Molecular cloning and characterization of human cardiac homeobox gene CSX1

Circulation Research

Volumn 79, Issue 5, 1996, Pages 920-929

  Shiojima, Ichiro ^a   Komuro, Issei ^a   Mizuno, Takehiko ^a   Aikawa, Ryuichi ^a   Akazawa, Hiroshi ^a   Oka, Toru ^a   Yamazaki, Tsutomu ^a   Yazaki, Yoshio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

alternative splicing; cardiac development; cardiac specific gene expression; evolution; transcription factor

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL DIFFERENTIATION; DROSOPHILA; EVOLUTION; GENE EXPRESSION REGULATION; GROWTH REGULATION; HEART DEVELOPMENT; HOMEOBOX; HUMAN; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

EID: 0029972345     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.79.5.920     Document Type: Article

References (51)

1. Scott MP, Tamkun JW, Hartzell GW. The structure and function of the homeodomain. Biochem Biophys Acta. 1989;989:25-48.
2. Gehring WJ, Qian YQ, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, Affolter M, Otting G, Wuthrich K. Homeodomain-DNA recognition. Cell. 1994;78:211-223.
3. Hayashi S, Scott M. What determines the specificity of action of Drosophila homeodomain proteins? Cell. 1990;63:883-894.
4. Lawrence PA, Morata G. Homeobox genes: their function in Drosophila segmentation and pattern formation. Cell. 1994;78:181-189.
5. Krumlauf R. Hox genes in vertebrate development. Cell 1994; 78:191-201.
6. Duboule D, Dolle P. The structure and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 1989;8:1497-1505.
7. Graham A, Papalopulu N, Krumlauf R. The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell. 1989;57:367-378.
8. Malicki J, Schughart K, McGinnis W. Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell. 1990;63:961-967.
9. McGinnis N, Kuziora MA, McGinnis W. Human Hox-4.2 and Drosophila Deformed encode similar regulatory specificities in Drosophila embryos and larvae. Cell 1990;63:969-976.
10. Chisaka O, Capecchi M. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-l.5. Nature. 1991;350:473-479.
11. Lufkin T, Dierich A, LeMeur M, Mark M, Chambon P. Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostal domain of expression. Cell. 1991;66: 1105-1119.
12. Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell K, Turner D, Rupp R, Hollenberg S, Zhuang Y, Lassar A. The MyoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991;251:761-766.
13. Olson EN. Regulation of muscle transcription by the MyoD family: the heart of the matter. Circ Res. 1993;72:1-6.
14. Ingraham HA, Chen R, Mangalam HJ, Elsholtz HP, Flynn SE, Lin CR, Simmons DM, Swanson L, Rosenfeld MG. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Cell 1988;55:519-529.
15. Guazzi S, Price M, De Felce M, Damante G, Mattei MG, Di Lauro R. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 1990;9: 3631-3639.
16. Lazzaro D, Price M, De Felce M, Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the forebrain. Development. 1991; 113:1093-1104.
17. Komuro I, Schalling M, Jahn L, Bodmer R, Jenkins NA, Copeland N, Izumo S. Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional represser activity in vitro for a serum-inducible promoter. EMBO J. 1993;12:1387-1401.
18. Castrillo JL, Theill LE, Karin M. Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science. 1991;253:197-199.
19. Bodmer R, Jan LY, Jan YN. A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development. 1990;110:661-669.
20. Azpiazu N, Frasch M. tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 1993;7:1325-1340.
21. Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development. 1993; 118:719-729.
22. Komuro I, Izumo S. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci U S A. 1993;90:8145-8149.
23. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP. Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development. 1993;119: 419-431.
24. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995;9:1654-1666.
25. Heikinheimo M, Scandrett JM, Wilson DB. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development, Dev Biol. 1994;164:361-373.
26. Edmondson DG, Lyons GE, Martin JF, Olson EN. Mef2 gene expression marks the cardiac and skeletal muscle lineage during mouse embryogenesis. Development. 1994; 120: 1251-1263.
27. +-proton exchanger. Circ Res. 1995;76:148-153.
28. Civitareale D, Lonigro R, Sinclair A, Di Lauro R. A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J. 1989;8:2537-2542.
29. Nordeen SK. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques. 1989;6:454-458.
30. Chen C, Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Moll Cell Biol. 1987;7:2745-2752.
31. Kozak M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 1987;15:8125-8148.
32. Shaw G, Kamen R. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986;46:659-667.
33. Proudfoot N. Poy(A) signals. Cell. 1991;64:671-674.
34. Tonissen KF, Drysdale TA, Lints TJ, Harvey RP, Kreig PA. XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. Dev Biol. 1993;162: 325-328.
35. Evans MS, Yan W, Murillo MP, Ponce J, Papalopulu N. tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homolog of tinman. Development. 1995;121:3889-3899.
36. Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R. Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992; 8:241-255.
37. Bodmer R. Heart development in Drosophila and its relationship to vertebrates. Trends Cardiovasc Med. 1995;5:21-28.
38. Chen CY, Schwartz RJ. Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J Biol Chem. 1995;270:15628-15633.
39. Kim Y, Nirenberg M, Drosophila NK-homeobox genes. Proc Natl Acad Sci U S A. 1989;86:7716-7720.
40. Shiojima I, Komuro I, Inazawa J, Nakahori Y, Matsumura I, Abe T, Nagai R, Yazaki Y. Assignment of cardiac homeobox gene CSX to human chromosome 5q34. Genomics. 1995;27:204-206.
41. Kumar D, Heath PR, Blank CE. Clinical manifestations of trisomy 5q. J Med Genet 1987;24:180-184.
42. Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E. The human HOX gene family. Nucleic Acids Res. 1989;17:10385-10402.
43. Berleth T, Burri M, Gudrun T, Bopp D, Richstein S, Frigerio G, Noll M, Nusslein-Volhard C. The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo. EMBO J. 1988;7:1749-1756.
44. Wright CVE, Cho KWY, Fritz A, Burglin TR, E. M. Robertis EM. A Xenopus laevis gene encodes both homeobox-containing and homeobox-less transcripts. EMBO J. 1987;6:4083-4094.
45. Condie BG, Brivanlou AH, Harland RM. Most of the homeobox-containing Xhox 36 transcripts in early Xenopus embryos cannot encode a homeodomain protein. Moll Cell Biol. 1990;10:3376-3385.
46. Larosa GJ, Gudas LJ. Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: alternative splicing creates transcripts for a homeobox-containing protein and one lacking the homeobox. Mol Cell Biol. 1988;8:3906-3917.
47. Chan SK, Jaffe L, Capovilla M, Botas J, Mann RS. The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell. 1994;78:603-615.
48. van Dijk MA, Murre C. extradenticle raises the DNA binding specificity of homeotic selector gene product. Cell. 1994;78:617-624.
49. Ananthan J, Bader R, Morrissey D, Zuo J, Lan Y, Weir M, Voellmy R. Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu hemeoprotein and can occur without DNA binding by the protein. Mol Cell Biol. 1993;13: 1599-1609.
50. Copeland JWR, Nasiadka A, Dietrich BH, Krause HM. Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide. Nature. 1996;379:162-165.
51. Molkentin JD, Black BL, Martin JF, Olson EN. Cooperative activation of muscle specific gene expression by MEF2 and myogenic bHLH proteins. Cell. 1995;83:1125-1136.