Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer

Development

Volumn 126, Issue 1, 1999, Pages 75-84

  Lien, Ching Ling ^a   Wu, Chuanzhen ^a   Mercer, Brian ^a   Webb, Robert ^b   Richardson, James A ^b   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cardiac lineage; GATA; Mesoderm; Nkx2 5; Transcription

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; EMBRYO DEVELOPMENT; ENHANCER REGION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART DEVELOPMENT; HEART RIGHT VENTRICLE; MESODERM; MOUSE; NONHUMAN; PHARYNX; PRIORITY JOURNAL; STOMACH; THYROID GLAND; TRANSGENE;

ANIMALS; BASE SEQUENCE; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART VENTRICLES; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; MYOCARDIUM; REGULATORY SEQUENCES, NUCLEIC ACID; STOMACH; THYROID GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; XENOPUS PROTEINS;

ANIMALIA; MAMMALIA; MUS MUSCULUS; VERTEBRATA;

EID: 0032937224     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. Andree, B., Duprez D., Vorbusch B., Arnold H. H. and Brand T. (1998). BMP-2 induces ectopic expression of cardiac lineage markers and interferes with somite formation in chicken embryos. Mech. Dev. 70, 119-131.
2. Arceci, R. J., King, A. A. J., Simon, M. C., Orkin, S. H. and Wilson, D. B. (1993). Mouse GATA-4: A retinoic acid-induciblc GATA-binding transcription factor expressed in endodermally-derived tissues and heart. Mol. Cell Biol. 13, 2235-2246.
3. Azpiazu, N. and Frasch, M. (1993). tinman and bagpipe: Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7, 1325-1340.
4. Biben, C. and Harvey, R. P. (1997). Homeodomain factor Nkx2-5 controls left/right asymmetric expression of the bHLH gene eHAND during murine heart development. Genes Dev. 11, 1357-1369.
5. Biben, C., Hatzistavrou, T. and Harvey, R.P. (1998). Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech. Dev. 73, 125-127.
6. Bodmer, R. (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719-729.
7. Bodmer, R. (1995). Heart development in Drosophila and its relationship to vertebrates. Trend Card. Med. 5, 21-28.
8. Bodmer, R., Jan, L.Y., and Jan, Y. N. (1990). A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation in Drosophila. Development 110, 661-669.
9. Brand, T., Andree, B., Schneider, A., Buchberger, A. and Arnold, H.-H. (1997). Chicken Nkx2-8, a novel homeobox gene expressed during early heart and foregut development. Mech. Dev. 64,53-59.
10. Brennan, T. J. and Olson, E. N. (1990). Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization. Genes Dev. 4, 582-595.
11. Buchberger, A., Pabst, O., Brand, T., Seidl, K. and Arnold, H.-H. (1996). Chick Nkx2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx2.3 and cNKx2-5 during heart and gut development. Mech. Dev. 56, 151-163.
12. Chen, J.-N. and Fishman, M. C. (1996). Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122, 3809-3816.
13. Cheng, T. C., Wallace, M. C., Merlie, J. P. and Olson, E. N. (1993). Separable regulatory elements governing myogenin transcription during mouse embryogenesis. Science 261, 215-218.
14. Cleaver, O. B., Patterson, K. D. and Krieg, P. A. (1996). Overexpression of the tinman-related genes XNkx2-5 and XNkx2-3 in Xenopus embryos results in myocardial hyperplasia. Development 122, 3549-3556.
15. Cserjesi, P., Brown, D., Lyons, G. E. and Olson, E. N. (1995). Expression of the novel basic-helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev. Biol. 170, 664-678.
16. Durocher, D., Charron, F., Warren, R., Schwartz, R. J. and Nemer, M. (1997). The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16, 5687-5696.
17. Edmondson, D. G., Lyons, G. E., Martin, J. F. and Olson, E. N. (1994). Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 120, 1251.
18. Evans, S. M., Van, W., Murillo, P. M., Ponce, J. and Papalopulu, N. (1995). tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrtaes: XNkx2.3, a second vertebrate homologue of tinman. Development 121, 3889-3899.
19. Evans, T. (1997). Regulation of cardiac gene expression by GATA-4/5/6. Trend Card. Med. 7, 75-83.
20. Firulli, A. B. and Olson, E. N. (1997). Modular regulation of muscle gene transcription: A mechanism for muscle cell diversity. Trends Genet. 13, 364-369.
21. Firulli, A. B., McFadden, D. G., Lin, Q., Srivastava, D. and Olson, E. N. (1998). Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand 1. Nat. Gen. 18, 266-270.
22. Fishman, M. C. and Chien K. R. (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2117.
23. Fishman, M. C. and Olson, E. N. (1997). Parsing the heart: genetic modules for organ assembly. Cell 91, 153-156.
24. Frasch, M. (1995). Induction of visceral and cardiac mesoderm by ectopic Dpp in the earlyDrosophila embryo. Nature 374, 464-467.
25. Franco, D., Kelly, R., Lamers, W. H., Buckingham, M. and Moorman, A. F. M. (1997). Regionalized transcriptional domains of myosin light chain 3f transgenes in the embryonic mouse heart: morphogenetic implications. Dev. Biol. 188, 17-33.
26. Fu, Y. and Izumo S. (1995). Cardiac myogenesis: overexpression of XCsx2 or XMef2A in whole Xenopus embryos induces the precocious expression of XMHCα gene.Roux's. Arch. Dev. Biol. 205, 198-202.
27. Gajewski, K., Kim, Y., Lee, Y. M., Olson, E. N. and Schulz, R. A. (1997). D-Mef2: A target for tinman activation during Drosophila heart development. EMBO J. 16, 515-522.
28. Grepin, C., Nemer, G. and Nemer, M. (1997). Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 124, 2387-2395.
29. Harvey, R. P. (1996). NK-2 homeobox genes and heart development. Dev. Biol. 178, 203-216.
30. Ip, H. S., Wilson, D. B., Heikinheimo, M., Tang, Z., Ting, C. N., Simon, M. C., Leiden, J. M. and Parmacek, M. S. (1994). The GATA4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in non-muscle cells. Mol. Cell. Biol. 14, 7517-5126.
31. Jiang, Y. and Evans T. (1996). The Xenopus GATA4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol. 174, 258-270.
32. Kasahara, H., Bartunkova, S., Martina, M., Tanaka, M. and Izumo, S. (1997). Cardiac and extracardiae expression of Csx/Nkx2.5 homeodomain protein. Circ Res. 82, 936-946.
33. Kelly, R., Alonso, S., Tajhakhsh, S., Cossu, G. and Buckingham, M. (1995). Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice. J. Cell Biol. 129, 383-396.
34. Ko, L. J. and Engel, J. D. (1993). DNA-binding specificities of the GATA transcription factor family. Mol. Cell Biol. 13, 4011-4022.
35. Komuro, I. and Izumo, S. (1993). Csx: A murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl Acad. Sci. USA 90, 8145-8149.
36. Kothary, R., Clapoff, S., Darling, S., Perry, M. D., Moran, L. A. and Rossant, J. (1989). Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development 105, 707-714.
37. Kuisk, I. R. Li, H., Tran, D. and Capelanaki, Y. (1996). A single MEF2 site governs desmin transcription in both heart and skeletal muscle during mouse embryogenesis. Dev. Biol. 174, 1-13.
38. Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Soudais, C. and Leiden, J. M. (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11, 1048-1060.
39. Laverriere, A. C., NacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B. E. and Evans, T. (1994). GATA-4/5/6: A subfamily of three transcription factors expressed in developing heart and gut. J Biol. Chem. 269,23, 177-23, 184.
40. Lee, K. H, Xu, Q. and Breitbart R. E. (1996). A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol. 180, 722-731.
41. Lee, Y. M., Park, T., Schulz, R. A. and Kim, Y. (1997). Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct clusters of E-box regulatory elements. J. Biol. Chem. 272, 17531-17541.
42. Li, L., Miano, J. M., Mercer B. and Olson, E. N. (1996). Expression of the SM22 α-promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells. J. Cell Biol. 132, 849-859.
43. Lin, Q., Schwarz, J., Bucana, C. and Olson, E. N. (1997). Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276, 1404-1407.
44. Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P. (1993).Nkx2-5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.
45. Lough, J. M., Barron, M., Brogley, M., Sugi, Y., Bolender, D. L. and Zhu, X. L. (1996). Combined BMP-2 and FGF-4. but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. Dev. Biol. 178, 198-202.
46. Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5.Genes Dev. 9, 1654-1666.
47. Merika, M. and Orkin, S. H. (1993). DNA-binding specificity GATA family transcription factors. Mol. Cell Biol. 13, 3999-4010.
48. Moller, W. and Moller, G. (1994). Chemical dehydration for rapid paraffin embedding. Biotechnic & Histochemistry. 69, 289-290.
49. Molkentin, J. D., Kalvakolanu, D. V. and Markham, B. E. (1994). Transcription factor GATA4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol. Cell Biol. 14, 4947-4957.
50. Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N. (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11, 1061-1072.
51. Morrisey, E. E., Ip, H. S., Lu, M. M. and Parmacek, M. S. (1996). GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev. Biol. 177, 309-322.
52. Morissey, E. E., Ip, H. S., Tang, Z., Lu, M. M. and Parmacek, M. S. (1997). GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev. Biol. 182, 21-36.
53. Murphy, A. M., Thompson, W. R., Peng, L. F. and Jones, L. 2nd (1997) Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4. Biochem. J. 322, 393-401.
54. Nascone, N. and Mercola, M. (1996). Endoderm and cardiogenesis: New insights. Trends Card. Med. 6, 211-216
55. Olson, E. N and Srivastava, D. (1996). Molecular pathways controlling heart development. Science 272, 671-676.
56. Park, M., Wu, X., Golden, K., Axelrod, J. D. and Bodmer, R. (1996). The wingless signaling pathway is directly involved in Drosophila heart development. Dev. Biol. 177, 104-116.
57. Ranganayakulu, G., Elliott, D., Harvey, R. and Olson, E. (1998). Divergent roles for Nk-2 class homeobox genes in cardiogenesis in flies and mice. Development 125, 3037-3048.
58. Reecy, J.M., Yamada, M., Cummings, K., Sosic, D., Chen, C.Y., Eichle, G., Olson, E. N. and Schwartz, R.J. (1997). Chicken Nkx2-8: A novel homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm. Dev. Biol. 188, 295-311.
59. Ross, R. S., Navankasattusas, S., Harvey, R. P. and Chien, K. R. (1996). An HF-1a/HF-1b/MEF combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Development 122, 1799-1809.
60. Schultheiss, T. M., Burch, J. B. E. and Lassar, A. B. (1996). A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev. 11, 451-461.
61. Schultheiss, T. M., Xydas, S. and Lassar, A. B. (1995). Induction of avian cardiac myogenesis by anterior endoderm. Development 121, 4203-4214.
62. Searcy, R. D., Vincent, E. B., Liberatore, C. M. and Yutzey, K. E. (1998). A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice. Development 125, 4461-4470.
63. Srivastava, D., Cserjesi, P. and Olson, E. N. (1995). New subclass of bHLH proteins required for cardiac morphogenesis. Science 270, 1995-1999.
64. Staehling-Hampton, K., Laughon, A. and Hoffmann, F. (1995). A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EPl is required for dpp signalling. Development 121, 3393-3403.
65. Sugi, Y., and Lough, J. (1995). Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis in vitro. Dev. Biol. 169, 567-574.
66. Thuerauf, D. J., Hanford, D. S. and Glembotski, C. C. (1994). Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. J. Biol. Chem. 269, 17772-17775.
67. Yin, Z. and Frasch, M. (1998). Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila. Dev. Genet. 22, 187-200.
68. Yin, Z., Xu, X. -L. and Frasch, M. (1997). Regulation of the Twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development 124, 4871-4982.
69. Xu, X., Yin, Z., Hudson, J. B., Ferguson, E. L. and Frasch, M. (1998). Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 12, 2354-2370.
70. Wu, X., Golden K. and Bodmer R. (1995). Heart development in Drosophila requires the segment polarity gene wingless. Dev. Biol. 169, 619-628.