Zinc and Alzheimer's disease: Is there a direct link?

Brain Research Reviews

Volumn 23, Issue 3, 1997, Pages 219-236

  Cuajungco, Math P ^a   Lees, Gordon J ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

amyloid; Alzheimer's disease; zinc; zinc metabolism

Indexed keywords

AMYLOID BETA PROTEIN; ZINC;

ALZHEIMER DISEASE; APOPTOSIS; HUMAN; HUMAN TISSUE; NEUROTOXICITY; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE;

ALZHEIMER DISEASE; BRAIN; DISEASE PROGRESSION; HUMANS; NERVE DEGENERATION; NEUROTOXINS; ZINC;

EID: 0030891254     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(97)00002-7     Document Type: Review

References (249)

1. Allen, S.J., MacGowan, S.H., Treanor, J.J.S., Feeney, R., Wilcock, G.K. and Dawbarn, D., Normal β-NGF content in Alzheimer's disease cerebral cortex and hippocampus, Neurosci. Lett., 131 (1991) 135-139.
2. Aloe, L., Bracci-Laudiero, L., Lambiase, A., Micera, A. and Tirassa, P., Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes, Proc. Natl. Acad. Sci. USA, 91 (1994) 10440-10444.
3. Ancsin, J.B. and Kisilevsky, R., Laminin interactions important for basement membrane assembly are promoted by zinc and implicate laminin zinc finger-like sequences, J. Biol. Chem., 271 (1996) 6845-6851.
4. 2+ from brain tissue during activity, Nature, 308 (1984) 734-736.
5. 2+, Brain Res., 557 (1991) 103-108.
6. Baba, A., Kihara, T., Sawada, T. and Iwata, H., Excitatory amino acids enhance dissociation of zinc from soluble protein in cytosol of rat hippocampus, Brain Res., 486 (1989) 372-375.
7. Backstrom, J.R., Miller, C.A. and Tokes, Z.A., Characterization of neutral proteinases from Alzheimer-affected and control brain specimens: identification of calcium-dependent metalloproteinases from the hippocampus, J. Neurochem., 58 (1992) 983-992.
8. Baeuerle, P.A., The inducible transcription activator NF-κB: regulation by distinct protein subunits, Biochim. Biophys. Acta, 1072 (1991) 63-80.
9. Ball, M.J., Hippocampal histopathology - a critical substrate for dementia of the Alzheimer type. In J. Ulrich (Ed.), Interdisciplinary Topics in Gerontology: Histology and Histopathology of the Aging Brain, 25, Karger, Basel, 1988, pp. 16-37.
10. Baramova, E. and Foidart, J.M., Matrix metalloproteinase family, Cell Biol. Int., 19 (1995) 239-242.
11. Basun, H., Forssell, L.G., Wetterberg, L. and Winbald, B., Metals and trace elements in plasma and cerebrospinal fluid in normal ageing and Alzheimer's disease, J. Neural Transm. Parkinson's Dis. Dementia Sect., 4 (1991) 231-258.
12. Baudier, J. and Gerard, D., Ions binding to S-100 proteins: structural changes induced by calcium and zinc on S-100α and S-100β proteins, Biochemistry, 22 (1983) 3360-3369.
13. Baudier, J., Haglid, K., Haiech, J. and Gerard, D., Zinc ion binding to human brain calcium-binding proteins calmodulin and S-100β protein, Biochem. Biophys. Res. Commun., 114 (1983) 1138-1146.
14. Bauman, J.W., Liu, J., Liu, P. and Klaassen, C.D., Increase in metallothionein produced by chemicals that induce oxidative stress, Toxicol. Appl. Pharmacol., 110 (1991) 347-354.
15. Beal, M.F., Hyman, B.T. and Koroshetz, W., Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative disease?, Trends Neurosci., 16 (1993) 125-131.
16. Beaulieu, C., Dyck, R. and Cynader, M., Enrichment of glutamate in zinc-containing terminals of the cat visual cortex, NeuroReport, 3 (1992) 861-864.
17. Bergamaschi, S., Binetti, G., Govoni, S., Wetsel, W.C., Battaini, F., Trabucchi, M., Bianchetti, A. and Racchi, M., Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts, Neurosci. Lett., 201 (1995) 1-4.
18. Bergeron, C., Petrunka, C. and Weyer, L., Copper/zinc superoxide dismutase expression in the human central nervous system: correlation with selective neuronal vulnerability, Am. J. Pathol., 148 (1996) 273-279.
19. Bettger, W.J. and O'Dell, B.L., A critical physiological role of zinc in the structure and function of biomembrane, Life Sci., 28 (1981) 1425-1438.
20. Bischoff, S.C. and Dahinden, C.A., Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils, Blood, 79 (1992) 2662-2669.
21. Blaauwgeers, H.G.T., Sillevis Smitt, P.A.E., Vianney de Jong, J.M.B. and Troost, D., Localization of metallothionein in the mammalian central nervous system, Biol. Signals, 3 (1994) 181-187.
22. Blair-West, J.R., Denton, D.A., Gibson, A.P. and McKinley, M.J., Opening the blood-brain barrier to zinc, Brain Res., 507 (1990) 6-10.
23. Bramham, C.R., Torp, R., Zhang, N., Storm-Mathisen, J. and Ottersen, O.P., Distribution of glutamate-like immunoreactivity in excitatory hippocampal pathways, a semiquantitative electron microscopic study in rats, Neuroscience, 39 (1990) 405-417.
24. Bredesen, D.E., Neural apoptosis, Ann. Neurol., 38 (1995) 839-851.
25. Bremner, I. and May, P.M., Systemic interactions of zinc. In C.F. Mills (Ed.), Zinc in Human Biology, Springer-Verlag, London, 1989, pp. 95-108.
26. Bruijn, L.I. and Cleveland, D.W., Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease, Neuropathol. Applied Neurobiol., 22 (1996) 373-387.
27. Brun, A., Gustafson, L. and Englund, E., Subcortical pathology of Alzheimer's disease. In R.J. Wurtman, S. Corkin, J.H. Growdon and E. Ritter-Walker (Eds.), Adv. Neurol., 51, Raven Press, New York, 1990, pp. 73-77.
28. Burnet, F.M., A possible role of zinc in the pathology of dementia, Lancet, 1 (1981) 186-188.
29. Bush, A.I., Atwood, C.S., Huang, X., Moir, R.D., Glabe, C.G. and Tanzi, R.E., Abnormal homeostasis of pH and zinc: the prelude for cerebral Aβ amyloid formation?, Eur. Neuropsychopharmacol., 6 (Suppl.) (1996) 20 (S-4-2).
30. Bush, A.I., Moir, R.D., Rosenkranz, K.M. and Tanzi, R.E., Zinc and Alzheimer's disease, Science, 268 (1995) 1921-1923.
31. Bush, A.I., Multhaup, G., Moir, R.D., Williamson, T.G., Small, D.H., Rumble, B., Pollwein, P., Beyreuther, K. and Masters, C.L., A novel zinc(II) binding site modulates the function of the βA4 amyloid protein precursor of Alzheimer's disease, J. Biol. Chem., 268 (1993) 16109-16112.
32. Bush, A.I., Pettingel, W.H., Multhaup, G., Paradis, M.D., Vonsattel, J.P., Gusella, J.F., Beyreuther, K., Masters, C.L. and Tanzi, R.E., Rapid induction fo Alzheimer Aβ amyloid formation by zinc, Science, 265 (1994a) 1464-1467.
33. Bush, A.I., Pettingel, W.H., Paradis, M.D. and Tanzi, R.E., Modulation of Aβ adhesiveness and secretase site cleavage by zinc, J. Biol Chem., 269 (1994b) 12152-12158.
34. Calissano, P., Alema, S. and Fasella, P., Interaction of S-100 protein with cations and liposomes, Biochemistry, 13 (1974) 4553-4560.
35. Calissano, P., Moore, B.W., Friesen, A., Effect of calcium ion on S-100, a protein of the nervous system, Biochemistry, 8 (1969) 4318-4326.
36. Cano-Gauci, D.F. and Sarkar, B., Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger, FEBS Lett., 386 (1996) 1-4.
37. Cao, G.H. and Chen, J.D., Effects of dietary zinc deficiency on free radical generation, lipid peroxidation and superoxide dismutase in trained mice, Arch. Biochem. Biophys., 291 (1991) 147-153.
38. Carter, B.D., Kaltschmidt, C., Kaltschmidt, B., Offenhauser, N., Bohm-Matthaei, R., Baeuerle, P.A. and Barde, Y.A., Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor p75, Science, 272 (1996) 543-545.
39. Ceballos, I., Javoy-Agid, F., Hirsch, E.C., Dumas, S., Kamoun, P.P., Sinet, P.M. and Agid, Y., Localization of copper-zinc superoxide dismutase mRNA in human hippocampus by in situ hybridization, Neurosci. Lett., 105 (1989) 41-46.
40. Chen, S., Frederickson, R.C.A. and Brunden, K.R., Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: complement activation and therapeutic approaches, Neurobiol. Aging, 17 (1996) 781-787.
41. Choi, D.W., Bench to bedside: the glutamate connection, Science, 258 (1992) 241-243.
42. Choi, D.W. and Rothman, S.M., The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death, Annu. Rev. Neurosci., 13 (1990) 171-182.
43. Choi, D.W., Yokoyama, M. and Koh, J., Zinc neurotoxicity in cortical cell culture, Neuroscience, 24 (1988) 67-79.
44. Chong, Y.H. and Suh, Y.H., Amyloidogenic processing of Alzheimer's amyloid precursor protein in vitro and its modulation by metal ions and tacrine, Life Sci., 59 (1996) 545-557.
45. Chuah, M.I., Tennet, R. and Jacobs, I., Response of olfactory Schwann cells to intranasal zinc sulfate irrigation, J. Neurosci. Res., 42 (1995) 470-478.
46. Clements, A., Allsop, D., Walsh, D.M., Williams, C.H., Aggregation and metal-binding of mutant forms of the amyloid Aβ peptide of Alzheimer's disease, J. Neurochem., 66 (1996) 740-747.
47. Cohen, J.J. and Duke, R.C., Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death, J. Immunol., 132 (1984) 38-42.
48. Connor, B., Young, D., Lawlor, P., Gai, W., Waldvogel, H., Faull, R.L.M. and Dragunow, M., Trk alterations in Alzheimer's disease, Mol. Brain Res., 42 (1996) 1-17.
49. Constantinidis, J., Alzheimer's disease: the zinc theory, L'Encephale, 16 (1990) 231-239.
50. Constantinidis, J., The hypothesis of zinc deficiency in the pathogenesis of neurofibrillary tangles, Med. Hypo., 35 (1991) 319-323.
51. Corrigan, F.M., Reynolds, G.P. and Ward, N.I., Hippocampal tin, aluminum and zinc in Alzheimer's disease, Biometals, 6 (1993) 149-154.
52. Cosgaya, J.M., Latasa, M.J. and Pascual, A., Nerve growth factor and ras regulate β-amyloid precursor protein gene expression in PC12 cells, J. Neurochem., 67 (1996) 98-104.
53. Coyle, J.T. and Puttfarcken, P., Oxidative stress, glutamate and neurodegenerative disorders, Science, 262 (1993) 689-695.
54. Crawford, I.L. and Connor, J.D., Zinc in maturing rat brain, hippocampal concentration and localization, J. Neurochem., 19 (1972) 1451-1458.
55. Crutcher, K.A., Scott, S.A., Liang, S., Everson, W.V. and Weingartner, J., Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease, J. Neurosci., 13 (1993) 2540-2550.
56. Csermely, P., Szamel, M., Resch, K. and Somogyi, J., Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes, J. Biol. Chem., 263 (1988) 6487-6490.
57. Cuajungco, M.P. and Lees, G.J., Prevention of zinc neurotoxicity in vivo by N,N,N′,N′-tetakis(2-pyridylmethyl)ethylenediamine (TPEN), NeuroReport, 7 (1996) 1301-1304.
58. Danscher, G., Howell, G., Perez-Clausell, J. and Hertel, N., The dithizone, Timm's sulphide silver and selenium methods demonstrate a chelatable pool of zinc in CNS, Histochemistry, 83 (1985) 419-422.
59. Danscher, G., The autometallographic zinc-sulphide method. A new approach involving in vivo creation of nanometer-sized zinc sulphide crystal lattices in zinc-enriched synaptic and secretory vesicles, Histochem. J., 28 (1996) 361-373.
60. Davies, P. and Maloney, A.J.F., Selective loss of central cholinergic neurons in Alzheimer's disease, Lancet, 2 (1976) 1403.
61. Delacourte, A., Defossez, A., Ceballos, I., Nicole, A. and Sinet, P.M., Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease, Neurosci. Lett., 92 (1988) 247-253.
62. Deng, Q.S., Turk, G.C., Brady, D.R. and Smith, Q.R., Evaluation of brain element composition in Alzheimer's disease using inductively coupled plasma mass spectrometry, Neurobiol. Aging, 15 (Suppl.) (1994) S113 (A464).
63. Dicou, E., Masson, C., Jabbour, W. and Nerriere, V., Increased frequency of NGF in sera of rheumatoid arthritis and systemic lupus erythematous patients, NeuroReport, 5 (1993) 321-324.
64. +-ATPase, Can. J. Biochem., 49 (1971) 1217-1224.
65. Donato, R., Michetti, F. and Miani, N., Soluble and membrane-bound S-100 protein in cerebral cortex synaptosomes: properties of the S-100 receptor, Brain Res., 98 (1975) 561-573.
66. Drachman, D.A. and Leavitt, J., Human memory and the cholinergic system, Arch. Neurol., 30 (1974) 113-121.
67. Dragunow, M., Faull, R.L.M., Lawlor, P., Beilharz, E.J., Singleton, K., Walker, E.B. and Mee, E., In Situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes, NeuroReport, 6 (1995) 1053-1057.
68. Duguid, J.R., Bohmont, C.W., Liu, N. and Tourtellotte, W.W., Changes in brain gene expression shared by scrapie and Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 86 (1989) 7260-7264.
69. Duncan, M.W., Marini, A.M., Watters, R., Kopin, I.J. and Markey, S.P., Zinc, a neurotoxin to cultured neurons, contaminates cycad flour prepared by traditional Guamanian methods, J. Neurosci., 12 (1992) 1523-1537.
70. Durnam, D.M. and Palmiter, R.D., Transcriptional regulation of the mouse metallothionein-I gene by heavy metals, J. Biol. Chem., 256 (1981) 5712-5716.
71. Eagle, G.R., Zombola, R.R. and Himes, R.H., Tubulin-zinc interactions: binding and polymerization studies, Biochemistry, 22 (1983) 221-228.
72. Ebadi, M., Metallothioneins and other zinc-binding proteins in brain, Methods Enzymol., 205 (1991) 363-387.
73. Ebadi, M. and Hama, Y., Zinc-binding proteins in the brain, Adv. Exp. Med. Biol., 203 (1986) 557-570.
74. Erickson, J.C., Sewell, A.K., Jensen, L.T., Winge, D.R. and Palmiter, R.D., Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF), Brain Res., 649 (1994) 297-304.
75. Esler, W.P., Stimson, E.R., Jennings, J.M., Ghilardi, J.R., Mantyh, P.W. and Maggio, J.E., Zinc-induced aggregation of human and rat β-amyloid peptides in vitro, J. Neurochem., 66 (1996) 723-732.
76. Fabris, N. and Mocchegiani, E., Zinc, human diseases and aging, Aging Clin. Exp. Res., 7 (1995) 77-93.
77. Fitzgerald, D.J., Zinc and Alzheimer's disease, Science, 268 (1995) 1920.
78. Fliss, H. and Menard, M., Hypochlorous acid-induced mobilization of zinc from metalloproteins, Arch. Biochem. Biophys., 287 (1991) 175-179.
79. Fliss, H. and Menard, M., Oxidant-induced mobilization of zinc from metallothionein, Arch. Biochem. Biophys., 293 (1992) 195-199.
80. Fliss, H., Menard, M. and Desai, M., Hypochlorous acid mobilizes cellular zinc, Can. J. Physiol. Pharmacol., 69 (1991) 1686-1691.
81. Forbes, I.J., Zalewski, P.D. and Giannakis, C., Role for zinc in a cellular response mediated by protein kinase C in human B lymphocytes, Exp. Cell Res., 195 (1991) 224-229.
82. Forbes, I.J., Zalewski, P.D., Giannakis, C. and Betts, W.H., Zinc induces specific association of PKC with membrane cytoskeleton, Biochem. Int., 22 (1990) 741-748.
83. Forbes, I.J., Zalewski, P.D., Giannakis, C., Petkoff, H.S. and Cowled, P.A., Interaction between protein kinase C and regulatory ligand is enhanced by a chelatable pool of cellular zinc, Biochim. Biophys. Acta, 1053 (1990b) 113-117.
84. Frederickson, C.J., Neurobiology of zinc and zinc-containing neurons, Int. Rev. Neurobiol., 31 (1989) 145-238.
85. Frederickson, C.J., Hernandez, M.D. and McGinty, J.F., Translocation of zinc may contribute to seizure-induced death of neurons, Brain Res., 480 (1989) 317-321.
86. Frederickson, C.J., Klitenick, M.A., Manton, W.I. and Kirkpatrick, J.B., Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat, Brain Res., 273 (1983) 335-339.
87. 2+-induced neurotoxicity in rat primary cortical cultures: involvement of L-type calcium channels, Brain Res., 654 (1994) 257-264.
88. Friedlich, A.L. and Butcher, L.L., Involvement of free oxygen radicals in β-amyloidosis: an hypothesis, Neurobiol. Aging, 15 (1994) 443-455.
89. Furuta, A., Price, D.L., Pardo, C.A., Troncoso, J.C., Xu, Z.S., Taniguchi, N. and Martin, L.J., Localization of superoxide dismutase in Alzheimer's disease and Down's syndrome neocortex and hippocampus, Am. J. Pathol., 146 (1995) 357-367.
90. Gabrielsson, B., Robson, T., Norris, D. and Chung, S.H., Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions, Brain Res., 384 (1986) 218-223.
91. Gaskin, F., Kress, Y., Brosnan, C. and Bornstein, M., Abnormal tubulin aggregates induced by zinc sulfate in organotypic cultures of nerve tissue, Neuroscience, 3 (1978) 1117-1128.
92. Goedert, M., Spillantini, M.G., Jakes, R., Crowther, R.A., Vanmechelen, E., Probst, A., Gotz, J., Burki, K. and Cohen, P., Molecular dissection of paired helical filament, Neurobiol. Aging, 16 (1995) 325-334.
93. Goldblum, S.E., Cohen, D.A., Jay, M. and McClain, C.J., Interleukin 1-induced depression of iron and zinc: role of granulocytes and lactoferrin, Am. J. Physiol., 252 (1987) E27-E32.
94. Gottschall, P.E. and Yu, X., Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes, J. Neurochem., 64 (1995) 1513-1520.
95. Griffin, W.S.T., Stanley, L.C., Ling, C., White, L., MacLeod, V., Perrot, L.J., White III, C.L. and Araoz, C., Brain interleukin-1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer's disease, Proc. Natl. Acad. Sci. USA, 86 (1989) 7611-7615.
96. Grilli, M., Ribola, M., Alberici, A., Valerio, A., Memo, M. and Spano, P., Identification and characterization of a κB/Rcl binding site in the regulatory region of the amyloid precursor protein gene, J. Biol. Chem., 270 (1995) 26774-26777.
97. 1-42 peptide is cell type dependent, J. Neurochem., 65 (1995) 292-300.
98. Gsell, W., Conrad, R., Hickethier, M., Sofic, E., Frolich, L., Wichart, I., Jellinger, K., Moll, G., Ransmayr, G., Beckmann, H. and Riederer, P., Decreased catalase activity but unchanged superoxide dismutase activity in brains of patients with dementia of Alzheimer type, J. Neurochem., 64 (1995) 1216-1223.
99. Hansson, A., Extracellular zinc ions induces mitogen-activated protein kinase activity and protein tyrosine phosphorylation in bombesin-sensitive Swiss 3T3 fibroblasts, Arch. Biochem. Biophys., 328 (1996) 233-238.
100. 2+: an endogenous modulator of ligand- and voltage-gated ion channels, Neuropharmacology, 33 (1994) 935-952.
101. Hattori, A., Tanaka, E., Murase, K., Ishida, N., Chatani, Y., Tsujimoto, M., Hayashi, K. and Kohno, M., Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells, J. Biol. Chem., 268 (1993) 2577-2582.
102. Haug, F.M.S., Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure, Histochemie, 8 (1967) 355-368.
103. Hayn, M., Kremser, K., Singewald, N., Cairns, N., Nemethova, M., Lubec, B. and Lubec, G., Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down's syndrome and Alzheimer's disease, Life Sci., 59 (1996) 537-544.
104. Hershey, C.O., Hershey, L.A., Varnes, A., Vibhakar, S.D., Lavin, P. and Strain, W.H., Cerebrospinal fluid trace element content in dementia: clinical, radiologic and pathologic correlations, Neurology, 33 (1983) 1350-1352.
105. Hesse, L., Beher, D., Masters, C.L. and Multhaup, G., The βA4 amyloid precursor protein binding to copper, FEBS Lett., 349 (1994) 109-116.
106. Hexum, T.D., Studies on the reaction catalyzed by transport (Na,K) adenosine triphosphatase-I: effects of divalent metals, Biochem. Pharmacol., 23, (1974) 3441-3447.
107. Hidalgo, J., Garcia, A., Oliva, A.M., Giralt, M., Gasull, T., Gonzalez, B., Milnerowicz, H., Wood, A. and Bremner, I., Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain, Chem. Biol. Int., 93 (1994) 197-219.
108. Holland, D.R., Cousens, L.S., Meng, W. and Matthews, B.W., Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites, J. Mol. Biol., 239 (1994) 385-400.
109. Howell, G.A., Welch, M.G. and Frederickson, C.J., Stimulation-induced uptake and release of zinc in hippocampal slices, Nature, 308 (1984) 736-738.
110. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. and Cole, G., Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice, Science, 274 (1996) 99-102.
111. Hubbard, S.R., Bishop, W.R., Kirschmeier, P., George, S.J., Cramer, S.P. and Hendrickson, W.A., Identification and characterization of zinc binding sites in protein kinase C, Science, 254 (1991) 1776-1779.
112. Hunter, F.E. Jr. and Ford, L., Inactivation of oxidative and phosphorylative systems in mitochondria by preincubation with phosphate and other ions, J. Biol. Chem., 216 (1955) 357-369.
113. Ihara, Y., Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease, Brain Res., 459 (1988) 138-144.
114. Itoh, M., Ebadi, M. and Swanson, S., The presence of zinc-binding proteins in brain, J. Neurochem., 41 (1983) 823-829.
115. Iversen, L.L., Mortishire-Smith, R.J., Pollack, S.J. and Shearman, M.S., The toxicity in vitro of β-amyloid protein, Biochem. J., 311 (1995) 1-16.
116. Jette, N., Cole, M.S. and Fahnestock, M., NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients, Mol. Brain Res., 25 (1994) 242-250.
117. Kaiser, J., Alzheimer's: could there be a zinc link?, Science, 265 (1994) 1365.
118. Kasarskis, E.J., Zinc metabolism in normal and zinc-deficient rat brain, Exp. Neurol., 85 (1984) 114-127.
119. Kelly, E.J., Quaife, C.J., Froelick, G.J. and Palmiter, R.D., Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice, J. Nutr., 126 (1996) 1782-1790.
120. Kenn, C. and Gibb, E., The role of zinc in senile dementia, Br. J. Psychiatry, 149 (1986) 221-223.
121. Kerr, J.F.R., Wyllie, A.H. and Currie, A.R., Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br. J. Cancer, 26 (1972) 239-257.
122. Kesslak, J.P., Frederickson, C.J. and Gage, F.H., Quantification of hippocampal noradrenaline and zinc changes after selective cell destruction, Exp. Brain Res., 67 (1987) 77-84.
123. Kligman, D. and Marshak, D.R., Purification and characterization of a neurite extension factor from bovine brain, Proc. Natl. Acad. Sci. USA, 82 (1985) 7136-7139.
124. Koh, J.Y. and Choi, D.W., Zinc alters excitatory amino acid neurotoxicity on cortical neurons, J. Neurosci., 8 (1988) 2164-2171.
125. Koh, J.Y. and Choi, D.W., Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors, Neurosci., 60 (1994) 1049-1057.
126. Koh, J.Y., Suh, S.W., Gwag, B.J., He, Y.Y., Hsu, C.Y. and Choi, D.W., The role of zinc in selective neuronal death after transient global cerebral ischemia, Science, 272 (1996) 1013-1016.
127. Koh, J.Y., Yang, L.L. and Cotman, C.W., β-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage, Brain Res., 533 (1990) 315-320.
128. Koo, E.H., Squazzo, S.L., Selkoe, D.J. and Koo, C.H., Trafficking of cell-surface amyloid β-protein precursor I: secretion, endocytosis and recycling as detected by labeled monoclonal antibody, J. Cell Sci., 109 (1996) 991-998.
129. Kress, Y., Gaskin, F., Brosnan, C.F. and Levine, S., Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat, Brain Res., 220 (1981) 139-149.
130. Krezoski, S.K., Villalobos, J., Shaw, III, C.F. and Petering, D.H., Kinetic lability of zinc bound to metallothionein in Erblich cells, Biochem. J., 255 (1988) 483-491.
131. LaFerla, F.M., Tinkle, B.T., Bieberich, C.J., Haudenschild, C.C. and Jay, G., The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice, Nature Gen., 9 (1995) 21-29.
132. Lees, G.J., Contributory mechanisms in the causation of neurodegenerative disorders, Neuroscience, 54 (1993) 287-322.
133. Lees, G.J. and Leong, W., Brain lesions induced by specific and non-specific inhibitors of sodium-potassium ATPase, Brain Res., 649 (1994) 225-233.
134. Lees, G.J., Lehmann, A., Sandberg, M. and Hamberger, A., The neurotoxicity of zinc in the rat hippocampus, Neurosci. Lett., 120 (1990) 155-158.
135. Levi-Montalcini, R., The nerve growth factor 35 years later, Science, 237 (1987) 1154-1162.
136. Li, Q.X., Evin, G., Small, D.H., Multhaup, G., Beyreuther, K. and Masters, C.L., Proteolytic processing of Alzheimer's disease βA4 amyloid precursor protein in human platelets, J. Biol. Chem., 270 (1995) 14140-14147.
137. Licastro, F., Davis, L.J., Mocchegiani, E. and Fabris, N., Impaired peripheral zinc metabolism in patients with senile dementia of probable Alzheimer's type as shown by low plasma concentrations of thymulin, Biol. Trace Elem. Res., 51 (1996) 55-62.
138. Lim, G.P., Backstrom, J.R., Cullen, M.J., Miller, C.A., Atkinson, R.D. and Tokes, Z.A., Matrix metalloproteinase in the neocortex and spinal cord of amyotrophic lateral sclerosis patients, J. Neurochem., 67 (1996) 251-259.
139. Lin, Y.S., Kao, S.F., Jan, M.S., Cheng, M.L., Wing, L.Y.C., Chang, W.C., Lei, H.Y. and Lin, M.T., Changes of protein kinase C subspecies in staphylococcal enterotoxin-B-induced thymocyte apoptosis, Biochem. Biophys. Res. Commun., 213 (1995) 1132-1139.
140. Lindsay, R.M., Wiegand, S.J., Altar, C.A. and DiStefano, P.S., Neurotrophic factors: from molecule to man, Trends Neurosci., 17 (1994) 182-190.
141. 1 complex by blocking a protonable group, J. Biol. Chem., 270 (1995) 25001-25006.
142. Lyon, A.W., Narindrasorasak, S., Young, I.D., Anastassiades, T., Couchman, J.R., McCarthy, K.J. and Kisilevsky, R., Co-deposition of basement membrane components during the induction of murine splenic AA amyloid, Lab. Invest., 64 (1991) 785-790.
143. Makar, T.K., Nedergaard, M., Preuss, A., Gelbard, A.S., Perumal, A.S. and Cooper, A.J.L., Vitamin E, ascorbate, glutathione, glutathione disulfide and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain, J. Neurochem., 62 (1994) 45-53.
144. Makowski, G.S. and Sunderman, F.W. Jr., The interactions of zinc, nickel and cadmium with Xenopous transcription factor IIIA, assessed by equilibrium dialysis, J. Inorg. Biochem., 48 (1992) 107-119.
145. Mantyh, P.W., Ghilardi, J.R., Rogers, S., DeMaster, E., Allen, C.J., Stimson, E.R. and Maggio, J.E., Aluminum, iron and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide, J. Neurochem., 61 (1993) 1171-1174.
146. Maret, W., Oxidative metal release from metallothionein via zincthiol/disulfide interchange, Proc. Natl. Acad. Sci. USA, 91 (1994) 237-241.
147. Maret, W., Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc, Neurochem. Int., 27 (1995) 111-117.
148. Marklund, S.L., Adolfsson, R., Gottfries, C.G. and Winbald, B., Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type, J. Neurol. Sci., 67 (1985) 319-325.
149. Marshak, D.R., Pesce, S.A., Stanley, L.C. and Griffin, W.S.T. Increased S-100β neurotrophic activity in Alzheimer's disease temporal lobe, Neurobiol. Aging, 13 (1991) 1-7.
150. Masters, B.A., Quaife, C.A., Erickson, J.C., Kelly, E.J., Froelick, G.J., Zambrowicz, B.P., Brinster, R.L. and Palmiter, R.D., Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles, J. Neurosci., 14 (1994) 5844-5857.
151. Mattson, M.P., Untangling the pathophysiochemistry of β-amyloid, Nature Struc. Biol., 2 (1995a) 926-928.
152. Mattson, M.P., Degenerative and protective signalling mechanisms in the neurofibrillary pathology of AD, Neurobiol. Aging, 16 (1995b) 447-463.
153. Mattson, M.P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I. and Rydel, R.E., β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity, J. Neurosci., 12 (1992) 376-389.
154. Mayer, M.L. and Vyklicky, L. Jr., The action of zinc on synaptic transmission and neuronal excitability in cultures of mouse hippocampus, J. Physiol., 415 (1989) 351-365.
155. Mayer, M.L., Vyklicky, L. Jr. and Westbrook, G.L., Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones, J. Physiol., 415 (1989) 329-350.
156. McGeer, P.L. and McGeer, E.G., The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases, Brain Res. Rev., 21 (1995) 195-218.
157. Mobley, W.C., Neve, R.L., Prusiner, S.B. and McKinley, M.P., Nerve growth factor increases mRNA levels for prion protein and the β-amyloid protein precursor in developing hamster brain, Proc. Natl. Acad. Sci. USA, 85 (1988) 9811-9815.
158. Muir, D., Metalloproteinaise-dependent neurite outgrowth within a synthetic extracellular matrix is induced by nerve growth factor, Exp. Cell Res., 210 (1994) 243-252.
159. Multhaup, G., Bush, A.I., Pollwein, P. and Masters, C.L., Interaction between zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP), FEBS Lett., 355 (1994) 151-154.
160. Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C.L. and Beyreuther, K., The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I), Science, 271 (1996) 1406-1409.
161. 2+, J. Biol. Chem., 262 (1987) 13902-13906.
162. Murphy, P., Wadiwala, I., Sharland, D.E. and Rai, G.S., Copper and zinc levels in 'healthy' and 'sick' elderly, J. Am. Geriatrics Soc., 33 (1985) 847-849.
163. Murtomaki, S., Risteli, J., Risteli, L., Koivisto, U.M., Johansson, S. and Liesi, P., Laminin and its neurite outgrowth-promoting domain in the brain in Alzheimer's disease and Down's syndrome patients, J. Neurosci. Res., 32 (1992) 261-273.
164. Mustafa, M.G., Cross, C.E., Munn, R.J. and Hardie, J.A., Effects of divalent metal ions on alveolar macrophage membrane adenosine triphosphatase activity, J. Lab. Clin. Med., 77 (1971) 563-571.
165. Narindrasorasak, S., Altman, R.A., Gonzales-DeWhitt, P., Greenberg, B.D. and Kisilevsky, R., An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease, Lab. Invest., 72 (1995), 272-282.
166. Narindrasorasak, S., Lowery, D.E., Altman, R.A., Gonzales-De-Whitt, P.A., Greenberg, B.D. and Kisilevsky, R., Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins, Lab. Invest., 67 (1992) 643-652.
167. Narindrasorasak, S., Lowery, D., Gonzalez-De Whitt, P., Poorman, R.A., Greenberg, B. and Kisilevsky, R., High affinity interactions between the Alzheimer's β-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan, J. Biol. Chem., 266 (1991) 12878-12883.
168. Nichols, D. and Attwell, D., The release and uptake of excitatory amino acids, Trends Pharmacol. Sci., 11 (1990) 462-469.
169. O'Halloran, T.V., Transition metals in control of gene expression, Science, 261 (1993) 715-725.
170. Olanow, C.W., A radical hypothesis for neurodegeneration, Trends Neurosci., 16 (1993) 439-444.
171. Palmiter, R.D., Constitutive Expression of metallothionein-III (MT-III), but not MT-I, inhibits growth when cells become zinc deficient, Toxicol. Appl. Pharmacol., 135 (1995) 139-146.
172. Palmiter, R.D. and Findley, S.D., Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc, EMBO J., 14 (1995) 639-649.
173. Palmiter, R.D., Cole, T.B. and Findley, S.D., ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration, EMBO J., 15 (1996) 1784-1791.
174. Pappolla, M.A., Omar, R.A., Kim, K.S. and Robakis, N.K., Immunohistochemical evidence of antioxidant stress in Alzheimer's disease, Am. J. Pathol., 140 (1992) 621-628.
175. Pattison, S.E. and Dünn, M.F., On the mechanism of divalent metal ion chelator induced activation of the 7S nerve growth factor esteropeptidase: activation by 2,2′,2′-terpyridine and by 8-hydroxyquinoline-5-sulfonic acid, Biochemistry, 15 (1976a) 3691-3696.
176. Pattison, S.E. and Dunn, M.F., On the mechanism of divalent metal ion chelator induced activation of the 7S nerve growth factor esteropeptidase: thermodynamics and kinetics of activation, Biochemistry, 15 (1976b) 3696-3703.
177. Persechini, A., McMillan, K. and Masters, B.S.S., Inhibition of nitric oxide synthase activity by zinc ion, Biochemistry, 34 (1995) 15091-15095.
178. 65Zn uptake from blood into brain in the rat, J. Neurochem., 56 (1991) 485-489.
179. Purcell, W.M. and Atterwill, C.K., Mast cells in neuroimmune function. Neurotoxicological and neuropharmacological perspectives, Neurochem. Res., 20 (1995) 521-532.
180. Rinaudo, M.S., Su, K., Falk, L.A., Haldar, S. and Mufson, R.A., Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cells, Blood, 86 (1995) 80-88.
181. Roher, A.E., Kasunic, T.C., Woods, A.S., Cotter, R.J., Ball, M.J. and Fridman, R., Proteolysis of Aβ peptide from Alzheimer's disease brain by gelatinase A, Biochem. Biophys. Res. Commun., 205 (1994) 1755-1761.
182. Rosen, D.R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J.P., Deng, H.X., Rahmani, Z., Krizus, A., Mckenna-Yasek, D., Cayabyab, A., Gaston, S.M., Berger, R., Tanzi, R.E., Halperin, J.J., Herzfeldt, B., Van den Bergh, R., Hung, W.Y., Bird, T., Deng, G., Mulder, D.W., Smyth, C., Laing, N.G., Soriano, E., Pericak-Vance, M.A., Haines, J., Rouleau, G.A., Gusella, J.S., Horvitz, H.R. and Brown, R.H.J., Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, Nature, 362 (1993) 59-62.
183. Rubin, E.H., Psychopathology of senile dementia of the Alzheimer type. In R.J. Wurtman, S. Corkin, J.H. Growdon and E. Ritter-Walker (Eds.), Adv. Neurol., 51, Raven Press, New York, 1990, pp. 53-59.
184. Rubin, H. and Koide, T., Stimulation of DNA synthesis and 2-deoxy-D-glucose transport in chick embryo cultures by excessive metal concentrations and by a carcinogenic hydrocarbon, J. Cell. Physiol., 81 (1973) 387-396.
185. Ruz, M., Cavan, K.R., Bettger, W.J., Fischer, P.W. and Gibson, R.S., Indices of iron and copper status during experimentally induced, marginal zinc deficiency in human, Biol. Trace Elem. Res., 34 (1992) 197-212.
186. Sagara, J., Makino, N. and Bannai, S., Glutathione efflux from cultured astrocytes, J. Neurochem., 66 (1996) 1876-1881.
187. Sahu, R.N., Pandey, R.S., Subhash, M.N., Arya, B.Y.T., Padmashree, T.S. and Srinivas, K.N., CSF zinc in Alzheimer's type dementia, Biol. Psychiatry, 24 (1988) 480-482.
188. Salehi, A., Verhaagen, J., Dijkhuizen, P.A. and Swaab, D.F., Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease, Neuroscience, 75 (1996) 373-387.
189. Samudralwar, D.L., Diprete, C.C., Ni, B.F., Ehmann, W.D. and Markesbery, W.R., Elemental imbalances in the olfactory pathway in Alzheimer's disease, J. Neurol. Sci., 130 (1995) 139-145.
190. Sawada, J.I., Kikuchi, Y., Shibutani, M., Mitsumori, K., Inoue, K. and Kasahara, T., Induction of metallothionein in astrocytes by cytokines and heavy metals, Biol. Signals, 3 (1994) 157-168.
191. Scott, S.A., Mufson, E.J., Weingartner, J.A., Skau, K.A. and Crutcher, K.A., Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J. Neurosci. 15 (1995) 6213-6221.
192. Selkoe, D.J., Podlisny, M.B., Gronbeck, A., Mammen, A. and Kosik, K.S., Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease. In R.J. Wurtman, S. Corkin, J.H. Growdon and E. Ritter-Walker (Eds.), Adv. Neurol., 51, Raven Press, New York, 1990, pp. 171-179.
193. Shaheen, A.A. and el-Fattah, A.A., Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues, Int. J. Biochem. Cell Biol., 27 (1995) 89-95.
194. Shashoua, V.E., Hesse, G.W. and Moore, B.W., Proteins of the brain extracellular fluid: evidence for release of S-100 protein, J. Neurochem., 42 (1984) 1536-1541.
195. Shimizu, T., Kubota, M., Tanizawa, A., Sano, H., Kasai, Y., Hashimoto, H., Akiyama, Y. and Mikawa, H., Inhibition of both etoposide-induced DNA fragmentation and activation of poly(ADP-ribose) synthesis by zinc ion, Biochem. Biophys. Res. Commun., 169 (1990) 1172-1177.
196. Shivakumar, B.R., Kolluri, S.V.R. and Ravindranath, V., Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia, J. Pharmacol. Exp. Ther., 274 (1995) 1167-1173.
197. Shore, D., Henkin, R.I., Nelson, N.R., Agarwal, R.P. and Wyatt, R.J., Hair and serum copper, zinc, calcium, and magnesium concentrations in Alzheimer-type dementia, J. Am. Geriatrics Soc., 32 (1984) 892-895.
198. Slivka, A., Spina, M.B. and Cohen, G., Reduced and oxidized glutathione in human and monkey brain, Neurosci. Lett., 74 (1987) 112-118.
199. Slomianka, L., Neurons of origin of zinc-containing pathways and the distribution of zinc-containing boutons in the hippocampal region of the rat, Neuroscience, 48 (1992) 325-352.
200. Slomianka, L., Danscher, G. and Frederickson, C.J., Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium selenite, Neuroscience, 38 (1990) 843-854.
201. Smart, T.G., Xie, X. and Krishek, B.J., Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc, Prog. Neurobiol., 42 (1994) 393-441.
202. Smith, M.A., Sayre, L.M., Monnier, V.M. and Perry, G., Radical AGEing in Alzheimer's disease, Trends Neurosci., 18 (1995) 172-176.
203. Snow, A.D., Mar, H., Nochlin, D., Kimata, K., Kato, M., Suzuki, S., Hassell, J. and Wight, T.N., The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease, Am. J. Pathol., 133 (1988) 456-463.
204. Snow, A.D., Willmer, J. and Kisilevsky, R., Sulfated glycosamino-glycans: a common constituent of all amyloids?, Lab. Invest., 56 (1987) 120-123.
205. Stewart, G.R., Frederickson, C.J., Howell, G.A. and Gage, F.H. Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation, Brain Res., 290 (1984) 43-51.
206. Storm-Mathisen, J. and Ottersen, O.P., Immunocytochemistry of glutamate at the synaptic level, J. Histochem. Cytochem., 38 (1990) 1733-1743.
207. Su, J.H., Anderson, A.J., Cummings, B.J. and Cotman, C.W., Immunohistochemical Evidence for apoptosis in Alzheimer's disease, NeuroReport, 5 (1994) 2529-2533.
208. Takeda, A., Akiyama, T., Sawashita, J. and Okada, S., Brain uptake of trace metals, zinc and manganese, in rats, Brain Res., 640 (1994) 341-344.
209. Takeda, A., Sawashita, J. and Okada, S., Biological half-lives of zinc and manganese in rat brain, Brain Res., 695 (1995) 53-58.
210. Taubeneck, M.W., Daston, G.P., Rogers, J.M., Gershwin, M.E., Ansari, A. and Keen, C.L., Tumor necrosis factor-α alters maternal and embryonic zinc metabolism and is developmentally toxic in mice, J. Nutr., 125 (1995) 908-919.
211. Terai, K., Matsuo, A. and McGeer, P.L., Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease, Brain Res., 735 (1996) 159-168.
212. Thompson, C.M., Markesbery, W.R., Ehmann, W.D., Mao, Y.X. and Vance, D.E., Regional brain trace-element studies in Alzheimer's disease, Neurotoxicology, 9 (1988) 1-7.
213. Tonder, N., Johansen, F.F., Frederickson, C.J., Zimmer, J. and Diemer, N.H., Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat, Neurosci. Lett., 109 (1990) 247-252.
214. Tsuji, S., Kobayashi, H., Uchida, Y., Ihara, Y. and Miyatake, T., Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease, EMBO J., 11 (1992) 4843-4850.
215. Tully, C.L., Snowdon, D.A. and Markesbery, W.R., Serum zinc, senile plaques, and neurofibrillary tangles: findings from the nun study. NeuroReport, 6 (1995) 2105-2108.
216. Tuszynski, M.H., Sang, H., Amaral, D.G. and Gage, F.H. Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration, J. Neurosci., 10 (1990) 3604-3614.
217. Uchida, Y., Growth-inhibitory factor, metallothionein-like protein, and neurodegenerative diseases, Biol. Signals, 3 (1994) 211-215.
218. Uchida, Y., Ihara, Y. and Tomonaga, M., Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats, Biochem. Biophys. Res. Commun., 150 (1988) 1263-1267.
219. Uchida, Y., Takio, K., Titani, K., Ihara, Y. and Tomonaga, M., The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein, Neuron, 7 (1991) 337-347.
220. Vallee, B.L., Zinc in biology and biochemistry. In T.G. Spiro (Ed.), Zinc Enzymes, Wiley and Sons, New York, 1983, pp. 1-24.
221. Vallee, B.L. and Falchuk, K.H., The biochemical basis of zinc physiology, Physiol. Rev., 73 (1993) 79-117.
222. Vallee, B.L., Coleman, J.E. and Auld, D.S., Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains, Proc. Natl. Acad. Sci. USA, 88 (1991) 999-1003.
223. Vener, A.V., Aksenova, M.V. and Burbaeva, G.S., Drastic reduction of the zinc- and magnesium-stimulated protein tyrosine kinase activities in Alzheimer's disease hippocampus, FEBS Lett., 328 (1993) 6-8.
224. Wang, H.Y., Pisano, M.R. and Friedman, E., Attenuated protein kinase C activity and translocation in Alzheimer's disease brain, Neurobiol. Aging, 15 (1994) 293-298.
225. Ward, N.I. and Mason, J.A., Neutron activation analysis for identifying elemental status in Alzheimer's disease, J. Radioanal. Nucl. Chem., 113 (1987) 515-526.
226. Weiss, J.H., Hartley, D.M., Koh, J.Y. and Choi, D.W., AMPA receptor activation potentiates zinc neurotoxicity, Neuron, 10 (1993) 43-49.
227. 65Zn in subcellular fractions of brain of rat under normal and zinc-deficient conditions, Biol. Trace Elem. Res., 14 (1987) 127-141.
228. Wensink, J., Molenaar, A.J., Woroniecka, U.D. and Van den Hamer, C.J.A. Zinc uptake into synaptosomes, J. Neurochem., 50 (1988) 782-789.
229. Wenstrup, D., Ehmann, W.D. and Markesbery, W.R., Trace element imbalances in isolated subcellular fractions of Alzheimer's disease brains, Brain Res., 533 (1990) 125-131.
230. Whitemore, P.J., Price, D.L., Stable, R.G., Clark, A.W., Coyle, J.T. and DeLong, M.R., Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain, Science, 215 (1982) 1237- 1239.
231. Williams, R.J.P., An introduction to the biochemistry of zinc. In C.F. Mills (Ed.), Zinc in Human Biology, Springer-Verlag, London, 1989, pp. 15-31.
232. Wurtman, R.J., Blusztajn, J.K., Ulus, I.H., Coviella, I.L.G., Buyukuysal, R.L., Growdon, J.H. and Slack, B.E., Choline metabolism in cholinergic neurons: implications for the pathogenesis of neurodegenerative diseases. In R.J. Wurtman, S. Corkin, J.H. Growdon and E. Ritter-Walker (Eds.), Adv. Neurol., 51, Raven Press, New York, 1990, pp. 117-125.
233. Wyllie, A.H., Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation, Nature, 284 (1980) 555-556.
234. Wyllie, A.H., Kerr, J.F.R. and Currie, A.R., Cell death in the normal neonatal rat adrenal cortex, J. Pathol., 111 (1973) 255-261.
235. Yamazaki, T., Koo, E.H. and Selkoe, D.J., Trafficking of cell-surface amyloid β-protein precursor II: endocytosis, recycling and lysosomal targeting detected by immunolocalization, J. Cell Sci., 109 (1996) 999-1008.
236. Yang, J.P., Merin, J.P., Nakano, T., Kato, T., Kitade, Y. and Okamoto, T., Inhibition of DNA-binding activity of NF-κB by gold compounds in vitro, FEBS Lett., 361 (1995) 89-96.
237. Yankner, B.A., Caceres, A. and Duffy, L.K., Nerve growth factor potentiates the neurotoxicity of β-amyloid, Proc. Natl. Acad. Sci. USA, 87 (1990) 9020-9023.
238. 2+-permeable AMPA/Kainate channels and triggers selective neural injury, NeuroReport, 6 (1995) 2553-2556.
239. Yokoyama, M., Koh, J. and Choi, D.W., Brief exposure to zinc is toxic to cortical neurons, Neurosci. Lett., 71 (1986) 351-355.
240. Young, J.K., Glial metallothionein, Biol. Signals, 3 (1994) 169-175.
241. Yu, C. and Crutcher, K.A., Nerve growth factor immunoreactivity and sympathetic sprouting in the rat hippocampal formation, Brain Res., 672 (1995) 55-67.
242. Yurchenco, P.D. and Schittny, J.C., Molecular architecture of basement membranes, FASEB J., 4 (1990) 1577-1590.
243. Zabel, U., Schreck, R. and Baeuerle, P.A., DNA binding of purified transcription factor NF-κB, J. Biol. Chem., 266 (1991) 252-260.
244. Zalewski, P.D., Forbes, I.J. and Betts, W.H., Correlation of apoptosis with change in intracellular labile Zn(II) using Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy) acetic acid], a new specific fluorescent probe for Zn(II), Biochem. J., 296 (1993) 403-408.
245. 2+-dependent interaction with actin, Biochem. Int., 24 (1991) 1103-1110.
246. Zalewski, P.D., Forbes, I.J., Giannakis, C., Cowled, P.A. and Betts, W.H., Synergy between zinc and phorbol ester in translocation of protein kinase C to cytoskeleton, FEBS Lett., 273 (1990) 131-134.
247. Zalewski, P.D., Forbes, I.J., Seamark, R.F., Borlinghaus, R., Betts, W.H., Lincoln, S.F. and Ward, A.D., Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin, Chem. Biol., 1 (1994) 153-161.
248. Zhang, P., Damier, P., Hirsch, E.C., Agid, Y., Ceballos-Picot, I., Sinet, P.M., Nicole, A., Laurent, M. and Javoy-Agid, F., Preferential expression of superoxide dismutase messenger RNA in melanized neurons in human mesencephalon, Neuroscience, 55 (1993) 167-175.
249. Zhao, H. and Eide, D., The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation, Proc. Natl. Acad. Sci. USA, 93 (1996) 2454-2458.