Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein

Circulation Research

Volumn 82, Issue 9, 1998, Pages 936-946

  Kasahara, Hideko ^a   Bartunkova, Sonia ^a   Schinke, Martina ^a   Tanaka, Makoto ^a   Izumo, Seigo ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cardiac development; Csx; Homeobox gene; Immunohistochemistry; NK 2; Nkx2.5

Indexed keywords

ANIMAL TISSUE; ARTICLE; EMBRYO DEVELOPMENT; GENE TARGETING; GENETIC CONSERVATION; HEART DEVELOPMENT; HEART MUSCLE CELL; HOMEOBOX; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROCESSING;

EID: 0032543267     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.82.9.936     Document Type: Article

References (46)

1. Olson EN, Srivastava D. Molecular pathways controlling heart development. Science. 1996;272:671-676.
2. Lyons GE. Vertebrate heart development. Curr Opin Genet Dev. 1996; 6:454-460.
3. Lin Q, Schwarz J, Bucana C, Olson EN. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997;276:1404-1407.
4. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995;9: 1654-1666.
5. Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11:1048-1060.
6. Molkentin JD, Lin Q, Duncan SA, Oison EN. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997;11:1061-1072.
7. Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development. 1993;118:719-729.
8. Komuro I, Izumo S. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A. 1993;90:8145-8149.
9. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development. 1993;119:419-431.
10. Buchberger A, Pabst O, Brand T, Seidl K, Arnold HH. Chick NKx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development. Mech Dev. 1996;56:151-163.
11. Evans SM, Yan W, Murillo MP, Ponce J, Papalopulu N. tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Development. 1995;121:3889-3899.
12. Lee KH, Xu Q, Breitbart RE. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev Biol. 1996;180:722-731.
13. Reecy IM, Yamada M, Cummings K, Sosic D, Chen C-Y, Eichele G, Olson EN, Schwanz RJ. Chicken Nkx-2.8: a novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm. Dev Biol. 1997;188:295-311.
14. Pabst O, Schneider A, Brand T, Arnold HH. The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. Dev Dyn. 1997;209:29-35.
15. Double D. Guidebook to the Homeobox Genes. New York, NY: Oxford University Press; 1994.
16. Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G. Nucleolar localisation of three Hox homeoproteins. J Cell Sci. 1995;108:187-193.
17. Driever W, Nusslein-Volhard C. A gradient of bicoid protein in Drosophila embryos. Cell. 1988;54:83-93.
18. Driever W, Nusslein-Volhard C. The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo. Nature. 1989;337:138-143.
19. Condie BG, Brivanlou AH, Harland RM. Most of the homeoboxcontaining Xhox 36 transcripts in early Xenopus embryos cannot encode a homeodomain protein. Mol Cell Biol. 1990;10:3376-3385.
20. Lopez AJ, Hogness DS. Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1991;88:9924-9928.
21. Mlodzik M, Gehring WJ. Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell. 1987;48:465-478.
22. Rivera-Pomar R, Niessing D, Schmidt-Ott U, Gehring WJ, Jackle H. RNA binding and translational suppression by bicoid. Nature. 1996;379:746-749.
23. Lazzaro D, Price M, de Felice M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development. 1991;113:1093-1104.
24. Harlow E, Lane D. Antibodies: A Laboratory Manual. New York, NY: Cold Spring Harbor Laboratory; 1988.
25. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
26. Sato TN, Tozawa Y, Deutsch U, Wolburg-Buchholz K, Fujiwara Y, Gendron-Maguire M, Gridley T, Wolburg H, Risau W, Qin Y. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature. 1995;376:70-74.
27. Sadoshima J, Jahn L, Takahashi T, Kulik TJ, Izumo S. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells: an in vitro model of load-induced cardiac hypertrophy. J Biol Chem. 1992;267:10551-10560.
28. Harvey RP. NK-2 homeobox genes and heart development. Dev Biol. 1996;178:203-216.
29. Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R. Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992;8:241-255.
30. Kimura S, Hara Y, Pineau T, Femandez-Salguero P, Fox CH, Ward JM, Gonzalez FJ. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 1996;10:60-69.
31. Sadler T. Longman's Medical Embryology. Baltimore, Md: Williams & Wilkins; 1995.
32. Chen JN, Fishman MC. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development. 1996;122:3809-3816.
33. Tonissen KF, Drysdale TA, Lints TJ, Harvey RP, Krieg PA. XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. Dev Biol. 1994;162:325-328.
34. Schultheiss TM, Xydas S, Lassar AB. Induction of avian cardiac myogenesis by anterior endoderm. Development. 1995;121:4203-4214.
35. Turbay D, Wechsler SB, Blanchard KM, Izumo S. Molecular cloning, chromosomal mapping, and characterization of the human cardiacspecific homeobox gene hCsx. Mol Med. 1996;2:86-96.
36. Shiojima I, Komuro I, Mizuno T, Aikawa R, Akazawa H, Oka T. Yamazaki T, Yazaki Y. Molecular cloning and characterization of human cardiac homeobox gene CSX1. Circ Res. 1996;79:920-929.
37. Larsen W. Human Embryology. New York, NY: Churchill Livingstone Inc; 1993.
38. Mikawa T, Gourdie RG. Perkardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol. 1996;174:221-232.
39. Heikinheimo M, Scandrett JM, Wilson DB. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol. 1994;164:361-373.
40. Firulli AB, Miano JM, Bi W, Johnson AD, Casscells W, Olson EN, Schwarz JJ. Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells: association with the activated phenotype. Circ Res. 1996;78:196-204.
41. Subramanian SV, Nadal-Ginard B. Early expression of the different isoforms of the myocyte enhancer factor-2 (MEF2) protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis. Mech Dev. 1996;57:103-112.
42. Nascone N, Mercola M. Endoderm and cardiogenesis: new insights. Trends Cardiovasc Med. 1996;6:211-216.
43. Dubnau J, Struhl G. RNA recognition and translational regulation by a homeodomain protein. Nature. 1996;379:694-699.
44. Rushbrook JI, Weiss C, Ko K, Feuerman MH, Carleton S, Ing A, Jacoby J. Identification of alpha-cardiac myosin heavy chain mRNA and protein in extraocular muscle of the adult rabbit. J Muscle Res Cell Motil. 1994;15:505-515.
45. Bredman JJ, Wessels A, Weijs WA, Korfage JA, Soffers CA, Moorman AF. Demonstration of 'cardiac-specific' myosin heavy chain in masticatory muscles of human and rabbit. Histochem J. 1991;23:160-170.
46. Rucci L, Gammarota L, Borghi Cirri MB. Carcinoma of the anterior commissure of the larynx, I: embryological and anatomic considerations. Ann Otol Rhinol Laryngol. 1996;105:303-308.