-
1
-
-
0030058657
-
The repertoire of T cells shaped by a single MHC/peptide ligand
-
Ignatowicz, L., Kappler, J. & Marrack, P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84, 521-529 (1996).
-
(1996)
Cell
, vol.84
, pp. 521-529
-
-
Ignatowicz, L.1
Kappler, J.2
Marrack, P.3
-
2
-
-
0030935007
-
The MHC reactivity of the T cell repertoire prior to positive and negative selection
-
Zerrahn, J., Held, W. & Raulet, D. H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88, 627-636 (1997).
-
(1997)
Cell
, vol.88
, pp. 627-636
-
-
Zerrahn, J.1
Held, W.2
Raulet, D.H.3
-
3
-
-
0029835390
-
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
-
Laufer, T. M., DeKoning, J., Markowitz, J. S., Lo, D. & Glimcher, L. H. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383, 81-85 (1996).
-
(1996)
Nature
, vol.383
, pp. 81-85
-
-
Laufer, T.M.1
DeKoning, J.2
Markowitz, J.S.3
Lo, D.4
Glimcher, L.H.5
-
4
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
Wardemann, H. et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003).
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
-
5
-
-
0031240055
-
Epidemiology and estimated population burden of selected autoimmune diseases in the United States
-
Jacobson, D. L., Gange, S. J., Rose, N. R. & Graham, N. M. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin. Immunol. Immumpathol. 84, 223-243 (1997).
-
(1997)
Clin. Immunol. Immumpathol.
, vol.84
, pp. 223-243
-
-
Jacobson, D.L.1
Gange, S.J.2
Rose, N.R.3
Graham, N.M.4
-
6
-
-
0037375554
-
Antigen receptor selection by editing or downregulation of V(D)J recombination
-
Nemazee, D. & Hogquist, K. A. Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr. Opin. Immunol. 15, 182-189 (2003).
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 182-189
-
-
Nemazee, D.1
Hogquist, K.A.2
-
7
-
-
0031897046
-
Positive versus negative signaling by lymphocyte antigen receptors
-
Healy, J. I. & Goodnow, C. C. Positive versus negative signaling by lymphocyte antigen receptors. Annu. Rev. Immunol. 16, 645-670 (1998).
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 645-670
-
-
Healy, J.I.1
Goodnow, C.C.2
-
9
-
-
0034210015
-
Self-tolerance: Context-dependent tuning of T cell antigen recognition
-
Grossman, Z. & Paul, W. E. Self-tolerance: context-dependent tuning of T cell antigen recognition. Semin. Immunol. 12, 197-203 (2000).
-
(2000)
Semin. Immunol.
, vol.12
, pp. 197-203
-
-
Grossman, Z.1
Paul, W.E.2
-
10
-
-
0027447188
-
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
-
Hartley, S. B. et al. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72, 325-335 (1993).
-
(1993)
Cell
, vol.72
, pp. 325-335
-
-
Hartley, S.B.1
-
11
-
-
0242407710
-
The regulation of lupus-associated autoantibodies: Immunoglobulin transgenic models
-
Fields, M. L. & Erikson, J. The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models. Curr. Opin. Immunol. 15, 709-717 (2003).
-
(2003)
Curr. Opin. Immunol.
, vol.15
, pp. 709-717
-
-
Fields, M.L.1
Erikson, J.2
-
12
-
-
0038692705
-
BAFF and APRIL: A tutorial on B cell survival
-
Mackay, F., Schneider, P., Rennert, P. & Browning, J. BAFF and APRIL: a tutorial on B cell survival. Annu. Rev. Immunol. 21, 231-264 (2003).
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 231-264
-
-
Mackay, F.1
Schneider, P.2
Rennert, P.3
Browning, J.4
-
13
-
-
2542485540
-
RAGs and regulation of autoantibodies
-
Jankovic, M., Casellas, R., Yannoutsos, N., Wardemann, H. & Nussenzweig, M. C. RAGs and regulation of autoantibodies. Annu. Rev. Immunol. 22, 485-501 (2004).
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 485-501
-
-
Jankovic, M.1
Casellas, R.2
Yannoutsos, N.3
Wardemann, H.4
Nussenzweig, M.C.5
-
14
-
-
0037496129
-
The control of apoptosis in lymphocyte selection
-
Strasser, A. & Bouillet, P. The control of apoptosis in lymphocyte selection. Immunol. Rev. 193, 82-92 (2003).
-
(2003)
Immunol. Rev.
, vol.193
, pp. 82-92
-
-
Strasser, A.1
Bouillet, P.2
-
15
-
-
0031468121
-
Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells
-
Akkaraju, S., Canaan, K. & Goodnow, C. C. Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells. J. Exp. Med. 186, 2005-2012 (1997).
-
(1997)
J. Exp. Med.
, vol.186
, pp. 2005-2012
-
-
Akkaraju, S.1
Canaan, K.2
Goodnow, C.C.3
-
16
-
-
0038725685
-
Negative selection - Clearing out the bad apples from the T-cell repertoire
-
Palmer, E. Negative selection - clearing out the bad apples from the T-cell repertoire. Nature Rev. Immunol. 3, 383-391 (2003).
-
(2003)
Nature Rev. Immunol.
, vol.3
, pp. 383-391
-
-
Palmer, E.1
-
17
-
-
0037089616
-
Perinatal blockade of B7-1 and B7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells
-
Gao, J. X. et al. Perinatal blockade of B7-1 and B7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. J. Exp. Med. 195, 959-971 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 959-971
-
-
Gao, J.X.1
-
18
-
-
0032539536
-
Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reaction
-
Kanagawa, O., Martin, S. M., Vaupel, B. A., Carrasco-Marin, E.& Unanue, E. R. Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. Proc. Natl Acad Sci. USA 95, 1721-1724 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1721-1724
-
-
Kanagawa, O.1
Martin, S.M.2
Vaupel, B.A.3
Carrasco-Marin, E.4
Unanue, E.R.5
-
19
-
-
0028922437
-
Genetic control of autoimmune diabetes in the NOD mouse
-
Wicker, L. S., Todd, J. A. & Peterson, L. B. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13, 179-200 (1995).
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 179-200
-
-
Wicker, L.S.1
Todd, J.A.2
Peterson, L.B.3
-
20
-
-
17944376135
-
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice
-
Salomon, B. et al. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J. Exp. Med. 194, 677-684 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 677-684
-
-
Salomon, B.1
-
21
-
-
16944367194
-
Positional cloning of the APECED gene
-
Nagamine, K. et al. Positional cloning of the APECED gene. Nature Genet. 17, 393-398 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 393-398
-
-
Nagamine, K.1
-
22
-
-
0346599403
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
-
Aaltonen, J. et al. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nature Genet. 17, 399-403 (1997).
-
(1997)
Nature Genet.
, vol.17
, pp. 399-403
-
-
Aaltonen, J.1
-
23
-
-
0037084784
-
Aire-deficient mice develop multiple features of APECED phenotype and show altered immune response
-
Ramsey, C. et al. Aire-deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum. Mol. Genet. 11, 397-409 (2002).
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 397-409
-
-
Ramsey, C.1
-
24
-
-
0037112047
-
Projection of an immunological self-shadow within the thymus by the Aire protein
-
Anderson, M. S. et al. Projection of an immunological self-shadow within the thymus by the Aire protein. Science 298, 1395-1403 (2002).
-
(2002)
Science
, vol.298
, pp. 1395-1403
-
-
Anderson, M.S.1
-
25
-
-
0037383758
-
Aire regulates negative selection of organ-specific T cells
-
Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C. C. Aire regulates negative selection of organ-specific T cells. Nature Immunol. 4, 350-354 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 350-354
-
-
Liston, A.1
Lesage, S.2
Wilson, J.3
Peltonen, L.4
Goodnow, C.C.5
-
26
-
-
7244227646
-
Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
-
Liston, A. et al. Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity J. Exp. Med. 200, 1015-1026 (2004).
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1015-1026
-
-
Liston, A.1
-
27
-
-
0032401760
-
Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
-
Hanahan, D. Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. Curr. Opin. Immunol. 10, 656-662 (1998).
-
(1998)
Curr. Opin. Immunol.
, vol.10
, pp. 656-662
-
-
Hanahan, D.1
-
28
-
-
18244421874
-
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
-
Pugliese, A. et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nature Genet. 15, 293-297 (1997).
-
(1997)
Nature Genet.
, vol.15
, pp. 293-297
-
-
Pugliese, A.1
-
29
-
-
0031018819
-
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
-
Vafiadis, P. et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nature Genet. 15, 289-292 (1997).
-
(1997)
Nature Genet.
, vol.15
, pp. 289-292
-
-
Vafiadis, P.1
-
30
-
-
0037855934
-
Scenarios for autoimmunization of T and B cells in myasthenia gravis
-
Shiono, H. et al. Scenarios for autoimmunization of T and B cells in myasthenia gravis. Ann. NY Acad. Sci. 998, 237-256 (2003).
-
(2003)
Ann. NY Acad. Sci.
, vol.998
, pp. 237-256
-
-
Shiono, H.1
-
31
-
-
0345414139
-
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
-
Sakaguchi, N. et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 426, 454-460 (2003).
-
(2003)
Nature
, vol.426
, pp. 454-460
-
-
Sakaguchi, N.1
-
32
-
-
0035229933
-
Disruption of T cell signaling networks and development by Grb2 haploid insufficiency
-
Gong, Q. et al. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nature Immunol. 2, 29-36 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 29-36
-
-
Gong, Q.1
-
33
-
-
12344298492
-
Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes
-
McCarty, N. et al. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nature Immunol. 6, 65-72 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 65-72
-
-
McCarty, N.1
-
34
-
-
0036794390
-
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
-
Rathmell, J. C., Lindsten, T., Zong, W. X., Cinalli, R. M. & Thompson, C. B. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature Immunol. 3, 932-939 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 932-939
-
-
Rathmell, J.C.1
Lindsten, T.2
Zong, W.X.3
Cinalli, R.M.4
Thompson, C.B.5
-
35
-
-
0029914914
-
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
-
Zhou, T. et al. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells. J. Exp. Med. 183, 1879-1892 (1996).
-
(1996)
J. Exp. Med.
, vol.183
, pp. 1879-1892
-
-
Zhou, T.1
-
36
-
-
10344231974
-
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
-
Liston, A. et al. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity 21, 817-830 (2004).
-
(2004)
Immunity
, vol.21
, pp. 817-830
-
-
Liston, A.1
-
37
-
-
0035175577
-
A defect in central tolerance in NOD mice
-
Kishimoto, H. & Sprent, J. A defect in central tolerance in NOD mice. Nature Immunol. 2, 1025-1031 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 1025-1031
-
-
Kishimoto, H.1
Sprent, J.2
-
38
-
-
0037020857
-
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes
-
Lesage, S. et al. Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J. Exp. Med. 196, 1175-1188 (2002).
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1175-1188
-
-
Lesage, S.1
-
39
-
-
4644327995
-
Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience
-
Choisy-Rossi, C. M., Holl, T. M., Pierce, M. A., Chapman, H. D. & Serreze, D. V. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J. Immunol. 173, 3791-3800 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 3791-3800
-
-
Choisy-Rossi, C.M.1
Holl, T.M.2
Pierce, M.A.3
Chapman, H.D.4
Serreze, D.V.5
-
40
-
-
0036679733
-
It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation
-
Kane, L. P., Lin, J. & Weiss, A. It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends Immunol. 23, 413-420 (2002).
-
(2002)
Trends Immunol.
, vol.23
, pp. 413-420
-
-
Kane, L.P.1
Lin, J.2
Weiss, A.3
-
41
-
-
0036630358
-
The thymus and negative selection
-
Sprent, J. & Kishimoto, H. The thymus and negative selection. Immunol. Rev. 185, 126-135 (2002).
-
(2002)
Immunol. Rev.
, vol.185
, pp. 126-135
-
-
Sprent, J.1
Kishimoto, H.2
-
42
-
-
2342458871
-
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
-
Villunger, A. et al. Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc. Natl Acad. Sci. USA 101, 7052-7057 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7052-7057
-
-
Villunger, A.1
-
43
-
-
0031746760
-
Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: A lesson from the mouse model
-
Nagata, S. Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model. J. Hum. Genet. 43, 2-8 (1998).
-
(1998)
J. Hum. Genet.
, vol.43
, pp. 2-8
-
-
Nagata, S.1
-
44
-
-
0035129651
-
Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive
-
Benschop, R. J. et al. Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity 14, 33-43 (2001).
-
(2001)
Immunity
, vol.14
, pp. 33-43
-
-
Benschop, R.J.1
-
45
-
-
0028157607
-
A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes
-
Bell, S. E. & Goodnow, C. C. A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes. EMBO J. 13, 816-826 (1994).
-
(1994)
EMBO J.
, vol.13
, pp. 816-826
-
-
Bell, S.E.1
Goodnow, C.C.2
-
46
-
-
1842633887
-
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
-
Lesley, R. et al. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 20, 441-453 (2004).
-
(2004)
Immunity
, vol.20
, pp. 441-453
-
-
Lesley, R.1
-
47
-
-
0037501347
-
Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
-
Rui, L., Vinuesa, C. G., Blasioli, J. & Goodnow, C. C. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nature Immunol. 4, 594-600 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 594-600
-
-
Rui, L.1
Vinuesa, C.G.2
Blasioli, J.3
Goodnow, C.C.4
-
48
-
-
0034613151
-
Immune inhibitory receptors
-
Ravetch, J. V. & Lanier, L. L. Immune inhibitory receptors. Science 290, 84-89 (2000).
-
(2000)
Science
, vol.290
, pp. 84-89
-
-
Ravetch, J.V.1
Lanier, L.L.2
-
49
-
-
0034610978
-
CD5 maintains tolerance in anergic B cells
-
Hippen, K. L., Tze, L. E. & Behrens, T. W. CD5 maintains tolerance in anergic B cells. J. Exp. Med. 191, 883-890 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 883-890
-
-
Hippen, K.L.1
Tze, L.E.2
Behrens, T.W.3
-
50
-
-
0035927093
-
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands
-
Wong, P., Barton, G. M., Forbush, K. A. & Rudensky, A. Y. Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands J. Exp. Med. 193, 1179-1187 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 1179-1187
-
-
Wong, P.1
Barton, G.M.2
Forbush, K.A.3
Rudensky, A.Y.4
-
51
-
-
0035168144
-
Sensory adaptation in naive peripheral CD4 T cells
-
Smith, K. et al. Sensory adaptation in naive peripheral CD4 T cells. J. Exp. Med. 194, 1253-1261 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1253-1261
-
-
Smith, K.1
-
53
-
-
0036360019
-
The enemy within: Keeping self-reactive T cells at bay in the periphery
-
Walker, L. S. & Abbas, A. K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nature Rev. Immunol. 2, 11-19 (2002).
-
(2002)
Nature Rev. Immunol.
, vol.2
, pp. 11-19
-
-
Walker, L.S.1
Abbas, A.K.2
-
54
-
-
10344261513
-
+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance
-
+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance. J. Immunol. 173, 7239-7248 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 7239-7248
-
-
Inobe, M.1
Schwartz, R.H.2
-
55
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
Ueda, H. et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423, 506-511 (2003).
-
(2003)
Nature
, vol.423
, pp. 506-511
-
-
Ueda, H.1
-
56
-
-
12144290293
-
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
-
Heissmeyer, V. et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nature Immunol. 5, 255-265 (2004)
-
(2004)
Nature Immunol.
, vol.5
, pp. 255-265
-
-
Heissmeyer, V.1
-
58
-
-
4143137360
-
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
-
Jeon, M. S. et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21, 167-177 (2004).
-
(2004)
Immunity
, vol.21
, pp. 167-177
-
-
Jeon, M.S.1
-
59
-
-
0036911112
-
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation
-
Naramura, M. et al. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nature Immunol. 3, 1192-1199 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 1192-1199
-
-
Naramura, M.1
-
60
-
-
2542501657
-
Ubiquitin ligases and the immune response
-
Liu, Y. C. Ubiquitin ligases and the immune response. Annu. Rev. Immunol. 22, 81-127 (2004).
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 81-127
-
-
Liu, Y.C.1
-
61
-
-
0036699521
-
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
-
Yokoi, N. et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nature Genet. 31, 391-394 (2002).
-
(2002)
Nature Genet.
, vol.31
, pp. 391-394
-
-
Yokoi, N.1
-
62
-
-
0028064578
-
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
-
Cyster, J. G., Hartley, S. B. & Goodnow, C. C. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371, 389-395 (1994).
-
(1994)
Nature
, vol.371
, pp. 389-395
-
-
Cyster, J.G.1
Hartley, S.B.2
Goodnow, C.C.3
-
63
-
-
2942518502
-
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
-
Thien, M. et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 20, 785-798 (2004).
-
(2004)
Immunity
, vol.20
, pp. 785-798
-
-
Thien, M.1
-
64
-
-
0036794398
-
BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells
-
Claudio, E., Brown, K., Park, S., Wang, H. & Siebenlist, U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nature Immunol. 3, 958-965 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 958-965
-
-
Claudio, E.1
Brown, K.2
Park, S.3
Wang, H.4
Siebenlist, U.5
-
65
-
-
0036697292
-
Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1
-
Xu, L. G., Wu, M., Hu, J., Zhai, Z. & Shu, H. B. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J. Leukoc. Biol. 72, 410-416 (2002).
-
(2002)
J. Leukoc. Biol.
, vol.72
, pp. 410-416
-
-
Xu, L.G.1
Wu, M.2
Hu, J.3
Zhai, Z.4
Shu, H.B.5
-
66
-
-
0042626302
-
Theserine/threonine kinase Pim-2 isatranscriptionally regulated apoptotic inhibitor
-
Fox, C. J. et al. Theserine/threonine kinase Pim-2 isatranscriptionally regulated apoptotic inhibitor. Genes Dev. 17, 1841-1854 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 1841-1854
-
-
Fox, C.J.1
-
69
-
-
0037450727
-
T cell regulation as a side effect of homeostasis and competition
-
Barthlott, T., Kassiotis, G. & Stockinger, B. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197, 451-460 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 451-460
-
-
Barthlott, T.1
Kassiotis, G.2
Stockinger, B.3
-
70
-
-
3242881686
-
Artemis sheds new light on V(D)J recombination
-
Le Deist, F., Poinsignon, C., Moshous, D., Fischer, A. & de Villartay, J. P. Artemis sheds new light on V(D)J recombination. Immunol. Rev. 200, 142-155 (2004).
-
(2004)
Immunol. Rev.
, vol.200
, pp. 142-155
-
-
Le Deist, F.1
Poinsignon, C.2
Moshous, D.3
Fischer, A.4
De Villartay, J.P.5
-
71
-
-
0037736679
-
Autoimmunity in Wiskott-Aldrich syndrome: Risk factors, clinical features, and outcome in a single-center cohort of 55 patients
-
Dupuis-Girod, S. et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics 111, e622-e627 (2003).
-
(2003)
Pediatrics
, vol.111
-
-
Dupuis-Girod, S.1
-
72
-
-
0033552391
-
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiplesclerosis
-
Coles, A. J. et al. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiplesclerosis. Lancet 354, 1691-1695 (1999).
-
(1999)
Lancet
, vol.354
, pp. 1691-1695
-
-
Coles, A.J.1
-
73
-
-
0036062788
-
Lymphopenia in the BB rat model of type 1 diabetes is dueto a mutation in a novel immune-associated nucleotide (lan)-related gene
-
MacMurray, A. J. et al. Lymphopenia in the BB rat model of type 1 diabetes is dueto a mutation in a novel immune-associated nucleotide (lan)-related gene. Genome Res. 12, 1029-1039 (2002).
-
(2002)
Genome Res.
, vol.12
, pp. 1029-1039
-
-
MacMurray, A.J.1
-
74
-
-
0036263450
-
The diabetes-prone BB rat carries a frameshift mutation in lan4, a positional candidate of lddm1
-
Hornum, L., Romer, J. & Markholst, H. The diabetes-prone BB rat carries a frameshift mutation in lan4, a positional candidate of lddm1. Diabetes 51, 1972-1979 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 1972-1979
-
-
Hornum, L.1
Romer, J.2
Markholst, H.3
-
75
-
-
1942453326
-
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
-
King, C., Ilic, A., Koelsch, K. & Sarvetnick, N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117, 265-277 (2004).
-
(2004)
Cell
, vol.117
, pp. 265-277
-
-
King, C.1
Ilic, A.2
Koelsch, K.3
Sarvetnick, N.4
-
76
-
-
0029983837
-
Immune regulation by CD40 and its ligand gp39
-
Foy, T. M., Aruffo, A., Bajorath, J., Buhlmann, J. E. & Noelle, R. J. Immune regulation by CD40 and its ligand gp39. Annu. Rev. Immunol. 14, 591-617 (1996).
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 591-617
-
-
Foy, T.M.1
Aruffo, A.2
Bajorath, J.3
Buhlmann, J.E.4
Noelle, R.J.5
-
77
-
-
9644295710
-
Cytokines and immunodeficiency diseases: Critical roles of the gamma(c)-dependent cytokines interleukins 2,4,7,9,15, and 21, and their signaling pathways
-
Kovanen, P. E. & Leonard, W. J. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2,4,7,9,15, and 21, and their signaling pathways. Immunol. Rev. 202, 67-83 (2004).
-
(2004)
Immunol. Rev.
, vol.202
, pp. 67-83
-
-
Kovanen, P.E.1
Leonard, W.J.2
-
78
-
-
0842324619
-
The Guillain-Barré syndrome: A true case of molecular mimicry
-
Ang, C. W., Jacobs, B. C. & Laman, J. D. The Guillain-Barré syndrome: a true case of molecular mimicry. Trends Immunol. 25, 61-66 (2004).
-
(2004)
Trends Immunol.
, vol.25
, pp. 61-66
-
-
Ang, C.W.1
Jacobs, B.C.2
Laman, J.D.3
-
79
-
-
3142654210
-
Inferences, questions and possibilities in Toll-like receptor signalling
-
Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430, 257-263 (2004).
-
(2004)
Nature
, vol.430
, pp. 257-263
-
-
Beutler, B.1
-
80
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter, E. A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002).
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
-
81
-
-
0142247168
-
DNA methylation and autoimmune disease
-
Richardson, B. DNA methylation and autoimmune disease. Clin. Immunol. 109, 72-79 (2003).
-
(2003)
Clin. Immunol.
, vol.109
, pp. 72-79
-
-
Richardson, B.1
-
82
-
-
0034618113
-
A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
-
Taylor, P. R. et al. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J. Exp. Med. 192, 59-366 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 59-366
-
-
Taylor, P.R.1
-
83
-
-
0028292951
-
Genetic and structural evidence for antigen selection of anti-DNA antibodies
-
Radic, M. Z. & Weigert, M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12, 487-520 (1994).
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 487-520
-
-
Radic, M.Z.1
Weigert, M.2
-
84
-
-
0029933460
-
Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease
-
Ray, S. K., Putterman, C. & Diamond, B. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl Acad. Sci. USA 93, 2019-2024 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2019-2024
-
-
Ray, S.K.1
Putterman, C.2
Diamond, B.3
-
85
-
-
0032033127
-
Humoral immunity due to long-lived plasma cells
-
Slifka, M. K., Antia, R., Whitmire, J. K. & Ahmed, R. Humoral immunity due to long-lived plasma cells. Immunity 8, 363-372 (1998).
-
(1998)
Immunity
, vol.8
, pp. 363-372
-
-
Slifka, M.K.1
Antia, R.2
Whitmire, J.K.3
Ahmed, R.4
-
86
-
-
0034957380
-
Clearing the way to mechanisms of autoimmunity
-
Rosen, A. & Casciola-Rosen, L. Clearing the way to mechanisms of autoimmunity. Nature Med. 7, 664-665 (2001).
-
(2001)
Nature Med.
, vol.7
, pp. 664-665
-
-
Rosen, A.1
Casciola-Rosen, L.2
-
87
-
-
0034843773
-
Ectopic lymphoid organogenesis: A fast track for autoimmunity
-
Weyand, C. M., Kurtin, P. J. & Goronzy, J. J. Ectopic lymphoid organogenesis: a fast track for autoimmunity. Am. J. Pathol. 159, 787-793 (2001).
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 787-793
-
-
Weyand, C.M.1
Kurtin, P.J.2
Goronzy, J.J.3
-
88
-
-
0037195132
-
Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node
-
Mandik-Nayak, L., Wipke, B. T., Shih, F. F., Unanue, E. R. & Allen, P. M. Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node. Proc. Natl Acad. Sci. USA 99, 14368-14373 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14368-14373
-
-
Mandik-Nayak, L.1
Wipke, B.T.2
Shih, F.F.3
Unanue, E.R.4
Allen, P.M.5
-
89
-
-
0037034880
-
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
-
Reif, K. et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416, 94-99 (2002).
-
(2002)
Nature
, vol.416
, pp. 94-99
-
-
Reif, K.1
-
90
-
-
0029014435
-
Antigen-induced B-cell death and elimination during germinal-centre immune responses
-
Shokat, K. M. & Goodnow, C. C. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375, 334-338 (1995).
-
(1995)
Nature
, vol.375
, pp. 334-338
-
-
Shokat, K.M.1
Goodnow, C.C.2
-
91
-
-
0029059370
-
Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
-
Pulendran, B., Kannourakis, G., Nouri, S., Smith, K. G. & Nossal, G. J. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375, 331-334 (1995).
-
(1995)
Nature
, vol.375
, pp. 331-334
-
-
Pulendran, B.1
Kannourakis, G.2
Nouri, S.3
Smith, K.G.4
Nossal, G.J.5
-
92
-
-
0029052398
-
Cellular interaction in germinal centers: Roles of CD40 ligand and B7-2 in established germinal centers
-
Han, S. et al. Cellular interaction in germinal centers: roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155, 556-567 (1995).
-
(1995)
J. Immunol.
, vol.155
, pp. 556-567
-
-
Han, S.1
-
93
-
-
2342557037
-
Emerging paradigms of T-cell co-stimulation
-
Kroczek, R. A., Mages, H. W. & Hutloff, A. Emerging paradigms of T-cell co-stimulation. Curr. Opin. Immunol. 16, 321-327 (2004).
-
(2004)
Curr. Opin. Immunol.
, vol.16
, pp. 321-327
-
-
Kroczek, R.A.1
Mages, H.W.2
Hutloff, A.3
-
94
-
-
0007970554
-
Co-stimulation and selection for T-cell help for germinal centres: The role of CD28 and OX40
-
Walker, L. S., Gulbranson-Judge, A., Flynn, S., Brocker, T. & Lane, P. J. Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol. Today 21, 333-337 (2000).
-
(2000)
Immunol. Today
, vol.21
, pp. 333-337
-
-
Walker, L.S.1
Gulbranson-Judge, A.2
Flynn, S.3
Brocker, T.4
Lane, P.J.5
-
95
-
-
0037448564
-
SAP is required for generating long-term humoral immunity
-
Crotty, S., Kersh, E. N., Cannons, J., Schwartzberg, P. L. & Ahmed, R. SAP is required for generating long-term humoral immunity. Nature 421, 282-287 (2003).
-
(2003)
Nature
, vol.421
, pp. 282-287
-
-
Crotty, S.1
Kersh, E.N.2
Cannons, J.3
Schwartzberg, P.L.4
Ahmed, R.5
-
96
-
-
0028466130
-
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
-
Kearney, E. R., Pape, K. A., Loh, D. Y. & Jenkins, M. K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339 (1994)
-
(1994)
Immunity
, vol.1
, pp. 327-339
-
-
Kearney, E.R.1
Pape, K.A.2
Loh, D.Y.3
Jenkins, M.K.4
-
97
-
-
21144438325
-
A novel RING-type ubiquitin ligase family member essential to repress follicular helper T cells and autoimmunity
-
doi:10.1038/nature03555 (this issue)
-
Vinuesa, C. G. et al. A novel RING-type ubiquitin ligase family member essential to repress follicular helper T cells and autoimmunity. Nature doi:10.1038/nature03555 (this issue).
-
Nature
-
-
Vinuesa, C.G.1
-
98
-
-
2342523339
-
Autoantibodies as predictors of disease
-
Scofield, R. H. Autoantibodies as predictors of disease. Lancet 363, 1544-1546 (2004).
-
(2004)
Lancet
, vol.363
, pp. 1544-1546
-
-
Scofield, R.H.1
-
99
-
-
2942625705
-
Staging the initiation of autoantibody-induced arthritis: A critical role for immune complexes
-
Wipke, B. T., Wang, Z., Nagengast, W., Reichert, D. E. & Allen, P. M. Staging the initiation of autoantibody-induced arthritis: a critical role for immune complexes. J. Immunol. 172, 7694-7702 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 7694-7702
-
-
Wipke, B.T.1
Wang, Z.2
Nagengast, W.3
Reichert, D.E.4
Allen, P.M.5
-
100
-
-
1142274317
-
The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease
-
Wonach, P. A., Benoist, C. & Mathis, D. The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv. Immunol. 82, 217-248 (2004).
-
(2004)
Adv. Immunol.
, vol.82
, pp. 217-248
-
-
Wonach, P.A.1
Benoist, C.2
Mathis, D.3
|