The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development

Development

Volumn 126, Issue 6, 1999, Pages 1269-1280

  Tanaka, Makoto ^a   Chen, Zhi ^b   Bartunkova, Sonia ^a   Yamasaki, Naohito ^a   Izumo, Seigo ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Cardiac development; Csx Nkx2.5; Gene expression; Heart; Mouse; Transcription factor; Vasculogenesis

Indexed keywords

ATRIAL NATRIURETIC FACTOR; TRANSCRIPTION FACTOR;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEMATOPOIESIS; HOMEOBOX; IN SITU HYBRIDIZATION; MOUSE; MOUSE MUTANT; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; YOLK SAC;

ANIMALS; CARDIOVASCULAR ABNORMALITIES; CHIMERA; CHROMOSOME MAPPING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, ESSENTIAL; GENES, HOMEOBOX; HEART; HEMATOPOIESIS; HOMEODOMAIN PROTEINS; MICE; MICE, MUTANT STRAINS; MORPHOGENESIS; MULTIGENE FAMILY; NEOVASCULARIZATION, PHYSIOLOGIC; TRANSCRIPTION FACTORS; XENOPUS PROTEINS; YOLK SAC;

ANIMALIA; HEXAPODA; VERTEBRATA;

EID: 0032907924     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Azpiazu, N. and Frasch, M. (1993) Tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7, 1325-1340.
2. Biben, C. and Harvey, R. P. (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHAND during murine heart development. Genes Dev. 11, 1357-1369.
3. Bodmer, R. (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719-729.
4. Bodmer, R., Jan, L. Y. and Jan, Y. N. (1990). A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development 110, 661-669.
5. Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F. and Copeland, N. G. (1994) Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8, 1019-1029.
6. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W. and Nagy, A. (1996a). Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-9.
7. Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressens, P., Van Vlaenderen, I., Demunck, H., Kasper, M., Breier, G., Evrard, P., Muller, M., Risau, W., Edgington, T. and Collen, D. (1996b). Role of tissue factor in embryonic blood vessel development. Nature 383, 73-5.
8. Chan-Thomas, P. S., Thompson, R. P., Robert, B., Yacoub, M. H. and Barton, P. J. (1993). Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick. Dev. Dyn. 197, 203-216.
9. Charron, J., Malynn, B. A., Fisher, P., Stewart, V., Jeannotte, L., Goff, S. P., Robertson, E. J. and Alt, F. W. (1992). Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 6, 2248-2257.
10. Chen, C. Y., Croissant, J., Majesky, M., Topouzis, S., McQuinn, T., Frankovsky, M. J. and Schwartz, R. J. (1996). Activation of the cardiac alpha-actin promoter depends upon serum response factor. Tinman homologue, Nkx-2. 5, and intact serum response elements. Dev. Genet. 19, 119-130.
11. Chen, Z., Friedrich, G. A. and Soriano, P. (1994). Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 8, 2293-2301.
12. Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S. and Akhurst, R. J. (1995). Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121, 1845-54.
13. Durocher, D., Charron, F., Warren, R., Schwartz, R. and Nemer, M. (1997). The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16, 5687-5696.
14. Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, K. N. (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251-1263.
15. Eisenberg, L. M. and Markwald, R. R. (1995). Molecular regulation of atrioventricular valvuloseptal morphogenesis. Circ. Res. 77, 1-6.
16. Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell-Braxton, L., Hillan, K. J. and Moore, M. W. (1996). Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-42.
17. Firulli, A., McFadden, D., Lin, Q., Srivastava, D. and Olson, E. (1998) Heart and extra-embryonic mesodermal detects in mouse embryos lacking the bHLH transcription factor HAND1. Nature Genet. 18, 266-270.
18. Gajewski, K., Kim, Y., Lee, Y. M., Olson, E. N. and Schulz, R. A. (1997). D-mef2 is a target for Tinman activation during Drosophila heart development. EMBO J. 16, 515-522.
19. Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R. and Lemke, G. (1995) Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394.
20. George, E. L., Baldwin, H. S. and Hynes, R. O. (1997). Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood 90, 3073-81.
21. Harvey, R. P. (1996). NK-2 homeobox genes and heart development. Dev. Biol. 178, 203-216.
22. Kaufman, M. (1992) The Atlas of Mouse Development. London UK: Academic Press.
23. Komuro, I. and Izumo, S. (1993). Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. USA 90, 8145-8149.
24. Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C. and Leiden, J. M. (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11, 1048-1060.
25. Lee, R. T., Bloch, K. D., Pfeffer, J. M., Pfeffer, M. A., Neer, E. J. and Seidman, C. E. (1988). Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy. J. Clin. Invest. 81, 431-434.
26. Lin, Q., Schwarz, J., Bucana, C. and Olson, E. N. (1997). Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276, 1404-1407.
27. Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P. (1993) Nkx-2. 5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-31.
28. Lyons, G. E. (1996). Vertebrate heart development. Curr. Opin. Genet. Dev. 6, 454-460.
29. Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 9, 1654-1666.
30. Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A. and Simon, M. C. (1997). Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386, 403-7.
31. Miller-Hance, W. C., LaCorbiere, M., Fuller, S. J., Evans, S. M., Lyons, G., Schmidt, C., Robbins, J. and Chien, K. R. (1993). In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. J. Biol. Chem. 268, 25244-25252.
32. Moens, C. B., Stanton, B. R., Parada, L. F. and Rossant, J. (1993). Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development 119, 485-499.
33. Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N. (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11, 1061-1072.
34. Mortensen, R. M., Conner, D. A., Chao, S., Geisterfer-Lowrance, A. A. and Seidman, J. G. (1992). Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell Biol. 12, 2391-2195.
35. Mugrauer, G., Alt, F. and Ekblom, P. (1988). N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J. Cell Biol. 107, 1325-1335.
36. Nagy, A. and Rossant, J. (1993) In Production of Completely ES cell derived fetuses. (ed. A. Joyner) pp. 147-179. New York: IRL Press
37. Olson, E. N. and Srivastava, D. (1996). Molecular pathways controlling heart development. Science, 272, 671-676.
38. Radice, G. L., Rayburn, H., Matsunami, H., Knudsen, K. A., Takeichi, M. and Hynes, R. O. (1997) Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol. 181, 64-78.
39. Riley, P., Anson-Cartwright, L. and Cross, J. (1998). The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nature Genet. 18, 271-275.
40. Rossant, J. (1996). Mouse mutants and cardiac development: new molecular insights into cardiogenesis. Circ. Res. 78, 349-353.
41. Sassoon, D. A., Garner, I. and Buckingham, M. (1988). Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo. Development 104, 155-164.
42. Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W. and Qin, Y. (1995). Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376, 70-74.
43. Schlaeger, T. M., Qin, Y., Fujiwara, Y., Magram, J. and Sato, T. N. (1995). Vascular endothelial cell lineage-specific promoter in transgenic mice. Development 121, 1089-1098.
44. Schott, J.-J., Bensun, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E. and Seidman, J. G. (1998). Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 281, 108-111.
45. Soriano, P. (1997). The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124, 2691-2700.
46. Srivastava, D., Thomas, T., Lin, Q., Kirby, M. L., Brown, D. and Olson, E. N. (1997). Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Genetics 16, 154-160.
47. Stanton, B. R., Perkins, A. S., Tessarollo, L., Sassoon, D. A. and Parada, L. F. (1992). Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 6. 2235-2247.
48. Tanaka, M., Kasahara, H., Bartunkova, S., Schinke, M., Komuro, I., Inagaki, H., Lee, Y., Lyons, G. and Izumo, S. (1998). Vertebrate homologs of tinman and bagpipe. Roles of the homeobox genes in cardiovascular development. Dev. Genet. 22, 239-249.
49. Tybulewicz, V. L., Crawford, C. E., Jackson, P. K., Bronson, R. T. and Mulligan, R. C. (1991). Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163.
50. Winnier, G., Blessing, M., Labosky, P. A. and Hogan, B. L. (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9, 2105-16.
51. Zou, Y., Evans, S., Chen, J., Kuo, H. C., Harvey, R. P. and Chien, K. R. (1997). CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development 124, 793-804.