish tinman homologue demarcates heart field and initiates myocardial differentiation
    • Chen, J-N., and Fishman, M. C. (1996). Zebrafish tinman homologue demarcates heart field and initiates myocardial differentiation. Development 122, 3809-3816.
    • (1996) Development , vol.122 , pp. 3809-3816
    • Chen, J.-N.1    Fishman, M.C.2
  • 11
    • 0029955134 scopus 로고    scopus 로고
    • Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia
    • Cleaver, O. B., Patterson, K. P., and Krieg, P. A. (1996). Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development 122, 3549-3556.
    • (1996) Development , vol.122 , pp. 3549-3556
    • Cleaver, O.B.1    Patterson, K.P.2    Krieg, P.A.3
  • 12
    • 0023107421 scopus 로고
    • Fate map for the 32-cell stage of Xenopus laevis
    • Dale, L., and Slack, J. M. W. (1987). Fate map for the 32-cell stage of Xenopus laevis. Development 99, 527-551.
    • (1987) Development , vol.99 , pp. 527-551
    • Dale, L.1    Slack, J.M.W.2
  • 13
    • 0027996950 scopus 로고
    • Cardiac troponin I is a heart-specific marker in the Xenopus embryo: Expression during abnormal heart morphogenesis
    • Drysdale, T. A., Tonissen, K. F., Patterson, K. D., Crawford, M. J., and Krieg, P. A. (1994). Cardiac troponin I is a heart-specific marker in the Xenopus embryo: Expression during abnormal heart morphogenesis. Dev. Biol. 165, 432-441.
    • (1994) Dev. Biol. , vol.165 , pp. 432-441
    • Drysdale, T.A.1    Tonissen, K.F.2    Patterson, K.D.3    Crawford, M.J.4    Krieg, P.A.5
  • 14
    • 0029779002 scopus 로고    scopus 로고
    • The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium
    • Durocher, D., Chen, C. Y., Ardati, A., Schwartz, R. J., and Nemer, M. (1996). The atrial natriuretic factor promoter is a downstream target for Nkx-2.5 in the myocardium. Mol. Cell. Biol. 16, 4648-4655.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4648-4655
    • Durocher, D.1    Chen, C.Y.2    Ardati, A.3    Schwartz, R.J.4    Nemer, M.5
  • 15
    • 0030799792 scopus 로고    scopus 로고
    • The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
    • Durocher, D., Charron, F., Warren, R., Schwartz, R. J., and Nemer, M. (1997). The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16, 5687-5696.
    • (1997) EMBO J. , vol.16 , pp. 5687-5696
    • Durocher, D.1    Charron, F.2    Warren, R.3    Schwartz, R.J.4    Nemer, M.5
  • 16
    • 0028863326 scopus 로고
    • Tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman
    • Evans, S. M., Yan, W., Murillo, M. P., Ponce, J., and Papalopulu, N. (1995). tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Development 121, 3889-3899.
    • (1995) Development , vol.121 , pp. 3889-3899
    • Evans, S.M.1    Yan, W.2    Murillo, M.P.3    Ponce, J.4    Papalopulu, N.5
  • 17
    • 0031033603 scopus 로고    scopus 로고
    • D-mef-2 is a target for Tinman activation duringDrosophila heart development
    • Gajewski, K., Kim, Y., Lee, Y. M., Olson, E. N., and Shulz, R. A. (1997). D-mef-2 is a target for Tinman activation duringDrosophila heart development. EMBO J. 16, 515-522.
    • (1997) EMBO J. , vol.16 , pp. 515-522
    • Gajewski, K.1    Kim, Y.2    Lee, Y.M.3    Olson, E.N.4    Shulz, R.A.5
  • 18
    • 0028325785 scopus 로고
    • Recognition of a DNA operator by a dimer composed of two different homeodomain proteins
    • Goutte, C., and Johnson, A. D. (1994). Recognition of a DNA operator by a dimer composed of two different homeodomain proteins. EMBO J. 13, 1434-1442.
    • (1994) EMBO J. , vol.13 , pp. 1434-1442
    • Goutte, C.1    Johnson, A.D.2
  • 19
    • 0029000759 scopus 로고
    • Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins
    • Grueneberg, D. A., Simon, K. J., Brennan, K., and Gilman, M. (1995). Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins. Mol. Cell. Biol. 15, 3318-3326.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3318-3326
    • Grueneberg, D.A.1    Simon, K.J.2    Brennan, K.3    Gilman, M.4
  • 20
    • 0026285616 scopus 로고
    • In situ hybridization: An improved whole-mount method for Xenopus embryos
    • Harland, R. M. (1991). In situ hybridization: An improved whole-mount method for Xenopus embryos. Methods Cell Biol. 36, 685-695.
    • (1991) Methods Cell Biol. , vol.36 , pp. 685-695
    • Harland, R.M.1
  • 21
    • 0030587603 scopus 로고    scopus 로고
    • NK-2 homeobox genes and heart development
    • Harvey, R. P. (1996). NK-2 homeobox genes and heart development. Dev. Biol. 178, 203-216.
    • (1996) Dev. Biol. , vol.178 , pp. 203-216
    • Harvey, R.P.1
  • 22
    • 0028905206 scopus 로고
    • Multiallelic recognition: Nonself-dependent dimerization of the bE and bW homeodomain proteins in Ustilago maydis
    • Kamper, J., Reichmann, M., Romeis, T., Bolker, M., and Kahmann, R., (1995). Multiallelic recognition: Nonself-dependent dimerization of the bE and bW homeodomain proteins in Ustilago maydis. Cell 81, 73-83.
    • (1995) Cell , vol.81 , pp. 73-83
    • Kamper, J.1    Reichmann, M.2    Romeis, T.3    Bolker, M.4    Kahmann, R.5
  • 23
    • 0026264917 scopus 로고
    • Injection of oocytes and embryos
    • Kay, B. K. (1991). Injection of oocytes and embryos. Methods Cell Biol. 36, 663-669.
    • (1991) Methods Cell Biol. , vol.36 , pp. 663-669
    • Kay, B.K.1
  • 25
    • 0027184211 scopus 로고
    • Csx: A murine homeobox-containing gene specifically expressed in the developing heart
    • Komuro, I., and Izumo, S. (1993). Csx: A murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. USA 90, 8145-8149.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8145-8149
    • Komuro, I.1    Izumo, S.2
  • 26
    • 0027424656 scopus 로고
    • Neurotrophic activity of the Antennapedia homeodomain depends on its specific DNA-binding properties
    • Le Roux, I., Joliot, A. H., Bloch-Gallego, E., Prochiantz, A., and Volovitch, M. (1993). Neurotrophic activity of the Antennapedia homeodomain depends on its specific DNA-binding properties. Proc. Natl. Acad. Sci. USA 90, 9120-9124.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9120-9124
    • Le Roux, I.1    Joliot, A.H.2    Bloch-Gallego, E.3    Prochiantz, A.4    Volovitch, M.5
  • 27
    • 0030589617 scopus 로고    scopus 로고
    • A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in Zebrafish heart and pharyngeal endoderm
    • Lee, K-H., Xu, Q., and Brietbart, R. E. (1996). A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in Zebrafish heart and pharyngeal endoderm. Dev. Biol. 180, 722-731.
    • (1996) Dev. Biol. , vol.180 , pp. 722-731
    • Lee, K.-H.1    Xu, Q.2    Brietbart, R.E.3
  • 28
    • 0031844382 scopus 로고    scopus 로고
    • The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression
    • Lee, Y., Shioi, T., Kasahara, H., Jobe, S. M., Wiese, R. J., Markham, B. E., and Izumo, S. (1998). The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol. Cell. Biol. 18, 3120-3129.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3120-3129
    • Lee, Y.1    Shioi, T.2    Kasahara, H.3    Jobe, S.M.4    Wiese, R.J.5    Markham, B.E.6    Izumo, S.7
  • 29
    • 0027700251 scopus 로고
    • Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
    • Lints, T., Parsons, L., Hartley, L., Lyons, I., and Harvey, R. (1993). Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.
    • (1993) Development , vol.119 , pp. 419-431
    • Lints, T.1    Parsons, L.2    Hartley, L.3    Lyons, I.4    Harvey, R.5
  • 30
    • 0029054140 scopus 로고
    • Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes
    • Lu, Q., Knoepfler, P. S., Scheele, J., Wright, D. D., and Kamps, M. P. (1995). Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15, 3786-3795.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3786-3795
    • Lu, Q.1    Knoepfler, P.S.2    Scheele, J.3    Wright, D.D.4    Kamps, M.P.5
  • 31
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx-2.5
    • Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L., and Harvey, R. P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx-2.5. Genes Dev. 9, 1654-1666.
    • (1995) Genes Dev. , vol.9 , pp. 1654-1666
    • Lyons, I.1    Parsons, L.M.2    Hartley, L.3    Li, R.4    Andrews, J.E.5    Robb, L.6    Harvey, R.P.7
  • 32
    • 0029740603 scopus 로고    scopus 로고
    • Bmp-4-responsive regulation of dorsal-ventral patterning by homeobox protein Mix.1
    • Mead, P. E., Brivanlou, I. H., Kelley, C. M., and Zon, L. I. (1996). Bmp-4-responsive regulation of dorsal-ventral patterning by homeobox protein Mix.1. Nature 382, 357-360.
    • (1996) Nature , vol.382 , pp. 357-360
    • Mead, P.E.1    Brivanlou, I.H.2    Kelley, C.M.3    Zon, L.I.4
  • 33
    • 0021231377 scopus 로고
    • Cell type-specific activation of actin genes in the early amphibian embryo
    • Mohun, T. J., Brennan, S., Dathan, N., Fairman, S., and Gurdon, J. B. (1984). Cell type-specific activation of actin genes in the early amphibian embryo. Nature 311, 716-721.
    • (1984) Nature , vol.311 , pp. 716-721
    • Mohun, T.J.1    Brennan, S.2    Dathan, N.3    Fairman, S.4    Gurdon, J.B.5
  • 34
    • 0030921213 scopus 로고    scopus 로고
    • The XHex homeobox gene is expressed during development of the vascular endothelium: Overexpression leads to an increase in vascular endothelial cell number
    • Newman, C. S., Chia, F., and Krieg, P. A. (1997). The XHex homeobox gene is expressed during development of the vascular endothelium: Overexpression leads to an increase in vascular endothelial cell number. Mech. Dev. 66, 83-93.
    • (1997) Mech. Dev. , vol.66 , pp. 83-93
    • Newman, C.S.1    Chia, F.2    Krieg, P.A.3
  • 35
    • 0031835362 scopus 로고    scopus 로고
    • Tinman-related genes expressed during heart development in Xenopus
    • Newman, C. S., and Krieg, P. A. (1998). tinman-related genes expressed during heart development in Xenopus. Dev. Genet. 22, 230-238.
    • (1998) Dev. Genet. , vol.22 , pp. 230-238
    • Newman, C.S.1    Krieg, P.A.2
  • 36
    • 0031406027 scopus 로고    scopus 로고
    • Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos
    • Nikolova, M., Chen, X., and Lufkin, T. (1997). Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos. Mech. Dev. 69, 215-218.
    • (1997) Mech. Dev. , vol.69 , pp. 215-218
    • Nikolova, M.1    Chen, X.2    Lufkin, T.3
  • 37
    • 0031812546 scopus 로고    scopus 로고
    • Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm
    • Onichtchouk, D., Glinka, A., and Niehrs, C. (1998). Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm. Development 125, 1447-1456.
    • (1998) Development , vol.125 , pp. 1447-1456
    • Onichtchouk, D.1    Glinka, A.2    Niehrs, C.3
  • 38
    • 0030899175 scopus 로고    scopus 로고
    • The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development
    • Pabst, O., Schneider, A., Brand, T., and Arnold, H-H. (1997). The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. Dev. Dyn. 209, 29-35.
    • (1997) Dev. Dyn. , vol.209 , pp. 29-35
    • Pabst, O.1    Schneider, A.2    Brand, T.3    Arnold, H.-H.4
  • 39
    • 0031571635 scopus 로고    scopus 로고
    • Chicken Nkx2-8: Novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm
    • Reecy, J. M., Yamada, M., Cummings, K., Sosic, D., Chen, C. Y., Eichele, G., Olson, E. N., and Schwartz, R. J. (1997). Chicken Nkx2-8: Novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm. Dev. Biol. 188, 295-311.
    • (1997) Dev. Biol. , vol.188 , pp. 295-311
    • Reecy, J.M.1    Yamada, M.2    Cummings, K.3    Sosic, D.4    Chen, C.Y.5    Eichele, G.6    Olson, E.N.7    Schwartz, R.J.8
  • 41
    • 0029583152 scopus 로고
    • Induction of avian cardiac myogenesis by anterior endoderm
    • Schultheiss, T. M., Xydas, S., and Lassar, A. B. (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121, 4203-4214.
    • (1995) Development , vol.121 , pp. 4203-4214
    • Schultheiss, T.M.1    Xydas, S.2    Lassar, A.B.3
  • 42
    • 0031815073 scopus 로고    scopus 로고
    • GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: Role for regulating early cardiac gene expression
    • Sepulveda, J. L., Belaguli, N., Nigam, V., Chen, C. Y., Nemer, M., and Schwartz, R. J. (1998). GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: Role for regulating early cardiac gene expression. Mol. Cell. Biol. 18, 3405-3415.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3405-3415
    • Sepulveda, J.L.1    Belaguli, N.2    Nigam, V.3    Chen, C.Y.4    Nemer, M.5    Schwartz, R.J.6
  • 43
    • 0028294694 scopus 로고
    • XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development
    • Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P., and Krieg, P. A. (1994). XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development. Dev. Biol. 162, 325-328.
    • (1994) Dev. Biol. , vol.162 , pp. 325-328
    • Tonissen, K.F.1    Drysdale, T.A.2    Lints, T.J.3    Harvey, R.P.4    Krieg, P.A.5
  • 45
    • 0031029447 scopus 로고    scopus 로고
    • CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway
    • Zou, Y., Evans, S., Chen, J., Kuo, H. C., Harvey, R. P., and Chien, K. R. (1997). CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development 124, 793-804.
    • (1997) Development , vol.124 , pp. 793-804
    • Zou, Y.1    Evans, S.2    Chen, J.3    Kuo, H.C.4    Harvey, R.P.5    Chien, K.R.6


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