α2-Macroglobulin as a β-amyloid peptide-binding plasma protein

Journal of Neurochemistry

Volumn 69, Issue 1, 1997, Pages 299-305

  Du, Yansheng ^a   Ni, Binhui ^a   Glinn, Michele ^a   Dodel, Richard C ^a   Bales, Kelly R ^a   Zhang, Zhiyuan ^a   Hyslop, Paul A ^a   Paul, Steven M ^a,b  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Brain; Senile plaques; 2 Macroglobulin; Amyloid peptide

Indexed keywords

ALPHA 2 MACROGLOBULIN; AMYLOID BETA PROTEIN; BINDING PROTEIN; ALPHA 1 ANTICHYMOTRYPSIN; CALCIUM; DIAGNOSTIC AGENT; RADIOACTIVE IODINE; ZINC;

ALZHEIMER DISEASE; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; HUMAN; PLASMA CLEARANCE; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; SENILE PLAQUE; BINDING COMPETITION; DOSE RESPONSE; DRUG EFFECT; ELECTROPHORESIS; METABOLISM; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA-MACROGLOBULINS; AMYLOID BETA-PROTEIN; BINDING, COMPETITIVE; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS; HUMANS; IODINE RADIOISOTOPES; PRECIPITIN TESTS; SENSITIVITY AND SPECIFICITY; ZINC;

EID: 0030610309     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69010299.x     Document Type: Article

References (33)

1. 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52, 487-501.
2. Banks W. A., Kastin A. J., Barrera C. M., and Maness L. M. (1991) Lack of saturable transport across the blood-brain barrier in either direction for β-amyloid 1-28 (Alzheimer's disease protein). Brain Res. Bull. 27, 819-823.
3. 2-macroglobulin with proteases. Biochem. J. 133, 709-724.
4. 2-macroglobulin. J. Biol. Chem. 262, 12837-12844.
5. 2-Macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J. 6, 3345-3353.
6. 2-macroglobulin as a cytokine binding plasma protein. J. Biol. Chem. 254, 5818-5825.
7. Bush A. I., Pettingell W. H., Multhaup G., Paradis M., Vonsattel J.-P., Gusella J. F., Beyreuther K., Masters C. L., and Tanzi R. E. (1994) Rapid induction of Alzheimer Aβ amyloid formation by zinc. Science 265, 1464-1467.
8. Das S. and Potter H. (1995) Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron 14, 447-456.
9. 1-Antichymotrypsin binding to Alzheimer Aβ peptides is sequence specific and induces fibril disaggregation in vitro. J. Neurochem. 61, 298-305.
10. Games D., Adams D., Alessandrini R., Barbour R., Berthelotte P., Blackwell C., Carr T., Clemens J., Donaldson T., Gillespie F., Guido T., Hagopian S., Johnson-Wood K., Khan K., Lee M., Leibowitz P., Lieberburg I., Little S., Masliah E., McConlogue L., Montoya-Zavala M., Mucke L., Paganini L., and Penniman E. (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373, 523-527.
11. Ganrot P. O. (1966) The combining ratio between trypsin and serum alpha-2-macroglobulin. Acta Chem. Scand. 20, 2299-2300.
12. Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., Lieberburg I., Koo E. H., Schenk D., Teplow D. B., and Selkoe D. J. (1992) Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359, 322-325.
13. Haverback B. J., Dyee B., Bundy H. F., Wirtschaffer S. K., and Edmondson H. A. (1962) Protein binding of pancreatic proteolytic enzymes. J. Clin. Invest. 41, 972-980.
14. Ikai A., Osada T., and Nishigai M. (1988) Conformational changes of alpha-macroglobulin and ovomacroglobulin from the green turtle (Cheloniamydas japonica). J. Biochem. (Tokyo) 103, 218-224.
15. 2-macroglobulin. Immunol. Today 11, 163-166.
16. Kang J., Lemaire H. G., Unterbeck A., Salbaum J. M., Masters C. L., and Grzeschik K. H. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell surface-receptor. Nature 325, 733-736.
17. Kuo Y. M., Emmerling M. R., Vigo-Pelfrey C., Kasunic T. C., Kirkpatrick J. B., Murdoch G. H., Ball M. J., and Roher A. E. (1996) Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. Biol. Chem. 271, 4077-4081.
18. 2-macroglobulin. J. Biol. Chem. 270, 8381-8384.
19. Lui E., Fisman M., Wong C., and Diaz F. (1990) Metals and the liver in Alzheimer's disease. An investigation of hepatic zinc, copper, cadmium, and metallothionein. J. Am. Geriatr. Soc. 38, 633-699.
20. 2-macroglobulin receptor contains high affinity calcium binding sites important for receptor conforma-tion and ligand recognition. J. Biol. Chem. 265, 12623-12628.
21. 2-macroglobulin studies on electrophoretic heterogeneity. Biochim. Biophys. Acta 623, 46-56.
22. 2-macroglobulin from human serum. Biochemistry 9, 2421-2426.
23. Pike C. J., Walencewicz A. J., Glabe C. G., and Cotman C. W. (1991) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563, 311-314.
24. Rebeck G. W., Reiter J. S., Strickland D. K., and Hyman B. T. (1993) Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interaction. Neuron 11, 575-580.
25. Selkoe D. J. (1994) Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 10, 373-403.
26. 2-Macroglobulins: structure, shape, and mechanisms of protease complex formation. J. Biol. Chem. 264, 11539-11542.
27. 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab. Invest. 66, 223-230.
28. Strittmatter W. J. and Roses A. D. (1995) Apolipoprotein E and Alzheimer's disease. Proc. Natl. Acad. Sci. USA 92, 4725-4727.
29. Tabaton M., Nunzi M. G., Xue R., Usiak M., Autilio-Gambetti L., and Gambetti P. (1994) Soluble amyloid β-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid. Biochem. Biophys. Res. Commun. 200, 1598-1603.
30. 2-macroglobulin receptor in Alzheimer and control postmortem human brain. Mol. Chem. Neuropathol. 18, 153-160.
31. 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiol. Aging 14, 233-237.
32. Van Gool W. A., Kuiper M. A., Walstra E. C., and Bolhuis P. A. (1995) Concentrations of amyloid β protein in cerebrospinal fluid of patients with Alzheimer's disease. Ann. Neurol. 37, 277-279.
33. 1-antichymotrypsin. Amyloid Int. J. Exp. Clin. Invest. 3, 156-161.