Negative selection of semimature CD4+8-HSA + thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 18, 2004, Pages 7052-7057

  Villunger, Andreas ^a,b   Marsden, Vanessa S ^a   Zhan, Yifan ^a   Erlacher, Miriam ^b   Lew, Andrew M ^a   Bouillet, Philippe ^a   Berzins, Stuart ^c   Godfrey, Dale I ^c   Heath, William R ^a   Strasser, Andreas ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Apaf 1; Bcl 2 family; Caspase 9; FADD Mort1; Fas (APO 1 CD95)

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BIM PROTEIN; CASPASE 9; CD3 ANTIGEN; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL PROTECTION; CELL SELECTION; CONTROLLED STUDY; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; IMMUNOLOGICAL TOLERANCE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD4; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CARRIER PROTEINS; CASPASE 9; CASPASES; CLONAL DELETION; MEMBRANE PROTEINS; MICE; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THYMUS GLAND;

ANIMALIA; MUS MUSCULUS;

EID: 2342458871     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0305757101     Document Type: Article

References (28)

1. Marsden, V. & Strasser, A. (2003) Annu. Rev. Immunol. 21, 71-105.
2. Strasser, A., O'Connor, L. & Dixit, V. M. (2000) Annu. Rev. Biochem. 69, 217-245.
3. Shi, Y. (2002) Mol. Cell 9, 459-470.
4. Strasser, A., Harris, A. W., Huang, D. C. S., Krammer, P. H. & Cory, S. (1995) EMBO J. 14, 6136-6147.
5. Wang, X. (2001) Genes Dev. 15, 2922-2933.
6. Huang, D. C. S. & Strasser, A. (2000) Cell 103, 839-842.
7. Marsden, V., O'Connor, L., O'Reilly, L. A., Silke, J., Metcalf, D., Ekert, P., Huang, D. C. S., Cecconi, F., Kuida, K., Tomaselli, K. J., et al. (2002) Nature 419, 634-637.
8. Strasser, A., Harris, A. W., Corcoran, L. M. & Cory, S. (1994) Nature 368, 457-460.
9. Strasser, A., Harris, A. W., Von Boehmer, H. & Cory, S. (1994) Proc. Natl. Acad. Sci. USA 91, 1376-1380.
10. Linette, G. P., Grusby, M. J., Hedrick, S. M., Hansen, T. H., Glimcher, L. H. & Korsmeyer, S. J. (1994) Immunity 1, 197-205.
11. Surh, C. D. & Sprent, J. (1994) Nature 372, 100-103.
12. Smith, K. G. C., Strasser, A. & Vaux, D. L. (1996) EMBO J. 15, 5167-5176.
13. Newton, K., Harris, A. W., Bath, M. L., Smith, K. G. C. & Strasser, A. (1998) EMBO J. 17, 706-718.
14. Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M. & Strasser, A. (2002) Nature 415, 922-926.
15. Rathmell, J. C., Lindsten, T., Zong, W.-X., Cinalli, R. M. & Thompson, C. B. (2002) Nat. Immunol. 3, 932-939.
16. Kishimoto, H., Surh, C. D. & Sprent, J. (1998) J. Exp. Med. 187, 1427-1438.
17. Bouillet, P., Metcalf, D., Huang, D. C. S., Tarlinton, D. M., Kay, T. W. H., Köntgen, F., Adams, J. M. & Strasser, A. (1999) Science 286, 1735-1738.
18. Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A. & Gruss, P. (1998) Cell 94, 727-737.
19. Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P. & Flavell, R. A. (1998) Cell 94, 325-337.
20. Ogilvy, S., Metcalf, D., Print, C. G., Bath, M. L., Harris, A. W. & Adams, J. M. (1999) Proc. Natl. Acad. Sci. USA 96, 14943-14948.
21. Barnden, M. J., Allison, J., Heath, W. R. & Carbone, F. R. (1998) Immunol. Cell Biol. 76, 34-40.
22. O'Connor, L., Strasser, A., O'Reilly, L. A., Hausmann, G., Adams, J. M., Cory, S. & Huang, D. C. S. (1998) EMBO J. 17, 384-395.
23. Hara, H., Takeda, A., Takeuchi, M., Wakeham, A. C., Itie, A., Sasaki, M., Mak, T. W., Yoshimura, A., Nomoto, K. & Yoshida, H. (2002) J. Immunol. 168, 2288-2295.
24. Strasser, A., Harris, A. W. & Cory, S. (1991) Cell 67, 889-899.
25. Lamhamedi-Cherradi, S. E., Zheng, S. J., Maguschak, K. A., Peschon, J. & Chen, Y. H. (2003) Nat. Immunol. 4, 255-260.
26. Kishimoto, H. & Sprent, J. (2001) Nat. Immunol. 2, 1025-1031.
27. Cretney, E., Uldrich, A. P., Berzins, S. P., Strasser, A., Godfrey, D. I. & Smyth, M. J. (2003) J. Exp. Med. 198, 491-496.
28. Bouillet, P., Cory, S., Zhang, L.-C., Strasser, A. & Adams, J. M. (2001) Dev. Cell 1, 645-653.