Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice

Toxicology and Applied Pharmacology

Volumn 148, Issue 1, 1998, Pages 148-157

  Quaife, Carol J ^a   Kelly, Edward J ^a   Masters, Brian A ^b   Brinster, Ralph L ^b   Palmiter, Richard D ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; MESSENGER RNA; METALLOTHIONEIN; ZINC;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; MOUSE; NECROSIS; NONHUMAN; PANCREAS INSUFFICIENCY; TRANSGENIC MOUSE;

EID: 0031906795     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1997.8321     Document Type: Article

References (50)

1. Braun R. E., Lo D., Pinkert C. A., Widera G., Flavell R. A., Palmiter R. D., Brinster R. L. Infertility in male transgenic mice: Disruption of sperm development by HSV-tk in postmeiotic germ cells. Biol. Reprod. 43:1990;684-685.
2. 35. Chem.-Biol. Interact. 23:1978;355-357.
3. Brinster R. L., Chen H. Y., Trumbauer M. E., Yagle M. K., Palmiter R. D. Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc. Natl. Acad. Sci. USA. 82:1985;4438-4442.
4. Choudhuri S., Liu L. W. L., Berman N. E., Klaassen D. C. Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. Toxicol. Lett. 84:1996;127-133.
5. Compere S. J., Palmiter R. D. DNA methylation controls inducability of the mouse metallothionein-I gene in lymphoid cells. Cell. 25:1981;233-240.
6. Cunnane S. C. Clinical and Biological Significance. 1988;CRC Press, Boca Raton.
7. Dalton T., Fu K., Palmiter R. D., Andrews G. K. Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency. J. Nutr. 126:1996;825-833.
8. Debec A., Mokdad A. R., Wegnez M. Metallothioneins and resistance to cadmium poisoning inDrosophila. Biochem. Biophys. Res. Commun. 127:1985;143-152.
9. Durnam D. M., Palmiter R. D. Analysis of the detoxification of heavy metal ions by mouse metallothioneins. Experientia. 52:1987;457-463.
10. Eaton D. L., Toal B. F. A simplified method for quantitating metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66:1982;134-142.
11. Erickson J. C., Hollopeter G., Thomas S. A., Froelick G. J., Palmiter R. D. Disruption of the metallothionein III gene in mice: Analysis of brain zinc, behavior, and neuron vulnerability to metals, aging and seizures. J. Neurosci. 15:1997;1271-1281.
12. Erickson J. C., Masters B. A., Kelly E. J., Brinster R. L., Palmiter R. D. Expression of human metallothionein III in transgenic mice. Neurochem. Int. 27:1995;35-41.
13. Erickson J. C., Sewell A. K., Jensen L. T., Winge D. R., Palmiter R. D. Enhanced neurotropic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein III (GIF). Brain Res. 649:1994;297-304.
14. Fassel V. A. Quantitative elemental analysis by plasma emission. Science. 202:1978;1983-1991.
15. Frederickson C. J. Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 31:1989;145-238.
16. Frederickson C. J., Moncrieff D. W. Zinc-containing neurons. Biol. Signals. 3:1994;127-139.
17. G'omez-Dumm C. L., Atwater I., Epstein P. N., Gagliardino J. J. Quantitative immunocytochemical study of islet cell populations in diabetic calmodulin-transgenic mice. Virchows. Arch. 425:1994;73-77.
18. Hamer D. Metallothionein. Annu. Rev. Biochem. 55:1986;913-951.
19. Iszard M. B., Liu J., Liu Y., Dalton T., Andrews G. K., Palmiter R. D., Klaassen C. D. Characterization of metallothionein-I-transgenic mice. Toxicol. Appl. Pharmacol. 133:1995;305-312.
20. Kägi J. H. R. Evolution, structure, and chemical activity of class I metallothioneins: An overview. Metallothionein III: Biological Roles and Medical Implications. 1993;Birkhäuser Verlag, Bäsel. p. 29-55.
21. Kelly E. J., Quaife C. J., Froelick G. J., Palmiter R. D. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J. Nutr. 126:1996;1782-1790.
22. Labarca C., Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102:1980;344-352.
23. Lastowski D., Otto E., Maroni G. Nucleotide sequence and expression of aDrosophila. J. Biol. Chem. 260:1985;1527-1530.
24. Lieberman M. W., Beach L. R., Palmiter R. D. Ultraviolet radiation-induced metallothionein-1 gene activation is associated with extensive DNA demethylation. Cell. 36:1983;207-214.
25. Lo D., Burkly L. C., Flavell R. A., Palmiter R. D., Brinster R. L. Antigen presentation in MHC class II transgenic mice: Stimulation versus tolerization. Immunol. Rev. 117:1990;121-134.
26. Lu J., Combs G. F. Effect of excess dietary zinc on pancreatic exocrine function in the chick. J. Nutr. 118:1988;681-689.
27. Masters B. A., Kelly E. J., Quaife C. J., Brinster R. L., Palmiter R. D. Targeted disruption of metallothionein-I and -II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA. 91:1994a;584-588.
28. Masters B. A., Quaife C. J., Erickson J. C., Kelly E. J., Froelick G. J., Zambrowicz B. P., Brinster R. L., Palmiter R. D. Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles. J. Neurosci. 14:1994b;5844-5847.
29. Mehra R. K., Garey J. R., Butt T. R., Gray W. R., Winge D. R. Candida glabrata. J. Biol. Chem. 264:1989;19747-19753.
30. Mehra R. K., Tarbet E. B., Gray W. R., Winge D. R. Metal-specific synthesis of two metallothioneins and glutamyl peptides inCandida glabrata. Proc. Natl. Acad. Sci. USA. 85:1988;8815-8819.
31. Merali Z., Singhal R. L. Prevention by zinc of cadmium-induced alterations in pancreatic and hepatic functions. Br. J. Pharmacol. 57:1976;573-579.
32. Michalska A. E., Choo K. H. Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse. Proc. Natl. Acad. Sci. USA. 90:1993;8088-8092.
33. Moriyama T., Guilhot S., Klopchin K., Moss B., Pinkhert C. A., Palmiter R. D., Brinster R. L., Kanagawa O., Chisari F. V. Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science. 248:1990;361-364.
34. Palmiter R. D. Constitutive expression of metallothionein-III (MT-III), but not MT-I inhibits growth when cells become zinc deficient. Toxicol. Appl. Pharmacol. 135:1995;139-146.
35. Palmiter R. D., Findley S. D., Whitmore T. E., Durnam D. D. MT-III, a brain-specific member of the metallothionein gene family. Proc. Natl. Acad. Sci. USA. 89:1992;6333-6337.
36. Palmiter R. D., Sandgren E. P., Koeller D. M., Brinster R. D. Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol. Cell Biol. 13:1993a;5266-5275.
37. Palmiter R. D., Sandgren E. P., Koeller D. M., Findley S. D., Brinster R. D. Metallothionein genes and their regulation in transgenic mice. Suzuki K. T., Imura N., Kimura M. Metallothionein III: Biological Roles and Medical Implications. 1993b;399-406 Birkhäuser Verlag, Bäsel.
38. Quaife C. J., Findley S. D., Erickson J. C., Froelick G. L., Kelly E. J., Zambrowicz B. P., Palmiter R. D. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry. 33:1994;7250-7259.
39. Rao M. S., Yeldandi A. V., Subbarao V., Reddy J. K. Role of apoptosis in copper deficiency-induced pancreatic involution in the rat. Am. J. Pathol. 142:1993;1952-1957.
40. Rhim J. A., Sandgren E. P., Palmiter R. D., Brinster R. L. Complete reconstruction of mouse liver with xenogenetic hepatocytes. Proc. Natl. Acad. Sci. USA. 92:1995;4942-4946.
41. Ribar T. J., Jan C. R., Augustine G. J., Means A. R. Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. J. Biol. Chem. 270:1995;28688-28695.
42. Sato M., Bremner I. Oxygen free radicals and metallothionein. Free Radical Biol. Med. 14:1993;325-337.
43. Sewell A. K., Jensen L. T., Erickson J. C., Palmiter R. D., Winge D. R. Bioactivity of metallothionein-3 correlates with its novel β domain sequence rather than metal binding properties. Biochemistry. 34:1995;4740-4747.
44. Sheehan D. C., Hrapchack B. B. Nuclear and cytoplasmic stains. Theory and Practice of Histotechnology. 1980;C. V. Mosby, St. Louis. p. 137-153.
45. Uchida Y., Takio K., Ihara Y., Tomonaga M. The growth inhibitory factor that is deficient in Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron. 7:1991;337-347.
46. Vallee B. L. The function of metallothionein. Neurochem. Int. 27:1995;399-406.
47. Walsh C. T., Sandstead H. H., Prasad A. S., Newborne P. M., Fraker P. J. Zinc health effects and research priorities for the 1990s. Environ. Health Perspect. 102:1994;5-46.
48. West A. D., Stalling R., Hildebrand C. E., Chiu R., Karin M., Richards R. I. Human metallothionein genes: Structure of the functional locus at 16q13. Genetics. 8:1990;513-518.
49. Wilkie T. M., Braun R. E., Ehrman W. J., Palmiter R. D., Hammer R. E. Germline intrachromosomal recombination restores fertility in transgenic MyK-103 male mice. Genes Dev. 5:1991;38-48.
50. Yagle M. K., Palmiter R. D. Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids. Mol. Cell Biol. 13:1985;5266-5275.