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Volumn 25, Issue 3, 2004, Pages 407-416

Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum

Author keywords

Age related learning deficits; Hippocampus; Nonperforated synapses; Normal aging; Perforated synapses; Postsynaptically silent synapses

Indexed keywords

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SIZE; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING DISORDER; MALE; MAZE TEST; NONHUMAN; PERFORATION; PRIORITY JOURNAL; RAT; STEREOMETRY; SYNAPSE; TASK PERFORMANCE;

EID: 1242338796     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2003.12.001     Document Type: Article
Times cited : (137)

References (71)
  • 1
    • 0000968097 scopus 로고
    • Hippocampal formation
    • Paxinos G, editor. New York: Academic Press;
    • Amaral DG, Witter MP. Hippocampal formation. In: Paxinos G, editor. The rat nervous system. 2nd ed. New York: Academic Press; 1995. p. 443-93.
    • (1995) The Rat Nervous System. 2nd Ed. , pp. 443-493
    • Amaral, D.G.1    Witter, M.P.2
  • 2
    • 0028107456 scopus 로고
    • Normal aging: Regionally specific changes in hippocampal synaptic transmission
    • Barnes C.A. Normal aging: regionally specific changes in hippocampal synaptic transmission. Trends Neurosci. 17(1):1994;13-18.
    • (1994) Trends Neurosci. , vol.17 , Issue.1 , pp. 13-18
    • Barnes, C.A.1
  • 3
    • 0030755342 scopus 로고    scopus 로고
    • R-mediated excitatory postsynaptic potential in hippocampal region CA1
    • R-mediated excitatory postsynaptic potential in hippocampal region CA1. Neurobiol. Aging. 18(4):1997;445-452.
    • (1997) Neurobiol. Aging , vol.18 , Issue.4 , pp. 445-452
    • Barnes, C.A.1    Rao, G.2    Shen, J.3
  • 4
    • 0026938051 scopus 로고
    • Region-specific are effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1
    • Barnes C.A., Rao G., Foster T.C., McNaughton B.L. Region-specific are effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1. Hippocampus. 2(4):1992;457-468.
    • (1992) Hippocampus , vol.2 , Issue.4 , pp. 457-468
    • Barnes, C.A.1    Rao, G.2    Foster, T.C.3    McNaughton, B.L.4
  • 5
    • 0026744863 scopus 로고
    • Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices
    • Bauman L.A., Mahle C.D., Boissard C.G., Gribkoff V.K. Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices. J. Neurophysiol. 68(2):1992;629-638.
    • (1992) J. Neurophysiol. , vol.68 , Issue.2 , pp. 629-638
    • Bauman, L.A.1    Mahle, C.D.2    Boissard, C.G.3    Gribkoff, V.K.4
  • 6
    • 0027476024 scopus 로고
    • A synaptic model of memory: Long-term potentiation in the hippocampus
    • Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361(6407):1993;31-39.
    • (1993) Nature , vol.361 , Issue.6407 , pp. 31-39
    • Bliss, T.V.P.1    Collingridge, G.L.2
  • 7
    • 0022997792 scopus 로고
    • The impact of recent stereological advances on quantitative studies of the nervous system
    • Braendgaard H., Gundersen H.J.G. The impact of recent stereological advances on quantitative studies of the nervous system. J. Neurosci. Methods. 18(1/2):1986;39-78.
    • (1986) J. Neurosci. Methods , vol.18 , Issue.1-2 , pp. 39-78
    • Braendgaard, H.1    Gundersen, H.J.G.2
  • 9
    • 0026316550 scopus 로고
    • Divergence of biological and chronological aging: Evidence from rodent studies
    • Collier T.J., Coleman P.D. Divergence of biological and chronological aging: evidence from rodent studies. Neurobiol. Aging. 12(6):1991;685-693.
    • (1991) Neurobiol. Aging , vol.12 , Issue.6 , pp. 685-693
    • Collier, T.J.1    Coleman, P.D.2
  • 10
    • 0032579934 scopus 로고    scopus 로고
    • Enhanced expression of AMPA receptor protein at perforated axospinous synapses
    • Desmond N.L., Weinberg R.J. Enhanced expression of AMPA receptor protein at perforated axospinous synapses. NeuroReport. 9(5):1998;857-860.
    • (1998) NeuroReport , vol.9 , Issue.5 , pp. 857-860
    • Desmond, N.L.1    Weinberg, R.J.2
  • 11
    • 0001909614 scopus 로고
    • Individual differences in hippocampal synaptic plasticity as a function of aging: Behavioral, electrophysiological and morphological evidence
    • Petit TL, Ivy GO, editors. New York: Liss;
    • deToledo-Morrell L, Geinisman Y, Morrell F. Individual differences in hippocampal synaptic plasticity as a function of aging: behavioral, electrophysiological and morphological evidence. In: Petit TL, Ivy GO, editors. Neural plasticity: a lifespan approach. New York: Liss; 1988. p. 283-328.
    • (1988) Neural Plasticity: A Lifespan Approach , pp. 283-328
    • Detoledo-Morrell, L.1    Geinisman, Y.2    Morrell, F.3
  • 12
    • 0027193830 scopus 로고
    • Age-related alterations in potentiation in the CA1 region in F344 rats
    • Deupree D.L., Bradley J., Turner D.A. Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol. Aging. 14(2):1993;249-258.
    • (1993) Neurobiol. Aging , vol.14 , Issue.2 , pp. 249-258
    • Deupree, D.L.1    Bradley, J.2    Turner, D.A.3
  • 13
    • 0029921194 scopus 로고    scopus 로고
    • Long-term potentiation and functional synapse induction in developing hippocampus
    • Durand G.M., Kovalchuk Y., Konners A. Long-term potentiation and functional synapse induction in developing hippocampus. Nature. 381(6577):1996;71-75.
    • (1996) Nature , vol.381 , Issue.6577 , pp. 71-75
    • Durand, G.M.1    Kovalchuk, Y.2    Konners, A.3
  • 14
    • 0018187970 scopus 로고
    • Organization of the mossy fiber system of the rat studied in extended hippocampi. I. Terminal area related to number of granule and pyramidal cells
    • Gaarskjaer F.B. Organization of the mossy fiber system of the rat studied in extended hippocampi. I. Terminal area related to number of granule and pyramidal cells. J. Comp. Neurol. 178(1):1978;49-72.
    • (1978) J. Comp. Neurol. , vol.178 , Issue.1 , pp. 49-72
    • Gaarskjaer, F.B.1
  • 15
    • 0024160442 scopus 로고
    • Spatial learning deficits in old rats: A model for memory decline in the aged
    • Gallagher M., Pelleymounter M.A. Spatial learning deficits in old rats: a model for memory decline in the aged. Neurobiol. Aging. 9(5/6):1988;549-556.
    • (1988) Neurobiol. Aging , vol.9 , Issue.5-6 , pp. 549-556
    • Gallagher, M.1    Pelleymounter, M.A.2
  • 16
    • 0030639472 scopus 로고    scopus 로고
    • The use of animal models to study the effects of aging on cognition
    • Gallagher M., Rapp P.R. The use of animal models to study the effects of aging on cognition. Annu. Rev. Psychol. 48:1997;339-370.
    • (1997) Annu. Rev. Psychol. , vol.48 , pp. 339-370
    • Gallagher, M.1    Rapp, P.R.2
  • 17
    • 0027214025 scopus 로고
    • Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze
    • Gallagher M., Burwell R., Burchinal M. Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav. Neurosci. 107(4):1993;618-626.
    • (1993) Behav. Neurosci. , vol.107 , Issue.4 , pp. 618-626
    • Gallagher, M.1    Burwell, R.2    Burchinal, M.3
  • 18
    • 0001056121 scopus 로고
    • Pairwise multiple comparison procedures with unequal n's and/or variances
    • Games P.A., Howell J.F. Pairwise multiple comparison procedures with unequal n's and/or variances. J. Educ. Stat. 1(1):1976;113-125.
    • (1976) J. Educ. Stat. , vol.1 , Issue.1 , pp. 113-125
    • Games, P.A.1    Howell, J.F.2
  • 19
    • 0346780703 scopus 로고    scopus 로고
    • Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities
    • Ganeshina O., Berry R.W., Petralia R.S., Nicholson D.A., Geinisman Y. Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities. J. Comp. Neurol. 468(1):2004;86-95.
    • (2004) J. Comp. Neurol. , vol.468 , Issue.1 , pp. 86-95
    • Ganeshina, O.1    Berry, R.W.2    Petralia, R.S.3    Nicholson, D.A.4    Geinisman, Y.5
  • 20
    • 0032747284 scopus 로고    scopus 로고
    • Age-related decline in memory function: Is it associated with a loss of synapses?
    • Geinisman Y. Age-related decline in memory function: is it associated with a loss of synapses? Neurobiol. Aging. 20(3):1999;353-356.
    • (1999) Neurobiol. Aging , vol.20 , Issue.3 , pp. 353-356
    • Geinisman, Y.1
  • 21
    • 0033797823 scopus 로고    scopus 로고
    • Structural synaptic modifications associated with hippocampal LTP and behavioral learning
    • Geinisman Y. Structural synaptic modifications associated with hippocampal LTP and behavioral learning. Cereb. Cortex. 10(10):2000;952-962.
    • (2000) Cereb. Cortex , vol.10 , Issue.10 , pp. 952-962
    • Geinisman, Y.1
  • 22
    • 0025935249 scopus 로고
    • Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities
    • Geinisman Y., deToledo-Morrell L., Morrell F. Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities. Brain Res. 566(1):1991;77-88.
    • (1991) Brain Res. , vol.566 , Issue.1 , pp. 77-88
    • Geinisman, Y.1    Detoledo-Morrell, L.2    Morrell, F.3
  • 23
    • 0028895747 scopus 로고
    • Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives
    • Geinisman Y., deToledo-Morrell L., Morrell F., Heller R.E. Hippocampal markers of age-related memory dysfunction: behavioral, electrophysiological and morphological perspectives. Prog. Neurobiol. 45(3):1995;223-252.
    • (1995) Prog. Neurobiol. , vol.45 , Issue.3 , pp. 223-252
    • Geinisman, Y.1    Detoledo-Morrell, L.2    Morrell, F.3    Heller, R.E.4
  • 24
    • 0030467291 scopus 로고    scopus 로고
    • Unbiased stereological estimation of the total number of synapses in a brain region
    • Geinisman Y., Gundersen H.J.G., Van der Zee E., West M.J. Unbiased stereological estimation of the total number of synapses in a brain region. J. Neurocytol. 25(12):1996;805-819.
    • (1996) J. Neurocytol. , vol.25 , Issue.12 , pp. 805-819
    • Geinisman, Y.1    Gundersen, H.J.G.2    Van Der Zee, E.3    West, M.J.4
  • 26
    • 84985187820 scopus 로고
    • Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson
    • Gundersen H.J.G. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microsc. (Lond.). 143(Pt 1):1986;3-45.
    • (1986) J. Microsc. (Lond.) , vol.143 , Issue.PT 1 , pp. 3-45
    • Gundersen, H.J.G.1
  • 27
    • 0028330166 scopus 로고
    • Dendritic spines: Structural specializations imparting both stability and flexibility to synaptic function
    • Harris K.M., Kater S.B. Dendritic spines: structural specializations imparting both stability and flexibility to synaptic function. Annu. Rev. Neurosci. 17:1994;341-371.
    • (1994) Annu. Rev. Neurosci. , vol.17 , pp. 341-371
    • Harris, K.M.1    Kater, S.B.2
  • 30
    • 0029162513 scopus 로고
    • Evidence for silent synapses: Implications for the expression of LTP
    • Isaac J.T.R., Nicoll R.A., Malenka R.C. Evidence for silent synapses: implications for the expression of LTP. Neuron. 15(2):1995;427-434.
    • (1995) Neuron , vol.15 , Issue.2 , pp. 427-434
    • Isaac, J.T.R.1    Nicoll, R.A.2    Malenka, R.C.3
  • 31
    • 0028845656 scopus 로고
    • A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus
    • Ishizuka N., Cowan W.M., Amaral D.G. A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus. J. Comp. Neurol. 362(1):1995;17-45.
    • (1995) J. Comp. Neurol. , vol.362 , Issue.1 , pp. 17-45
    • Ishizuka, N.1    Cowan, W.M.2    Amaral, D.G.3
  • 32
    • 0025935624 scopus 로고
    • Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging
    • Kerr D.S., Campbell L.W., Applegate M.D., Brodish A., Landfield P.W. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. J. Neurosci. 11(5):1991;1316-1324.
    • (1991) J. Neurosci. , vol.11 , Issue.5 , pp. 1316-1324
    • Kerr, D.S.1    Campbell, L.W.2    Applegate, M.D.3    Brodish, A.4    Landfield, P.W.5
  • 35
    • 0022558769 scopus 로고
    • 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats
    • 2+ ratios on frequency potentiation in hippocampal slices of young and aged rats. J. Neurophysiol. 56(3):1986;797-811.
    • (1986) J. Neurophysiol. , vol.56 , Issue.3 , pp. 797-811
    • Landfield, P.W.1    Pitler, T.A.2    Applegate, M.D.3
  • 36
    • 0029018512 scopus 로고
    • Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice
    • Liao D., Hessler N.A., Malinow R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature. 375(6530):1995;400-404.
    • (1995) Nature , vol.375 , Issue.6530 , pp. 400-404
    • Liao, D.1    Hessler, N.A.2    Malinow, R.3
  • 38
    • 0026089090 scopus 로고
    • Mechanisms underlying long-term potentiation of synaptic transmission
    • Madison D.V., Malenka R.C., Nicoll R.A. Mechanisms underlying long-term potentiation of synaptic transmission. Annu. Rev. Neurosci. 14:1991;379-397.
    • (1991) Annu. Rev. Neurosci. , vol.14 , pp. 379-397
    • Madison, D.V.1    Malenka, R.C.2    Nicoll, R.A.3
  • 39
    • 0033578855 scopus 로고    scopus 로고
    • Long-term potentiation - A decade of progress?
    • Malenka R.C., Nicoll R.A. Long-term potentiation - a decade of progress? Science. 285(5435):1999;1870-1874.
    • (1999) Science , vol.285 , Issue.5435 , pp. 1870-1874
    • Malenka, R.C.1    Nicoll, R.A.2
  • 40
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • Malinow R., Malenka R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25:2002;103-126.
    • (2002) Annu. Rev. Neurosci. , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 42
    • 0034042406 scopus 로고    scopus 로고
    • Synaptic plasticity and memory: An evaluation of the hypothesis
    • Martin S.J., Grimwood P.D., Morris R.G.M. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23:2000;649-711.
    • (2000) Annu. Rev. Neurosci. , vol.23 , pp. 649-711
    • Martin, S.J.1    Grimwood, P.D.2    Morris, R.G.M.3
  • 43
    • 0035046162 scopus 로고    scopus 로고
    • Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation
    • Montgomery J.M., Pavlidis P., Madison D.V. Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation. Neuron. 29(3):2001;691-701.
    • (2001) Neuron , vol.29 , Issue.3 , pp. 691-701
    • Montgomery, J.M.1    Pavlidis, P.2    Madison, D.V.3
  • 44
    • 0019957779 scopus 로고
    • Place navigation is impaired in rats with hippocampal lesions
    • Morris R.G.M., Garrud P., Rawlins N.J.P., O'Keefe J.O. Place navigation is impaired in rats with hippocampal lesions. Nature. 297(5868):1982;681-683.
    • (1982) Nature , vol.297 , Issue.5868 , pp. 681-683
    • Morris, R.G.M.1    Garrud, P.2    Rawlins, N.J.P.3    O'Keefe, J.O.4
  • 45
    • 0034662335 scopus 로고    scopus 로고
    • Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning
    • Moyer J.R. Jr., Power J.M., Thompson L.T., Disterhoft J.F. Increased excitability of aged rabbit CA1 neurons after trace eyeblink conditioning. J. Neurosci. 20(14):2000;5476-5482.
    • (2000) J. Neurosci. , vol.20 , Issue.14 , pp. 5476-5482
    • Moyer Jr., J.R.1    Power, J.M.2    Thompson, L.T.3    Disterhoft, J.F.4
  • 46
    • 0026437728 scopus 로고
    • Molecular diversity of glutamate receptors and implications for brain function
    • Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science. 258(5082):1992;597-603.
    • (1992) Science , vol.258 , Issue.5082 , pp. 597-603
    • Nakanishi, S.1
  • 47
    • 0032167980 scopus 로고    scopus 로고
    • Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus
    • Nusser Z., Lujan R., Laube G., Roberts J.D.B., Molnar E., Somogyi P. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron. 21(3):1998;545-559.
    • (1998) Neuron , vol.21 , Issue.3 , pp. 545-559
    • Nusser, Z.1    Lujan, R.2    Laube, G.3    Roberts, J.D.B.4    Molnar, E.5    Somogyi, P.6
  • 48
    • 0142027042 scopus 로고    scopus 로고
    • Watermaze learning enhances excitability of CA1 pyramidal neurons
    • Oh M.M., Kuo A.G., Wu W.W., Sametsky E.A., Disterhoft J.F. Watermaze learning enhances excitability of CA1 pyramidal neurons. J. Neurophysiol. 90(4):2003;2171-2179.
    • (2003) J. Neurophysiol. , vol.90 , Issue.4 , pp. 2171-2179
    • Oh, M.M.1    Kuo, A.G.2    Wu, W.W.3    Sametsky, E.A.4    Disterhoft, J.F.5
  • 50
    • 0033363480 scopus 로고    scopus 로고
    • Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses
    • Petralia R.S., Esteban J.A., Wang Y.X., Partridge J.G., Zhao H.M., Wenthold R.J.et al. Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses. Nat. Neurosci. 2(1):1999;31-36.
    • (1999) Nat. Neurosci. , vol.2 , Issue.1 , pp. 31-36
    • Petralia, R.S.1    Esteban, J.A.2    Wang, Y.X.3    Partridge, J.G.4    Zhao, H.M.5    Wenthold, R.J.6
  • 52
    • 0034175501 scopus 로고    scopus 로고
    • NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area
    • Racca C., Stephenson F.A., Streit P., Roberts J.D.B., Somogyi P. NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. J. Neurosci. 20(7):2000;2512-2522.
    • (2000) J. Neurosci. , vol.20 , Issue.7 , pp. 2512-2522
    • Racca, C.1    Stephenson, F.A.2    Streit, P.3    Roberts, J.D.B.4    Somogyi, P.5
  • 53
    • 0002938986 scopus 로고
    • Cognitive neuroscience perspectives on aging in nonhuman primates
    • Nakajima T, Ono T, editors. Tokyo: Japan Scientific Societies;
    • Rapp PR. Cognitive neuroscience perspectives on aging in nonhuman primates. In: Nakajima T, Ono T, editors. Emotion, memory and behavior. Tokyo: Japan Scientific Societies; 1995. p. 197-211.
    • (1995) Emotion, Memory and Behavior , pp. 197-211
    • Rapp, P.R.1
  • 54
    • 0026682533 scopus 로고
    • Individual differences in cognitive and neurobiological consequences of normal aging
    • Rapp P.R., Amaral D.G. Individual differences in cognitive and neurobiological consequences of normal aging. Trends Neurosci. 15(9):1992;340-345.
    • (1992) Trends Neurosci. , vol.15 , Issue.9 , pp. 340-345
    • Rapp, P.R.1    Amaral, D.G.2
  • 55
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp P.R., Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc. Natl. Acad. Sci. U.S.A. 93(18):1996;9926-9930.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , Issue.18 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 56
    • 0030053883 scopus 로고    scopus 로고
    • Memory impaired aged rats: No loss of principal hippocampal and subicular neurons
    • Rasmussen T., Schliemann T., Sorensen J.C., Zimmer J., West M.J. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol. Aging. 17(1):1996;143-147.
    • (1996) Neurobiol. Aging , vol.17 , Issue.1 , pp. 143-147
    • Rasmussen, T.1    Schliemann, T.2    Sorensen, J.C.3    Zimmer, J.4    West, M.J.5
  • 57
    • 0027453413 scopus 로고
    • Comparing age-related changes in the basal forebrain and hippocampus of the rhesus monkey
    • Rosene D.L. Comparing age-related changes in the basal forebrain and hippocampus of the rhesus monkey. Neurobiol. Aging. 14(6):1993;669-670.
    • (1993) Neurobiol. Aging , vol.14 , Issue.6 , pp. 669-670
    • Rosene, D.L.1
  • 58
    • 0037936789 scopus 로고    scopus 로고
    • Impact of aging on hippocampal function: Plasticity, network dynamics, and cognition
    • Rosenzweig E.S., Barnes C.A. Impact of aging on hippocampal function: plasticity, network dynamics, and cognition. Prog. Neurobiol. 69(3):2003;143-179.
    • (2003) Prog. Neurobiol. , vol.69 , Issue.3 , pp. 143-179
    • Rosenzweig, E.S.1    Barnes, C.A.2
  • 59
    • 0025826694 scopus 로고
    • Stereology: A method for analyzing images
    • Royet J.-P. Stereology: a method for analyzing images. Prog. Neurobiol. 37(5):1991;433-474.
    • (1991) Prog. Neurobiol. , vol.37 , Issue.5 , pp. 433-474
    • Royet, J.-P.1
  • 60
    • 0021918196 scopus 로고
    • Strain comparison of synaptic density in hippocampal CA1 of aged rats
    • Scheff S.W., Anderson K.J., DeKosky S.T. Strain comparison of synaptic density in hippocampal CA1 of aged rats. Neurobiol. Aging. 6(1):1985;29-34.
    • (1985) Neurobiol. Aging , vol.6 , Issue.1 , pp. 29-34
    • Scheff, S.W.1    Anderson, K.J.2    Dekosky, S.T.3
  • 61
    • 0037174634 scopus 로고    scopus 로고
    • Postsynaptic signaling and plasticity mechanisms
    • Sheng M., Kim M.J. Postsynaptic signaling and plasticity mechanisms. Science. 298(5594):2002;776-780.
    • (2002) Science , vol.298 , Issue.5594 , pp. 776-780
    • Sheng, M.1    Kim, M.J.2
  • 62
    • 0032531712 scopus 로고    scopus 로고
    • Three-dimensional structure and composition of CA3→CA1 axons in rat hippocampal slices: Implications for presynaptic connectivity and compartmentalization
    • Shepherd G.M.G., Harris K.M. Three-dimensional structure and composition of. CA3→CA1 axons in rat hippocampal slices: implications for presynaptic connectivity and compartmentalization J. Neurosci. 18(20):1998;8300-8310.
    • (1998) J. Neurosci. , vol.18 , Issue.20 , pp. 8300-8310
    • Shepherd, G.M.G.1    Harris, K.M.2
  • 63
    • 0034279244 scopus 로고    scopus 로고
    • Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairments in aged rats
    • Smith T.D., Adams M.M., Gallagher M., Morrison J.H., Rapp P.R. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairments in aged rats. J. Neurosci. 20(17):2000;6587-6593.
    • (2000) J. Neurosci. , vol.20 , Issue.17 , pp. 6587-6593
    • Smith, T.D.1    Adams, M.M.2    Gallagher, M.3    Morrison, J.H.4    Rapp, P.R.5
  • 64
    • 0027234184 scopus 로고
    • Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1
    • Sorra K.E., Harris K.M. Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1. J. Neurosci. 13(9):1993;3736-3748.
    • (1993) J. Neurosci. , vol.13 , Issue.9 , pp. 3736-3748
    • Sorra, K.E.1    Harris, K.M.2
  • 65
    • 0021234096 scopus 로고
    • The unbiased estimation of number and sizes of arbitrary particles using the dissector
    • Sterio D.C. The unbiased estimation of number and sizes of arbitrary particles using the dissector. J. Microsc. (Lond.). 134(Pt 2):1984;127-136.
    • (1984) J. Microsc. (Lond.) , vol.134 , Issue.PT 2 , pp. 127-136
    • Sterio, D.C.1
  • 66
    • 0342375000 scopus 로고    scopus 로고
    • Different models of expression of AMPA and NMDA receptors in hippocampal synapses
    • Takumi Y., Ramírez-León V., Laake P., Rinvik E., Ottersen O.P. Different models of expression of AMPA and NMDA receptors in hippocampal synapses. Nat. Neurosci. 2(7):1999;618-624.
    • (1999) Nat. Neurosci. , vol.2 , Issue.7 , pp. 618-624
    • Takumi, Y.1    Ramírez-León, V.2    Laake, P.3    Rinvik, E.4    Ottersen, O.P.5
  • 67
    • 0035452433 scopus 로고    scopus 로고
    • Total regional and global numbers of synapses in the human brain neocortex
    • Tang Y., Nyengaard J.R., De Groot D.M.G., Gundersen H.J.G. Total regional and global numbers of synapses in the human brain neocortex. Synapse. 41(3):2001;258-273.
    • (2001) Synapse , vol.41 , Issue.3 , pp. 258-273
    • Tang, Y.1    Nyengaard, J.R.2    De Groot, D.M.G.3    Gundersen, H.J.G.4
  • 68
    • 0000462603 scopus 로고
    • I fatti I le induzione nell'odierna istologia del sistema nervoso
    • Tanzi E. I fatti I le induzione nell'odierna istologia del sistema nervoso. Riv. Sperim. Freniatr. Med. Leg. 19:1893;419-472.
    • (1893) Riv. Sperim. Freniatr. Med. Leg. , vol.19 , pp. 419-472
    • Tanzi, E.1
  • 70
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • West M.J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging. 14(4):1993;287-293.
    • (1993) Neurobiol. Aging , vol.14 , Issue.4 , pp. 287-293
    • West, M.J.1
  • 71
    • 0029744424 scopus 로고    scopus 로고
    • Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rats
    • Woolley C.S., Wenzel H.J., Schwartzkroin P.A. Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rats. J. Comp. Neurol. 373(1):1996;108-117.
    • (1996) J. Comp. Neurol. , vol.373 , Issue.1 , pp. 108-117
    • Woolley, C.S.1    Wenzel, H.J.2    Schwartzkroin, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.