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Volumn 17, Issue 15, 2003, Pages 1841-1854

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

Author keywords

Akt; Kinase; Pim 2; TOR; Transcriptional regulation

Indexed keywords

PIM 2 PROTEIN KINASE; PROTEIN BAD; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

EID: 0042626302     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1105003     Document Type: Article
Times cited : (292)

References (50)
  • 1
    • 0028347772 scopus 로고
    • Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line
    • Algate, P.A., Steelman, L.S., Mayo, M.W., Miyajima, A., and McCubrey, J.A. 1994. Regulation of the interleukin-3 (IL-3) receptor by IL-3 in the fetal liver-derived FL5.12 cell line. Blood 83: 2459-2468.
    • (1994) Blood , vol.83 , pp. 2459-2468
    • Algate, P.A.1    Steelman, L.S.2    Mayo, M.W.3    Miyajima, A.4    McCubrey, J.A.5
  • 2
    • 0030265199 scopus 로고    scopus 로고
    • Complementation tagging of cooperating oncogenes in knockout mice
    • Allen, J.D. and A. Berns. 1996. Complementation tagging of cooperating oncogenes in knockout mice. Semin Cancer Biol 7: 299-306.
    • (1996) Semin. Cancer Biol. , vol.7 , pp. 299-306
    • Allen, J.D.1    Berns, A.2
  • 3
    • 0030829781 scopus 로고    scopus 로고
    • Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc
    • Allen, J.D., Verhoeven, E., Domen, J., van der Valk, M., and Berns, A. 1997. Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene 15: 1133-1141.
    • (1997) Oncogene , vol.15 , pp. 1133-1141
    • Allen, J.D.1    Verhoeven, E.2    Domen, J.3    Van der Valk, M.4    Berns, A.5
  • 4
    • 0024408829 scopus 로고
    • The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias
    • Amson, R., Sigaux, F., Przedborski, S., Flandrin, G., Givol, D., and Telerman, A. 1989. The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc. Natl. Acad. Sci. 86: 8857-8861.
    • (1989) Proc. Natl. Acad. Sci. , vol.86 , pp. 8857-8861
    • Amson, R.1    Sigaux, F.2    Przedborski, S.3    Flandrin, G.4    Givol, D.5    Telerman, A.6
  • 5
    • 0037099707 scopus 로고    scopus 로고
    • Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling
    • Arden, K.C. and Biggs III, W.H. 2002. Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling. Arch. Biochem. Biophys. 403: 292-298.
    • (2002) Arch. Biochem. Biophys. , vol.403 , pp. 292-298
    • Arden, K.C.1    Biggs W.H. III2
  • 6
    • 0037131187 scopus 로고    scopus 로고
    • Akt forms an intracellular complex with Hsp90 and Cdc37 and is destabilized by inhibitors of Hsp90 function
    • Basso, A.D., Solit, D.B., Chiosis, G., Giri, B., Tsichlis, P., and Rosen, N. 2002. Akt forms an intracellular complex with Hsp90 and Cdc37 and is destabilized by inhibitors of Hsp90 function. J. Biol. Chem. 42: 39858-39866
    • (2002) J. Biol. Chem. , vol.42 , pp. 39858-39866
    • Basso, A.D.1    Solit, D.B.2    Chiosis, G.3    Giri, B.4    Tsichlis, P.5    Rosen, N.6
  • 7
    • 0024453705 scopus 로고
    • Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas
    • Breuer, M.L., Cuypers, H.T., and Berns, A. 1989. Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. EMBO J. 8: 743-781.
    • (1989) EMBO J. , vol.8 , pp. 743-781
    • Breuer, M.L.1    Cuypers, H.T.2    Berns, A.3
  • 9
    • 0033920969 scopus 로고    scopus 로고
    • Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells
    • Clemens, M.J., Bushell, M., Jeffrey, I. W., Pain, V. M., and Morley, S.J. 2000. Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells. Cell Death Differ. 7: 603-615.
    • (2000) Cell Death Differ , vol.7 , pp. 603-615
    • Clemens, M.J.1    Bushell, M.2    Jeffrey, I.W.3    Pain, V.M.4    Morley, S.J.5
  • 10
    • 0036716281 scopus 로고    scopus 로고
    • The bcl2 family: Regulators of the cellular life-or-death switch
    • Cory, S. and Adams, J.M. 2002. The bcl2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2: 647-656.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 11
    • 0034710719 scopus 로고    scopus 로고
    • Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one
    • Covey, D.F., Han, M., Kumar, A.S., de La Cruz, M.A., Meadows, E.S., Hu, Y., Tonnies, A., Nathan, D., Coleman, M., Benz, A., et al. 2000. Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3α, 5α)- and (3α, 5β)-3-hydroxypregnan-20-one. J. Med. Chem. 43; 3201-3204.
    • (2000) J. Med. Chem. , vol.43 , pp. 3201-3204
    • Covey, D.F.1    Han, M.2    Kumar, A.S.3    De La Cruz, M.A.4    Meadows, E.S.5    Hu, Y.6    Tonnies, A.7    Nathan, D.8    Coleman, M.9    Benz, A.10
  • 14
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger, A.L. and Thompson, C.B. 2002. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell 13: 2276-2288.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 16
    • 0036117745 scopus 로고    scopus 로고
    • Genes preferentially induced by depolarization after concussive brain injury: Effects of age and injury severity
    • Giza, C.C., Prins, M.L., Hovda, D.A., Herschman, H.R., and Feldman, J.D. 2002. Genes preferentially induced by depolarization after concussive brain injury: Effects of age and injury severity. J. Neurotrauma 19: 387-402.
    • (2002) J. Neurotrauma , vol.19 , pp. 387-402
    • Giza, C.C.1    Prins, M.L.2    Hovda, D.A.3    Herschman, H.R.4    Feldman, J.D.5
  • 17
    • 0037071398 scopus 로고    scopus 로고
    • The proto-oncogene c-myc in hematopoietic development and leukemogenesis
    • Hoffman, B., Amanullah, A., Shafarenko, M., and Liebermann, D.A. 2002. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21: 3414-3421.
    • (2002) Oncogene , vol.21 , pp. 3414-3421
    • Hoffman, B.1    Amanullah, A.2    Shafarenko, M.3    Liebermann, D.A.4
  • 18
    • 0037013143 scopus 로고    scopus 로고
    • The conformational plasticity of protein kinases
    • Huse, M. and Kuriyan, J. 2002. The conformational plasticity of protein kinases. Cell 109: 275-282.
    • (2002) Cell , vol.109 , pp. 275-282
    • Huse, M.1    Kuriyan, J.2
  • 22
    • 0035947608 scopus 로고    scopus 로고
    • Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition
    • Li, J., Peet, G.W., Balzarano, D., Li, X., Massa, P., Barton, R.W., and Marcu, K.B. 2001. Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition. J. Biol. Chem. 276: 18579-18590.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18579-18590
    • Li, J.1    Peet, G.W.2    Balzarano, D.3    Li, X.4    Massa, P.5    Barton, R.W.6    Marcu, K.B.7
  • 23
    • 0036195727 scopus 로고    scopus 로고
    • Translational control of cell fate: Availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency
    • Li, S., Sonenberg, N., Gingras, A.C., Peterson, M., Avdulov, S., Polunovsky, V.A., and Bitterman, P.B. 2002. Translational control of cell fate: Availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Mol. Cell. Biol. 22: 2853-2861.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2853-2861
    • Li, S.1    Sonenberg, N.2    Gingras, A.C.3    Peterson, M.4    Avdulov, S.5    Polunovsky, V.A.6    Bitterman, P.B.7
  • 24
    • 0033536203 scopus 로고    scopus 로고
    • The Pim-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway
    • Lilly, M., Sandholm, J., Cooper, J.J., Koskinen, P.J., and Kraft, A. 1999. The Pim-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene 18: 4022-4031.
    • (1999) Oncogene , vol.18 , pp. 4022-4031
    • Lilly, M.1    Sandholm, J.2    Cooper, J.J.3    Koskinen, P.J.4    Kraft, A.5
  • 26
    • 0029938724 scopus 로고    scopus 로고
    • Regulation of cell division cycle progression by bcl-2 expression: A potential mechanism for inhibition of programmed cell death
    • Mazel, S., Burtrum, D., and Petrie, H.T. 1996. Regulation of cell division cycle progression by bcl-2 expression: A potential mechanism for inhibition of programmed cell death. J. Exp. Med. 183: 2219-2226.
    • (1996) J. Exp. Med. , vol.183 , pp. 2219-2226
    • Mazel, S.1    Burtrum, D.2    Petrie, H.T.3
  • 27
    • 0036729878 scopus 로고    scopus 로고
    • High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
    • Mikkers, H., Allen, J., Knipscheer, P., Romeyn, L., Hart, A., Vink, E., and Berns, A. 2002. High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat. Genet. 32: 153-159.
    • (2002) Nat. Genet. , vol.32 , pp. 153-159
    • Mikkers, H.1    Allen, J.2    Knipscheer, P.3    Romeyn, L.4    Hart, A.5    Vink, E.6    Berns, A.7
  • 28
    • 0035666968 scopus 로고    scopus 로고
    • Potential cellular signatures of viral infections in human hematopoietic cells
    • Mikovits, J., Ruscetti, F., Zhu, W., Bagni, R., Dorjsuren, D., and Shoemaker, R. 2001. Potential cellular signatures of viral infections in human hematopoietic cells. Dis Markers 17: 173-178.
    • (2001) Dis. Markers , vol.17 , pp. 173-178
    • Mikovits, J.1    Ruscetti, F.2    Zhu, W.3    Bagni, R.4    Dorjsuren, D.5    Shoemaker, R.6
  • 29
    • 0033603454 scopus 로고    scopus 로고
    • Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway
    • Mochizuki, T., Kitanaka, C., Noguchi, K., Muramatsu, T., Asai, A., and Kuchino, Y. 1999. Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J. Biol. Chem. 274: 18659-18666.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18659-18666
    • Mochizuki, T.1    Kitanaka, C.2    Noguchi, K.3    Muramatsu, T.4    Asai, A.5    Kuchino, Y.6
  • 30
    • 0025986962 scopus 로고
    • E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice
    • Moroy, T., Verbeek, S., Ma, A., Achacoso, P., Berns, A., and Alt, F. 1991. E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice. Oncogene 6: 1941-1948.
    • (1991) Oncogene , vol.6 , pp. 1941-1948
    • Moroy, T.1    Verbeek, S.2    Ma, A.3    Achacoso, P.4    Berns, A.5    Alt, F.6
  • 33
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson, K.M. and Anderson, N.G. 2002. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14: 381-395.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 34
    • 0029114101 scopus 로고
    • Staurosporine, a potentially important gift from a microorganism
    • Omura, S., Sasaki, Y., Iwai, Y., and Takeshima, H. 1995. Staurosporine, a potentially important gift from a microorganism. J. Antibiot. (Tokyo) 48: 535-548.
    • (1995) J. Antibiot. (Tokyo) , vol.48 , pp. 535-548
    • Omura, S.1    Sasaki, Y.2    Iwai, Y.3    Takeshima, H.4
  • 35
    • 0030476922 scopus 로고    scopus 로고
    • The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
    • O'Reilly, L.A., Huang, D.C., and Strasser, A. 1996. The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J. 15: 6979-6990.
    • (1996) EMBO J. , vol.15 , pp. 6979-6990
    • O'Reilly, L.A.1    Huang, D.C.2    Strasser, A.3
  • 36
    • 0036781812 scopus 로고    scopus 로고
    • c-myc: More than just a matter of life and death
    • Pelengaris, S., Khan, M., and Evan, G. 2002. c-myc: More than just a matter of life and death. Nat. Rev. Cancer 2: 764-776.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 764-776
    • Pelengaris, S.1    Khan, M.2    Evan, G.3
  • 37
    • 0034721081 scopus 로고    scopus 로고
    • Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death
    • Pircher, T.I., Zhao, S., Geiger, J.N., Joneja, B., and Wojchowski, D.M. 2000. Pim-1 kinase protects hematopoietic FDC cells from genotoxin-induced death. Oncogene 19: 3684-3692.
    • (2000) Oncogene , vol.19 , pp. 3684-3692
    • Pircher, T.I.1    Zhao, S.2    Geiger, J.N.3    Joneja, B.4    Wojchowski, D.M.5
  • 39
    • 0033635249 scopus 로고    scopus 로고
    • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
    • Rathmell, J.C., Vander Heiden, M.G., Harris, M.H., Frauwirth, K.A., and Thompson, C.B. 2000. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6: 683-692.
    • (2000) Mol. Cell , vol.6 , pp. 683-692
    • Rathmell, J.C.1    Vander Heiden, M.G.2    Harris, M.H.3    Frauwirth, K.A.4    Thompson, C.B.5
  • 41
    • 0022100028 scopus 로고
    • Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas
    • Selten, G., Cuypers, H.T., and Berns, A. 1985. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO J. 4: 1793-1798.
    • (1985) EMBO J. , vol.4 , pp. 1793-1798
    • Selten, G.1    Cuypers, H.T.2    Berns, A.3
  • 44
    • 0033925204 scopus 로고    scopus 로고
    • Fos family members: Regulation, structure and role in oncogenic transformation
    • Tulchinsky, E. 2000. Fos family members: Regulation, structure and role in oncogenic transformation. Histol. Histopathol. 15: 921-928.
    • (2000) Histol. Histopathol. , vol.15 , pp. 921-928
    • Tulchinsky, E.1
  • 45
    • 0028988929 scopus 로고
    • Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2
    • van der Lugt, N.M., Domen, J., Verhoeven, E., Linders, K., van der Gulden, H., Allen, I., and Berns, A. 1995. Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2. EMBO J. 14: 2536-2544.
    • (1995) EMBO J. , vol.14 , pp. 2536-2544
    • Van der Lugt, N.M.1    Domen, J.2    Verhoeven, E.3    Linders, K.4    Van der Gulden, H.5    Allen, I.6    Berns, A.7
  • 46
    • 0026022673 scopus 로고
    • Mice bearing the E μ-myc and E μ-pim-1 transgenes develop pre-B-cell leukemia prenatally
    • Verbeek, S., van Lohuizen, M., van der Valk, M., Domen, J., Kraal, G., and Berns, A. 1991. Mice bearing the E μ-myc and E μ-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol. Cell. Biol. 11: 1176-1179.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1176-1179
    • Verbeek, S.1    Van Lohuizen, M.2    Van der Valk, M.3    Domen, J.4    Kraal, G.5    Berns, A.6
  • 47
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos, C.I., Matter, W.F., Hui, K.Y., and Brown, R.F. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem. 269: 5241-5248.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.I.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 48
    • 0035370441 scopus 로고    scopus 로고
    • Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells
    • Wang, Z., Bhattacharya, N., Meyer, M.K., Seimiya, H., Tsuruo, T., Tonani, J.A., and Magnuson, N.S. 2001. Pim-1 negatively regulates the activity of PTP-U2S phosphatase and influences terminal differentiation and apoptosis of monoblastoid leukemia cells. Arch. Biochem. Biophys 390: 9-18.
    • (2001) Arch. Biochem. Biophys. , vol.390 , pp. 9-18
    • Wang, Z.1    Bhattacharya, N.2    Meyer, M.K.3    Seimiya, H.4    Tsuruo, T.5    Tonani, J.A.6    Magnuson, N.S.7
  • 49
    • 0036697292 scopus 로고    scopus 로고
    • Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1
    • Xu, L.G., Wu, M., Hu, J., Zhai, Z., and Shu, H.B. 2002. Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J. Leukoc. Biol. 72: 410-416.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 410-416
    • Xu, L.G.1    Wu, M.2    Hu, J.3    Zhai, Z.4    Shu, H.B.5
  • 50
    • 0033599015 scopus 로고    scopus 로고
    • Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5′-RACE and LA-PCR analyses of biopsy samples
    • Yoshida, S., Kaneita, Y., Aoki, Y., Seto, M., Mori, S., and Moriyama, M. 1999. Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5′-RACE and LA-PCR analyses of biopsy samples. Oncogene 18: 7994-7999.
    • (1999) Oncogene , vol.18 , pp. 7994-7999
    • Yoshida, S.1    Kaneita, Y.2    Aoki, Y.3    Seto, M.4    Mori, S.5    Moriyama, M.6


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